I-TASSER results

I-TASSER results for job id Rv2229c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (245 residues)
MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHNAANDRMAALRIAAED
LDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELDSLQRRQASLEDALLEV
LERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQARHQHSSQRDMLTATLDPE
LAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAAAEDEVVRCPECGAILLRL
EGFEE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHNAANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELDSLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQARHQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAAAEDEVVRCPECGAILLRLEGFEE
Prediction	CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCEHCCHHHHHHHHHCCCCCEEHCCCCCEEEEEHCCCCC
Conf.Score	99899999999999999999999999999979999999999999999999999999999999999999999999999999999999997558999999999999999999999999999999999999999999999999999999999999999999999999999999999997899999999999998997799985886545556759999999998588977868999879998455689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHNAANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELDSLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQARHQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAAAEDEVVRCPECGAILLRLEGFEE
Prediction	87243730430250151153155046416615545415504641551464155145415514542562554155146425524641564454462254145315515543551364145235425615652551454155146515512541553255155325514641551276035502520540375642000303742031040303462143036347530140340100002265278
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCEHCCHHHHHHHHHCCCCCEEHCCCCCEEEEEHCCCCC
MKAGVAQQRSLLELAKLDAELTRIAHRATHLPQRAAYQQVQAEHNAANDRMAALRIAAEDLDGQVSRFESEIDAVRKRGDRDRSLLTSGATDAKQLADLQHELDSLQRRQASLEDALLEVLERREELQAQQTAESRALQALRADLAAAQQALDEALAEIDQARHQHSSQRDMLTATLDPELAGLYERQRAGGGPGAGRLQGHRCGACRIEIGRGELAQISAAAEDEVVRCPECGAILLRLEGFEE

4iloA

0.17

0.16

0.96

2.52

MUSTER

--SNAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKTDIRRKVEEKEQEMEKLKDQIKGGEKRIQEISDQINKLENQQAAV-KKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRKINEEGRSLLSQRTQLKETTDPELFSVYERLLNNKKRVVVPIENRVCSGCHIALTPQHENLVRKQ--DHLVFCEHCSRILYWQ-----

4iloA

0.17

0.16

0.96

2.69

dPPAS

--SNAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKTDIRRKVEEKEQEMEKLKDQIKGGEKRIQEISDQINKLENQQAAV-KKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRKINEEGRSLLSQRTQLKETTDPELFSVYERLLNNKKRVVVPIENRVCSGCHIALTPQHENLVRK--QDHLVFCEHCSRILYWQ-----

4iloA

0.17

0.16

0.96

3.90

wdPPAS

--SNAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKTDIRRKVEEKEQEMEKLKDQIKGGEKRIQEISDQINKLENQQAAV-KKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRKINEEGRSLLSQRTQLKETTDPELFSVYERLLNNKDRVVVPIENRVCSGCHIALTPQHENLVRKQ--DHLVFCEHCSRILYWQ-----

4iloA

0.17

0.16

0.96

3.32

wMUSTER

---NAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKTDIRRKVEEKEQEMEKLKDQIKGGEKRIQEISDQINKLENQQAAV-KKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRKINEEGRSLLSQRTQLKETTDPELFSVYERLLNNKDRVVVPIENRVCSGCHIALTPQHENLVRKQ--DHLVFCEHCSRILYW-----Q

4iloA

0.17

0.16

0.96

4.13

wPPAS

--SNAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKTDIRRKVEEKEQEMEKLKDQIKGGEKRIQEISDQINKLENQQAAV-KKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRKINEEGRSLLSQRTQLKETTDPELFSVYERLLNNKDRVVVPIENRVCSGCHIALTPQHENLVRKQ--DHLVFCEHCSRILYW-----Q

4iloA

0.17

0.16

0.96

6.33

dPPAS2

--SNAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKTDIRRKVEEKEQEMEKLKDQIKGGEKRIQEISDQINKLENQQAAV-KKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRKINEEGRSLLSQRTQLKETTDPELFSVYERLLNNKKRVVVPIENRVCSGCHIALTPQHENLVRK--QDHLVFCEHCSRILYWQ-----

