I-TASSER results

I-TASSER results for job id Rv2227

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (233 residues)
MGQTRRLRRLGRHRCRGQRVRWRTATSADHPRRGRPAAQAVRRRRPVSLDGRYGIQAVRR
RAVSIFPCPLSRVIERLKQALYPKLLPIARNWWAKLGREAPWPDSLDDWLASCHAAGQTR
STALMLKYGTNDWNALHQDLYGELVFPLQVVINLSDPETDYTGGEFLLVEQRPRAQSRGT
AMQLPQGHGYVFTTRDRPVRTSRGWSASPVRHGLSTIRSGERYAMGLIFHDAA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MGQTRRLRRLGRHRCRGQRVRWRTATSADHPRRGRPAAQAVRRRRPVSLDGRYGIQAVRRRAVSIFPCPLSRVIERLKQALYPKLLPIARNWWAKLGREAPWPDSLDDWLASCHAAGQTRSTALMLKYGTNDWNALHQDLYGELVFPLQVVINLSDPETDYTGGEFLLVEQRPRAQSRGTAMQLPQGHGYVFTTRDRPVRTSRGWSASPVRHGLSTIRSGERYAMGLIFHDAA
Prediction	CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCEEEEEEHCCCCCCCCEEHCCCCCCEEEEHCCCCCCCCCCCCEHCCCCCCEEEHCCCEEEEEEEEEHCCC
Conf.Score	98658889875678888877768899888765665456548989999999976776666556665589997999999999978999999999999899999976899999999998887865778763889964445788887557557888766999888997689987567665665676578885999975788888888755545545545654786899999986689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MGQTRRLRRLGRHRCRGQRVRWRTATSADHPRRGRPAAQAVRRRRPVSLDGRYGIQAVRRRAVSIFPCPLSRVIERLKQALYPKLLPIARNWWAKLGREAPWPDSLDDWLASCHAAGQTRSTALMLKYGTNDWNALHQDLYGELVFPLQVVINLSDPETDYTGGEFLLVEQRPRAQSRGTAMQLPQGHGYVFTTRDRPVRTSRGWSASPVRHGLSTIRSGERYAMGLIFHDAA
Prediction	75445404614234121422516403540344010202511446304403531547432210131172201400550263014401310230163173645117405502630373415403310340475222002343505200000000002436632410100021323444344421417301000000442225344232304121001404534210000001328
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCEEEEEEHCCCCCCCCEEHCCCCCCEEEEHCCCCCCCCCCCCEHCCCCCCEEEHCCCEEEEEEEEEHCCC
MGQTRRLRRLGRHRCRGQRVRWRTATSADHPRRGRPAAQAVRRRRPVSLDGRYGIQAVRRRAVSIFPCPLSRVIERLKQALYPKLLPIARNWWAKLGREAPWPDSLDDWLASCHAAGQTRSTALMLKYGTNDWNALHQDLYGELVFPLQVVINLSDPETDYTGGEFLLVEQRPRAQSRGTAMQLPQGHGYVFTTRDRPVRTSRGWSASPVRHGLSTIRSGERYAMGLIFHDAA

4iw3A

0.14

0.11

0.81

1.24

MUSTER

-----------------HPM-LAAVVDDLATHGWSQQAHFLPADLVRALAAECRREGELNPA-GVGRGATQEVRETIRGDIDPGQAEACDQYLAAM-------DQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRRDDDRRMVSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

4xaaA

0.11

0.09

0.82

1.05

dPPAS

----------------TATLDRAAAIERFRRDGFANAGPVLAPDAIARLKAGADEGLRSDDYWNFPVEGDERPVLYRVHNLEKQDWAPERDLLHR-----------EELAQLAAAFVDGPVVPTAYALYRAAEVPWHRDRVNVGPRTVCNLSICLDDAGPHNGCLEAVSHLLPDDAGPVVPVPVSQGDVVVHDVR--------------LVHGSGPNANGSRRTIVIEYADPA

4iw3A

0.15

0.11

0.77

1.56

wdPPAS

-----------------HPM-LAAVVDDLATHGWSQQAHFLPADLVRALAAECRREGELRGATQEVR-------ETIRGDIDPGQAEACDQYLAAM-------DQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRFRD----VSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

4iw3A

0.14

0.11

0.79

1.35

wMUSTER

-----------------HPM-LAAVVDDLATHGWSQQAHFLPADLVRALAAECRREGELRGATQEVR-------ETIRGDIDPGQAEACDQYLAAM-------DQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRRDDDRRMVSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

4iw3A

0.15

0.11

0.77

1.20

wPPAS

-----------------HPM-LAAVVDDLATHGWSQQAHFLPADLVRALAAECDAEGELRGATQEVR-------ETIRGDIDPGQAEACDQYLAAM-------DQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRFRD----VSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

