I-TASSER results

I-TASSER results for job id Rv2242

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (414 residues)
MNDNQLAPVARPRSPLELLDTVPDSLLRRLKQYSGRLATEAVSAMQERLPFFADLEASQR
ASVALVVQTAVVNFVEWMHDPHSDVGYTAQAFELVPQDLTRRIALRQTVDMVRVTMEFFE
EVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRG
DTGPELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAAL
TDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASEAISGMNA
VAGWRGAPRPVLARELLPERALMGDASAIVALHTDVMRPLADAGPTLIETLDAYLDCGGA
IEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNDNQLAPVARPRSPLELLDTVPDSLLRRLKQYSGRLATEAVSAMQERLPFFADLEASQRASVALVVQTAVVNFVEWMHDPHSDVGYTAQAFELVPQDLTRRIALRQTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAALTDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALHTDVMRPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH
Prediction	CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCEEEEEHCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
Conf.Score	999999998888888655678899999999999999999999999998846655885788999999999999999999789988646789999876777776675889999999999999997887688788899999999999999999999999999999999999999999999979998999999999899999868999999588887765457899999999999987577679987799999997799876999999999986887689866789999999999999999999986588897689763578899869999999999999988886586999999999998999999999989999999999999999989999999999999999999985788999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNDNQLAPVARPRSPLELLDTVPDSLLRRLKQYSGRLATEAVSAMQERLPFFADLEASQRASVALVVQTAVVNFVEWMHDPHSDVGYTAQAFELVPQDLTRRIALRQTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAALTDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALHTDVMRPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH
Prediction	545563324443643453144024400520373145004200510272133025045633530120012003100410343543452233013202321112020420130000001101400330124553134014101300330030003003402443442243113200211042632430240044140415100000000034454344242223201410241024211100001422000000012323124004301520350320021013204302400310130041044145552000000000000012236203400440041037334301400210043623143006304103100310051026007231730330010000000020435438
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCEEEEEHCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCC
MNDNQLAPVARPRSPLELLDTVPDSLLRRLKQYSGRLATEAVSAMQERLPFFADLEASQRASVALVVQTAVVNFVEWMHDPHSDVGYTAQAFELVPQDLTRRIALRQTVDMVRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSRAAALNWDTTAPATVLVGTPAPGPNGSNSDGDSERASQDVRDTAARHGRAALTDVHGTWLVAIVSGQLSPTEKFLKDLLAAFADAPVVIGPTAPMLTAAHRSASEAISGMNAVAGWRGAPRPVLARELLPERALMGDASAIVALHTDVMRPLADAGPTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLNYPTPH

3onqA

0.30

0.18

0.59

1.29

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLHTDDTTIERLAFECLLTNTD--DRVVSLNILGWQGDFNCFAIGGVPSAS---------LASTSLAIRKAVRDLGGHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRNPDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

5cwqA

0.10

0.06

0.56

1.07

dPPAS2

----------------------------------------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQG--------------------DDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRL-----AEEAEQLAREARRHVQECRGGWLEHHH--------------------------------------------------------------------------------------------------------

3onqA

0.29

0.17

0.59

1.49

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNTD--DRVVSLNILGWQGDFNCFAIGGVPSAS--------LASTSLAIRKAVRDLGGEHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

3onqA

0.30

0.18

0.59

2.60

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNTD--DRVVSLNILGWQGDFNCFAIGGVPSAS---------LASTSLAIRKAVRDLGEHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

3onqA

0.30

0.18

0.59

1.72

wMUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSTDDTTIERLAFECLLTNTD--DRVVSLNILGWQGDFNCFAIGGVPSAS---------LASTSLAIRKAVRDLGGHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRNPDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

3onqA

0.30

0.18

0.59

3.56

wPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNT--DDRVVSLNILGWQGDFNCFAIGGVPSAS---------LASTSLAIRKAVRDLGEHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

3onqA

0.30

0.18

0.59

3.30

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNTD--DRVVSLNILGWQGDFNCFAIGGVPSAS---------LASTSLAIRKAVRDLGEHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

3onqA

0.29

0.17

0.59

2.56

PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNTD--DRVVSLNILGWQGDFNCFAIGGVPSAS--------LASTSLAIRKAVRDLGGEHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

3onqA

0.29

0.17

0.59

4.05

Env-PPAS

--------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHT-------------DDTTIERLAFECLLTNTD--DRVVSLNILGWQGDFNCFAIGGVPSAS---------LASTSLAIRKAVRDLGEHVVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGEDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----