4iloA

0.17

0.16

0.96

3.31

PPAS

--SNAMHDALQSILAIQELDIKMIRLMRVKKEHQNELAKIQALKTDIRRKVEEKEQEMEKLKDQIKGGEKRIQEISDQINKLENQQAAV-KKMDEFNALTQEMTAANKERRTLEHQLSDLMDKQAGSEDLLISLKESLSSTENSSSAIEEEIRENIRKINEEGRSLLSQRTQLKETTDPELFSVYERLLNNKDRVVVPIENRVCSGCHIALTPQHENLVRKQ--DHLVFCEHCSRILYWQ-----

3na7A

0.14

0.13

0.96

3.44

Env-PPAS

LGS---NTHLKQLIEISHLDKEIDSLEPLIREKRKDLDKALNDKEAKNKAILNLEEEKLALKLQVSKNEQTLQDTNAKIASIQKKMSEI-KSERELRSLNIEEDIAKERSNQANREIENLQNEIKRKSEKQEDLKKEMLELEKLALELESLVENEVKNIKETQQIIFKKKEDLVEKTEPKIYSFYERIRRWANTSIVTIKKQACGGCFIRLNDKIYTEVLTS--GDMITCPYCGRILYAEGA---

3na7A

0.14

0.13

0.96

2.24

MUSTER

LGS---NTHLKQLIEISHLDKEIDSLEPLIREKRKDLDKALNDKEAKNKAILNLEEEKLALKLQVSKNEQTLQDTNAKIASIQKKMSEI-KSERELRSLNIEEDIAKERSNQANREIENLQNEIKRKSEKQEDLKKEMLELEKLALELESLVENEVKNIKETQQIIFKKKEDLVEKTEPKIYSFYERIRRWANTSIVTIKKQACGGCFIRLNDKIYTEVLTS--GDMITCPYCGRILYAEGA---

3na7A

0.14

0.13

0.96

2.35

dPPAS

-LGSNTHLKQLIEISHLDKEIDSLEPLIREKRKDLDKALNDKEAKNKAILNLEEEKLALKLQVSKNEQTLQDTNAKIASIQKKMSEI---KSERELRSLNIEEDIAKERSNQANREIENLQNEIKRKSEKQEDLKKEMLELEKLALELESLVENEVKNIKETQQIIFKKKEDLVEKTEPKIYSFYERIRRWAKTSIVTIKKQACGGCFIRLNDKIYTEVLTS--GDMITCPYCGRILYAEGA---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.09

Estimated TM-score = 0.86±0.07

Estimated RMSD = 3.6±2.5Å

Download Model 2

C-score=-1.96

Download Model 3

C-score=-2.19

Download Model 4

C-score=-4.62

Download Model 5

C-score=-2.53

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4iloA	0.949	0.62	0.170	0.959
2	3na7A	0.585	5.01	0.112	0.906
3	1vw1A	0.585	4.28	0.108	0.792
4	4hpqC	0.547	3.69	0.047	0.698
5	2x0lA	0.529	4.73	0.082	0.747
6	4wpeA	0.521	3.71	0.081	0.682
7	2efkA	0.507	3.00	0.065	0.608
8	3qweA	0.500	4.45	0.072	0.706
9	4wpcA	0.498	3.86	0.060	0.673
10	4aurA	0.495	3.62	0.088	0.649

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	3	5kj7A	CA	Rep, Mult	123,126
2	0.06	2	1i4d1	III	Rep, Mult	59,62,65,66,69,70,72,73,74,76,77,114,117,121,124,125
3	0.06	2	2w6dB	CPL	Rep, Mult	87,88,99,100,102
4	0.06	2	3b60C	ANP	Rep, Mult	85,99,100,101,102
5	0.04	1	3na7A	ZN	Rep, Mult	204,207,230,233
6	0.03	1	3rk2B	CA	Rep, Mult	43,46
7	0.03	1	1efrG	III	Rep, Mult	48,55,138
8	0.03	1	1vsgA	UUU	Rep, Mult	71,74,75,78,81,106
9	0.03	1	2y04B	2CV	Rep, Mult	75,76,106,110,113
10	0.03	1	3mq7E	CA	Rep, Mult	13,16
11	0.03	1	3hd7A	GGG	Rep, Mult	49,50
12	0.03	1	4wpcA	I6P	Rep, Mult	41,45
13	0.03	1	2e50A	TRE	Rep, Mult	134,137,141

