I-TASSER results

I-TASSER results for job id Rv2303c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (307 residues)
MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTISAEQFGAYAESLR
RTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNASVAAVAARYPDRFLPFAGADILA
GDSAVDEFERWVVEHGFRGLSLRPFMIGRPASDPAYFPCYAKCVELGVPVSIHTSADWTR
TRLSDLGHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLELAAHRPKYFA
SPGAGWEPLMRFGQTTIRNKIVYGTGGFLINRPYLQLCDEMRALPVPREVLEDWLWRNAT
RVLRLDT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTISAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNASVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRPFMIGRPASDPAYFPCYAKCVELGVPVSIHTSADWTRTRLSDLGHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLELAAHRPKYFASPGAGWEPLMRFGQTTIRNKIVYGTGGFLINRPYLQLCDEMRALPVPREVLEDWLWRNATRVLRLDT
Prediction	CCCCCCCCCEEEEEEHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHCCCHHHHHHHHHHHCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEHCCCCHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
Conf.Score	9988887768999865588864566666557677888877765456765554555676569999999999998998999957898755446677699999999988997999986799886999999999999989959998588888899998999999999998995999689999888765558888999999989999599977988679999999985998689855677655567777689999999996977667756899999979999999998799999999999799999989999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTISAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNASVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRPFMIGRPASDPAYFPCYAKCVELGVPVSIHTSADWTRTRLSDLGHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLELAAHRPKYFASPGAGWEPLMRFGQTTIRNKIVYGTGGFLINRPYLQLCDEMRALPVPREVLEDWLWRNATRVLRLDT
Prediction	8637456020000000001463214302430244014204414443243640442364242214300520473501200000122632341022003200300562241000000000420540041024007524010000002233130224102300410372600000000111233211310102200300441250200000001000210020036143010000022342024432114002300420256234230400114320440041057170456216441462137556878
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCEEEEEEHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHCCCCHHHHCCCHHHHHHHHHHHCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEHCCCCHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
MTAPEPRVPVIDMWAPFVPSAEVIDDLREGFPVELLSYFEVFTKTTISAEQFGAYAESLRRTDDQILDSLDDAGITRSLITGFDERSTCGVTFVHNASVAAVAARYPDRFLPFAGADILAGDSAVDEFERWVVEHGFRGLSLRPFMIGRPASDPAYFPCYAKCVELGVPVSIHTSADWTRTRLSDLGHPRHIDDVACRFPELTILMSHGGYPWVLQACLIAWKHPNVYLELAAHRPKYFASPGAGWEPLMRFGQTTIRNKIVYGTGGFLINRPYLQLCDEMRALPVPREVLEDWLWRNATRVLRLDT

3irsA

0.24

0.21

0.90

2.34

MUSTER

-------LKIIDFRLRPPAMGFLNARIYTR-PDIRNRFTRQLG--------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSV---LGSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDL--IRIVNLEPGVWPMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGPD--ITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDMYLYNL-----PGHADFIQAANSFLADRMLFGTAYPMC--PLKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

3irsA

0.24

0.22

0.91

3.39

dPPAS

-------LKIIDFRLR--PPAMGFLNARIYTRPDIRNRFTRQLG-------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSVL---GSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDLG-IRIVNLEPWATPMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGPD--ITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDMYL-----YNLPGHADFIQAANSFLADRMLFGTAYPMCP--LKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

3irsA

0.23

0.21

0.90

3.86

wdPPAS

-------LKIIDFRLRPPAMGFLNARIYTR--PDIRNRFTRQLG-------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSVL---GSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDL--IRIVNLEPWATPMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGPD--ITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDMYLYN-----LPGHADFIQAANSFLADRMLFGTAYPMCP--LKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

3irsA

0.24

0.21

0.90

2.93

wMUSTER

--------KIIDFRLRPPAMGFLNARIYTR-PDIRNRFTRQLG--------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSV---LGSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDL--IRIVNLEPGVWPMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGPD--ITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDM-----YLYNLPGHADFIQAANSFLADRMLFGTAYPMC--PLKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

3irsA

0.23

0.21

0.90

3.97

wPPAS

-------LKIIDFRLRPPAMGFLNARIYTR--PDIRNRFTRQLG-------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSV---LGSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDL--IRIVNLEPGVWPMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGPD--ITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDMYLYNL-----PGHADFIQAANSFLADRMLFGTAYPMCP--LKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

3irsA

0.24

0.22

0.91

6.85

dPPAS2

-------LKIIDFRLR--PPAMGFLNARIYTRPDIRNRFTRQLG-------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSVL---GSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDLG-IRIVNLEPWATPMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGPD--ITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDMYL-----YNLPGHADFIQAANSFLADRMLFGTAYPMCP--LKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

3irsA

0.25

0.22

0.90

3.47

PPAS

-------LKIIDFRLR--PPAMGFLNARIYTRPDIRNRFTRQLG-------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSVL---GSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDL--IRIVNLEPWATPMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGP--DITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDMYLYNL-----PGHADFIQAANSFLADRMLFGTAYPMCP--LKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

