I-TASSER results

I-TASSER results for job id Rv2219

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (250 residues)
MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDKRLLPYMIGAFLLIVGA
SVGVGVWAGGFTMFTMIPLGVLLGALVAFVIFGRRAQRTVYRKAEGQTGAAAWALDNLRG
KWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPLLAQEKKRTARLVGDVPIYDI
IVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLAALGSRAGAGVMPKGPLPTTAKM
RSVQRTVRRK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDKRLLPYMIGAFLLIVGASVGVGVWAGGFTMFTMIPLGVLLGALVAFVIFGRRAQRTVYRKAEGQTGAAAWALDNLRGKWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPLLAQEKKRTARLVGDVPIYDIIVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLAALGSRAGAGVMPKGPLPTTAKMRSVQRTVRRK
Prediction	CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHCEEHCCCCCEEEEEEHCCCCEEEEHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9987764666677777665555665789999999999999987658999999999999999999999989999999999999999999999999999999998769987799999986688577655655887558999866885899967996899999999999988647999869999958999755699999999767679999999999999999657888999998999988787655444459
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDKRLLPYMIGAFLLIVGASVGVGVWAGGFTMFTMIPLGVLLGALVAFVIFGRRAQRTVYRKAEGQTGAAAWALDNLRGKWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPLLAQEKKRTARLVGDVPIYDIIVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLAALGSRAGAGVMPKGPLPTTAKMRSVQRTVRRK
Prediction	7555665565555556565565564552141014004203640430001112333233233323233333333333233333313332321003203430044146332002000321475042432233453220000022330000001134620450155145424412470301101004473313065035304402651457315403510520374554341021211762514634343458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEHCEEHCCCCCEEEEEEHCCCCEEEEHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCEEHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MAKPRNAAESKAAKAQANAARKAAARQRRAQLWQAFTLQRKEDKRLLPYMIGAFLLIVGASVGVGVWAGGFTMFTMIPLGVLLGALVAFVIFGRRAQRTVYRKAEGQTGAAAWALDNLRGKWRVTPGVAATGNLDAVHRVIGRPGVIFVGEGSAARVKPLLAQEKKRTARLVGDVPIYDIIVGNGDGEVPLAKLERHLTRLPANITVKQMDTVESRLAALGSRAGAGVMPKGPLPTTAKMRSVQRTVRRK

4x5mA

0.18

0.06

0.34

1.16

dPPAS2

-------------DTILLTGLFAAFFTTFAFAPQSIKTIRTRNEGISVVMYIMFLTGVISWIAYGIMRSDFAVLIANIVTLFLAAPVLVITLINRRKK--------------------------------------------------------------------------------------------------------------------------------------------------------

4ke2A

0.16

0.08

0.48

1.11

dPPAS2

TAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------------------------------------------------------------------------------------------------

5cwnA

0.13

0.11

0.82

0.74

MUSTER

---MDPEEILERAKESLERAREASERGDEEEFRKAAEKALELAKRLVEQAKKEG--DPELVLEAAKVALRVAELAAKNGDKEVFKKAAESALEVAKRLVEVASKEGDPELVLEAAKVA---LRVAELAAKNGDKEVF-----------------KKAAESALEVAKRLVEVASK--------GDPELVEEAAKVAEEVRKLAKKQDEEVYEKARETAREVKEELKRVREEKGGWLEHH------------

5cwdA

0.10

0.07

0.68

0.71

dPPAS

---TKEDARSTCEKAARKAAESNDEEVAKQAAKDCLEVAKQAGMPTKEAARSFCEAAARAAAESNEEVAKIAAKACLEVAKQAGMPTKEAARSFCEAAARAAAESNDEEVAKIAAKAC-----LEVAKQAGMPTKEAARSFCEAAKRAAKESNDEEVEKIAKKACKEVAKQAGMPWLE------------------------------------------------------------------------

5cwkA

0.13

0.08

0.64

0.57

wdPPAS

-SNDE-KEKLKELLKRAEELAKSPDPEDLKEAVRLAEEVVRERPG--NLAKKALEIILRAAEELAKLPD-----PEALKEAVKAAEKVVREQSNLAKKALEIIL-----RAAEELAKLP---------------------------------DPEALKEAVKAAEKVVRE-----P-------GSE----IERAAEELKKSPD--PEAQKEAKKAEQKVREERPG-------------------------

5dn7A

0.14

0.12

0.84

0.73

wMUSTER

LLDNRTQAVEELKQLLGKFNPSSTPHASLVGFISLLYNLLD-DSN-FKVVHGTLQVLHLLVIRLGEQVQQFLGPVIAASVKVLA--LVIKQEYMKIFLKLMKEV-GPQRVLSLLLENLKKHSRVREEVV-----NICICSLLTYPS-LS-----FDLAPALVDSKRRVRQAALEA-FAVLSMGSGK----TNVLFKAVDTVEL----GVMNAVQARLA--------KTLPRGFVEYAILMPS--------

