I-TASSER results

I-TASSER results for job id Rv2230c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (379 residues)
MSVRLADVIDVLDQAYPPRLAQSWDSVGLVCGDPDDVVDSVTVAVDATPAVVDQVPQAGL
LLVHHPLLLRGVDTVAANTPKGVLVHRLIRTGRSLFTAHTNADSASPGVSDALAHAVGLT
VDAVLDPVPGAADLDKWVIYVPRENSEAVRAAVFEAGAGHIGDYSHCSWSVAGTGQFLAH
DGASPAIGSVGTVERVAEDRVEVVAPARARAEVLAAMRAAHPYEEPAFDIFALVPPPVGS
GLGRIGRLPKPEPLRTFVARLEAALPPTATGVRAAGDPDLLVSRVAVCGGAGDSLLATVA
AADVQAYVTADLRHHPADEHCRASQVALIDVAHWASEFPWCGQAAEVLRSHFGASLPVRV
CTICTDPWNLDHETGRDQA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSVRLADVIDVLDQAYPPRLAQSWDSVGLVCGDPDDVVDSVTVAVDATPAVVDQVPQAGLLLVHHPLLLRGVDTVAANTPKGVLVHRLIRTGRSLFTAHTNADSASPGVSDALAHAVGLTVDAVLDPVPGAADLDKWVIYVPRENSEAVRAAVFEAGAGHIGDYSHCSWSVAGTGQFLAHDGASPAIGSVGTVERVAEDRVEVVAPARARAEVLAAMRAAHPYEEPAFDIFALVPPPVGSGLGRIGRLPKPEPLRTFVARLEAALPPTATGVRAAGDPDLLVSRVAVCGGAGDSLLATVAAADVQAYVTADLRHHPADEHCRASQVALIDVAHWASEFPWCGQAAEVLRSHFGASLPVRVCTICTDPWNLDHETGRDQA
Prediction	CCCCHHHHHHHHHHHCCHHHHCCCCCCEEEHCCCCCCCCEEEEEHCCCHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCCCEEEEHCCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCEEEHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCEEEEHCCCCCCC
Conf.Score	9735999999999988988855678875886788876568999985999999999998959997676667875567888678999999998998999555455688866799999989866555667776554445655577568999999888867876566556788766776667777888777877667887667899997557888999999875764554444445566777775789998599889999999999998999679998588887556999976885799999999899899995887579999999979989986875788999999999999998999779998557898799986899999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSVRLADVIDVLDQAYPPRLAQSWDSVGLVCGDPDDVVDSVTVAVDATPAVVDQVPQAGLLLVHHPLLLRGVDTVAANTPKGVLVHRLIRTGRSLFTAHTNADSASPGVSDALAHAVGLTVDAVLDPVPGAADLDKWVIYVPRENSEAVRAAVFEAGAGHIGDYSHCSWSVAGTGQFLAHDGASPAIGSVGTVERVAEDRVEVVAPARARAEVLAAMRAAHPYEEPAFDIFALVPPPVGSGLGRIGRLPKPEPLRTFVARLEAALPPTATGVRAAGDPDLLVSRVAVCGGAGDSLLATVAAADVQAYVTADLRHHPADEHCRASQVALIDVAHWASEFPWCGQAAEVLRSHFGASLPVRVCTICTDPWNLDHETGRDQA
Prediction	6613043005102710236104611300010213644030000000003400520271300000000103204404474122300230053400000000000204412020003102223222222122222222222221342242033122412243234022000103324322134204221143243230221000000122224423404332222432322222222221220000003064513053004102620715100000024334302100000000120043026350100000202112011004534000000032100100052005203741647030200434411030204356668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHCCHHHHCCCCCCEEEHCCCCCCCCEEEEEHCCCHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCCCEEEEHCCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCEEEHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCEEEEHCCCCCCC
MSVRLADVIDVLDQAYPPRLAQSWDSVGLVCGDPDDVVDSVTVAVDATPAVVDQVPQAGLLLVHHPLLLRGVDTVAANTPKGVLVHRLIRTGRSLFTAHTNADSASPGVSDALAHAVGLTVDAVLDPVPGAADLDKWVIYVPRENSEAVRAAVFEAGAGHIGDYSHCSWSVAGTGQFLAHDGASPAIGSVGTVERVAEDRVEVVAPARARAEVLAAMRAAHPYEEPAFDIFALVPPPVGSGLGRIGRLPKPEPLRTFVARLEAALPPTATGVRAAGDPDLLVSRVAVCGGAGDSLLATVAAADVQAYVTADLRHHPADEHCRASQVALIDVAHWASEFPWCGQAAEVLRSHFGASLPVRVCTICTDPWNLDHETGRDQA

