I-TASSER results

I-TASSER results for job id Rv2262c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (360 residues)
MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPLLLVVRAAPTSWEGAL
RAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWLPAGWLAHRLLSVPVTTCRVGAAL
VVVPSAWVAAEAVRSWQSLGGPWALLGASQWSQPVTLASASLGGVWLTSFLLVATNTAIA
SVLVCRATGGRLVALGCVIGCAGLGPASYLLGSVPVGGPTVRVALVQAGDIADAAARLAA
GEEFTAAVADQRPDLVVWGESSVGQDLTRHPDVLARLAELSQRVGADLLVNVDAPAPDGG
IYKSAVLVGAHEAVGSYRKTRLVPFGEYVLRCARFSAGSPATARPPQRIGSAAPGRWCWR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPLLLVVRAAPTSWEGALRAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWLPAGWLAHRLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGGPWALLGASQWSQPVTLASASLGGVWLTSFLLVATNTAIASVLVCRATGGRLVALGCVIGCAGLGPASYLLGSVPVGGPTVRVALVQAGDIADAAARLAAGEEFTAAVADQRPDLVVWGESSVGQDLTRHPDVLARLAELSQRVGADLLVNVDAPAPDGGIYKSAVLVGAHEAVGSYRKTRLVPFGEYVLRCARFSAGSPATARPPQRIGSAAPGRWCWR
Prediction	CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEHCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCCHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
Conf.Score	998865555489999999999999998668898569999999999999988986889999999999999999988988888799999999999999999999999998766555557899999999999999999856788666788875678678887776655899999999999999999875556678999999999999999876466778887658999959997668899999999999998579989995899998875558899999999998769969996777668987789999995998646776546788533578788899988887765566788888777789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPLLLVVRAAPTSWEGALRAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWLPAGWLAHRLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGGPWALLGASQWSQPVTLASASLGGVWLTSFLLVATNTAIASVLVCRATGGRLVALGCVIGCAGLGPASYLLGSVPVGGPTVRVALVQAGDIADAAARLAAGEEFTAAVADQRPDLVVWGESSVGQDLTRHPDVLARLAELSQRVGADLLVNVDAPAPDGGIYKSAVLVGAHEAVGSYRKTRLVPFGEYVLRCARFSAGSPATARPPQRIGSAAPGRWCWR
Prediction	652433442320000000120121200001133122002112210100012243321001112222321222231213333333213212332223212211022002222333331110002011000102312331332302210100002010112100210331122001000000101232433311000000001011100111132244653312000000213642451053025004502745010000010000111641440052025006436000000001237733000000001475232302021000000201244004301300420353124022031018
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEEEHCCCCCEEEEEEEHCCCCCEEEEEEHCCCCCCHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MALRAGARRQPVIGCAAALVFGGLPALAFPAPSWWWLAWFGLVPLLLVVRAAPTSWEGALRAWTGMGGFVLATQYWLVTSAGPMLVLLAAGLGVLWLPAGWLAHRLLSVPVTTCRVGAALVVVPSAWVAAEAVRSWQSLGGPWALLGASQWSQPVTLASASLGGVWLTSFLLVATNTAIASVLVCRATGGRLVALGCVIGCAGLGPASYLLGSVPVGGPTVRVALVQAGDIADAAARLAAGEEFTAAVADQRPDLVVWGESSVGQDLTRHPDVLARLAELSQRVGADLLVNVDAPAPDGGIYKSAVLVGAHEAVGSYRKTRLVPFGEYVLRCARFSAGSPATARPPQRIGSAAPGRWCWR

5ezmA

0.13

0.12

0.92

1.03

wMUSTER

MLMGQHPDASVAARRGWMVACWAAMGVAILTKGLVGIALPGLVLVVYTLVTRDWGLWRRLHLALGVVVMLVITVPWFYLVSVREFPNFFFYFLPLVIGGFLPWAGIFPKLWTAMRARFRPALMAGIWAIAIFVFFSISRSIPGILAGVALDRLSPRSWGKQLIGMAIVAACGLLASPVVATLIPNSFYRAYAVWVAVAFVVMLLGIAVARLLLRRGVLPSVAVYAM-ALLGHETVGRPASGADIAPQIAQPEMPLYGV-DHTLPLMMVGQADELTFGATVEPQR---VVP-TKLWKNGQPA---MAVMSPD----TYLAAPTLSM--YVVARDVV--VANVASLAGPQ------------

