I-TASSER results

I-TASSER results for job id Rv2307c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (281 residues)
MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQ
DGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNP
GRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPF
TSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAA
AEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEHCCCCCEEEEEEHCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCHHHHHHHHHCCCCCEEEEHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEEHCCCCCCCHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
Conf.Score	98646799999999999999999999999987434799999998577588868999997999889999995899999859999879999988999999999999997999879998899998654549999999999999985999974999998566899999997789878999689898999999977776578888757895888875999889998589987899999999999599978999889987654335879999999999999864689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ
Prediction	45233331120022123333221111122022001204435244365334523403040634240100002158754210000020101102100400320272400000000001242714221400120030004002632715653200000010000001002533010000000120023003430221001300244040263067051340311145451121610441063167513101044031020233446402521564274234368
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCEEEEEHCCCCCEEEEEEHCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCHHCHHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCHHHHHHHHHCCCCCEEEEHCCCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHCCCCEEEEEHCCCCCCCHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
MSLKRCRALPVVAIVALVASGVIMFIWSQQRRLIYFPSAGPVPSASSVLPAGRDVVVETQDGMRLGGWYFPHTSGGSGPAVLVCNGNAGDRSMRAELAVALHGLGLSVLLFDYRGYGGNPGRPSEQGLAADARAAQEWLSGQSDVDPARIAYFGESLGAAVAVGLAVQRPPAALVLRSPFTSLAEVGAVHYPWLPLRRLLLDHYPSIERIASVHAPVLVIAGGSDDIVPATLSERLVAAAAEPKRYVVVPGVGHNDPELLDGRVMLDAIRRFLTETAVLGQ

5cmlA

0.22

0.17

0.78

2.03

MUSTER

-------------------------------------------------MQIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCFTCSLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYEPP---ALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHRPFRIKKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRY--VG-

5cmlA

0.22

0.17

0.78

3.33

dPPAS

-------------------------------------------------MQIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCFSKNLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYEPP---ALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHLLRPALKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRYVG---

5cmlA

0.22

0.17

0.78

2.80

wdPPAS

-------------------------------------------------MQIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCCSKNLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYEPP---ALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHLLRPALKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRYVG---

5cmlA

0.22

0.17

0.77

2.42

wMUSTER

--------------------------------------------------QIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCFTCSLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYEPP---ALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHRPFRIKKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRY--VG-

5cmlA

0.22

0.17

0.78

2.77

wPPAS

-------------------------------------------------MQIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCFSKNLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYE---PPALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHLLRPALKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRYVG---

5cmlA

0.22

0.17

0.78

4.58

dPPAS2

-------------------------------------------------MQIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCFSKNLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYEPP---ALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHLLRPALKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRYVG---

5cmlA

0.22

0.17

0.78

2.59

PPAS

-------------------------------------------------MQIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCFSKNLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYEPP---ALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHLLRPALKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRY--VG-

5cmlA

0.22

0.17

0.78

3.21

Env-PPAS

-------------------------------------------------MQIKTVTFENNRGERLAARLDLPVDTQPVAYALFAHCFSKNLKAVTTISRALTTQGYAVLRFDFTGLGATN--------FEDLRAACRFLSAQYEPP---ALLIGHSLGGAAVLAVAGEFPVKAVATIGAPCDPAHVRHLLRPALKQFLEELERVNLEDQVRTMRRPLLLFHSPTDQIVGIENAACLFQAARHPKSFVSLDQADHLLSNSDDAAFVGEVLGAWARRY--VG-

2wtnB

0.19

0.15

0.79

1.90

MUSTER

----------------------------------------------------GAMYIDC-DGIKLNAYLDPKNNPEKCPLCIIIHGFTGHSRHIVAVQETLNEIGVATLRADMYGHGKSDGKFEDHTWLTNILAVVDYAKKLDFVT--DIYMAGHSQGGLSVMLAAAMERIKALIPLSPAAMIPEIARTGRKLKGNYVRVAQTIRVEDFVDKYTKPVLIVHGDQDEAVPYEASVAFSKQYK-NCKLVTIPGDTHC--YDHHLELVTEAVKEFMLEQIAK--

3trdA

0.23

0.16

0.72

3.04

dPPAS

----------------------------------------------SYVMTNEDFLIQGPVG-QLEVMITRPKGIEKSVTGIICHGGTMNNKVVTTLAKALDELGLKTVRFNFRGVGKSQGRYDNVGEVEDLKAVLRWVEHHW--SQDDIWLAGFSFGAYISAKVAYDQKVAQLISVAPPVFYEGFAS---------------------LTQMASPWLIVQGDQDEVVPFEQVKAFVNQISSPVEFVVMSGASH--FFHGRLIELRELLVRNLA-------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.02