2gx8C

0.34

0.32

0.94

2.36

MUSTER

IP-NGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPT-YAEEMKKVVVFVPVTHAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEG--------GQLERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2gx8C

0.32

0.30

0.94

2.92

dPPAS

IP-NGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPTYAEEMKKVVVFVPV-THAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEGGQL--------ERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2gx8C

0.33

0.31

0.94

4.44

wdPPAS

I-PNGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPTYAEE-MKKVVVFVPVTHAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEG--------GQLERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2gx8C

0.34

0.32

0.94

2.83

wMUSTER

I-PNGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPT-YAEEMKKVVVFVPVTHAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEG--------GQLERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2gx8C

0.33

0.31

0.94

5.11

wPPAS

I-PNGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPTYAEE-MKKVVVFVPVTHAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEG--------GQLERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2gx8C

0.33

0.31

0.94

5.54

dPPAS2

IP-NGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPTYAE-EMKKVVVFVPVTHAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEG--------GQLERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2gx8C

0.33

0.31

0.94

4.39

PPAS

IP-NGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPTYAE-EMKKVVVFVPVTHAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEG--------GQLERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2gx8C

0.34

0.32

0.94

6.81

Env-PPAS

IP-NGHEIISLFESMYPKHLAMEGDKIGLQIGALNKPVRHVLIALDVTEEVVDEAIQLNVIIAHHPLIFNPLKAIHTDKAYGKIIEKCIKNDIAIYAAHTNVDVAKGGVNDLLAEALGLQNTEVLAPT-YAEEMKKVVVFVPVTHAEEVRKALGDAGAGHIGNYSHCTFSSEGTGTFVPQEG--------GQLERVEEVRIETIIPASLQRKVIKAMVTAHPYEEVAYDVYPLDNKGETLGLGKIGYLQEEMTLGQFAEHVKQSLDVKG--ARVVGKLDDKVRKVAVLGGDGNKYINQAKFKGADVYVTGDMYYHVAHDAMMLG-LNIVDPGH-NVEKVMKQGVQKQLQEKVDLNVHIHASQLHTDPFIFV--------

2nydB

0.30

0.27

0.90

2.22

MUSTER

MPMKIADLMTLLDHHVPFSTAESWDNVGLLIGDEDVEVTGVLTALDCTLEVVNEAIEKNTIISHHPLIFKGVTSLKAN-GYGLIIRKLIQHDINLIAMHTNLDVNPYGVNMMLAKVMGLKNISIINN--QQDVYYKVQTYIPKDNVGPFKDKLSENGLAQEGNYEYCFFESED----------------------VDEVKIEFMIDAYQKSRAEQLIKQYHPYETPVFDFIE-IKQTSLYGLGVMAEVDNQMTLEDFAADIKSKLNIPS--VRFVGESNQKIKRIAIIGGSGIGYEYQAVQQGADVFVTGDIKHHDALDAKIHG-VNLIDINH-YSEYVMKEGLKTLLMNWFNINIDVEASTINTDPFQYI--------

