I-TASSER results

Input Sequence in FASTA format

>protein (212 residues)
MDQSANHACLPTPLASTTGRGQDHEMPVEETSTPQKLPQFRYHPDPVGTGSIVADEVSCV
SCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATFTDAMWAVPDDVPEDVTEE
VLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPDALDALRNEYRGYDWPADKIE
EFILTLDRNGLATAYLFRCLSCGVHLAYADFA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MDQSANHACLPTPLASTTGRGQDHEMPVEETSTPQKLPQFRYHPDPVGTGSIVADEVSCVSCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATFTDAMWAVPDDVPEDVTEEVLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPDALDALRNEYRGYDWPADKIEEFILTLDRNGLATAYLFRCLSCGVHLAYADFA
Prediction	CCCCCCCEHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHCCCEHCCCCCEEEEEEHCCCCCCCCCCCCCCHHHCCCCHHHHHHCCEHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEHCCCCEEEEEEHCC
Conf.Score	99888754456887655566545554444544557899888999853459888768565579955568996777665578777684446877888876986556777788889989999999849999888886466457746777753899999885567999999998568988899999999768998699999986788799999759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MDQSANHACLPTPLASTTGRGQDHEMPVEETSTPQKLPQFRYHPDPVGTGSIVADEVSCVSCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATFTDAMWAVPDDVPEDVTEEVLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPDALDALRNEYRGYDWPADKIEEFILTLDRNGLATAYLFRCLSCGVHLAYADFA
Prediction	76434342004324455555455455445557455611504022312423204557430411444331213132103542432011212440420441513222333336342455224302442432421345203311530020243043640552552352035205535144630440162027412000000102313311001028
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEHCCCEHCCCCCEEEEEEHCCCCCCCCCCCCCCHHHCCCCHHHHHHCCEHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEHCCCCEEEEEEHCC
MDQSANHACLPTPLASTTGRGQDHEMPVEETSTPQKLPQFRYHPDPVGTGSIVADEVSCVSCEQRRPYTYTGPVYAEEELNEAICPWCIADGSAASRFDATFTDAMWAVPDDVPEDVTEEVLCRTPGFTGWLQEEWLHHCGDAAAFLGPVGASEVADLPDALDALRNEYRGYDWPADKIEEFILTLDRNGLATAYLFRCLSCGVHLAYADFA

4lyaA

0.12

0.95

0.64

MUSTER

KKDNAALTQIYLPADGEDEVLENVKREERLKEVYQHIPKPKPIPLPPRLSSVFTNTYVQHRASGFIPVGLDEQTVRPVAINRTDPHCLIQSRKGKTNVVKVILESLLVQEP--ESIGL--LDGIDRGLAGYANRDDITYIEA-----KERLAQWLNEADAVLQQREREYIQVNWPPDSLLRLQQETDSIQGRIAN--QYSHLGFHVFVAGNA

5cr4A

0.06

0.05

0.89

0.75

dPPAS

FWRNVLWSDETKIELFGHNDHRYVWRKKGEACKPKNTIPTVKHGGGSIMLWGCFAAG-------GTGALHKIDGIMDAVQYVDILKQHLKTSVRKLKLGRKWVFQHDNDPKHTSKVVAKWLKDNKVKVLEWPSQSPDLNPIENLWAELKKRVRARRPTNLTQLHQLCQEEWAKIHPNYCGKLVEGYPKKGNATKY-----------------

5aj3m

0.18

0.08

0.48

0.60

wdPPAS

--------ATPSLRGRLARLGNPRRPILKPN-KPLIL------ANHVGERRREKGEATCIAC------------WKQNEFRDEACFDCASRAEAARKMRSI--QENLGELGSLPPKKLNKLLHRFPNKPHV---------------------------------------------------------------------------------

5dggA

0.24

0.17

0.72

0.60

wMUSTER

MPKSQGRIVVMAVLNRYDS--HSANAIIETLASDVFNPEVHY---PVGPGH--------------RGVYLSKPAY---DL-ELFDPY----GEGAAVLDDYVLDLLNQCG--VPKELVN---IRHTGPKHPQGDAY--SCGDTCAYSHKKGAPEGSYNPILIDTLDNLGNEDNVLRMTTREETRALV-------------------------