3p8kA

0.18

0.07

0.37

1.13

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVPRGSHKVQIYQLPIFGDSSKNETQITQWFEKNNA-EVDVVVLPEWNNGYDLEHLGQSFSFIKHLAEKYKVDIVAGSVSNIRNNQIFNTAFSVNKSGQINEYDKVHLVPLRELTA------------EYVAEPF-QLSDGTICYD

4ke2A

0.14

0.08

0.54

1.40

dPPAS2

------MNIDPAARAAAAAAASKAAVTA------ADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAA-----AAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------------------------------------------------------------------------------------------------------------------

4kjsA

0.08

0.07

0.82

1.19

PPAS

---------IFFILVAAGVPLSVIGSLMWPSAVLFAVYCVTIIALASYMGRATESLSIRIGGLLNATFGNAVELIISMFALKELTGIVLASLTGSVLGNLLLVAGLSFFVGGLKYARQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSEL------IGVI-----VAIVGNAAEHASAIIMAFKNKMDIAV------------EIAVGSTLQIAMFVAPVLVICSIF---------------------------FPTSMPVFTLPELVAMVSAVLLMIAI-----SNDGDS-FE

3wajA

0.09

0.97

0.98

wMUSTER

RWKGHDLTARQMAYPVIAGITIGLYVLSWGAGFIIAPIILAFMFFAFVLAGFADRKNLSLVAVVTFAVSALIYLPFAFNYPGPFQLLVLLGSAVIAAAFYQIEKWNDVGFFERVGMPLAVIVLTALIMGLFFVLTNAVLHFGILYSAYRFLFPEMALLIWAIAMAYYFAAVSAVYSALALSVVFDKLRVAFALLIALAAIYPTYILADAQSSYAGGPNKQWYDALMRENTPDGEKYDEYYLQLYPTP-YPFETYGVIWMPIANPFQAGIG---ESYAEFVAEKLNVYVVSDAVWAEGDEKYYGGYFYYSPTGTFGYANSQWDIPIPLRIPSELYYSMEAKLHLFDGSGLSHYR-----YE

3hkxA

0.23

0.08

0.37

1.11

wPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SSGLVIRGSHMRIALMQHTAPLDPQHNLDLIDDAAARASEQGAQLLLTPELGFGYVPSQVDAARSRLRGIARDRGIALVWSLPGPEGPEQRGITAELADEHGVLASYQKVQL--YGEFVP------------EQPPP---GGRQSLVCYD

3wdoA2

0.12

0.06

0.54

1.26

dPPAS2

GMVKGSFSKVLAEPRLLKLNFGIMCLHM-----LLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKE---SP--------AGY-----KGTAMGVYSTSQFLGVAIGGSLGGWIDGMFDGQGVFLAGAMLAAVWLAVASTMKEPPY------------------------------------------------------------------------------------------------------------------------------------------------

5ezmA

0.13

0.12

0.94

1.14

PPAS

MLMGQHPDASVAARRGWMVACWAAMGVAILTKGLVGIALPGLVLVVYTLVTRDWGLWRRLHLALGVVVMLVITVPWFYLVSVREFPNFFFYFLPLVIGGFLPWAGIFPKLWTAMRARFRPALMAGIWAIAIFVFFSISRSIPGILAGVALDRLSPRSWGKQLIGMAIVAACGLLASPVVATLNANSFYRAYAVWVAVAFVVMLLGIAVARLLLRRGVLPSVAVYAM-ALLGHETVGRPASGADIAPQIAQKLTPLYGVQDHTLPLMMVGQADELTFGATVEPQRVVPDVDSFTKLWKNGQ--PAMAVMSP----DTYLAAPTLSM--YVVARDWRRVVVANVASLAGPQ-----------

1j31A

0.23

0.08

0.34

1.11

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKVGYIQEPKILELDKNYSKAEKLIKEASKEGAKLVVLPEFDTGYNFESPEGETTTFLELARELGLYIVAGTAEKS-GNYLYNSAVVVGPRGYIGKYRKIHL-FYREFEP------------DLGFK--IGFAKGVICFD