5j65A

0.07

0.06

0.91

0.76

MUSTER

KLNSNKKYGPGDMTNGNQFIISKQEWATIGAYIQTGLG---EQQLRTHVNLSQDISPSDFSQLYDVYCSDKTSAEWWNKNLYPLIIKSANDIASYGFKVAGDPSIDGYFKKLQDELDNIVD-----NSDDDAIAKAIKDFKARCGILIKEAKQYEEAAKNIVTSLDQFLHGD------KLEGVINIQKRLKEVQTALNQAHG------ESSPAHKELLEKVKNLKTTLERTIKAEKVEYSFLLGPLLGFVVYEILENTAVQHIKNQIDEI----------KKQLDSAQHDLDRDVKIIGMLNSI--------NTDIDNLYSQGQEAIKVFQKLQGIWATIGAQIENLRTTSLQEVQDSDDADEIQIELEDASDAWLVVAQEARDFTLLEYKCPENNFMIYWYNNSDWYNNSDW-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.09

Estimated TM-score = 0.37±0.12

Estimated RMSD = 14.5±3.7Å

Download Model 2

C-score=-3.95

Download Model 3

C-score=-3.99

Download Model 4

C-score=-4.34

Download Model 5

C-score=-4.56

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4k1pA	0.807	1.07	0.077	0.819
2	5j65A	0.642	3.62	0.070	0.773
3	2nrjA	0.634	3.27	0.070	0.727
4	1qoyA	0.472	4.21	0.030	0.589
5	3g61A	0.417	6.06	0.046	0.606
6	4f4cA	0.413	6.13	0.050	0.616
7	4a01A	0.410	6.23	0.066	0.621
8	3ayfA	0.409	6.20	0.043	0.638
9	3ayxA	0.402	6.03	0.046	0.582
10	3uqyL	0.401	6.19	0.053	0.585

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1e3dB	FNE	Rep, Mult	26,27,28,353,354,355,364,367
2	0.04	2	1sq3A	FE	Rep, Mult	28,290,293,294
3	0.04	2	5fnyA	O	Rep, Mult	21,77,81,130,301,305
4	0.04	2	1cc1L	FCO	Rep, Mult	178,179,184,250,283,286
5	0.02	1	3prqX	CLA	Rep, Mult	340,347
6	0.02	1	3h3xQ	FCO	Rep, Mult	17,309,400,403
7	0.02	1	3wmgA	DMU	Rep, Mult	296,300
8	0.02	1	1yrhC	FMN	Rep, Mult	335,371
9	0.02	1	1cc1L	H2S	Rep, Mult	187,189,190,235,238
10	0.02	1	2x7aI	MG	Rep, Mult	316,320
11	0.02	1	1w5cB	CLA	Rep, Mult	291,298
12	0.02	1	1j7lA	MG	Rep, Mult	373,389
13	0.02	1	2bnwB	NUC	Rep, Mult	374,376
14	0.02	1	1q9xC	DOC	Rep, Mult	301,302,303
15	0.02	1	1t64A	CA	Rep, Mult	365,371
16	0.02	1	1uf3A	CA	Rep, Mult	387,389
17	0.02	1	3sjqC	PHU	Rep, Mult	146,147
18	0.02	1	5irxA	6EU	Rep, Mult	155,280,283,284
19	0.02	1	3c9iC	XE	Rep, Mult	155,158
20	0.02	1	2q6qB	CO	Rep, Mult	142,146

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1g8kA	0.361	7.28	0.053	0.614	1.20.98.1	NA
2	0.060	1eulA	0.341	6.48	0.060	0.522	3.6.3.8	181
3	0.060	1j3uA	0.342	6.19	0.041	0.512	4.3.1.1	383
4	0.060	3hjbA	0.344	6.97	0.068	0.575	5.3.1.9	NA
5	0.060	1jtnA	0.178	5.05	0.026	0.241	3.2.1.17	293
6	0.060	1yfmA	0.347	5.93	0.049	0.507	4.2.1.2	NA
7	0.060	1h2rL	0.371	5.88	0.036	0.534	1.12.2.1	308
8	0.060	1h2aL	0.371	5.88	0.039	0.534	1.12.2.1	NA
9	0.060	1dcnB	0.321	5.95	0.040	0.469	4.3.2.1	NA
10	0.060	1w27A	0.357	6.28	0.038	0.534	4.3.1.24	NA
11	0.060	1vdkA	0.350	5.83	0.079	0.505	4.2.1.2	391
12	0.060	1yfeA	0.344	5.92	0.071	0.502	4.2.1.2	NA
13	0.060	2ebsB	0.339	6.52	0.065	0.539	3.2.1.150	96
14	0.060	1no3A	0.337	6.32	0.037	0.510	1.13.11.12	NA
15	0.060	1tj7A	0.336	6.01	0.061	0.495	4.3.2.1	NA
16	0.060	2frvD	0.377	6.03	0.039	0.548	1.12.2.1	NA
17	0.060	1cc1L	0.374	5.66	0.048	0.524	1.12.99.6	NA
18	0.060	2iukB	0.338	6.51	0.049	0.524	1.13.11.12	NA
19	0.060	1g8kE	0.360	7.25	0.060	0.609	1.20.98.1	77