2ea1A

0.13

0.10

0.80

0.71

wPPAS

------------------------------LALQAKQYDFDRYQ-TSQHDRNRNERDECETTNKADFLTVHGPGLPKSVAARGVDERR-RFGCATRPIPNLPEARASSPETGLSLETAAKLSEVMPGAGGERYE-YAKHC-DPDAYFGT--MVRLNQEIKESEAGKFLADNYGVSRRDFDAAFAKSWGKENVKAVKLTCQGS-------DAI

2in3A

0.12

0.07

0.56

0.98

dPPAS2

---------------------------------------------------------------EKPVLWYIADP----------CSWCWGFAPVIENIRQEYSAFLGGTNTPLLPEKRAQILHHWPTFENALPEGFIYDTEPACRGVVSVSLIEPEKVFPFFAAIQRAFYVGQEDVAQLAILKKLAVDLG--------------------IP

5cr4A

0.07

0.94

0.87

PPAS

--------ARKKPL-----QNRHKKARLRFATAHGDKDRTFWRNVLWSDETKIELFGHNDHRYVWRKKGEACKPKNTIPTVKHGGGSIMLWGCFAAGGTGALHKIDGIMDAVQYVDILKQHLKTSVRKLKLGRKWVFQHDNDPKHTSKVVAKWLKDNKVKVLEWPSQSPDLNPIENLWAELKKRVRARRPTNLTQLHQLCQEEWAKIHPNYC

1vx7I

0.09

0.08

0.90

0.69

Env-PPAS

-----KHYNVKGKKKVLVPVNAKKTINKKYFGRKVASKKKYVVQRKLRK-SIEVGKVAIILTGKHMGKRCI--ITKILNSGLLAVPYEI-NGRVDSRYVTSTNIFNFENIAKLKDDFLNYAQDIDDSFI--KTLEIKK----KQKKLLKFMNNVIDKIKEIRKEDPKVQKLEGIQKDIGSLLKPEILKNKVFAHYKF-TLRND------MVL

5gxuA

0.09

0.08

1.00

0.60

MUSTER

LVEQGAQRLVQVGLGDDDQCDDFTAWREALWPELDTILYTVFDAQPYKANVAVKRELHTESDRSCIHLEFDIAGSGLTETGDHVGVLCDNLSETVDEALRLLSPDTYFSLPFPPCNLRTALTRYLSSPKKSALVALAAHASDEAERLKHLASPAGKDEYSKWVVLLEVMAEFPSAKPPLGVFFAGVAPRLQPRFYSI-SPKIAIHVTCAYEK

5lskD

0.11

0.09

0.80

0.68

dPPAS

ITELSRSISVDLAESKRLGCLLLSSFQFSIQKLEPFLRDF--SLESFRAKASSLSEE--------------LKHFADGLETDGTLQKCFESLEASVAEMKEYITKFSLERQTWDQQEAKEILSRSTTYLGSSQNEVLNTKPDYQKILQNQ-SKVFDCMELVMDELQGSVKQLQAFMDESTQCFQKVS-------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.10

Estimated TM-score = 0.28±0.09

Estimated RMSD = 15.4±3.4Å

Download Model 2

C-score=-3.80

Download Model 3

C-score=-4.48

Download Model 4

C-score=-4.35

Download Model 5

C-score=-4.83

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cr4A	0.823	2.27	0.060	0.906
2	3hotA	0.733	2.84	0.043	0.877
3	3f2kA	0.690	2.24	0.060	0.788
4	3l2rA	0.551	3.38	0.040	0.679
5	1c0mC1	0.542	3.22	0.035	0.674
6	3ecpA	0.540	3.93	0.057	0.717
7	3jcaA2	0.531	3.55	0.047	0.679
8	3f9kI	0.524	3.56	0.075	0.665
9	3hpgB	0.522	3.36	0.035	0.656
10	1bl3C	0.515	3.33	0.066	0.637