5dn7A

0.16

0.12

0.78

0.61

wPPAS

LLDNRTQAVEELKQLLGKFNPSSTPHASLVGFISLLYNLLD-DS---------FKVVHGTLQVLHLLVIRLGEQVQQFLGPVIAASVKVLLVIKQEYMKIFLKLMKEVG-PQRVLSLL-KHSRVREEVV-----NICICSLLTYPS-LS-----FDLAPALVDSKRRVRQAALEA-FAVLSMGSGK----TNVLFKAVDTVEL----GVMNAVQARLA--------KTLPRGLMPS--------------

4qncA

0.12

0.04

0.32

1.11

dPPAS2

-----------MENLIGYVA---AFLTTVSFLPQVLRVVMTKQTRISRNMYIMFFLGVVLWFVYGILRSDLPIILANVVTLFFVTIILYYKLTE------------------------------------------------------------------------------------------------------------------------------------------------------------

5cwnA

0.13

0.10

0.81

0.79

PPAS

MDPEEILERAKESLERAREASERGDEEEFRKAAEKALELAKRLVEQAKKEGDPELVLEAAKVALRVAELAAKN-------KEVFKKAAESALEVAKRLVEVASKEGDPELVLEAAKVA---LRVAELAAKNGDKEVFKKAAESALEVALVEVASKEGDPELVEEAAKVAEEVRKL------AKKQGDEEVYEKARETAREV-----KEELKRVREEKGGWLEHH--------------------------

3t9nA

0.11

0.10

0.90

0.86

Env-PPAS

IGIKFADFLIYRFYKLYSKSKIQLPQRKIDTLTSLTKNAVRY---IIYFLAGASILKLFMTSLLAVAGIGSLAIGFGAQNLVKDMISGFFIIFEDQFSVGYVTINGISGTVVTKIRGFSDGLHIIPKMVTNLTKDSMMAVV----NIAFPIDDVDKIIEGLQEICEEVKKSRDEGPTVLGITDMQDSKLVIM-VYQPMQKWA--VERDIRYRVKKMFDQKN-----ISFP---YP--------RTTVILS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.00

Estimated TM-score = 0.37±0.13

Estimated RMSD = 12.9±4.2Å

Download Model 2

C-score=-4.75

Download Model 3

C-score=-4.63

Download Model 4

C-score=-4.84

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5dn7A	0.691	3.19	0.111	0.864
2	3nowA	0.638	4.10	0.056	0.864
3	4by6A	0.627	4.66	0.030	0.884
4	3s4wB	0.620	4.61	0.052	0.876
5	1vsy5	0.617	4.49	0.076	0.864
6	3w3tA	0.608	4.61	0.092	0.860
7	4y5jA	0.607	3.79	0.096	0.808
8	4c0eA	0.606	4.43	0.077	0.848
9	3tj1A	0.606	4.49	0.041	0.836
10	5t8vA	0.605	4.74	0.050	0.860

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	3ungC	CA	Rep, Mult	151,152,186
2	0.04	2	2c37E	U5P	Rep, Mult	216,223
3	0.04	2	2gl7A	III	Rep, Mult	106,113,117,120,121,123,124,136,140,143
4	0.04	2	1d7qA	III	Rep, Mult	230,231
5	0.02	1	2islB	OXY	Rep, Mult	145,191
6	0.02	1	1icrA	NIO	Rep, Mult	151,152
7	0.02	1	1f59A	III	Rep, Mult	33,36,37,40,42,78,86
8	0.02	1	3fucC	AZI	Rep, Mult	235,239
9	0.02	1	5e9uG	MG	Rep, Mult	94,138
10	0.02	1	2xblA	M7P	Rep, Mult	164,170
11	0.02	1	1fp4B	CA	Rep, Mult	102,105
12	0.02	1	2vglA	IHP	Rep, Mult	139,140,156,160,175,176,179
13	0.02	1	2bptA	III	Rep, Mult	33,34,37,38,76,78,79,81,83,84,85,132
14	0.02	1	2bptA	III	Rep, Mult	112,115,116,118,119,151
15	0.02	1	1i7x0	III	Rep, Mult	81,115,116,117,125,154,155,158,159,161
16	0.02	1	3glnA	XE	Rep, Mult	194,217,220
17	0.02	1	3f1f1	MG	Rep, Mult	145,146
18	0.02	1	1pj2A	NAI	Rep, Mult	223,225
19	0.02	1	4y49M	G4P	Rep, Mult	41,86,126
20	0.02	1	1zavA	III	Rep, Mult	243,250

