I-TASSER results

Input Sequence in FASTA format

>protein (272 residues)
MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVN
LDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYSNYGFTVLAESVQRESGIEFG
RYLTEAVCEPLGMVTTRLDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQMHADATTV
QFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKA
DLALVVLTARDFGDWALDLWPAISDAVLAEYT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT
Prediction	CHHHHHHHHCCCCEEEEEEEHCCEEEEEHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEHCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCEEHCCCCCCEEEEEEHCCCEEEEEEHCCCCCHHHHHHHHHHHHHHHHHHC
Conf.Score	78999999889996999999899899875898875653567889999999999998999888898888889999987888999988876789994887666899999999999989999999999997765999888789988877656669999999999998798779988875445444688887788777888875666797678888766678888578758988769999958897999997899977889999999999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT
Prediction	55015206727010000000356410234135612020012001300200010125330404341555500000001000003434561134234423401100000020003007440340036100510404303144422000000101033004202301365304551143232243243523232323444311000000243622222143334200003133100000012441043440223236303500430141016428
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CHHHHHHHHCCCCEEEEEEEHCCEEEEEHCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCEEEHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEHCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCEEHCCCCCCEEEEEEHCCCEEEEEEHCCCCCHHHHHHHHHHHHHHHHHHC
MTALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAMHSDQALARPGTRRMYSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGMVTTRLDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQMHADATTVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.97

0.95

0.98

3.67

MUSTER

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLA-HSDQALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTR-LDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.96

0.94

0.98

6.87

dPPAS

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLA-HSDQALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTRLD-GGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.95

0.93

0.98

6.36

wdPPAS

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLAHSD-QALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTRLDG-GPAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.97

0.95

0.98

4.57

wMUSTER

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLA-HSDQALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTR-LDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.96

0.94

0.98

5.61

wPPAS

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLA-HSDQALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTRLDGG-PAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.96

0.94

0.98

7.58

dPPAS2

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLA-HSDQALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTRLD-GGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.96

0.94

0.98

4.84

PPAS

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLA-HSDQALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTRLD-GGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

3i7jA

0.97

0.95

0.98

5.94

Env-PPAS

-TALEVLGGWPVPAAAAAVIGPAGVLATHGDTARVFALASVTKPLVARAAQVAVEEGVVNLDTPAGPPGSTVRHLLAHTSGLA-HSDQALARPGTRR-YSNYGFTVLAESVQRESGIEFGRYLTEAVCEPLGVTTR-LDGGPAAAGFGATSTVADLAVFAGDLLRPSTVSAQHADAT-TVQFPGLDGVLPGYGVQRPNDWGLGFEIRNSKSPHWTGECNSTRTFGHFGQSGGFIWVDPKADLALVVLTARDFGDWALDLWPAISDAVLAEYT

5tgfA

0.20

0.19

0.97

2.45

MUSTER

LSIISSWDKGYYPGGAICVVKNDSVLFEKATGDTKVYVASAGKWVAAAVIGAVVDRTDLSWDDPVEKWGILLRQLLSHTSGVRPYLPDTVFTPGTRFEYGGLAQIAG---RAEVAGKEFEPLFQELIAAPLGTHSHFAPGGHAPLGGGLCTTLNDYIRFLKIYHNGRILKPETVQTQADQVVAPGEYVEKALGQHHTSIYGLGEWRE-----LVDEATGEAYQISSPGWAGAYPWINKRDGVYGFFIAHVQGEANKKDGSPVLSETVTKIVN

5tgfA

0.20

0.19

0.97

4.23

dPPAS

DSIISSWDKGYYPGGAICVVKNDSVLFEKATGDTKVYVASAGKWVAAAVIGAVVDRTDLSWDDPVEKWGILLRQLLSHTSGVRPYLPDTVFTPGTRFEYGGLAQIAG---RAEVAGKEFEPLFQELIAAPLGTHSHFADGGHAPLGGGLCTTLNDYIRFLKIYHNGRILKPETVQTQADQVRNAVVAPGEALGQHHTSIYGLGEWRELVDEATGEA-----YQISSPGWAGAYPWINKRDGVYGFFIAHVQGEANKKDGSPVLSETVTKIVN

