I-TASSER results

Input Sequence in FASTA format

>protein (323 residues)
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYG
LGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPN
PVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDAL
EDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATL
RAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAA
RAFRPVSTGRFLTDMVREKVSRR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR
Prediction	CCEEHCCCCCCCCEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEHCCCCCCCCCCHHHHHHHHHCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
Conf.Score	97687799886444336888889988888888999999999999999899835557788999747799999857787489997677889999999999999999879987888665578999996999999999999899548986689999999999986887678754568665665589999999999979985888788877877899988875568998888999999999999999999989999999999999899867678999999999999985775899999999999875688999888799999987569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR
Prediction	86416126544011000000010233112245233720240031001020100000000142300300040046325400000000123331510150024006215001000000000137020110040044016302020000000315001302621722000001100011141042002103625000000122120100021357454533144244134501630250052036007637031000000000436400000103326104300411715036611530350065265142511326215533668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCCCCCCCEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEHCCCCCCCCCCHHHHHHHHHCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEHCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
MKYLDVDGIGQVSRIGLGTWQFGSREWGYGDRYATGAARDIVKRARALGVTLFDTAEIYGLGKSERILGEALGDDRTEVVVASKVFPVAPFPAVIKNRERASARRLQLNRIPLYQIHQPNPVVPDSVIMPGMRDLLDSGDIGAAGVSNYSLARWRKADAALGRPVVSNQVHFSLAHPDALEDLVPFAELENRIVIAYSPLAQGLLGGKYGLENRPGGVRALNPLFGTENLRRIEPLLATLRAIAVDVDAKPAQVALAWLISLPGVVAIPGASSVEQLEFNVAAADIELSAQSRDALTDAARAFRPVSTGRFLTDMVREKVSRR

3n2tA

0.27

0.25

0.96

3.72

MUSTER

SDTIRIPGIDPLSRVALGTWAIGGW---MWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILARH---VPNPIDPTFMA------

3n2tA

0.27

0.26

0.95

6.86

dPPAS

SDTIRIPGIDPLSRVALGTWAIGGW---MWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILARHVPPIDPTFMA----------

3n2tA

0.27

0.25

0.96

6.24

wdPPAS

SDTIRIPGIDPLSRVALGTWAIGG---WMWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILARH---VPNPIDPTFMA------

3n2tA

0.27

0.25

0.96

4.20

wMUSTER

SDTIRIPGIDPLSRVALGTWAIGGW---MWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILARH---VPNPIDPTFMA------

3n2tA

0.27

0.25

0.96

4.31

wPPAS

SDTIRIPGIDPLSRVALGTWAIGG---WMWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILARH---VPNPIDPTFMA------

3n2tA

0.27

0.25

0.96

7.03

dPPAS2

SDTIRIPGIDPLSRVALGTWAIGGW---MWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILARH---VPNPIDPTFMA------

3n2tA

0.27

0.25

0.96

4.17

PPAS

SDTIRIPGIDPLSRVALGTWAIGG---WMWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILAR---HVPNPIDPTFMA------

3n2tA

0.27

0.25

0.96

5.64

Env-PPAS

SDTIRIPGIDPLSRVALGTWAIG---GWMWGGPDDDNGVRTIHAALDEGINLIDTAPVYGFGHSEEIVGRALAEKPNKAHVATKLGFRDSRPARIRKEVEDSLRRLRVETIDLEQIHWPDDKTPIDESARELQKLHQDGKIRALGVSNFSPEQMDIFREV--APLATIQPPLNLFERTIEKDILPYAEKHNAVVLAYGALCRGLLTGKMNRDTPKDDLRSNDPKFQKPNFEKYLAAMDEFEKLAEKRGKSVMAFAVRWVLDQGPVIALWGARKPGQVSGVKDVFGWSLTDEEKKAVDDILARH---VPNPIDPTFMA------