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1oocB	0.481	5.40	0.045	0.760	4.2.2.2	146,149
2	0.060	1llwA	0.463	4.75	0.069	0.668	1.4.7.1	NA
3	0.060	1ru4A	0.515	5.86	0.058	0.868	4.2.2.2	NA
4	0.060	1hg8A	0.458	5.80	0.048	0.736	3.2.1.15	135,138
5	0.060	2iq7A	0.468	5.47	0.070	0.732	3.2.1.15	NA
6	0.060	2p4eA	0.461	5.45	0.076	0.732	3.4.21.-	NA
7	0.060	1nhcA	0.465	4.94	0.072	0.696	3.2.1.15	116
8	0.060	2uveA	0.460	4.79	0.035	0.676	3.2.1.82	174,177
9	0.060	1rmgA	0.499	5.27	0.083	0.772	3.2.1.-	174
10	0.060	3draA	0.482	5.57	0.032	0.796	2.5.1.58,2.5.1.59	NA
11	0.060	1gq8A	0.464	5.27	0.061	0.716	3.1.1.11	110
12	0.060	1ofdA	0.463	4.84	0.080	0.672	1.4.7.1	NA
13	0.060	1ogmX	0.470	5.35	0.066	0.756	3.2.1.11	NA
14	0.060	1nhcE	0.458	5.00	0.059	0.696	3.2.1.15	NA
15	0.060	1wmrA	0.472	5.46	0.053	0.748	3.2.1.57	NA
16	0.060	3c5wA	0.564	4.36	0.090	0.792	3.1.3.16	NA
17	0.060	2gtqA	0.467	5.58	0.041	0.744	3.4.11.2	NA
18	0.060	1ia5A	0.463	5.47	0.044	0.732	3.2.1.15	NA
19	0.060	1z1wA	0.482	4.87	0.072	0.716	3.4.11.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.16	0.618	3.74	0.07	0.81	4g3aB	GO:0000022 GO:0000070 GO:0000775 GO:0000776 GO:0000922 GO:0005525 GO:0005634 GO:0005737 GO:0005813 GO:0005815 GO:0005819 GO:0005827 GO:0005856 GO:0005874 GO:0005875 GO:0005876 GO:0007049 GO:0007051 GO:0007052 GO:0007067 GO:0007275 GO:0007282 GO:0007411 GO:0008017 GO:0016325 GO:0019827 GO:0030154 GO:0030426 GO:0030723 GO:0031116 GO:0032154 GO:0035099 GO:0035371 GO:0040001 GO:0042995 GO:0045169 GO:0045172 GO:0046580 GO:0046602 GO:0048477 GO:0051225 GO:0051301 GO:0051315 GO:0090307
1	0.11	0.597	4.80	0.08	0.88	3opbA	GO:0005737 GO:0007533 GO:0008298 GO:0017022 GO:0030036
2	0.08	0.638	4.10	0.06	0.86	3nowA	GO:0007525 GO:0031034 GO:0034605 GO:0045824 GO:0050829 GO:0061077
3	0.07	0.607	3.79	0.10	0.81	4y5jA	GO:0000022 GO:0000132 GO:0000922 GO:0005813 GO:0005875 GO:0007017 GO:0007029 GO:0007067 GO:0007143 GO:0007344 GO:0007411 GO:0008017 GO:0015631 GO:0016325 GO:0031122 GO:0035371 GO:0045196 GO:0045450 GO:0048477 GO:0090063
4	0.07	0.627	4.66	0.03	0.88	4by6A	GO:0046872
5	0.07	0.566	4.77	0.08	0.84	1b3uA	GO:0000086 GO:0000159 GO:0000184 GO:0000188 GO:0000775 GO:0003823 GO:0004722 GO:0005634 GO:0005694 GO:0005737 GO:0005739 GO:0005829 GO:0006275 GO:0006355 GO:0006461 GO:0006470 GO:0006672 GO:0006915 GO:0007059 GO:0007084 GO:0007143 GO:0008380 GO:0008601 GO:0010033 GO:0015630 GO:0016020 GO:0019932 GO:0030111 GO:0030155 GO:0030308 GO:0034047 GO:0040008 GO:0042518 GO:0045595 GO:0046982 GO:0051232 GO:0051306 GO:0051754 GO:0070062 GO:0070262 GO:1903538 GO:2001241
6	0.07	0.620	4.61	0.05	0.88	3s4wB	GO:0000793 GO:0005634 GO:0005730 GO:0005737 GO:0006281 GO:0006974 GO:0007049 GO:0007129 GO:0007275 GO:0007276 GO:0010332 GO:0034599 GO:0045589 GO:0048854 GO:0050727 GO:0051090 GO:0070182 GO:0097150 GO:2000348
7	0.07	0.577	4.18	0.09	0.80	4qmhA	GO:0000022 GO:0000132 GO:0000922 GO:0005813 GO:0005875 GO:0007017 GO:0007029 GO:0007067 GO:0007143 GO:0007344 GO:0007411 GO:0008017 GO:0015631 GO:0016325 GO:0031122 GO:0035371 GO:0045196 GO:0045450 GO:0048477 GO:0090063