2nydB

0.29

0.26

0.90

2.70

dPPAS

DPMKIADLMTLLDHHVPFSTAESWDNVGLLIGDEDVEVTGVLTALDCTLEVVNEAIEKGYIISHHPLIFKGVTSLKA-NGYGLIIRKLIQHDINLIAMHTNLDVNPYGVNMMLAKVMGLKNISIINNQQD--VYYKVQTYIPKDNVGPFKDKLSENGLAQEGNYEYCFFESED----------------------VDEVKIEFMIDAYQKSRAEQLIKQYHPYETPVFDFIE-IKQTSLYGLGVMAEVDNQMTLEDFAADIKSKLNIPS--VRFVGESNQKIKRIAIIGGSGIGYEYQAVQQGADVFVTGDIKHHDALDAKIHG-VNLIDINH-YSEYVMKEGLKTLLMNWFNINIDVEASTINTDPFQYI--------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.89

Estimated TM-score = 0.83±0.08

Estimated RMSD = 4.8±3.1Å

Download Model 2

C-score=-0.67

Download Model 3

C-score=-4.93

Download Model 4

C-score=-5.00

Download Model 5

C-score=-0.47

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2gx8C	0.932	0.84	0.332	0.945
2	2nydB	0.752	3.40	0.222	0.876
3	2fywA	0.636	1.72	0.232	0.670
4	1nmpA	0.595	2.04	0.190	0.638
5	2yybA	0.575	2.23	0.207	0.625
6	4iwgA	0.564	2.47	0.236	0.625
7	3rxyA	0.440	4.08	0.104	0.559
8	3abzA	0.387	6.35	0.042	0.612
9	3e0dA	0.370	6.16	0.067	0.570
10	2okxA	0.368	6.91	0.055	0.617

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.43	13	3wsdF	FE	Rep, Mult	64,99,103,337
2	0.32	11	2nydA	ZN	Rep, Mult	65,334,337
3	0.05	3	3wsfF	CIT	Rep, Mult	65,99,103,242,289,290,291,334,337
4	0.02	1	2c3oA	SF4	Rep, Mult	277,279,280,281,282,283,305,327,328
5	0.02	1	1nmp1	III	Rep, Mult	255,256,259,270,277