1pz0A

0.30

0.28

0.91

3.60

MUSTER

-KKAKLGKSDQVFPIGLGTNAVGGHNL--YPNLNEETGKELVREAIRNGVTL-DTAYIYGIGRSEELIGEVLRENREDVVIATKAAHFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEKKA--KIRSIGVSNFSLEQLKEANK--DGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIILIPGAKRADQLIDNIKTADVTLSQEDISFIDKLFAPG--------------------

1pz0A

0.30

0.28

0.92

6.42

dPPAS

-KKAKLGKSDQVFPIGLGTNAVGGHNL--YPNLNEETGKELVREAIRNGVTL-DTAYIYGIGRSEELIGEVLRENREDVVIATKAAVFDNSPDFLKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEKKAG-KIRSIGVSNFSLEQLKEANK--DGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTEDTPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIILIPGAKRADQLIDNIKTADVTLSQEDISFIDKLFAPG--------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.62

Estimated TM-score = 0.94±0.05

Estimated RMSD = 3.1±2.2Å

Download Model 2

C-score=-3.75

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3n2tA	0.934	1.11	0.265	0.957
2	1pz0A	0.858	1.97	0.301	0.916
3	1pz1A	0.847	2.27	0.273	0.923
4	3eb4A	0.834	2.48	0.258	0.923
5	1lqaA	0.825	2.37	0.261	0.907
6	3erpA	0.807	2.07	0.246	0.870
7	4xk2A	0.805	2.99	0.268	0.910
8	3n6qA	0.803	2.22	0.265	0.876
9	5danA	0.788	1.86	0.321	0.839
10	1ynpB	0.787	2.48	0.257	0.864

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.68	221	4q7bA	NAP	Rep, Mult	18,19,20,21,54,59,84,117,147,148,169,197,198,199,200,201,202,203,252,268,269,270,271,272,273,276,279,280
2	0.33	99	4yvvB	GBM	Rep, Mult	20,58,59,86,117,118,148,218
3	0.01	5	1ry8A	RUT	Rep, Mult	20,58,59,117,120,148,197,217,218
4	0.01	3	1pz0A	NAP	Rep, Mult	59,117,147,148,169,197,198,199,200,201,202,203,206,208,252
5	0.01	4	4exaB	NAP	Rep, Mult	21,198,200,268,269,270,271,272,276,280
6	0.01	3	2wzmA	NA7	Rep, Mult	20,197,198,199,200,201,202,203,206,252,268,270,271,272,276,279,280
7	0.00	1	3n6qD	MG	Rep, Mult	31,66
8	0.00	1	1ynpB	SUC	Rep, Mult	3,51,78,79
9	0.00	1	3erpA	NA	Rep, Mult	84,117,147,148,169,197
10	0.00	2	3eb3A	PDN	Rep, Mult	8,9,143,163,164,165,166,190
11	0.00	1	3uzxB	AOX	Rep, Mult	20,59,117,217,218
12	0.00	2	1s2cA	FLF	Rep, Mult	2,3,4,14,260,264,265,285
13	0.00	1	2clpA	CA	Rep, Mult	228,231
14	0.00	1	1xjbA	ACT	Rep, Mult	2,13,14,15,49,51,285
15	0.00	1	3r8gA	IZP	Rep, Mult	58,59,117,148,197,312,319
16	0.00	1	1ynpB	NA	Rep, Mult	136,139,141,142