Estimated TM-score = 0.47±0.15

Estimated RMSD = 10.7±4.6Å

Download Model 2

C-score=-2.74

Download Model 3

C-score=-2.68

Download Model 4

C-score=-2.61

Download Model 5

C-score=-3.18

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cmlA	0.754	1.17	0.216	0.776
2	3fvrA	0.711	4.02	0.191	0.907
3	3pf8A	0.711	2.52	0.215	0.794
4	2wtnB	0.708	2.34	0.177	0.783
5	1vlqL	0.695	3.86	0.187	0.875
6	4z8zA	0.692	3.41	0.120	0.840
7	5l8sA2	0.689	3.31	0.198	0.822
8	4h18A	0.689	3.59	0.091	0.851
9	1ve6A	0.688	3.26	0.166	0.815
10	1thtA	0.687	3.01	0.164	0.801

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.25	11	1iuoA	ACT	Rep, Mult	86,156,157,189,227,254
2	0.09	4	4uhdA	ACT	Rep, Mult	85,86,156,157,254
3	0.06	3	3pfbB	ZYC	Rep, Mult	86,87,89,155,156,157,180,183,186,193,197,254
4	0.04	2	2xmgA	UUU	Rep, Mult	131,135,138,139,152
5	0.04	2	3djyA	UUU	Rep, Mult	120,121,122,124,125
6	0.02	1	3muoA	ZPR	Rep, Mult	83,108,153,155,156,178,254,266,270
7	0.02	1	3pfcA	NA	Rep, Mult	224,225,226,227,253,254
8	0.02	1	3pfcA	NA	Rep, Mult	163,174,176
9	0.02	1	3fytC	XYP	Rep, Mult	83,88,97

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.351	1i6wB	0.506	2.92	0.161	0.584	3.1.1.3	156,225,254
2	0.300	3cn7A	0.553	3.21	0.186	0.648	3.1.1.1	156,225,254
3	0.288	2ocgA	0.650	3.11	0.182	0.762	3.1.-.-	156,158,162,218,225,228,254
4	0.283	1auoA	0.569	3.26	0.186	0.665	3.1.1.1	156,225,254
5	0.237	3fcxB	0.659	3.37	0.125	0.797	3.1.2.12	254
6	0.188	1vkhA	0.620	3.52	0.137	0.754	3.5.1.9	NA
7	0.173	2h1iA	0.539	3.46	0.186	0.658	3.1.1.1	89,156,179
8	0.115	1thtA	0.687	3.01	0.164	0.801	2.3.1.-	156,254
9	0.112	2d5lA	0.680	3.20	0.159	0.804	3.4.14.-	156,225,254
10	0.085	1j1iA	0.634	3.20	0.181	0.733	3.7.1.8	86,88,156
11	0.085	1fj2A	0.585	3.44	0.142	0.701	3.1.4.39	NA
12	0.079	1va4A	0.643	3.00	0.190	0.747	3.1.1.2	111,156
13	0.076	1dinA	0.591	3.27	0.161	0.719	3.1.1.45	225
14	0.075	1a8qA	0.647	2.99	0.161	0.751	1.11.1.10	156,226
15	0.063	1e5tA	0.672	3.57	0.114	0.822	3.4.21.26	156,225,254
16	0.060	1zd3A	0.661	3.20	0.119	0.783	3.3.2.10	NA
17	0.060	2fj0A	0.665	3.92	0.136	0.829	3.1.1.1	NA
18	0.060	1thgA	0.665	3.79	0.117	0.829	3.1.1.3	NA
19	0.060	1vj5A	0.658	3.25	0.119	0.783	3.3.2.10,3.3.2.3	154
20	0.060	1gz7C	0.669	3.86	0.120	0.836	3.1.1.3	NA
21	0.060	1vlqA	0.704	3.93	0.189	0.886	3.1.1.41	225,254
22	0.060	2pm8A	0.668	3.83	0.113	0.836	3.1.1.8	NA
23	0.060	1maaD	0.668	3.71	0.132	0.826	3.1.1.7	NA
24	0.060	1eveA	0.667	3.81	0.107	0.836	3.1.1.7	NA
25	0.060	1cleA	0.668	3.92	0.120	0.836	3.1.1.3	NA
26	0.060	1ivyA	0.686	3.25	0.152	0.811	3.4.16.5	NA
27	0.060	1b41A	0.665	3.76	0.140	0.829	3.1.1.7	NA
28	0.060	1k8qA	0.676	3.11	0.154	0.790	3.1.1.3	254
29	0.060	3nwoA	0.659	3.13	0.189	0.772	3.4.11.5	156
30	0.060	3hjuA	0.691	2.96	0.195	0.801	3.1.1.23	117,156
31	0.060	2veoB	0.660	3.66	0.092	0.822	3.1.1.3	115,165