8	0.07	0.600	4.37	0.05	0.83	5fu7A	GO:0000122 GO:0000289 GO:0000932 GO:0004535 GO:0005615 GO:0005634 GO:0005737 GO:0005778 GO:0005829 GO:0006351 GO:0006355 GO:0006417 GO:0006977 GO:0007275 GO:0010606 GO:0016020 GO:0017148 GO:0019904 GO:0030014 GO:0030015 GO:0030331 GO:0031047 GO:0032947 GO:0033147 GO:0035195 GO:0042974 GO:0043231 GO:0044822 GO:0048387 GO:0060213 GO:0061014 GO:0070016 GO:0090503 GO:1900153 GO:2000036
9	0.07	0.569	4.84	0.05	0.84	4r0zA	GO:0002159 GO:0003713 GO:0004871 GO:0005198 GO:0005634 GO:0005737 GO:0005912 GO:0005913 GO:0007155 GO:0007275 GO:0009792 GO:0010172 GO:0016342 GO:0016477 GO:0019901 GO:0019903 GO:0019904 GO:0030054 GO:0032880 GO:0034333 GO:0042074 GO:0044333 GO:0045294 GO:0045296 GO:0045944 GO:0051782 GO:0090138
10	0.07	0.562	4.35	0.09	0.80	2qk1A	GO:0000776 GO:0000778 GO:0005200 GO:0005737 GO:0005816 GO:0005819 GO:0005856 GO:0005874 GO:0005876 GO:0005938 GO:0007020 GO:0008017 GO:0030472
11	0.07	0.570	5.35	0.07	0.90	3gq2A	GO:0000139 GO:0005730 GO:0005737 GO:0005783 GO:0005794 GO:0005795 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008565 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0042802 GO:0044822 GO:0045056 GO:0048193 GO:0048211 GO:0048219 GO:0048280 GO:0048471 GO:0051260 GO:0061025 GO:0090498
12	0.07	0.541	4.75	0.10	0.78	1ialA	GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0016020 GO:0042826 GO:0044822
13	0.07	0.528	4.77	0.07	0.78	4uaeA	GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0019054 GO:0042542 GO:0070062 GO:0075733
14	0.07	0.582	4.59	0.07	0.84	4i2wA	GO:0005886 GO:0005938 GO:0009792 GO:0018991 GO:0031625 GO:0032154 GO:0040011 GO:0042802 GO:0045214
15	0.06	0.366	5.75	0.04	0.60	4k6aA	GO:0003824 GO:0004807 GO:0005737 GO:0006094 GO:0006096 GO:0006098 GO:0008152 GO:0016853
16	0.06	0.355	5.31	0.09	0.56	1io0A	GO:0005523 GO:0046872 GO:0051015 GO:0051694
17	0.06	0.354	5.85	0.03	0.58	1aw1A	GO:0003824 GO:0004807 GO:0005737 GO:0006094 GO:0006096 GO:0006098 GO:0008152 GO:0016853
18	0.06	0.334	4.82	0.05	0.48	4wbsB	GO:0000166 GO:0005524 GO:0016887 GO:0043190 GO:0055085
19	0.06	0.271	5.59	0.08	0.45	1l6wA	GO:0003824 GO:0005737 GO:0005975 GO:0006000 GO:0016829 GO:0016832 GO:0097023

Consensus prediction of GO terms

Molecular Function	GO:0015631	GO:0035639	GO:0032550	GO:0032561
GO-Score	0.44	0.32	0.32	0.32
Biological Processes	GO:0000070	GO:0097485	GO:0007409	GO:0007052	GO:0007308	GO:0030951	GO:0051231	GO:0007100	GO:1902850	GO:0008608	GO:0098727	GO:0035162	GO:0046605	GO:0031112	GO:0070925	GO:0051293	GO:0045478	GO:0016477	GO:0032273	GO:0007088	GO:0007293	GO:0008356	GO:0051058	GO:0031113	GO:0046578
GO-Score	0.44	0.44	0.44	0.44	0.44	0.44	0.44	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32
Cellular Component	GO:0005815	GO:0043234	GO:1990752	GO:0044463	GO:0043231	GO:0097610	GO:0045171	GO:0030427	GO:0032155	GO:0043005	GO:0005876	GO:0098687	GO:0044444
GO-Score	0.44	0.44	0.44	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.