3irsA

0.25

0.22

0.91

4.46

Env-PPAS

-------LKIIDFRLR--PPAMGFLNARIYTRPDIRNRFTRQLG-------FEPAPSAEEKSLELMFEEMAAAGIEQGVCVGRNSSV---LGSVSNADVAAVAKAYPDKFHPVGSIEAATRKEAMAQMQEILDLG-IRIVNLEPGVWAMHVDDRRLYPLYAFCEDNGIPVIMMTGGNAGP--DITYTNPEHIDRVLGDFPDLTVVSSHGNWPWVQEIIHVAFRRPNLYLSPDMYLYNL-----PGHADFIQAANSFLADRMLFGTAYPMC--PLKEYTEWFLTLPIKPDAMEKILHGNAERLLAQAG

4l5pA

0.17

0.97

2.12

MUSTER

------SLRLIATEEAVTFQPVVDALRAHSRTDDASLDMILVRDVYGDEPARPAMIGRLSDVTGERLAEMDSNGVDMHLLSLFDAETGTRLARIANDLMAQTVAANPTRFAGLGTFAPQDPASAAREIERVATQLRLNGLVINSHTNDLYYDDPFFHPVFEAIEASGLALYIHPRAPSKQIDFRDYGMRMILSGLFDRFPRLKIVLGHMGEPFWLWRLDYMHGNATTFGGAPKLKLKAITSGVESHAALRYSIEVLGPENVMWAIDYPYQP--MAPAVQFIRTAPIPEDVKAMVAGGNAARIFRIT-

4l5pA

0.16

0.97

3.18

dPPAS

------SLRLIATEEAVTFQPVVDALRAHSRTDDASLDMILVRDVYGDEPARPAMIGRLSDVTGERLAEMDSNGVDMHLLSLTAPGVQTRLARIANDLMAQTVAANPTRFAGLGTFAPQDPASAAREIERVATQLRLNGLVINSHTNDLYYDDPFFHPVFEAIEASGLALYIHPRAPSKQIDRAFRDYRMILSGLFDRFPRLKIVLGHMGEPFWLWRLDYMHGNATTFGGAPKLKLKITTSGVESHAALRYSIEVLGPENVMWAIDYPYQP--MAPAVQFIRTAPIPEDVKAMVAGGNAARIFRIT-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.53

Estimated TM-score = 0.78±0.09

Estimated RMSD = 5.1±3.3Å

Download Model 2

C-score=-1.66

Download Model 3

C-score=-0.55

Download Model 4

C-score=-4.41

Download Model 5

C-score=-2.11

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3irsA	0.877	1.27	0.237	0.905
2	4infA	0.739	3.55	0.170	0.902
3	2dvtA	0.734	3.29	0.183	0.873
4	4l5pA	0.727	3.68	0.176	0.886
5	4hjwA	0.726	3.96	0.140	0.909
6	2f6kA	0.722	3.47	0.165	0.866
7	4b90A	0.716	3.63	0.101	0.873
8	4dziA	0.714	4.09	0.148	0.922
9	2vr2A	0.714	3.68	0.112	0.873
10	1gkqA	0.712	3.67	0.109	0.870

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.45	37	2hbvA	ZN	Rep, Mult	14,16,173,208,266
2	0.10	7	4kirB	MN	Rep, Mult	14,141,143,173,208,266
3	0.06	5	2dvxC	23A	Rep, Mult	16,173,266,269