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.558	3b3dA	0.730	2.19	0.235	0.796	1.-.-.-	54,59,84,117
2	0.549	1c9wA	0.752	2.66	0.211	0.839	1.1.1.21,1.1.1.2	54,59,84,117
3	0.546	1vbjA	0.733	2.21	0.237	0.796	1.1.1.188	54,59,84,117
4	0.541	1zuaX	0.748	2.67	0.216	0.830	1.1.1.-	54,59,84,117
5	0.540	1k8cB	0.749	2.79	0.201	0.848	1.1.1.21	54,59,84,117
6	0.539	2bgsA	0.731	2.33	0.196	0.805	1.1.1.21	54,59,84,117
7	0.538	3h7rA	0.726	2.74	0.202	0.814	1.1.1.-	54,59,84,117
8	0.530	2fvlA	0.754	2.62	0.200	0.839	1.1.1.225,1.1.1.50	54,59,84,117
9	0.516	1vp5A	0.726	2.32	0.244	0.796	1.1.1.274	54,59,84,117
10	0.511	1ry0A	0.756	2.73	0.203	0.842	1.1.1.213,1.1.1.64,1.1.1.188,1.3.1.20	54,59,84,117
11	0.482	3krbA	0.720	2.79	0.231	0.811	1.1.1.21	54,59,84,117
12	0.458	1pyfA	0.861	2.05	0.301	0.926	1.1.1.-	11,49,51,80
13	0.312	2c91A	0.778	3.09	0.240	0.898	1.-.-.-	200,278,282
14	0.302	1q5mA	0.754	2.64	0.192	0.839	1.1.1.149,1.1.1.189	117,183,198,200
15	0.271	2clpA	0.782	2.93	0.228	0.892	1.-.-.-	200,273,278
16	0.253	3dopB	0.763	2.52	0.223	0.842	1.3.1.3	NA
17	0.203	2p5nA	0.746	2.83	0.217	0.839	1.1.1.-	54,59,84,117
18	0.200	3h7uA	0.741	2.60	0.228	0.827	1.1.1.-	54,59,84,117
19	0.187	1a80A	0.731	2.29	0.210	0.802	1.1.1.274	54,59,84,117
20	0.156	3fx4A	0.752	2.65	0.204	0.839	1.1.1.2	54,59,84,117
21	0.151	1mzrB	0.731	2.24	0.213	0.796	1.1.1.274	54,59,84,117
22	0.145	1afsA	0.748	2.76	0.189	0.839	1.1.1.213,1.1.1.50	54,59,84,117
23	0.145	1ah0A	0.748	2.75	0.214	0.839	1.1.1.21	54,59,84,117
24	0.144	1q13A	0.753	2.66	0.192	0.839	1.1.1.189,1.1.1.149	54,59,84,117
25	0.126	1xjbA	0.748	3.02	0.201	0.855	1.3.1.20,1.1.1.213	54,59,84,117
26	0.099	2yw3E	0.499	2.96	0.105	0.585	4.1.2.14	NA
27	0.067	2cz5A	0.509	2.73	0.111	0.585	4.1.1.23	NA
28	0.060	3burA	0.761	2.53	0.227	0.842	1.3.1.3	54,59,84
29	0.060	1gveB	0.762	2.83	0.222	0.861	1.-.-.-	18,79
30	0.060	1gveA	0.777	3.09	0.217	0.895	1.-.-.-	200,273,275,278,282
31	0.060	1c7sA	0.621	4.30	0.066	0.805	3.2.1.52	56,57
32	0.060	1og6C	0.775	2.52	0.241	0.861	1.-.-.-	18,59,198,200,253
33	0.060	1el3A	0.751	2.52	0.223	0.827	1.1.1.21	83,116
34	0.060	1r8lB	0.623	4.06	0.074	0.789	3.2.1.89	NA
35	0.060	2gftB	0.623	4.05	0.074	0.789	3.2.1.89	NA
36	0.060	1cz1A	0.633	4.36	0.101	0.839	3.2.1.58	149
37	0.060	3f7jA	0.728	2.26	0.257	0.796	1.1.1.283	59,117,200,203