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.26	0.800	1.19	0.07	0.81	4k1pB	GO:0009405 GO:0016020
1	0.08	0.647	3.35	0.08	0.75	2nrjA	GO:0005576 GO:0009405 GO:0016020 GO:0016021 GO:0019835 GO:0020002 GO:0033644 GO:0044179
2	0.07	0.642	3.62	0.07	0.77	5j65A	GO:0030435
3	0.07	0.472	4.21	0.03	0.59	1qoyA	GO:0005576 GO:0009405 GO:0016020 GO:0016021 GO:0019835 GO:0020002 GO:0033644 GO:0042597 GO:0042802 GO:0044179 GO:0044532 GO:0051715
4	0.06	0.416	5.91	0.05	0.59	4m1mA	GO:0000086 GO:0000166 GO:0002481 GO:0002485 GO:0002489 GO:0002591 GO:0005524 GO:0005886 GO:0006810 GO:0006855 GO:0008559 GO:0009986 GO:0015893 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0042623 GO:0042626 GO:0042908 GO:0046581 GO:0055085 GO:0070062 GO:0072089
5	0.06	0.413	6.13	0.05	0.62	4f4cA	GO:0000166 GO:0005524 GO:0006810 GO:0006855 GO:0008559 GO:0010038 GO:0015562 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0016887 GO:0042626 GO:0042908 GO:0045087 GO:0050829 GO:0055085 GO:0093002
6	0.06	0.354	6.10	0.04	0.52	3wmgA	GO:0000166 GO:0005524 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0055085
7	0.06	0.351	6.57	0.03	0.53	3qf4B	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0055085
8	0.06	0.354	6.30	0.03	0.53	4q4aA	GO:0000166 GO:0005524 GO:0006810 GO:0006869 GO:0016020 GO:0016021 GO:0016887 GO:0034040 GO:0042626 GO:0046872 GO:0055085
9	0.06	0.342	5.90	0.03	0.49	4ayxA	GO:0000166 GO:0005215 GO:0005524 GO:0005739 GO:0005743 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0032592 GO:0042626 GO:0042803 GO:0055085
10	0.06	0.323	7.09	0.06	0.54	3uwxA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0090305
11	0.06	0.325	6.80	0.05	0.52	3zqjA	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0060543 GO:0090305
12	0.06	0.298	6.12	0.03	0.43	4a82A	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0042626 GO:0055085
13	0.06	0.328	6.49	0.04	0.51	4mrrA	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0046689 GO:0055085
14	0.06	0.319	7.32	0.06	0.54	3zqjC	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0060543 GO:0090305
15	0.06	0.317	7.60	0.04	0.56	3zqjD	GO:0000166 GO:0003677 GO:0003824 GO:0004518 GO:0005524 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006281 GO:0006289 GO:0006974 GO:0008270 GO:0009380 GO:0009381 GO:0009432 GO:0016887 GO:0046872 GO:0060543 GO:0090305
16	0.06	0.322	6.26	0.04	0.47	3b5wA	GO:0000166 GO:0005319 GO:0005524 GO:0005886 GO:0006810 GO:0006869 GO:0008144 GO:0008289 GO:0015437 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0034040 GO:0042626 GO:0043190 GO:0055085 GO:1901264
17	0.06	0.345	6.03	0.04	0.51	4pl0B	GO:0000166 GO:0005524 GO:0005886 GO:0006810 GO:0015031 GO:0016020 GO:0016021 GO:0016887 GO:0030153 GO:0042626 GO:0043213 GO:0055085
18	0.06	0.277	6.97	0.03	0.46	3ozxB	GO:0000054 GO:0000166 GO:0005506 GO:0005524 GO:0005623 GO:0005852 GO:0006413 GO:0006415 GO:0016887 GO:0043024

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0042802	GO:0008559
GO-Score	0.07	0.07	0.07
Biological Processes	GO:0009405
GO-Score	0.36
Cellular Component	GO:0031224
GO-Score	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.