4iw3A

0.14

0.10

0.76

1.81

dPPAS2

-----------------HPM-LAAVVDDLATHGWSQQAHFLPADLVRALAAECRVRETIRGDQIQWIDP--------------GQAEACDQYLAAM-------DQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRRDDDRRMVSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

4iw3A

0.14

0.11

0.79

1.16

PPAS

-----------------HPM-LAAVVDDLATHGWSQQAHFLPADLVRALAAECDAEGELRGATQEVRETI-------RGDIDPGQAEACDQYLAAM-------DQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRFDDDRRMVSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

4iw3A

0.13

0.10

0.81

1.38

Env-PPAS

-----------------HPM-LAAVVDDLATHGWSQQAHFLPADLVRALAAEC-RRRDAEGELNPAGVGRGATQEVRETIIDPGQAEACDQYLAAM-------DQLRLAINQGLFLGLEDFECHFALYPPGAFYRRHLDRFDDDRRMVSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

4nhxA1

0.12

0.10

0.85

1.19

MUSTER

VTEETLKKQVAEAWSRRTPFSHEVIVMDMDPFLHCVIPNFISQDFLEGLQKELMNLDFHEKYYKFQKKRREPHISTLRKILFEDFRSWLSDISK---IDLE-----------------STIDMSCAKYEFTDALLCHDDELEGRR--IAFILYLVPPWDRSMGGTLDLYSIDEHFQPKVKSLIPSWNKLVFFEVSPV------------SFHQVSEVLEKSRLSISGWFHGPS

4iw3A

0.13

0.10

0.75

1.02

dPPAS

------------------HPMLAAVVDDLATHGWSQQAHFLPADLVRALAAECVRETIRGDQIQWIDPGQAEACDQYLAAMDQLRLAINQGLFLGL----------------------EDFECHFALYPPGAFYRRHLDRRDDDRRMVSAVLYLNEGWQPHDGGQLRMFL----ADGVEHDVEPVAGCLVVFLSGEVP-------------HEVLPA-GRERLSLTGWFRRRG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.25

Estimated TM-score = 0.56±0.15

Estimated RMSD = 8.4±4.5Å

Download Model 2

C-score=-2.26

Download Model 3

C-score=-3.88

Download Model 4

C-score=-4.17

Download Model 5

C-score=-4.20

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4iw3A	0.728	2.37	0.117	0.794
2	2hbtA	0.702	2.50	0.097	0.790
3	4nhxA	0.677	3.42	0.119	0.833
4	3kt4A2	0.659	3.71	0.089	0.837
5	4naoA	0.653	3.29	0.122	0.794
6	5dapA1	0.650	3.48	0.082	0.803
7	5iqsA	0.633	3.45	0.113	0.803
8	4xabA	0.631	3.40	0.175	0.768
9	5ep9A	0.631	3.27	0.128	0.772
10	3pl0A	0.629	3.58	0.097	0.785

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.26	30	4nhmA	UN9	Rep, Mult	126,128,134,137,139,151,153,166,212,214,222,226,228
2	0.26	30	3kt4A	FE	Rep, Mult	137,139,212
3	0.01	1	2y34A	UN9	Rep, Mult	78,122,144,146,230
4	0.01	1	5l9rA	OGA	Rep, Mult	36,181,182,188
5	0.01	1	3hqrA	III	Rep, Mult	78,107,108,117,118,119,120,134,136,137,138,139,144,146,196,228,229,230
6	0.01	1	3gjbA	UUU	Rep, Mult	128,137,214,222

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	1unbA	0.596	3.79	0.068	0.777	1.14.20.1	61
2	0.060	2fknB	0.438	5.61	0.031	0.730	4.2.1.49	NA
3	0.060	2x38A	0.416	5.70	0.057	0.704	2.7.1.153	NA
4	0.060	1ds0A	0.428	5.08	0.104	0.674	1.14.11.21	NA
5	0.060	1bk0A	0.585	3.89	0.081	0.768	1.21.3.1	NA
6	0.060	2og6A	0.570	3.18	0.079	0.704	1.14.11.-	NA
7	0.060	2ixaA	0.404	6.13	0.059	0.730	3.2.1.49	NA
8	0.060	1uwkA	0.440	5.76	0.058	0.738	4.2.1.49	NA
9	0.060	1zrrA	0.409	4.18	0.047	0.549	1.13.11.54,1.13.11.53	35,150
10	0.060	2yu1A	0.537	3.87	0.104	0.704	1.14.11.27	120
11	0.060	1os7A	0.521	3.00	0.102	0.631	1.14.11.17	NA
12	0.060	3bu7B	0.460	3.96	0.073	0.614	1.13.11.4	NA
13	0.060	2rd0A	0.424	5.58	0.041	0.708	2.7.1.153	NA
14	0.060	3ms5A	0.492	3.32	0.116	0.601	1.14.11.1	139,213
15	0.060	2ixlC	0.442	3.89	0.055	0.567	5.1.3.13	NA
16	0.060	1xruB	0.416	4.54	0.045	0.579	5.3.1.17	NA
17	0.060	1ep0A	0.426	3.85	0.090	0.558	5.1.3.13	NA
18	0.060	1uofA	0.557	3.79	0.077	0.738	1.14.20.1	NA
19	0.060	1e5rB	0.468	3.74	0.087	0.614	1.14.11.28	170
20	0.060	2a1xA	0.593	3.78	0.095	0.751	1.14.11.18	212