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.54	0.934	1.11	0.27	0.96	3n2tA	GO:0016491 GO:0055114
1	0.50	0.807	2.07	0.25	0.87	3erpA
2	0.48	0.784	2.26	0.26	0.86	4astD	GO:0006974 GO:0009438 GO:0016491 GO:0016616 GO:0055114
3	0.48	0.779	2.40	0.31	0.85	4wghA	GO:0016491 GO:0055114
4	0.46	0.861	2.39	0.27	0.94	1pz1A	GO:0016491 GO:0055114
5	0.44	0.861	2.05	0.30	0.93	1pyfA	GO:0016491 GO:0055114
6	0.44	0.752	2.65	0.20	0.84	3fx4A	GO:0008106 GO:0016491 GO:0055114
7	0.41	0.834	2.48	0.26	0.92	3eauA	GO:0004033 GO:0005244 GO:0005249 GO:0005737 GO:0005829 GO:0005856 GO:0005874 GO:0005886 GO:0006810 GO:0006811 GO:0006813 GO:0015459 GO:0016020 GO:0016021 GO:0016491 GO:0030054 GO:0030424 GO:0031234 GO:0034705 GO:0034765 GO:0042995 GO:0043005 GO:0044224 GO:0044325 GO:0045202 GO:0045445 GO:0051291 GO:0055114 GO:0070995 GO:0071805 GO:1901379 GO:1990031 GO:2000008
8	0.41	0.763	2.38	0.33	0.84	5c7hA	GO:0000166 GO:0016491 GO:0055114
9	0.40	0.762	2.83	0.22	0.86	1gveB	GO:0004032 GO:0004033 GO:0005737 GO:0009636 GO:0016491 GO:0046222 GO:0046223 GO:0055114
10	0.40	0.727	2.31	0.23	0.80	3wbwA	GO:0000166 GO:0016491 GO:0055114
11	0.40	0.816	2.64	0.25	0.90	4aubB	GO:0006974 GO:0009438 GO:0016491 GO:0016616 GO:0055114
12	0.40	0.730	2.42	0.23	0.81	4gieA	GO:0000166 GO:0001516 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0016491 GO:0036131 GO:0047017 GO:0055114
13	0.39	0.733	2.21	0.24	0.80	1vbjA	GO:0000166 GO:0001516 GO:0004033 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0016491 GO:0019571 GO:0036131 GO:0045290 GO:0047017 GO:0055114
14	0.39	0.748	2.57	0.22	0.82	1qwkA	GO:0016491 GO:0055114
15	0.39	0.764	1.93	0.28	0.81	3v0uA	GO:0009820 GO:0016491 GO:0055114
16	0.39	0.805	2.99	0.27	0.91	4xk2A	GO:0016491 GO:0055114
17	0.39	0.775	2.52	0.24	0.86	1og6C	GO:0005829 GO:0016491 GO:0055114
18	0.39	0.825	2.37	0.26	0.91	1lqaA	GO:0004033 GO:0005829 GO:0016491 GO:0034198 GO:0055114
19	0.38	0.752	2.66	0.21	0.84	1c9wA	GO:0004032 GO:0005737 GO:0016491 GO:0055114
20	0.38	0.743	3.00	0.21	0.85	4h8nA	GO:0004033 GO:0016491 GO:0042180 GO:0047011 GO:0055114
21	0.38	0.787	2.48	0.26	0.86	1ynpB	GO:0016491 GO:0055114
22	0.37	0.782	2.93	0.23	0.89	2clpA	GO:0004033 GO:0005737 GO:0005829 GO:0006081 GO:0006805 GO:0009055 GO:0016491 GO:0055114 GO:0070062
23	0.37	0.728	2.26	0.26	0.80	3f7jA	GO:0016491 GO:0043892 GO:0055114
24	0.37	0.748	2.75	0.21	0.84	1ah0A	GO:0004032 GO:0005737 GO:0016491 GO:0055114
25	0.37	0.753	2.57	0.22	0.83	3o3rA	GO:0004032 GO:0004033 GO:0005737 GO:0005739 GO:0016491 GO:0055114
26	0.37	0.779	2.32	0.26	0.84	3uyiA	GO:0009820 GO:0016491 GO:0055114