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3bicB	0.333	6.81	0.050	0.549	5.4.99.2	NA
2	0.060	3eifA	0.336	7.31	0.035	0.591	3.4.21.110	NA
3	0.060	1llwA	0.341	6.58	0.102	0.557	1.4.7.1	NA
4	0.060	2fknB	0.347	6.39	0.056	0.543	4.2.1.49	NA
5	0.060	1lpsA	0.330	7.13	0.064	0.570	3.1.1.3	95
6	0.060	2w68C	0.177	5.13	0.037	0.248	3.2.1.18	NA
7	0.060	1ea0A	0.331	6.65	0.081	0.549	1.4.1.13	NA
8	0.060	1kitA	0.333	6.64	0.029	0.541	3.2.1.18	NA
9	0.060	1ogyI	0.340	6.74	0.059	0.559	1.7.99.4	99
10	0.060	1n63B	0.327	6.94	0.041	0.551	1.2.99.2	NA
11	0.060	3ecqB	0.345	6.75	0.038	0.581	3.2.1.97	13
12	0.060	1uwkA	0.346	6.50	0.060	0.551	4.2.1.49	292
13	0.060	3cf4A	0.348	6.92	0.048	0.583	1.2.99.2	111,129
14	0.060	1jqkF	0.337	6.44	0.022	0.530	1.2.99.2	296
15	0.060	1nj8A	0.327	6.90	0.026	0.554	6.1.1.15	NA
16	0.060	1h4sA	0.328	7.05	0.032	0.567	6.1.1.15	244
17	0.060	1gz7C	0.325	7.40	0.048	0.599	3.1.1.3	62
18	0.060	1k32A	0.283	7.42	0.033	0.507	3.4.21.-	290
19	0.060	2nyaA	0.330	6.67	0.064	0.546	1.7.99.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.52	0.714	2.45	0.27	0.78	3lnlA	GO:0046872
1	0.47	0.753	3.47	0.23	0.88	3lnlB	GO:0046872
2	0.37	0.651	1.63	0.23	0.68	2fywA	GO:0046872
3	0.34	0.596	2.03	0.19	0.64	1nmoA	GO:0005829 GO:0006281 GO:0006974 GO:0010212 GO:0042802 GO:0046872
4	0.23	0.932	0.84	0.33	0.94	2gx8C	GO:0005737 GO:0046872
5	0.06	0.254	6.64	0.07	0.41	2p1rA	GO:0000166 GO:0000287 GO:0001727 GO:0005524 GO:0005737 GO:0006629 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046834 GO:0046872
6	0.06	0.276	7.37	0.03	0.49	3ohaA	GO:0003677 GO:0003684 GO:0003887 GO:0005634 GO:0005657 GO:0005739 GO:0006260 GO:0006281 GO:0006974 GO:0007059 GO:0007064 GO:0016740 GO:0016779 GO:0042276 GO:0046872 GO:0070987 GO:0071897
7	0.06	0.251	5.82	0.09	0.37	1llcA	GO:0003824 GO:0004459 GO:0005737 GO:0005975 GO:0006096 GO:0016491 GO:0016616 GO:0019752 GO:0055114
8	0.06	0.207	6.47	0.07	0.33	4jgtA	GO:0001822 GO:0001889 GO:0004792 GO:0005737 GO:0005739 GO:0005829 GO:0009440 GO:0009636 GO:0016740 GO:0016784 GO:0019346 GO:0021510 GO:0030054 GO:0042802 GO:0043005 GO:0045202 GO:0070062 GO:0070814
9	0.06	0.228	1.79	0.13	0.24	3gsdA	GO:0005507 GO:0005737 GO:0010038 GO:0046872
10	0.06	0.215	6.54	0.05	0.35	4haoB	GO:0000166 GO:0003951 GO:0005524 GO:0005737 GO:0006741 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0019674 GO:0046872
11	0.06	0.246	5.79	0.05	0.35	4if2A	GO:0008270 GO:0009056 GO:0016787 GO:0016788 GO:0046872
12	0.06	0.207	7.01	0.02	0.35	4e54B	GO:0000209 GO:0000715 GO:0000717 GO:0003677 GO:0003684 GO:0004842 GO:0005634 GO:0005654 GO:0006281 GO:0006289 GO:0006290 GO:0006293 GO:0006294 GO:0006295 GO:0006296 GO:0006974 GO:0009411 GO:0016567 GO:0030054 GO:0031465 GO:0033683 GO:0035518 GO:0043234 GO:0051865 GO:0070911 GO:0070914 GO:0080008
13	0.06	0.230	1.91	0.13	0.24	4y65B	GO:0005507 GO:0005737 GO:0010038 GO:0046688 GO:0046872 GO:0051260
14	0.06	0.213	5.12	0.05	0.29	3f4wA	GO:0003824 GO:0004590 GO:0005975 GO:0006207 GO:0008152 GO:0016829 GO:0043801
15	0.06	0.189	6.00	0.05	0.29	4f2nB	GO:0004784 GO:0006801 GO:0016491 GO:0019430 GO:0046872 GO:0055114
16	0.06	0.176	4.54	0.05	0.23	4rltA	GO:0005886 GO:0019171 GO:0040007
17	0.06	0.181	5.53	0.02	0.26	3gzxB	GO:0003824 GO:0006725 GO:0016491 GO:0018687 GO:0019439 GO:0051213 GO:0055114
18	0.06	0.199	4.81	0.08	0.27	2xhzB	GO:0005975 GO:0009103 GO:0016853 GO:0019146 GO:0019294 GO:0030246 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0042802
GO-Score	0.92	0.34
Biological Processes	GO:0006281	GO:0010212
GO-Score	0.34	0.34
Cellular Component	GO:0005829
GO-Score	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.