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.72

Estimated TM-score = 0.96±0.05

Estimated RMSD = 2.6±1.9Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3i7jA	0.963	0.90	0.996	0.982
2	3hlgA	0.878	2.57	0.219	0.985
3	4p6bA	0.866	2.68	0.213	0.982
4	1ci8A	0.862	2.45	0.261	0.960
5	5tgfA	0.845	2.60	0.191	0.945
6	2efxA	0.840	2.41	0.222	0.945
7	2zm9A	0.836	2.72	0.180	0.960
8	4iviA	0.826	2.45	0.249	0.930
9	2qmiA	0.825	2.58	0.262	0.934
10	3wrtA	0.824	2.68	0.233	0.938

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.65	224	3o88A	BSH	Rep, Mult	39,40,43,84,85,99,101,147,228,229,230
2	0.06	24	1ikiA	DAL	Rep, Mult	40,99,205,226,227,228,229
3	0.01	3	2hdsA	4MB	Rep, Mult	85,97,99,201,202,204
4	0.01	3	3gtcB	GTC	Rep, Mult	40,85,86,229,230,251
5	0.01	3	2hdsA	4MB	Rep, Mult	73,74,94,185,211,212,213,214,215
6	0.01	4	2hduA	F12	Rep, Mult	147,229,230,251
7	0.01	3	2hdrB	4A3	Rep, Mult	89,90,91,92
8	0.00	1	3gv9A	GV9	Rep, Mult	151,152,153,156,247
9	0.00	1	3grjA	G14	Rep, Mult	115,116,117
10	0.00	1	2hdrA	4A3	Rep, Mult	140,141
11	0.00	1	2hduA	F12	Rep, Mult	48,51,52,55
12	0.00	1	2hdqA	C21	Rep, Mult	208,209,210
13	0.00	2	3gtcB	GTC	Rep, Mult	68,106,110,113
14	0.00	1	2hdrA	4A3	Rep, Mult	165,166,167,220
15	0.00	1	2hdqA	C21	Rep, Mult	163,164,166,182,218,220,238
16	0.00	2	4e3mA	0ND	Rep, Mult	61,176,179,180,183,192,215
17	0.00	2	2hdqB	C21	Rep, Mult	20,23,25,157,158,161
18	0.00	2	4e3lB	0NB	Rep, Mult	176,179,180,183,214,215,217
19	0.00	1	2hdqB	C21	Rep, Mult	11,13
20	0.00	2	2qmiH	DO3	Rep, Mult	61,62,73,202

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.254	1skfA	0.640	3.80	0.146	0.798	3.4.16.4	146,249
2	0.247	1djaA	0.666	3.38	0.150	0.809	3.5.2.6	40,100
3	0.180	2bcfA	0.621	3.80	0.169	0.783	3.4.16.4	40,45,156
4	0.140	2qz6A	0.818	2.60	0.203	0.930	3.5.2.6	40,43,99
5	0.127	1zkjA	0.816	2.69	0.202	0.934	3.5.2.6	40,43,99
6	0.119	1g68A	0.710	3.01	0.147	0.827	3.5.2.6	NA
7	0.116	2qmiA	0.825	2.58	0.262	0.934	3.5.2.6	40,43,99,101,226
8	0.111	1hzoA	0.689	3.23	0.188	0.824	3.5.2.6	NA
9	0.111	3cg5A	0.678	3.45	0.150	0.827	3.5.2.6	NA
10	0.110	3bydA	0.688	3.22	0.179	0.820	3.5.2.6	40,43,100
11	0.108	1iysA	0.689	3.19	0.188	0.820	3.5.2.6	37,137,139
12	0.100	2v1zA	0.708	2.88	0.173	0.820	3.5.2.6	40,43,100
13	0.097	1bueA	0.680	3.39	0.142	0.824	3.5.2.6	40,43
14	0.084	2j9oD	0.696	3.07	0.147	0.820	3.4.16.4	40,100,150
15	0.081	2rl3B	0.621	3.61	0.102	0.779	3.5.2.6	40
16	0.080	1eqsA	0.641	3.88	0.146	0.801	3.4.16.4	146
17	0.079	2jc7A	0.617	3.51	0.099	0.768	3.5.2.6	40
18	0.060	1mfoA	0.685	3.23	0.198	0.816	3.5.2.6	40,43,100
19	0.060	3lezA	0.671	3.38	0.158	0.816	3.5.2.6	37,100,101,139
20	0.060	3a3iA	0.674	3.63	0.107	0.838	3.4.16.4	40,100
21	0.060	3c4pA	0.700	3.03	0.186	0.824	3.5.2.6	137,139
22	0.060	1iyqA	0.687	3.15	0.179	0.816	3.5.2.6	40,43,100,144
23	0.060	1dy6A	0.686	3.29	0.147	0.827	3.5.2.6	NA
24	0.060	2ex2A	0.678	3.50	0.083	0.824	3.4.16.4	40
25	0.060	1ei5A	0.779	2.87	0.186	0.901	3.4.11.19	40,43,99,101,226
26	0.060	3bfdA	0.690	3.19	0.166	0.820	3.5.2.6	NA
27	0.060	1c3bA	0.821	2.66	0.218	0.934	3.5.2.6	40,43,205
28	0.060	1bsgA	0.679	3.29	0.165	0.820	3.5.2.6	40,43,138
29	0.060	1n4oB	0.700	2.99	0.142	0.820	3.5.2.6	100
30	0.060	1yljA	0.689	3.20	0.166	0.820	3.5.2.6	40,43,100
31	0.060	2j9pA	0.700	3.44	0.115	0.846	3.4.16.4	40
32	0.060	2blmA	0.671	3.30	0.136	0.809	3.5.2.6	40,43,100
33	0.060	2e8iA	0.839	2.68	0.180	0.960	3.5.1.46	123
34	0.060	1cefA	0.810	2.70	0.218	0.926	3.4.16.4	131
35	0.060	1ga0A	0.816	2.66	0.205	0.934	3.5.2.6	40,43,99