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.689	2.64	0.10	0.78	5a3uA	GO:0001666 GO:0005506 GO:0005634 GO:0005737 GO:0005829 GO:0016491 GO:0016705 GO:0016706 GO:0018401 GO:0019899 GO:0030821 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043433 GO:0045765 GO:0046872 GO:0051213 GO:0051344 GO:0055008 GO:0055114 GO:0060347 GO:0060412 GO:0060711 GO:0061418 GO:0071731
1	0.23	0.728	2.37	0.12	0.79	4iw3A	GO:0005506 GO:0016491 GO:0016705 GO:0031418 GO:0046872 GO:0055114
2	0.22	0.707	2.80	0.10	0.81	4kbzA	GO:0001666 GO:0005506 GO:0005634 GO:0005737 GO:0005829 GO:0016491 GO:0016705 GO:0016706 GO:0018401 GO:0019899 GO:0030821 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043433 GO:0045765 GO:0046872 GO:0051213 GO:0051344 GO:0055008 GO:0055114 GO:0060347 GO:0060412 GO:0060711 GO:0061418 GO:0071731
3	0.19	0.586	3.96	0.06	0.78	4nhyA	GO:0005506 GO:0005634 GO:0005737 GO:0006449 GO:0008283 GO:0010494 GO:0016491 GO:0016705 GO:0016706 GO:0018126 GO:0019511 GO:0031418 GO:0031543 GO:0031544 GO:0034063 GO:0046872 GO:0051213 GO:0055114
4	0.13	0.693	1.49	0.12	0.73	4j25A	GO:0005506 GO:0016491 GO:0016705 GO:0031418 GO:0046872 GO:0055114
5	0.11	0.663	3.66	0.08	0.84	3kt4A	GO:0000288 GO:0005506 GO:0005634 GO:0005737 GO:0006307 GO:0006415 GO:0006449 GO:0008143 GO:0008198 GO:0016491 GO:0016705 GO:0016706 GO:0018188 GO:0031418 GO:0031543 GO:0035511 GO:0035516 GO:0046872 GO:0051213 GO:0055114 GO:0070989
6	0.10	0.702	2.52	0.10	0.79	4bqxA	GO:0001666 GO:0005506 GO:0005634 GO:0005737 GO:0005829 GO:0016491 GO:0016705 GO:0016706 GO:0018401 GO:0019899 GO:0030821 GO:0031418 GO:0031543 GO:0031545 GO:0032364 GO:0043433 GO:0045765 GO:0046872 GO:0051213 GO:0051344 GO:0055008 GO:0055114 GO:0060347 GO:0060412 GO:0060711 GO:0061418 GO:0071731
7	0.10	0.676	3.58	0.09	0.85	4nhkA	GO:0000288 GO:0005506 GO:0005634 GO:0005737 GO:0006307 GO:0006415 GO:0006449 GO:0008143 GO:0008198 GO:0016491 GO:0016705 GO:0016706 GO:0018188 GO:0031418 GO:0031543 GO:0035511 GO:0035516 GO:0046872 GO:0051213 GO:0055114 GO:0070989
8	0.08	0.603	2.57	0.11	0.70	5c5uB	GO:0005506 GO:0016020 GO:0016021 GO:0016491 GO:0016705 GO:0031418 GO:0055114
9	0.08	0.596	3.62	0.11	0.74	5hv0A	GO:0005506 GO:0016491 GO:0016705 GO:0031418 GO:0055114
10	0.07	0.582	3.23	0.12	0.70	2jijB
11	0.07	0.592	3.40	0.13	0.72	2jigA
12	0.07	0.590	3.45	0.13	0.73	3dkqA	GO:0005506 GO:0016491 GO:0016705 GO:0016706 GO:0031418 GO:0046872 GO:0051213 GO:0055114
13	0.07	0.571	3.21	0.15	0.69	3dkqB	GO:0005506 GO:0016491 GO:0016705 GO:0016706 GO:0031418 GO:0046872 GO:0051213 GO:0055114
14	0.06	0.305	5.78	0.04	0.53	1sdjA	GO:0003824 GO:0009058 GO:0016853
15	0.06	0.276	6.23	0.03	0.51	1wp9A	GO:0000166 GO:0003676 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0006259 GO:0006281 GO:0046872 GO:0090305