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.17	10	3qwvA	ZN	Rep, Mult	59,62,85,88
2	0.09	5	3oybA	ZZX	Rep, Mult	49,140,142,167,169,170,175
3	0.09	5	3oyiA	MN	Rep, Mult	49,50,175,178
4	0.04	2	3nf6A	IMV	Rep, Mult	112,116,119,149,152,153,156
5	0.03	2	3f2kA	III	Rep, Mult	93,95,100,102,125,208
6	0.03	2	3nf9A	CD9	Rep, Mult	94,98,173,174,176,177,180,207
7	0.03	2	1asuA	EPE	Rep, Mult	88,90,91
8	0.02	1	3f2kA	III	Rep, Mult	95,97,98,100,128,209

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.067	1vsdA	0.523	3.12	0.044	0.641	2.7.7.49	103
2	0.060	1v4tA	0.391	4.73	0.082	0.585	2.7.1.2,2.7.1.1	177
3	0.060	1qhaA	0.437	4.59	0.054	0.637	2.7.1.1	45
4	0.060	3dlrA	0.481	3.26	0.070	0.594	2.7.7.7,2.7.7.49	108,141
5	0.060	2bmbA	0.422	4.15	0.032	0.599	2.5.1.15,2.7.6.3,4.1.2.25	NA
6	0.060	1ahpA	0.427	5.35	0.049	0.679	2.4.1.1	NA
7	0.060	1k6yA	0.491	2.89	0.065	0.590	2.7.7.49	139
8	0.060	1ekeB	0.427	3.76	0.058	0.580	3.1.26.4	210
9	0.060	2uv8G	0.426	5.14	0.035	0.660	2.3.1.86	NA
10	0.060	1zczB	0.419	4.63	0.036	0.637	3.5.4.10,2.1.2.3	NA
11	0.060	3f9mA	0.449	4.49	0.065	0.646	2.7.1.2	45
12	0.060	3f9kI	0.524	3.56	0.075	0.665	2.7.7.49	176,204
13	0.060	3hm8A	0.442	4.68	0.054	0.656	2.7.1.1	55
14	0.060	1u6zB	0.438	3.85	0.053	0.594	3.6.1.11	NA
15	0.060	1bl3C	0.515	3.33	0.066	0.637	2.7.7.49	138
16	0.060	2c4mC	0.431	5.25	0.049	0.684	2.4.1.1	NA
17	0.060	1ygpA	0.433	5.30	0.067	0.689	2.4.1.1	NA
18	0.060	2pffA	0.441	5.15	0.059	0.717	2.3.1.41,2.3.1.86	NA
19	0.060	1c0mA	0.543	3.21	0.035	0.674	2.7.7.49	41
20	0.060	2vkzG	0.426	5.15	0.035	0.660	2.3.1.38,3.1.2.14	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.14	0.739	2.80	0.04	0.88	4u7bA	GO:0003677 GO:0004518 GO:0004519 GO:0005634 GO:0006310 GO:0015074 GO:0016787 GO:0046872 GO:0090305
1	0.12	0.709	2.62	0.06	0.83	3k9kA	GO:0000014 GO:0000729 GO:0000737 GO:0000793 GO:0003677 GO:0003690 GO:0003697 GO:0003824 GO:0004518 GO:0004519 GO:0005634 GO:0005694 GO:0006281 GO:0006303 GO:0006974 GO:0008152 GO:0008168 GO:0008270 GO:0008283 GO:0010452 GO:0015074 GO:0016568 GO:0016740 GO:0016787 GO:0018024 GO:0031297 GO:0032259 GO:0034968 GO:0035861 GO:0042800 GO:0042803 GO:0043566 GO:0044547 GO:0044774 GO:0046872 GO:0046975 GO:0051568 GO:0071157 GO:0090305 GO:0097676 GO:2000373 GO:2001034 GO:2001251
2	0.09	0.697	2.41	0.05	0.81	2f7tA	GO:0003677 GO:0004518 GO:0004519 GO:0005634 GO:0006310 GO:0015074 GO:0016787 GO:0046872 GO:0090305
3	0.07	0.530	3.66	0.04	0.68	3jcaA	GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0003964 GO:0004518 GO:0004519 GO:0004523 GO:0006278 GO:0006310 GO:0008152 GO:0008270 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502
4	0.07	0.522	3.36	0.04	0.66	3hpgB	GO:0003676 GO:0003677 GO:0003824 GO:0003964 GO:0004170 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0009117 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0046080 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502 GO:0090503
5	0.07	0.551	3.36	0.04	0.68	4bacA	GO:0003676 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0030430 GO:0042025 GO:0046718 GO:0046872 GO:0071897 GO:0075713 GO:0075732 GO:0090305 GO:0090502
6	0.07	0.540	3.59	0.03	0.69	5ejkA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0005198 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0015074 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502
