I-TASSER results

I-TASSER results for job id Rv2258c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (353 residues)
MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEER
YVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKV
IRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGC
GSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYD
VITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLM
HCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK
Prediction	CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHEEEEHCCCCCEEHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCEEEEHCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCEEEEEHCC
Conf.Score	99888899999999999999999999999988887899999769999999999989997899999999887444787688877986888878765899875689999999999999999999998789999877656666667777778888999999999765665689997699987999899999999869979999979999999999999998999869998774459999985589874556668798999999999858996799999689988765558848888766766655445545677777777899999999999899987999868998558999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK
Prediction	76554731440043004102211200000002212004001724512053006417254510230030000010032357643030144002000246223101101210300141153015004642302122013014011412332022101420130033033204344411200230220011005304703000010146005302620573616403112010360336300000000000010430430030022032231000000001324125214220121011221121012123241422122132520350065044640413514431111001036
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHEEEEHCCCCCEEHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCCCEEEEHCCCHHHCCCHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCEEEEEHCC
MSGALETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMHCMTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.98

0.99

3.09

MUSTER

ME----TTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.98

0.99

4.19

dPPAS

----METTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.98

0.99

4.41

wdPPAS

ME----TTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.98

0.99

3.63

wMUSTER

----METTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.99

4.59

wPPAS

M----ETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.98

0.99

6.60

dPPAS2

----METTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.98

0.99

4.34

PPAS

ME----TTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA

1.00

0.99

5.62

Env-PPAS

M----ETTEEFGNRFVAAIDSAGLAILVSVGHQTGLLDTMAGLPPATSMEIAEAAGLEERYVREWLGGMTTGQIVEYDAGSSTYSLPAHRAGMLTRAAGPDNLAVIAQFVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA1

1.00

0.69

2.00

MUSTER

------------------------------------------------------------------------------------------------------------FVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

5f8cA1

1.00

0.69

2.75

dPPAS

------------------------------------------------------------------------------------------------------------FVSLLGEVEQKVIRCFREGGGVPYSEYPRFHKLMAEMSGMVFDAALIDVVLPLVDGLPDRLRSGADVADFGCGSGRAVKLMAQAFGASRFTGIDFSDEAVAAGTEEAARLGLANATFERHDLAELDKVGAYDVITVFDAIHDQAQPARVLQNIYRALRPGGVLLMVDIKASSQLEDNVGVPLSTYLYTTSLMH-MTVSLALDGAGLGTVWGRQLATSMLADAGFTDVTVAEIESDVLNNYYIARK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.72

Estimated TM-score = 0.96±0.05

Estimated RMSD = 3.1±2.2Å

Download Model 2

C-score=-4.21

Download Model 3

C-score=-4.25

Download Model 4

C-score=-4.42

Download Model 5

C-score=-4.43

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5f8cA	0.960	1.42	0.997	0.986
2	1kyzE	0.759	3.32	0.127	0.901
3	5cvuB	0.757	3.56	0.152	0.909
4	5iccA	0.747	3.47	0.142	0.895
5	3p9cA	0.741	3.63	0.172	0.904
6	1fp1D	0.730	3.78	0.129	0.898
7	2r3sA	0.727	3.62	0.138	0.881
8	4e70A	0.724	3.92	0.123	0.904
9	3gwzA	0.722	3.77	0.148	0.895
10	4a6dA	0.718	3.94	0.145	0.904

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.57	51	5f8fB	SFG	Rep, Mult	132,142,146,150,179,180,181,202,203,228,229,230,245,246,247,251
2	0.03	3	3gxoA	MQA	Rep, Mult	104,107,150,153,154,157,246,249,250,276,296,299,300,303

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.406	1fp1D	0.730	3.78	0.129	0.898	2.1.1.-	249
2	0.132	1kywC	0.750	3.44	0.133	0.901	2.1.1.68	249
3	0.125	2ip2A	0.688	3.91	0.149	0.873	2.1.1.-	NA
4	0.100	2qyoA	0.689	4.29	0.120	0.887	2.1.1.46	249
5	0.067	2ex4A	0.487	3.06	0.146	0.564	2.1.1.-	NA
6	0.066	1wznA	0.475	3.38	0.168	0.547	2.1.1.-	NA
7	0.060	1l1eA	0.488	3.59	0.155	0.581	2.1.1.79	NA
8	0.060	1kpgA	0.484	3.56	0.137	0.581	2.1.1.79	NA
9	0.060	1kyzE	0.759	3.32	0.127	0.901	2.1.1.68	145,185,250,315
10	0.060	1sqfA	0.474	4.66	0.098	0.632	2.1.1.-	NA
11	0.060	3i58A	0.691	3.99	0.140	0.873	2.1.1.-	249
12	0.060	2i62C	0.452	3.77	0.142	0.555	2.1.1.1	179,181,205,229
13	0.060	1fp2A	0.730	3.99	0.105	0.901	2.1.1.150	249
14	0.060	2a14A	0.453	3.64	0.169	0.550	2.1.1.49	132,179,181,203,205,247
15	0.060	2aovA	0.484	3.59	0.120	0.589	2.1.1.8	NA
16	0.060	2h11B	0.461	3.02	0.115	0.530	2.1.1.67	NA
17	0.060	3bgdA	0.459	3.08	0.129	0.530	2.1.1.67	185
18	0.060	3eppB	0.479	3.52	0.146	0.564	2.1.1.56	179
19	0.060	2fk8A	0.497	3.51	0.143	0.592	2.1.1.-	NA
20	0.060	1xxlA	0.464	2.42	0.161	0.510	2.1.1.-	249
21	0.060	1tw2B	0.704	4.07	0.120	0.898	2.1.1.-	NA
22	0.060	1gz3A	0.470	5.65	0.064	0.691	1.1.1.38	NA
23	0.060	3lccA	0.491	3.23	0.168	0.569	2.1.1.-	179
24	0.060	2vs1A	0.480	5.16	0.112	0.657	2.1.1.-	NA
25	0.060	2iipA	0.477	3.83	0.159	0.586	2.1.1.1	179,181,205,229