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.711	2.52	0.21	0.79	3pf8A	GO:0016787
1	0.32	0.660	3.02	0.17	0.77	4x00A	GO:0016787
2	0.32	0.711	4.02	0.19	0.91	3fvrA	GO:0008126 GO:0016787
3	0.28	0.655	3.04	0.22	0.76	1q0rA	GO:0016787 GO:0017000 GO:0052689
4	0.26	0.709	3.95	0.18	0.90	1l7aA	GO:0000272 GO:0005737 GO:0005975 GO:0016787 GO:0030245 GO:0046555 GO:0047739 GO:0052689
5	0.26	0.653	2.61	0.20	0.74	2fukA	GO:0016787
6	0.26	0.659	3.09	0.16	0.78	4rncA	GO:0016787 GO:0052689
7	0.24	0.610	2.70	0.18	0.70	1imjA	GO:0005634 GO:0005730 GO:0005737 GO:0005829 GO:0016787 GO:0045944 GO:0050427 GO:0070062
8	0.24	0.662	3.40	0.14	0.80	4wy5A	GO:0008152 GO:0016787 GO:0052689
9	0.24	0.691	2.96	0.20	0.80	3hjuA	GO:0004622 GO:0005654 GO:0005737 GO:0005789 GO:0005829 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0006954 GO:0009966 GO:0016020 GO:0016042 GO:0016787 GO:0019369 GO:0019433 GO:0019898 GO:0036155 GO:0042803 GO:0046464 GO:0047372 GO:0050727 GO:0051930 GO:0052689 GO:2000124
10	0.23	0.654	3.15	0.16	0.77	4f0jA	GO:0003824 GO:0016787
11	0.23	0.667	3.17	0.17	0.79	4opmA	GO:0004806 GO:0016787
12	0.23	0.668	3.35	0.17	0.81	4bzwA	GO:0008152 GO:0016787 GO:0042802
13	0.22	0.666	3.87	0.18	0.83	5hfnD	GO:0000272 GO:0005509 GO:0005737 GO:0005975 GO:0005976 GO:0008152 GO:0016787 GO:0030245 GO:0046555 GO:0046872 GO:0047739 GO:0052689
14	0.19	0.581	3.27	0.22	0.69	4fhzA	GO:0016787
15	0.19	0.634	3.20	0.18	0.73	1j1iA	GO:0016787
16	0.17	0.652	3.09	0.16	0.77	4qesA	GO:0003723 GO:0003824 GO:0004601 GO:0005198 GO:0005576 GO:0005654 GO:0005829 GO:0005886 GO:0016020 GO:0016032 GO:0016491 GO:0017000 GO:0019012 GO:0019061 GO:0019062 GO:0019064 GO:0019065 GO:0019068 GO:0019070 GO:0019072 GO:0019076 GO:0019083 GO:0030666 GO:0030683 GO:0031904 GO:0039573 GO:0039660 GO:0042025 GO:0046761 GO:0055036 GO:0055114 GO:0075733 GO:0098869
17	0.12	0.630	2.71	0.20	0.72	2i3dB	GO:0016787
18	0.11	0.703	3.91	0.19	0.89	3m83A	GO:0000272 GO:0005509 GO:0005737 GO:0005975 GO:0005976 GO:0008152 GO:0016787 GO:0030245 GO:0046555 GO:0046872 GO:0047739 GO:0052689
19	0.11	0.686	3.79	0.16	0.87	3fcyA
20	0.10	0.706	2.40	0.17	0.79	2wtmA
21	0.10	0.685	3.54	0.15	0.82	4zwnB	GO:0005737 GO:0005739 GO:0005741 GO:0005783 GO:0005811 GO:0006641 GO:0009966 GO:0016020 GO:0016787 GO:0019433 GO:0047372
22	0.09	0.652	3.09	0.17	0.77	2og1A	GO:0003824 GO:0016787 GO:0016823 GO:0018771 GO:0018774 GO:0019439
23	0.09	0.660	3.54	0.14	0.81	2y6vC	GO:0004806 GO:0005777 GO:0005782 GO:0007031 GO:0016298 GO:0016787 GO:0019433
24	0.09	0.676	3.11	0.15	0.79	1k8qA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787 GO:0016788
25	0.09	0.639	2.44	0.22	0.72	3trdA	GO:0016787
26	0.09	0.650	3.11	0.18	0.76	2ocgA	GO:0005739 GO:0005741 GO:0006520 GO:0006805 GO:0009636 GO:0016787 GO:0047658 GO:0070062
27	0.09	0.672	3.20	0.17	0.79	1hlgA	GO:0004806 GO:0005576 GO:0005739 GO:0006108 GO:0006629 GO:0006641 GO:0008289 GO:0016042 GO:0016615 GO:0016787 GO:0016788 GO:0055114
28	0.08	0.643	3.02	0.19	0.75	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
29	0.08	0.646	3.18	0.17	0.76	4dgqA	GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
30	0.08	0.647	2.99	0.16	0.75	1a8qA	GO:0003824 GO:0004601 GO:0016491 GO:0017000 GO:0055114 GO:0098869
31	0.08	0.640	3.06	0.16	0.75	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
32	0.07	0.641	3.01	0.15	0.75	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
33	0.07	0.658	3.47	0.15	0.80	4n5hX	GO:0008152 GO:0016787
34	0.07	0.660	3.02	0.14	0.77	3fnbA	GO:0004252 GO:0006508

Consensus prediction of GO terms

Molecular Function	GO:0019213	GO:0008126
GO-Score	0.53	0.32
Biological Processes	GO:0016999	GO:0044249	GO:0030243	GO:0051275
GO-Score	0.56	0.56	0.53	0.53
Cellular Component	GO:0044424
GO-Score	0.53

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.