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.44	0.812	2.57	0.23	0.92	4y7pA	GO:0004180 GO:0006508
1	0.42	0.816	2.36	0.20	0.91	4gdnA	GO:0005886 GO:0016020 GO:0016021
2	0.35	0.810	2.70	0.22	0.93	1cefA	GO:0004180 GO:0005576 GO:0006508 GO:0008233 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0071555
3	0.35	0.801	2.52	0.21	0.91	3ixgA	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0042597 GO:0046677
4	0.34	0.802	2.64	0.18	0.92	5eviB	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0046677
5	0.34	0.685	3.15	0.18	0.81	5e2eA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
6	0.33	0.810	2.64	0.20	0.93	3o3vA	GO:0008800 GO:0016020 GO:0016021 GO:0016787 GO:0017001 GO:0030288 GO:0046677
7	0.32	0.802	2.74	0.20	0.92	4e6xA	GO:0008800 GO:0016020 GO:0016021 GO:0016787 GO:0017001 GO:0030288 GO:0046677
8	0.30	0.820	2.56	0.23	0.93	5e2hA	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0046677
9	0.29	0.692	3.22	0.18	0.83	4yfmA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
10	0.27	0.688	3.22	0.18	0.82	3bydA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
11	0.26	0.666	3.38	0.15	0.81	1djaA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
12	0.25	0.689	3.18	0.19	0.82	4bd0A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
13	0.24	0.679	3.36	0.17	0.82	5ihvA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
14	0.24	0.820	2.80	0.17	0.94	4gb7A	GO:0016054 GO:0016787 GO:0019875
15	0.24	0.678	3.50	0.08	0.82	2ex2A	GO:0000270 GO:0004175 GO:0004180 GO:0004185 GO:0006508 GO:0007049 GO:0008360 GO:0008658 GO:0009002 GO:0009252 GO:0009253 GO:0009254 GO:0016787 GO:0016998 GO:0030288 GO:0042597 GO:0043093 GO:0046677 GO:0051301 GO:0071555
16	0.24	0.686	3.29	0.15	0.83	1dy6A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
17	0.23	0.678	3.14	0.17	0.81	5hx9A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
18	0.22	0.692	3.09	0.17	0.82	3w4oA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
19	0.22	0.678	3.26	0.14	0.81	3qhyA	GO:0008800 GO:0016787 GO:0017001 GO:0030655 GO:0046677
20	0.22	0.687	3.20	0.16	0.82	3hlwA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
21	0.22	0.694	3.10	0.15	0.82	3v3sA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
22	0.21	0.878	2.57	0.22	0.99	3hlfA	GO:0016740 GO:0016746 GO:0016787 GO:0017000 GO:0030639 GO:0050832
23	0.20	0.679	3.29	0.17	0.82	1bsgA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
24	0.20	0.862	2.45	0.26	0.96	1ci8A	GO:0005737 GO:0016787
25	0.20	0.868	2.31	0.25	0.97	4iviA	GO:0016787 GO:0052689
26	0.19	0.676	3.03	0.11	0.81	3a3eB	GO:0004185 GO:0006508
27	0.17	0.825	2.58	0.26	0.93	2qmiA
28	0.16	0.690	3.19	0.17	0.82	3bfdA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
29	0.16	0.698	3.36	0.18	0.83	2a3uA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
30	0.15	0.684	3.24	0.20	0.82	2cc1A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
31	0.14	0.687	3.21	0.17	0.82	4hbtA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
32	0.14	0.693	3.18	0.18	0.82	5hw3A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
33	0.13	0.683	3.22	0.17	0.82	3w4qA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