4q2eA

0.10

0.05

0.55

1.26

dPPAS2

ITLEMKERDARFFYVILLALYPVLYGLVF-EEPTQPLSILFITGVVFSLITDKDPSQVFKTVAAFSIALIYVTFFLSFFLPIYRDFGAANALLVLTSTWVFDSFAYFTGLKFGRTVIGGFLGVVIYTFLYRLVVNDLL--------------SVNVICFRTFLPFAATVAIMDTFGDIFECALKRHYMLDRIDGLLFVAPVSYIVFKILEGVVR--------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.66

Estimated TM-score = 0.31±0.10

Estimated RMSD = 15.7±3.3Å

Download Model 2

C-score=-4.61

Download Model 3

C-score=-4.65

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5ezmA	0.823	3.06	0.129	0.931
2	3wajA	0.583	4.77	0.059	0.786
3	3rceA	0.523	4.91	0.054	0.722
4	1r1hA	0.411	6.81	0.052	0.694
5	3dwbA	0.406	6.75	0.064	0.692
6	2ewfA	0.403	6.32	0.019	0.625
7	3v0aB	0.403	6.82	0.046	0.694
8	4bedB	0.402	6.27	0.050	0.650
9	1st6A	0.402	6.86	0.076	0.667
10	3cf4A	0.401	6.63	0.043	0.664

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	11	1t01A	III	Rep, Mult	101,161,162,165,168,169,172,175,176,206,226,228,231
2	0.05	4	1jylA	CDC	Rep, Mult	324,327
3	0.03	2	3dhfA	BEF	Rep, Mult	303,319
4	0.03	2	1ofdA	F3S	Rep, Mult	114,125,126,127,128,129,144,146
5	0.03	2	3s90A	III	Rep, Mult	101,154,155,158,161,162,165,168,199,213,224,226,227
6	0.01	1	5ezmA	DSL	Rep, Mult	1,21,22,25,37,40,41,43,44,123,127
7	0.01	1	1zw2A	III	Rep, Mult	158,159,162,165,166,169,172,202,209,220,224,226,231
8	0.01	1	1llzA	F3S	Rep, Mult	266,267,268,269,288,289
9	0.01	1	3g6wA	POP	Rep, Mult	317,319
10	0.01	1	4buoB	GLY	Rep, Mult	172,226
11	0.01	1	2ly0A	A2Y	Rep, Mult	155,158
12	0.01	1	1brrC	ARC	Rep, Mult	172,195,199
13	0.01	1	4c8lA	MG	Rep, Mult	131,134
14	0.01	1	1ofdB	F3S	Rep, Mult	27,36,37,38,41,42,43,131
15	0.01	1	1lm1A	F3S	Rep, Mult	259,268,269,289,308,316
16	0.01	1	2qenA	MG	Rep, Mult	169,260
17	0.01	1	1qhzA	CA	Rep, Mult	260,327
18	0.01	1	5ezmA	MPG	Rep, Mult	32,35,134,135
19	0.01	1	5ezmA	MPG	Rep, Mult	46,114,133
20	0.01	1	5ezmA	MPG	Rep, Mult	228,230,232

