I-TASSER results

I-TASSER results for job id Rv2275

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (289 residues)
MSYVAAEPGVLISPTDDLQSPRSAPAAHDENADGITGGTRDDSAPNSRFQLGRRIPEATA
QEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDV
HVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGARLCVRPMSEFQSNEAYR
ELHADLLTRLKDDEDLRAVCQDLVRRFLSTKVGPRQGATATQEQVCMDYICAEAPLFLDT
PAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQGHAIVTPDGSPAE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSYVAAEPGVLISPTDDLQSPRSAPAAHDENADGITGGTRDDSAPNSRFQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGARLCVRPMSEFQSNEAYRELHADLLTRLKDDEDLRAVCQDLVRRFLSTKVGPRQGATATQEQVCMDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQGHAIVTPDGSPAE
Prediction	CCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEHCCCHHHHHHHCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEHCCCCHHHHHHHHCCCCCCCCCCCCEEEEEHCCCCCC
Conf.Score	9866678876656776667876676554566666667777888875444444445776556775677678557787644886999976998877779999999999984895799988856766555549987899999999999999999999999777778756887466664989999999999999869999999999999999976777889999999999999999999997465554888757876577679999986888887789975899985888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSYVAAEPGVLISPTDDLQSPRSAPAAHDENADGITGGTRDDSAPNSRFQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGARLCVRPMSEFQSNEAYRELHADLLTRLKDDEDLRAVCQDLVRRFLSTKVGPRQGATATQEQVCMDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQGHAIVTPDGSPAE
Prediction	6522334210002236415515534444465152132234556345431410451345564540414121640540165451000000010431436203300400363054010000233232113034265550343036404501530340054134655421002013025362034005303610573640250025003300444155575444400420140012000100402310406210000133251043015462504146511001033574648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCEEEEHCCCHHHHHHHCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEHCCCCHHHHHHHHCCCCCCCCCCCCEEEEEHCCCCCC
MSYVAAEPGVLISPTDDLQSPRSAPAAHDENADGITGGTRDDSAPNSRFQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGARLCVRPMSEFQSNEAYRELHADLLTRLKDDEDLRAVCQDLVRRFLSTKVGPRQGATATQEQVCMDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAEMLYARGSGLRASRNQGHAIVTPDGSPAE

2x9qA

0.93

0.73

0.79

2.29

MUSTER

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAE-LYARGSGLRASRNQGHAIVTPD-----

2x9qA

0.92

0.72

0.79

3.04

dPPAS

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAELYA-RGSGLRASRNQGHAIVTPD-----

2x9qA

0.91

0.71

0.79

4.43

wdPPAS

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAELYARG-SGLRASRNQGHAIVTPD-----

2x9qA

0.93

0.73

0.79

2.82

wMUSTER

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAE-LYARGSGLRASRNQGHAIVTPD-----

2x9qA

0.91

0.71

0.79

4.48

wPPAS

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAELYARG-SGLRASRNQGHAIVTPD-----

2x9qA

0.92

0.72

0.79

6.49

dPPAS2

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAELYA-RGSGLRASRNQGHAIVTPD-----

2x9qA

0.93

0.73

0.79

3.87

PPAS

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAE-LYARGSGLRASRNQGHAIVTPD-----

2x9qA

0.92

0.72

0.79

4.20

Env-PPAS

------------------------------------------------FQLGRRIPEATAQEGFLVRPFTQQCQIIHTEGDHAVIGVSPGNSYFSRQRLRDLGLWGLTNFDRVDFVYTDVHVAESYEALGDSAIEARRKAVKNIRGVRAKITTTVNELDPAGAR-LCVRPSEFQSNEAYRELHADLLTRLKDDE-DRAVCQDLVRRFLSTKGAT------ATQEQVCDYICAEAPLFLDTPAILGVPSSLNCYHQSLPLAELYA-RGSGLRASRNQGHAIVTPD-----

3oqhA

0.26

0.19

0.74

2.21

MUSTER

--------------------------------------------------------------LFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPED--IHTFSDFANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAIL------VEVSADMLELAVEYVIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEA-----

3oqhA

0.26

0.19

0.74

3.01

dPPAS

--------------------------------------------------------------LFKTETLTQNCNEILKRRRHVLVGISPFNSRFSEDYIHRLIAWAVREFQSVSVLLAGKEAANLLEALGTPHGKAERKVRKEVSRNRRFAEKALEAHGGNPED--IHTFSDFANQTAYRNLRMEVEAAFFDQTHFRNACLEMSHAAILV-----VEVSADMLELAVEYVIAELPFFIAAPDILGVEETLLAYHRPWKLGEQISRNEFAVKMRPNQGYLMVSEA-----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.11

Estimated TM-score = 0.58±0.14

Estimated RMSD = 8.6±4.5Å

Download Model 2

C-score=-2.09

Download Model 3

C-score=-2.33

Download Model 4

C-score=-2.06

Download Model 5

C-score=-2.44

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1wq3A	0.540	4.56	0.077	0.730
2	2v0gA	0.493	4.68	0.043	0.689
3	1ivsA3	0.480	4.72	0.044	0.675
4	2d5bA	0.475	4.91	0.034	0.685
5	2e9mA	0.453	5.33	0.054	0.654
6	1gonA	0.452	5.94	0.052	0.706
7	1g59A	0.419	4.78	0.104	0.585
8	2zx9A	0.416	5.82	0.042	0.654
9	2uv9D3	0.413	5.75	0.071	0.654
10	1x6lA2	0.412	6.04	0.048	0.664