27	0.36	0.778	3.09	0.24	0.90	2c91A	GO:0005737 GO:0005739 GO:0005794 GO:0016491 GO:0016616 GO:0019119 GO:0044597 GO:0044598 GO:0055114 GO:0070062
28	0.36	0.741	2.60	0.23	0.83	3h7uA	GO:0004033 GO:0008106 GO:0009409 GO:0009414 GO:0009507 GO:0009636 GO:0009651 GO:0016229 GO:0016491 GO:0055114 GO:0070401
29	0.36	0.726	2.74	0.20	0.81	3h7rA	GO:0004033 GO:0005829 GO:0009409 GO:0009414 GO:0009636 GO:0009651 GO:0016229 GO:0016491 GO:0046686 GO:0055114 GO:0070401
30	0.36	0.731	2.73	0.24	0.82	1zgdA	GO:0000166 GO:0016491 GO:0055114
31	0.35	0.755	2.52	0.20	0.84	3wg6A	GO:0016491 GO:0042180 GO:0047011 GO:0055114
32	0.35	0.727	2.38	0.24	0.80	4mhbA	GO:0016491 GO:0055114
33	0.35	0.733	2.29	0.24	0.80	4q3mA	GO:0016491 GO:0055114
34	0.35	0.647	2.72	0.28	0.72	4exaF	GO:0000166
35	0.35	0.731	2.33	0.20	0.81	2bgsA	GO:0004032 GO:0016491 GO:0055114
36	0.35	0.749	2.79	0.20	0.85	1k8cB	GO:0005975 GO:0016491 GO:0042732 GO:0042843 GO:0055114
37	0.35	0.761	2.53	0.23	0.84	3burA	GO:0004033 GO:0005496 GO:0005737 GO:0005829 GO:0006629 GO:0006699 GO:0006707 GO:0007586 GO:0008202 GO:0008207 GO:0008209 GO:0016042 GO:0016491 GO:0030573 GO:0047787 GO:0055114 GO:0070062
38	0.34	0.726	2.32	0.24	0.80	1vp5A	GO:0000166 GO:0016491 GO:0055114
39	0.34	0.746	3.04	0.21	0.85	3wczA	GO:0006629 GO:0008202 GO:0016491 GO:0055114
40	0.34	0.742	2.23	0.22	0.80	3up8A	GO:0016491 GO:0050580 GO:0055114
41	0.34	0.729	2.24	0.25	0.80	4otkA	GO:0005618 GO:0005886 GO:0016491 GO:0040007 GO:0055114
42	0.33	0.753	2.66	0.19	0.84	1q13A	GO:0001516 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0016491 GO:0047006 GO:0050221 GO:0055114
43	0.33	0.735	2.17	0.24	0.80	4g5dA	GO:0000166 GO:0001516 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0006693 GO:0016491 GO:0036131 GO:0047017 GO:0055114
44	0.33	0.720	2.79	0.23	0.81	3krbA	GO:0000166 GO:0004032 GO:0016491 GO:0055114
45	0.33	0.754	2.62	0.20	0.84	2fvlA	GO:0001523 GO:0001758 GO:0004033 GO:0005737 GO:0005829 GO:0006699 GO:0008202 GO:0008209 GO:0009055 GO:0015125 GO:0015721 GO:0016491 GO:0016655 GO:0044597 GO:0044598 GO:0047023 GO:0047743 GO:0055114 GO:0070062 GO:0071395
46	0.33	0.777	3.09	0.22	0.89	1gveA	GO:0004032 GO:0004033 GO:0005737 GO:0009636 GO:0016491 GO:0046222 GO:0046223 GO:0055114
47	0.33	0.721	2.41	0.23	0.80	2wzmA	GO:0016491 GO:0055114
48	0.33	0.765	2.46	0.24	0.85	4r9oC	GO:0016491 GO:0055114
49	0.32	0.762	2.70	0.20	0.85	5az1A	GO:0016491 GO:0055114
50	0.32	0.731	2.24	0.21	0.80	1mzrB	GO:0005737 GO:0005829 GO:0008106 GO:0016491 GO:0016616 GO:0019853 GO:0050580 GO:0051596 GO:0055114