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2dq3A	0.353	3.38	0.049	0.424	6.1.1.11	79
2	0.060	3ffzA	0.358	5.03	0.036	0.502	3.4.24.69	NA
3	0.060	2vz8A	0.344	6.24	0.047	0.616	2.3.1.85	NA
4	0.060	2e9fB	0.365	5.26	0.065	0.547	4.3.2.1	NA
5	0.060	1bgwA	0.364	5.56	0.026	0.571	5.99.1.3	NA
6	0.060	1mhyD	0.369	4.78	0.078	0.522	1.14.13.25	NA
7	0.060	1yfmA	0.349	5.22	0.057	0.526	4.2.1.2	NA
8	0.060	3hz3A	0.401	6.07	0.052	0.714	2.4.1.5	148
9	0.060	3gtgB	0.353	5.93	0.018	0.588	2.7.7.6	NA
10	0.060	1wleB	0.351	3.81	0.050	0.445	6.1.1.11	71,109
11	0.060	3b8eC	0.360	6.32	0.028	0.649	3.6.3.9	NA
12	0.060	2vumB	0.338	6.22	0.052	0.592	2.7.7.6	51,56
13	0.060	2jfdA	0.256	6.30	0.057	0.465	2.3.1.85	NA
14	0.060	1dcnB	0.343	5.55	0.061	0.543	4.3.2.1	NA
15	0.060	3errA	0.375	4.38	0.046	0.522	6.1.1.11	71
16	0.060	1zvuA	0.373	4.63	0.052	0.526	5.99.1.-	NA
17	0.060	2vz8B	0.360	6.30	0.038	0.645	2.3.1.85	NA
18	0.060	1y2mB	0.397	5.38	0.050	0.616	4.3.1.24	NA
19	0.060	1u7lA	0.472	3.93	0.074	0.600	3.6.3.14	124