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.32	8	3oqiB	NHE	Rep, Mult	86,91,116,117,207,229,233,253,255
2	0.16	6	1x8xA	TYR	Rep, Mult	84,86,88,116,229,233,236,251
3	0.06	2	3oqiA	NHE	Rep, Mult	202,203,206,255,256,257,258,259
4	0.05	2	1j09A	GLU	Rep, Mult	85,87,89,118,229,233,253
5	0.03	1	2bytA	LEU	Rep, Mult	87,102,115,148,151

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2zryD	0.388	6.30	0.030	0.657	5.3.3.2	NA
2	0.060	2tmdA	0.381	5.70	0.039	0.588	1.5.8.2	205
3	0.060	1skaA	0.374	6.62	0.035	0.671	3.1.3.8	NA
4	0.060	1w9xA	0.320	5.50	0.045	0.491	3.2.1.1	NA
5	0.060	1kc7A	0.397	6.31	0.045	0.661	2.7.9.1	NA
6	0.060	1o01C	0.383	6.62	0.052	0.664	1.2.1.3	NA
7	0.060	1gonA	0.452	5.94	0.052	0.706	3.2.1.21	NA
8	0.060	1a8hA	0.479	4.91	0.044	0.689	6.1.1.10	NA
9	0.060	1didA	0.384	6.12	0.060	0.613	5.3.1.5	NA
10	0.060	1dkmA	0.392	6.02	0.069	0.647	3.1.3.26,3.1.3.2	NA
11	0.060	1xc6A	0.386	6.15	0.023	0.619	3.2.1.23	88,153
12	0.060	1zumI	0.332	6.56	0.026	0.585	1.2.1.3	NA
13	0.060	2dieA	0.347	5.69	0.045	0.554	3.2.1.1	98,101
14	0.060	2c29F	0.381	5.57	0.032	0.585	1.1.1.219	150
15	0.060	1djnA	0.391	6.88	0.067	0.713	1.5.8.2,1.5.99.7	117,239
16	0.060	2hs4A	0.395	5.82	0.060	0.633	6.3.5.3	NA
17	0.060	2gjpA	0.387	5.91	0.098	0.623	3.2.1.98	100
18	0.060	1g5aA	0.393	6.20	0.061	0.647	2.4.1.4	NA
19	0.060	2a9yA	0.379	6.08	0.040	0.619	2.7.1.20	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.14	0.586	3.52	0.08	0.73	3hv0A	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006436 GO:0016874
1	0.13	0.587	3.81	0.09	0.75	3a04A	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006436 GO:0016874
2	0.12	0.499	4.46	0.06	0.68	1h3fB	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006437 GO:0016874
3	0.11	0.622	4.13	0.10	0.81	3kt8D	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006436 GO:0016874
4	0.07	0.609	4.00	0.07	0.79	1r6tA	GO:0000166 GO:0001525 GO:0004812 GO:0004830 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006436 GO:0008285 GO:0016874 GO:0045765 GO:0070062
5	0.07	0.596	3.67	0.08	0.76	3focA	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006436 GO:0016874
6	0.07	0.598	3.50	0.07	0.74	4j75A	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0006418 GO:0006436 GO:0016874
7	0.07	0.596	3.49	0.06	0.74	4jfaC	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0006418 GO:0006436 GO:0016874
8	0.07	0.592	3.76	0.10	0.76	3tzeA	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006436 GO:0016874
9	0.07	0.557	4.47	0.07	0.75	5ihxA	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0005739 GO:0005829 GO:0006412 GO:0006418 GO:0006437 GO:0016874 GO:0043039
10	0.07	0.578	3.73	0.07	0.74	3i05B	GO:0000166 GO:0004812 GO:0004830 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006436 GO:0016874
11	0.07	0.551	4.48	0.09	0.74	2pidB	GO:0000049 GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0005739 GO:0005759 GO:0005829 GO:0006412 GO:0006418 GO:0006437 GO:0016874 GO:0042803 GO:0043039 GO:0044822 GO:0070184 GO:0072545
12	0.07	0.535	4.69	0.08	0.73	2janA	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006412 GO:0006418 GO:0006437 GO:0016874 GO:0040007 GO:0043039
13	0.07	0.540	3.82	0.10	0.70	2cybA	GO:0000166 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006437 GO:0016874
14	0.07	0.509	4.52	0.06	0.70	5ihxB	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0005739 GO:0005829 GO:0006412 GO:0006418 GO:0006437 GO:0016874 GO:0043039
15	0.07	0.541	4.38	0.07	0.72	2ts1A	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006437 GO:0016874
16	0.07	0.508	4.89	0.07	0.72	4ojmX	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0005739 GO:0005759 GO:0005829 GO:0006397 GO:0006412 GO:0006418 GO:0006437 GO:0016874 GO:0043039
17	0.07	0.550	4.19	0.07	0.72	1jilA	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006437 GO:0016874
18	0.07	0.553	4.59	0.08	0.74	5ijxA	GO:0000166 GO:0003723 GO:0004812 GO:0004831 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006437 GO:0016874

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0004830
GO-Score	0.46	0.38
Biological Processes	GO:0006436
GO-Score	0.38
Cellular Component	GO:0005737
GO-Score	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.