34	0.12	0.708	2.87	0.17	0.82	4id4A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
35	0.12	0.710	3.01	0.15	0.83	1g68A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
36	0.12	0.708	3.07	0.14	0.83	4d2oB	GO:0008800 GO:0016787 GO:0030655 GO:0046677
37	0.12	0.673	2.90	0.10	0.79	3cjmA	GO:0016020 GO:0016021
38	0.11	0.689	3.23	0.19	0.82	1hzoA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
39	0.11	0.705	3.02	0.14	0.82	1e25A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
40	0.11	0.671	3.38	0.16	0.82	3lezA	GO:0008800 GO:0016787 GO:0030655 GO:0046677 GO:0046872
41	0.11	0.696	3.04	0.15	0.82	4mx4A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
42	0.11	0.678	3.33	0.18	0.82	3dw0A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
43	0.10	0.694	3.07	0.16	0.82	5e43A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
44	0.10	0.708	2.88	0.17	0.82	2v1zA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
45	0.10	0.680	3.39	0.14	0.82	1bueA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
46	0.10	0.671	3.30	0.14	0.81	2blmA	GO:0005886 GO:0008800 GO:0016020 GO:0016787 GO:0030655 GO:0046677
47	0.10	0.674	3.49	0.14	0.83	4qb8A	GO:0005576 GO:0005886 GO:0008800 GO:0016020 GO:0016787 GO:0030655 GO:0033250 GO:0033251 GO:0042597 GO:0046677
48	0.10	0.700	2.99	0.14	0.82	1n4oB	GO:0008800 GO:0016787 GO:0030655 GO:0046677
49	0.10	0.682	3.07	0.10	0.81	3p09A	GO:0008800 GO:0016787 GO:0030655 GO:0046677
50	0.10	0.693	3.60	0.15	0.84	1tvfA	GO:0004180 GO:0006508 GO:0009002 GO:0016020 GO:0016021
51	0.09	0.689	3.22	0.16	0.82	4eqiB	GO:0008800 GO:0016787 GO:0030655 GO:0046677
52	0.08	0.696	3.07	0.15	0.82	2j9oD
53	0.08	0.664	3.58	0.17	0.81	1xp4A	GO:0004175 GO:0004180 GO:0005887 GO:0006508 GO:0009002 GO:0009252 GO:0016787
54	0.07	0.657	3.41	0.19	0.80	1xp4D	GO:0004175 GO:0004180 GO:0005887 GO:0006508 GO:0009002 GO:0009252 GO:0016787
55	0.07	0.578	3.42	0.13	0.70	1alqA	GO:0008800 GO:0016787 GO:0030655 GO:0046677
56	0.07	0.706	3.54	0.13	0.86	4b4xA	GO:0004180 GO:0004185 GO:0005576 GO:0006508 GO:0008233 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0046677 GO:0071555
57	0.07	0.700	3.44	0.12	0.85	2j9pA	GO:0004185 GO:0005576 GO:0006508 GO:0007049 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0051301 GO:0071555
58	0.07	0.646	3.85	0.12	0.80	5cerA	GO:0004180 GO:0004185 GO:0006508 GO:0009002 GO:0016787
59	0.07	0.673	3.52	0.10	0.83	3a3dA	GO:0004185 GO:0006508 GO:0007049 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0042597 GO:0046677 GO:0051301 GO:0071555
60	0.06	0.297	6.95	0.05	0.58	3qvfA	GO:0000166 GO:0005524 GO:0016301 GO:0016310 GO:0016740
61	0.06	0.293	7.06	0.05	0.57	3a15B	GO:0046872
62	0.06	0.330	6.20	0.10	0.57	4c20B	GO:0005737 GO:0005975 GO:0005996 GO:0006004 GO:0008736 GO:0016853 GO:0016861 GO:0019317 GO:0030145 GO:0042355 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0008800	GO:0009002
GO-Score	0.57	0.35
Biological Processes	GO:0006508	GO:0017001	GO:0046677	GO:0009252	GO:0008360	GO:0071555
GO-Score	0.64	0.57	0.57	0.35	0.35	0.35
Cellular Component	GO:0030288	GO:0016021	GO:0005886	GO:0005576
GO-Score	0.57	0.42	0.42	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv2257c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]