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.43	0.723	3.87	0.18	0.90	4kifB	GO:0008168 GO:0016740 GO:0017000 GO:0032259
1	0.34	0.752	3.56	0.17	0.90	3p9iA	GO:0008168 GO:0008171 GO:0016206 GO:0016740 GO:0032259 GO:0046983
2	0.31	0.750	3.44	0.13	0.90	1kywC	GO:0008168 GO:0008171 GO:0009699 GO:0009809 GO:0016740 GO:0032259 GO:0046983 GO:0047763
3	0.31	0.729	3.76	0.14	0.90	3gwzA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:1901663
4	0.31	0.689	4.29	0.12	0.89	2qyoA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
5	0.29	0.730	3.99	0.10	0.90	1fp2A	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0033800 GO:0046983
6	0.26	0.730	3.78	0.13	0.90	1fp1D	GO:0008168 GO:0008171 GO:0016740 GO:0030751 GO:0032259 GO:0033802 GO:0046983
7	0.26	0.722	3.70	0.15	0.88	3lstA	GO:0008168 GO:0008171 GO:0032259
8	0.26	0.452	2.71	0.17	0.50	3l8dA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
9	0.25	0.719	4.13	0.13	0.92	4eviA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
10	0.24	0.716	3.77	0.19	0.90	4qvgC	GO:0008168 GO:0008171 GO:0032259
11	0.24	0.453	2.71	0.22	0.50	3sm3A	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872
12	0.24	0.704	4.07	0.12	0.90	1tw2B	GO:0008168 GO:0008171 GO:0016740 GO:0017000 GO:0032259 GO:1901771
13	0.23	0.458	3.44	0.12	0.54	3bxoA	GO:0008168 GO:0008757 GO:0016740 GO:0017000 GO:0032259 GO:0042803
14	0.22	0.463	2.90	0.19	0.53	3mggB	GO:0008168 GO:0016740 GO:0032259
15	0.22	0.698	4.36	0.15	0.92	1x19A	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
16	0.22	0.500	3.09	0.13	0.57	3vc1D	GO:0008152 GO:0008168 GO:0008169 GO:0008757 GO:0016740 GO:0032259 GO:0042214
17	0.21	0.461	2.48	0.16	0.51	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
18	0.20	0.719	3.76	0.15	0.89	3mczA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
19	0.20	0.475	3.38	0.17	0.55	1wznA
20	0.19	0.468	3.00	0.19	0.53	3dh0B	GO:0005737 GO:0008757 GO:0032259 GO:0046872 GO:0051536 GO:0051539
21	0.19	0.491	2.80	0.23	0.55	3busA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
22	0.18	0.701	4.06	0.11	0.90	3dp7A	GO:0008168 GO:0008171 GO:0016740 GO:0032259
23	0.17	0.473	3.05	0.17	0.54	1ve3B	GO:0046872 GO:0051536 GO:0051539
24	0.16	0.727	3.62	0.14	0.88	2r3sA
25	0.15	0.752	3.75	0.14	0.92	5cvjA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983 GO:0050630
26	0.14	0.493	3.21	0.21	0.56	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
27	0.14	0.750	3.78	0.16	0.92	4pggA	GO:0005829 GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259 GO:0046872 GO:0046983 GO:0047763 GO:0051536 GO:0051539
28	0.13	0.718	3.94	0.14	0.90	4a6dA	GO:0005829 GO:0006412 GO:0008168 GO:0008171 GO:0008172 GO:0008757 GO:0016740 GO:0017096 GO:0030187 GO:0032259 GO:0042802 GO:0042803 GO:0046219
29	0.13	0.747	3.47	0.14	0.90	5iccA	GO:0008168 GO:0008171 GO:0016740 GO:0030786 GO:0032259 GO:0046983
30	0.12	0.688	3.91	0.15	0.87	2ip2A	GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259
31	0.07	0.484	3.42	0.16	0.57	5je1A	GO:0008168 GO:0016740 GO:0032259
32	0.07	0.501	2.99	0.16	0.57	4f86A	GO:0008168 GO:0008169 GO:0008757 GO:0016740 GO:0032259 GO:0042214

Consensus prediction of GO terms

Molecular Function	GO:0046983	GO:0016206	GO:0047763
GO-Score	0.69	0.34	0.31
Biological Processes	GO:0032259	GO:0017000	GO:0009809	GO:1901663
GO-Score	0.88	0.43	0.31	0.31
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.