16	0.06	0.253	6.28	0.04	0.47	1xm7A
17	0.06	0.229	5.28	0.01	0.36	3b7yB	GO:0000122 GO:0000151 GO:0000785 GO:0002250 GO:0003151 GO:0003197 GO:0004842 GO:0005634 GO:0005737 GO:0005794 GO:0005829 GO:0005886 GO:0005902 GO:0005938 GO:0006513 GO:0006622 GO:0006955 GO:0007041 GO:0007399 GO:0007528 GO:0008022 GO:0010766 GO:0010768 GO:0014068 GO:0014894 GO:0016020 GO:0016032 GO:0016241 GO:0016327 GO:0016567 GO:0016874 GO:0019089 GO:0019871 GO:0019904 GO:0030948 GO:0031175 GO:0031623 GO:0031698 GO:0032801 GO:0034644 GO:0034765 GO:0042110 GO:0042391 GO:0042787 GO:0042921 GO:0043130 GO:0043162 GO:0044111 GO:0045121 GO:0045732 GO:0046824 GO:0048471 GO:0048514 GO:0048814 GO:0050807 GO:0050815 GO:0050816 GO:0050847 GO:0051592 GO:0061630 GO:0070062 GO:0070063 GO:0070064 GO:0070534 GO:1901016 GO:2000650
18	0.06	0.236	4.42	0.05	0.33	2nsqA	GO:0000122 GO:0000209 GO:0003254 GO:0004842 GO:0005622 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006513 GO:0006814 GO:0006883 GO:0007588 GO:0010038 GO:0015459 GO:0016032 GO:0016567 GO:0016874 GO:0017080 GO:0019058 GO:0019870 GO:0019871 GO:0030104 GO:0030154 GO:0034220 GO:0034765 GO:0042176 GO:0042391 GO:0042787 GO:0043161 GO:0044325 GO:0045732 GO:0045807 GO:0060306 GO:0070062 GO:0070936 GO:0086005 GO:1901016 GO:1901017 GO:1901380 GO:1902306 GO:1903861 GO:2000009 GO:2000650 GO:2001288
19	0.06	0.214	5.26	0.03	0.34	3m7fB	GO:0000122 GO:0000151 GO:0000785 GO:0002250 GO:0003151 GO:0003197 GO:0004842 GO:0005634 GO:0005737 GO:0005794 GO:0005829 GO:0005886 GO:0005902 GO:0005938 GO:0006513 GO:0006622 GO:0006955 GO:0007041 GO:0007399 GO:0007528 GO:0008022 GO:0010766 GO:0010768 GO:0014068 GO:0014894 GO:0016020 GO:0016567 GO:0016874 GO:0019089 GO:0019871 GO:0019904 GO:0030948 GO:0031175 GO:0031623 GO:0031698 GO:0032801 GO:0034644 GO:0034765 GO:0035255 GO:0042110 GO:0042391 GO:0042787 GO:0042921 GO:0043130 GO:0043162 GO:0044111 GO:0045121 GO:0045732 GO:0046824 GO:0048471 GO:0048514 GO:0048814 GO:0050807 GO:0050815 GO:0050816 GO:0050847 GO:0061630 GO:0070062 GO:0070063 GO:0070064 GO:0070534 GO:1901016 GO:2000650
20	0.06	0.185	4.08	0.00	0.25	3j9wAS	GO:0000028 GO:0003723 GO:0003735 GO:0005840 GO:0006412 GO:0015935 GO:0019843 GO:0022627 GO:0030529

Consensus prediction of GO terms

Molecular Function	GO:0005506	GO:0031418	GO:0019899	GO:0031545
GO-Score	0.68	0.68	0.41	0.41
Biological Processes	GO:0055114	GO:0045765	GO:0060347	GO:0018401	GO:0043433	GO:0061418	GO:0060711	GO:0055008	GO:0071731	GO:0032364	GO:0060412	GO:0030821	GO:0051344	GO:0070925	GO:0022618	GO:0043244	GO:0006417	GO:0006415
GO-Score	0.68	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.41	0.39	0.39	0.39	0.39	0.39
Cellular Component	GO:0005634	GO:0005829	GO:0036464
GO-Score	0.53	0.41	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.