7	0.07	0.524	3.55	0.07	0.67	3f9kA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039657 GO:0042025 GO:0044174 GO:0046718 GO:0046872 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
8	0.07	0.514	3.36	0.07	0.64	1bi4C	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0005546 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039526 GO:0039651 GO:0039657 GO:0042025 GO:0042802 GO:0044174 GO:0046718 GO:0046872 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
9	0.07	0.516	2.75	0.07	0.61	4pa1A	GO:0003676 GO:0003677 GO:0003824 GO:0003964 GO:0004170 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0009117 GO:0015074 GO:0016740 GO:0016779 GO:0016787 GO:0046080 GO:0046718 GO:0046872 GO:0075713 GO:0090305 GO:0090502 GO:0090503
10	0.07	0.493	3.04	0.06	0.61	3kkrA	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0015074 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0039660 GO:0046718 GO:0046872 GO:0075521 GO:0075606 GO:0075713 GO:0090305 GO:0090502 GO:0090503
11	0.07	0.491	2.86	0.07	0.58	1k6yB	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0005546 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019076 GO:0020002 GO:0030430 GO:0033644 GO:0039526 GO:0039651 GO:0039657 GO:0042025 GO:0042802 GO:0044174 GO:0046718 GO:0046872 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
12	0.07	0.502	3.03	0.09	0.61	1ex4A	GO:0003676 GO:0003677 GO:0003723 GO:0003824 GO:0003887 GO:0003964 GO:0004190 GO:0004518 GO:0004519 GO:0004523 GO:0004533 GO:0005198 GO:0005576 GO:0005654 GO:0005829 GO:0005886 GO:0006278 GO:0006310 GO:0006508 GO:0008152 GO:0008233 GO:0008270 GO:0008289 GO:0008907 GO:0015074 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0019013 GO:0019028 GO:0019058 GO:0019061 GO:0019064 GO:0019068 GO:0019072 GO:0019076 GO:0020002 GO:0030260 GO:0030430 GO:0033644 GO:0039526 GO:0039651 GO:0039657 GO:0042025 GO:0042802 GO:0044174 GO:0046718 GO:0046872 GO:0051169 GO:0055036 GO:0072494 GO:0075713 GO:0075732 GO:0090305 GO:0090502 GO:0090503
13	0.06	0.409	5.30	0.05	0.66	1rblA	GO:0000287 GO:0004497 GO:0009853 GO:0015977 GO:0015979 GO:0016491 GO:0016829 GO:0016984 GO:0019253 GO:0046872 GO:0055114
14	0.06	0.282	5.70	0.04	0.48	4di3E	GO:0006810 GO:0030288
15	0.06	0.292	6.45	0.04	0.57	4etpA	GO:0000166 GO:0000741 GO:0000742 GO:0000743 GO:0003777 GO:0005524 GO:0005634 GO:0005737 GO:0005816 GO:0005856 GO:0005874 GO:0005881 GO:0007018 GO:0007049 GO:0007064 GO:0007067 GO:0007126 GO:0008017 GO:0008569 GO:0046982 GO:0051301 GO:0060236
16	0.06	0.271	5.31	0.05	0.45	2bv6A	GO:0003677 GO:0003700 GO:0005737 GO:0006351 GO:0006355 GO:0009405
17	0.06	0.267	5.93	0.09	0.50	4ri0A	GO:0001558 GO:0004175 GO:0004252 GO:0005520 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0030512 GO:0030514
18	0.06	0.280	4.62	0.02	0.42	1tiqA	GO:0004145 GO:0004596 GO:0006474 GO:0008080 GO:0016740 GO:0016746 GO:0030435 GO:0031248 GO:0043939

Consensus prediction of GO terms

Molecular Function	GO:0046914	GO:0003677	GO:0004519
GO-Score	0.46	0.39	0.39
Biological Processes	GO:0015074	GO:0090305	GO:0006310
GO-Score	0.39	0.39	0.32
Cellular Component	GO:0005634
GO-Score	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv2295

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]