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.416	3.39	0.04	0.50	4e68A	GO:0000790 GO:0000978 GO:0000981 GO:0001077 GO:0001103 GO:0001228 GO:0001659 GO:0001754 GO:0003677 GO:0003700 GO:0004871 GO:0004879 GO:0005634 GO:0005654 GO:0005737 GO:0005739 GO:0005743 GO:0005829 GO:0005886 GO:0006351 GO:0006355 GO:0006366 GO:0006606 GO:0006953 GO:0007165 GO:0007259 GO:0007568 GO:0008134 GO:0008283 GO:0008285 GO:0010033 GO:0010628 GO:0010730 GO:0014070 GO:0016310 GO:0019221 GO:0019827 GO:0019901 GO:0019903 GO:0019953 GO:0030522 GO:0031490 GO:0031730 GO:0032355 GO:0032870 GO:0033210 GO:0034097 GO:0035259 GO:0035278 GO:0040014 GO:0042493 GO:0042517 GO:0042593 GO:0042755 GO:0042802 GO:0043066 GO:0043434 GO:0043565 GO:0044212 GO:0044320 GO:0044321 GO:0045471 GO:0045747 GO:0045820 GO:0045893 GO:0045944 GO:0046902 GO:0046983 GO:0048708 GO:0051726 GO:0060019 GO:0060259 GO:0060396 GO:0060397 GO:0060548 GO:0070102 GO:0071345 GO:0071407 GO:0090575 GO:0097009 GO:1901215 GO:1902728 GO:1902895 GO:1904685 GO:2000637 GO:2000737 GO:2001171 GO:2001223
1	0.06	0.339	3.68	0.04	0.41	3cfoA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
2	0.06	0.274	5.85	0.04	0.45	1m1cA	GO:0019012 GO:0019028
3	0.06	0.318	1.73	0.08	0.34	1qsdA	GO:0005737 GO:0005856 GO:0005874 GO:0007021 GO:0007023 GO:0015631 GO:0048487
4	0.06	0.277	1.48	0.06	0.29	4c46C	GO:0000122 GO:0000790 GO:0000978 GO:0000981 GO:0001080 GO:0001084 GO:0001135 GO:0001190 GO:0001191 GO:0003677 GO:0003682 GO:0003700 GO:0005634 GO:0005667 GO:0006351 GO:0006355 GO:0006366 GO:0008652 GO:0010691 GO:0042802 GO:0043565 GO:0045899 GO:0060261 GO:1903833
5	0.06	0.237	6.08	0.05	0.42	4f8xA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493
6	0.06	0.235	3.42	0.04	0.29	4ojjC	GO:0000290 GO:0000776 GO:0000932 GO:0001731 GO:0003682 GO:0003723 GO:0003729 GO:0005634 GO:0005737 GO:0006397 GO:0006417 GO:0006446 GO:0007049 GO:0007059 GO:0010494 GO:0022627 GO:0033962 GO:0045947 GO:0051301 GO:0061641 GO:1990726
7	0.06	0.257	4.96	0.04	0.37	4w9uB	GO:0003995 GO:0004361 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
8	0.06	0.265	4.66	0.05	0.38	4xydB	GO:0009055 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0020037 GO:0055114
9	0.06	0.222	6.23	0.01	0.40	2ajrA	GO:0000166 GO:0005524 GO:0005975 GO:0008662 GO:0009024 GO:0016301 GO:0016310 GO:0016740 GO:0016773 GO:0046835 GO:0046872
10	0.06	0.210	5.44	0.01	0.33	4j7cB	GO:0005886 GO:0006810 GO:0006811 GO:0006813 GO:0008324 GO:0016020 GO:0098655
11	0.06	0.199	6.50	0.06	0.37	2qv7A	GO:0000166 GO:0003951 GO:0004143 GO:0005524 GO:0006629 GO:0008152 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046872
12	0.06	0.233	5.55	0.05	0.38	3lm8A	GO:0000166 GO:0004788 GO:0005524 GO:0006772 GO:0009229 GO:0016301 GO:0016310 GO:0016740 GO:0030975
13	0.06	0.239	4.21	0.01	0.30	1e1cA	GO:0003824 GO:0004494 GO:0008152 GO:0016853 GO:0016866 GO:0031419 GO:0046872
14	0.06	0.267	5.38	0.05	0.43	5d0uA	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0008026 GO:0016787
15	0.06	0.212	6.44	0.02	0.39	3wsyA	GO:0000042 GO:0001540 GO:0004888 GO:0005576 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005802 GO:0005887 GO:0006605 GO:0006622 GO:0006629 GO:0006810 GO:0006869 GO:0006892 GO:0006897 GO:0006898 GO:0007165 GO:0008202 GO:0008203 GO:0014910 GO:0016020 GO:0016021 GO:0030169 GO:0030306 GO:0031985 GO:0032091 GO:0032460 GO:0034362 GO:0043407 GO:0045053 GO:0045732 GO:0050768 GO:0051604 GO:0055037 GO:0070062 GO:0070863 GO:1901215 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:2001137
16	0.06	0.263	6.47	0.04	0.48	2y51A	GO:0000166 GO:0008152 GO:0016491 GO:0016620 GO:0055114
17	0.06	0.176	4.52	0.04	0.23	2ggmA	GO:0000086 GO:0000715 GO:0000717 GO:0005509 GO:0005622 GO:0005634 GO:0005654 GO:0005737 GO:0005813 GO:0005814 GO:0005829 GO:0005856 GO:0005929 GO:0006281 GO:0006289 GO:0006294 GO:0006974 GO:0007049 GO:0007067 GO:0007099 GO:0007283 GO:0008017 GO:0016925 GO:0031683 GO:0032391 GO:0032465 GO:0032795 GO:0036064 GO:0046872 GO:0051301 GO:0070911 GO:0071942
18	0.06	0.204	6.63	0.02	0.39	3vz2B	GO:0000166 GO:0008152 GO:0016491 GO:0016620 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0003676
GO-Score	0.36
Biological Processes	GO:0045471	GO:0048708	GO:0071897	GO:0039693	GO:2001171	GO:0001754	GO:0042755	GO:0006606	GO:0007568	GO:0030522	GO:0008285	GO:0070102	GO:1902728	GO:1901215	GO:0032355	GO:0010730	GO:2000637	GO:0051726	GO:0060259	GO:0040014	GO:0090305	GO:0042517	GO:0006953	GO:0019827	GO:0046902	GO:0042493	GO:0033210	GO:0060397	GO:0001659	GO:1904685	GO:0060019	GO:0097009	GO:0071407	GO:0019953	GO:0042593	GO:2000737	GO:0035278	GO:0045747	GO:0045820	GO:2001223	GO:0043066	GO:1902895	GO:1903833	GO:0007023	GO:0008652	GO:0001080	GO:0007021	GO:0010691	GO:0045899
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0000790	GO:0090575	GO:0005829	GO:0005654	GO:0005886	GO:0005743	GO:0005874	GO:0019028
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.