51	0.32	0.752	2.68	0.21	0.84	4l1wA	GO:0004032 GO:0005737 GO:0006629 GO:0006693 GO:0007186 GO:0007586 GO:0008202 GO:0008284 GO:0016491 GO:0016655 GO:0018636 GO:0030855 GO:0031406 GO:0032052 GO:0042448 GO:0044597 GO:0044598 GO:0047086 GO:0047115 GO:0051897 GO:0055114 GO:0071395 GO:0071799
52	0.31	0.748	2.76	0.19	0.84	1afsA	GO:0005737 GO:0008202 GO:0016229 GO:0016491 GO:0021766 GO:0047023 GO:0047042 GO:0055114
53	0.31	0.750	2.73	0.21	0.84	3cv6A	GO:0004032 GO:0004033 GO:0005737 GO:0005829 GO:0006629 GO:0006694 GO:0008202 GO:0016491 GO:0016655 GO:0018636 GO:0031406 GO:0032052 GO:0033764 GO:0047023 GO:0047042 GO:0047086 GO:0047115 GO:0055114 GO:0070062
54	0.31	0.733	2.05	0.25	0.79	4hbkA	GO:0004032 GO:0016491 GO:0055114
55	0.30	0.721	2.08	0.26	0.78	3o0kA	GO:0016491 GO:0055114
56	0.28	0.755	2.64	0.20	0.84	4zfcB	GO:0000060 GO:0001523 GO:0001758 GO:0004032 GO:0004033 GO:0004745 GO:0005622 GO:0005634 GO:0005737 GO:0005829 GO:0006693 GO:0007186 GO:0007584 GO:0008202 GO:0008284 GO:0008584 GO:0009267 GO:0010942 GO:0016488 GO:0016491 GO:0016655 GO:0018636 GO:0019371 GO:0030216 GO:0034614 GO:0035410 GO:0036130 GO:0036131 GO:0042448 GO:0042572 GO:0042574 GO:0044259 GO:0044597 GO:0044598 GO:0045550 GO:0045703 GO:0047017 GO:0047020 GO:0047023 GO:0047035 GO:0047045 GO:0047086 GO:0047115 GO:0047718 GO:0047787 GO:0048385 GO:0051897 GO:0052650 GO:0055114 GO:0061370 GO:0070062 GO:0070293 GO:0071276 GO:0071277 GO:0071379 GO:0071384 GO:0071395 GO:0071799 GO:1900053 GO:2000224 GO:2000353 GO:2000379
57	0.27	0.748	2.75	0.21	0.84	3rx2A	GO:0001894 GO:0004032 GO:0004033 GO:0005615 GO:0005654 GO:0005737 GO:0005829 GO:0005975 GO:0005996 GO:0006061 GO:0006700 GO:0006950 GO:0009055 GO:0009414 GO:0010033 GO:0016491 GO:0018931 GO:0031098 GO:0032838 GO:0033010 GO:0042415 GO:0042629 GO:0043220 GO:0043795 GO:0044597 GO:0044598 GO:0046370 GO:0046427 GO:0048471 GO:0048661 GO:0055114 GO:0060135 GO:0070062 GO:0070301 GO:0072061 GO:0097066 GO:0097238 GO:0097454 GO:1901653
58	0.24	0.746	2.78	0.20	0.84	4gq0A	GO:0001523 GO:0001758 GO:0004033 GO:0005576 GO:0005764 GO:0005829 GO:0006081 GO:0007586 GO:0008202 GO:0016488 GO:0016491 GO:0044597 GO:0044598 GO:0045550 GO:0047718 GO:0055114 GO:0070062
59	0.19	0.718	2.56	0.20	0.80	4ijcA	GO:0005737 GO:0005829 GO:0016491 GO:0044262 GO:0045290 GO:0055114
60	0.15	0.730	2.19	0.23	0.80	3b3dA	GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0016616
GO-Score	0.48
Biological Processes	GO:0055114	GO:0006974	GO:0009438
GO-Score	0.93	0.48	0.48
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv2298

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]