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.194	2wm1A	0.710	3.82	0.191	0.870	4.1.1.45	228,260
2	0.104	2wjfA	0.571	3.91	0.104	0.720	3.1.3.48	NA
3	0.082	2v81A	0.481	3.87	0.103	0.622	4.1.2.21	NA
4	0.080	1vlwB	0.473	3.94	0.143	0.616	4.1.3.16	NA
5	0.074	2fliC	0.501	3.95	0.085	0.648	5.1.3.1	NA
6	0.067	3ngfA	0.561	3.96	0.080	0.726	5.3.1.22	NA
7	0.067	1dvjA	0.546	3.99	0.079	0.697	4.1.1.23	NA
8	0.067	2cz5A	0.507	3.91	0.089	0.658	4.1.1.23	NA
9	0.067	1tqjC	0.494	4.22	0.115	0.661	5.1.3.1	NA
10	0.067	2czfA	0.502	4.03	0.084	0.661	4.1.1.23	146,172
11	0.066	1l6wA	0.489	3.67	0.077	0.606	4.1.2.-	NA
12	0.066	3ct7A	0.492	4.03	0.056	0.638	5.1.3.-	NA
13	0.066	1vqtA	0.465	4.03	0.074	0.603	4.1.1.23	NA
14	0.066	1h1yA	0.502	4.19	0.078	0.668	5.1.3.1	NA
15	0.066	1h1yB	0.502	4.26	0.073	0.671	5.1.3.1	NA
16	0.060	1zzmA	0.642	3.26	0.107	0.759	3.1.21.-	265
17	0.060	2ftwA	0.710	3.70	0.120	0.870	3.5.2.2	NA
18	0.060	3dc8A	0.705	3.70	0.109	0.860	3.5.2.2	NA
19	0.060	2vr2A	0.714	3.68	0.112	0.873	3.5.2.2	265
20	0.060	1onxA	0.674	3.63	0.138	0.821	3.4.19.-	NA
21	0.060	2z00A	0.680	3.57	0.145	0.831	3.5.2.3	192
22	0.060	3iacA	0.659	4.53	0.084	0.896	5.3.1.12	274
23	0.060	2vc7B	0.641	4.00	0.113	0.808	3.1.8.1	NA
24	0.060	1gkpA	0.716	3.61	0.105	0.870	3.5.2.2	265
25	0.060	3griB	0.666	3.59	0.100	0.814	3.5.2.3	126
26	0.060	3d6nA	0.684	3.60	0.118	0.831	3.5.2.3	265
27	0.060	2zc1A	0.651	3.86	0.090	0.801	3.1.8.1	142
28	0.060	2z26A	0.668	3.43	0.119	0.808	3.5.2.3	NA
29	0.060	2uz9A	0.633	4.31	0.086	0.834	3.5.4.3	NA
30	0.060	1gkrA	0.689	3.62	0.113	0.837	3.5.2.2	NA
31	0.060	1ybqA	0.675	3.61	0.127	0.818	3.4.19.1	82,84
32	0.060	1k1dA	0.703	3.73	0.104	0.866	3.5.2.-	NA
33	0.060	1a4lA	0.644	4.58	0.080	0.863	3.5.4.4	208
34	0.060	1m7jA	0.660	3.87	0.091	0.821	3.5.1.81	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.682	2.51	0.16	0.77	3cjpA	GO:0016787 GO:0046872
1	0.29	0.735	3.36	0.18	0.88	4qroA	GO:0016787 GO:0046872
2	0.28	0.711	3.73	0.18	0.87	4ofcA	GO:0001760 GO:0005829 GO:0006568 GO:0006569 GO:0008270 GO:0016787 GO:0016829 GO:0016831 GO:0046872 GO:0046874 GO:0051259 GO:0070062 GO:1904984 GO:1905004 GO:1905012
3	0.28	0.716	4.25	0.14	0.93	4dziC	GO:0016787
4	0.27	0.729	3.97	0.14	0.91	4hjwC	GO:0001760 GO:0006568 GO:0016787 GO:0046872 GO:1904984
5	0.27	0.704	3.77	0.13	0.86	4eraA	GO:0001760 GO:0006568 GO:0016787 GO:0046872 GO:1904984
6	0.25	0.724	3.66	0.18	0.88	4icmA	GO:0016787 GO:0046872
7	0.25	0.725	3.82	0.17	0.90	4hk5D	GO:0001760 GO:0006568 GO:0016787 GO:0046872 GO:1904984
8	0.23	0.740	3.54	0.17	0.90	4qrnA	GO:0016787 GO:0046872
9	0.22	0.699	3.68	0.14	0.87	3ij6A	GO:0016787 GO:0046872
10	0.20	0.877	1.27	0.24	0.91	3irsA	GO:0016787
11	0.13	0.734	3.29	0.18	0.87	2dvtA	GO:0016787 GO:0046872
12	0.13	0.731	3.41	0.16	0.87	2f6kA	GO:0016787 GO:0046872
13	0.11	0.677	3.82	0.18	0.83	2gwgA	GO:0016787 GO:0046872
14	0.10	0.694	3.40	0.17	0.83	3nurA	GO:0016787
15	0.07	0.679	3.43	0.12	0.81	2vunA	GO:0016787 GO:0016810 GO:0043792 GO:0046872 GO:0051187
16	0.07	0.525	4.06	0.06	0.68	2gsjA
17	0.07	0.493	4.00	0.07	0.65	3ve7A	GO:0003824 GO:0004590 GO:0006207 GO:0008152 GO:0016829
18	0.06	0.373	6.73	0.06	0.64	2vn4A
19	0.06	0.357	6.49	0.05	0.61	1u2vC	GO:0003779 GO:0005200 GO:0005737 GO:0005829 GO:0005856 GO:0005885 GO:0005925 GO:0015629 GO:0030833 GO:0034314 GO:0051015 GO:0070062
20	0.06	0.362	5.22	0.08	0.53	1e3wD	GO:0001540 GO:0003857 GO:0004303 GO:0005496 GO:0005739 GO:0007569 GO:0008033 GO:0016491 GO:0018454 GO:0030283 GO:0030331 GO:0033327 GO:0042802 GO:0047015 GO:0051287 GO:0051289 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0016787	GO:0046914	GO:0001760
GO-Score	0.81	0.56	0.47
Biological Processes	GO:1901606	GO:1905003	GO:0090357	GO:0030808	GO:1902688	GO:0006461	GO:0009074	GO:0046218	GO:0034354	GO:1904984
GO-Score	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.47
Cellular Component	GO:0031988	GO:1903561	GO:0044444
GO-Score	0.56	0.56	0.56

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.