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2z8yP	0.314	7.41	0.049	0.569	2.3.1.169	32,45,131
2	0.060	1w6jA	0.373	6.70	0.062	0.617	5.4.99.7	NA
3	0.060	1q16A	0.334	7.22	0.032	0.603	1.7.99.4	NA
4	0.060	1qleA	0.329	6.58	0.060	0.550	1.9.3.1	170
5	0.060	1iv8A	0.368	7.23	0.042	0.658	5.4.99.15	327
6	0.060	2hpiA	0.341	6.50	0.033	0.561	2.7.7.7	169,174
7	0.060	1eurA	0.216	7.48	0.044	0.403	3.2.1.18	305
8	0.060	1dmtA	0.411	6.85	0.056	0.697	3.4.24.11	NA
9	0.060	2vycA	0.367	6.74	0.083	0.619	4.1.1.19	NA
10	0.060	3eifA	0.382	6.84	0.051	0.656	3.4.21.110	NA
11	0.060	2zidA	0.371	6.37	0.052	0.600	3.2.1.70	257
12	0.060	3gtgB	0.373	6.91	0.042	0.650	2.7.7.6	NA
13	0.060	1llwA	0.392	6.73	0.047	0.664	1.4.7.1	NA
14	0.060	1sqfA	0.379	6.42	0.049	0.606	2.1.1.-	NA
15	0.060	1euuA	0.382	6.72	0.039	0.631	3.2.1.18	255,285
16	0.060	3hkzJ	0.382	6.79	0.060	0.650	2.7.7.6	NA
17	0.060	1zjaA	0.365	6.59	0.046	0.600	5.4.99.11	260
18	0.060	2zkmX	0.371	7.30	0.036	0.672	3.1.4.11	NA
19	0.060	2pffA	0.385	7.46	0.066	0.714	2.3.1.41,2.3.1.86	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.19	0.824	3.03	0.12	0.93	5f15A	GO:0016020 GO:0016021 GO:0016740
1	0.07	0.586	4.89	0.07	0.80	3wakA	GO:0004576 GO:0006486 GO:0016020 GO:0016021 GO:0016740 GO:0046872
2	0.07	0.523	4.91	0.05	0.72	3rceA	GO:0000287 GO:0004576 GO:0005886 GO:0006486 GO:0016020 GO:0016021 GO:0016740 GO:0016757 GO:0018279 GO:0046872
3	0.06	0.583	4.77	0.06	0.79	3wajA	GO:0004576 GO:0006486 GO:0016020 GO:0016021 GO:0016740 GO:0046872
4	0.06	0.311	7.04	0.06	0.54	1lshA	GO:0005319 GO:0006869 GO:0045735
5	0.06	0.329	6.89	0.05	0.56	3waiA	GO:0004576 GO:0005215 GO:0005363 GO:0006486 GO:0006810 GO:0006974 GO:0008643 GO:0015768 GO:0016020 GO:0016021 GO:0016740 GO:0030288 GO:0034289 GO:0042597 GO:0042956 GO:0043190 GO:0046872 GO:0055052 GO:0060326 GO:1901982 GO:1990060
6	0.06	0.326	6.16	0.08	0.49	5azaA	GO:0004576 GO:0005215 GO:0005363 GO:0006486 GO:0006810 GO:0006974 GO:0008643 GO:0015768 GO:0016020 GO:0016021 GO:0016740 GO:0030288 GO:0034289 GO:0042597 GO:0042956 GO:0043190 GO:0055052 GO:0060326 GO:1901982 GO:1990060
7	0.06	0.279	7.14	0.04	0.49	3wovA	GO:0004576 GO:0006486 GO:0016020 GO:0016021 GO:0016740 GO:0046872
8	0.06	0.283	7.19	0.02	0.50	4gklA	GO:0003824 GO:0005975
9	0.06	0.264	7.01	0.04	0.45	3vu1B	GO:0004576 GO:0006486 GO:0016020 GO:0016021 GO:0046872
10	0.06	0.250	6.90	0.03	0.42	2amxA	GO:0009168 GO:0019239
11	0.06	0.234	6.64	0.06	0.39	4v2pB	GO:0003824 GO:0004315 GO:0006633 GO:0008152 GO:0016740
12	0.06	0.200	5.83	0.04	0.30	3aagA	GO:0004576 GO:0005886 GO:0006486 GO:0006487 GO:0016020 GO:0016021 GO:0016740 GO:0016757 GO:0046872
13	0.06	0.217	4.11	0.04	0.28	3vu0B	GO:0004576 GO:0006486 GO:0016020 GO:0016021
14	0.06	0.223	6.40	0.04	0.36	4dguA	GO:0046872
15	0.06	0.213	4.62	0.06	0.28	3vgpA	GO:0004576 GO:0006486 GO:0016020 GO:0016021 GO:0016740
16	0.06	0.220	6.52	0.04	0.36	2lgzA	GO:0004576 GO:0004579 GO:0005783 GO:0005789 GO:0006486 GO:0006487 GO:0008250 GO:0016020 GO:0016021 GO:0016740 GO:0016757 GO:0018279 GO:0043687
17	0.06	0.227	6.32	0.06	0.36	3e20B	GO:0002184 GO:0005634 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0016149 GO:0018444
18	0.06	0.200	6.39	0.03	0.32	2anuA	GO:0003677 GO:0003824 GO:0003887 GO:0006260 GO:0046872 GO:0071897

Consensus prediction of GO terms

Molecular Function	GO:0016758	GO:0043169
GO-Score	0.37	0.37
Biological Processes	GO:0044763	GO:0043413	GO:0006464	GO:0009101
GO-Score	0.37	0.37	0.37	0.37
Cellular Component	GO:0016021
GO-Score	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.