I-TASSER results

I-TASSER results for job id Rv2216

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (301 residues)
MANAVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELHWNPESGEFDPHALTD
VDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSAAVADAGVATLINASAVGYYGNT
KDRVVDENDSAGTGFLAQLCVDWETATRPAQQSGARVVLARTGVVLSPAGGMLRRMRPLF
SVGLGARLGSGRQYMSWISLEDEVRALQFAIAQPNLSGPVNLTGPAPVTNAEFTTAFGRA
VNRPTPLMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAGFQFHHNTIGEALGYATTRP
G

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MANAVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELHWNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSAAVADAGVATLINASAVGYYGNTKDRVVDENDSAGTGFLAQLCVDWETATRPAQQSGARVVLARTGVVLSPAGGMLRRMRPLFSVGLGARLGSGRQYMSWISLEDEVRALQFAIAQPNLSGPVNLTGPAPVTNAEFTTAFGRAVNRPTPLMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAGFQFHHNTIGEALGYATTRPG
Prediction	CCCCEEEEHCCCCCHHHHHHHHHHHHCCEEEEEHCCCCCCCCEEEHCCCCCCCCHHHCCCCCEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHCCCEHCCHHHHHHCCCHCCCCHHHHHHHHHHCCC
Conf.Score	9998799988998556999999999899899998699888766886677766777885899899986866677788998999999997799999999999978998999965658768999876678889999977999999999999976659969999778755899997999999998789876899876777367999999999999889999977975897665999999999998999765676999999978865555548966554999998995558999999999986889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MANAVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELHWNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSAAVADAGVATLINASAVGYYGNTKDRVVDENDSAGTGFLAQLCVDWETATRPAQQSGARVVLARTGVVLSPAGGMLRRMRPLFSVGLGARLGSGRQYMSWISLEDEVRALQFAIAQPNLSGPVNLTGPAPVTNAEFTTAFGRAVNRPTPLMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAGFQFHHNTIGEALGYATTRPG
Prediction	8562330200106241323043127450300000234664263030204435214500540200000002000333226523520251004003200400472613100000000011446533131322246621140033024004405736010000000100044101032014103341003013150211120020001001100426604210000023101022003100511723020303321210011330430013223020520472605041240450045007468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEHCCCCCHHHHHHHHHHHHCCEEEEEHCCCCCCCCEEEHCCCCCCCCHHHCCCCCEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCEEEHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEHCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHCCCEHCCHHHHHHCCCHCCCCHHHHHHHHHHCCC
MANAVVAIAGSSGLIGSALTAALRAADHTVLRIVRRAPANSEELHWNPESGEFDPHALTDVDAVVNLCGVNIAQRRWSGAFKQSLRDSRITPTEVLSAAVADAGVATLINASAVGYYGNTKDRVVDENDSAGTGFLAQLCVDWETATRPAQQSGARVVLARTGVVLSPAGGMLRRMRPLFSVGLGARLGSGRQYMSWISLEDEVRALQFAIAQPNLSGPVNLTGPAPVTNAEFTTAFGRAVNRPTPLMLPSVAVRAAFGEFADEGLLIGQRAIPSALERAGFQFHHNTIGEALGYATTRPG

3oh8A

0.37

0.33

0.89

2.41

MUSTER

GSPLTVAITGSRGLVGRALTAQLQTGGHEVIQLVRKEPKP-GKRFWDPLNP--ASDLLDGADVLVHLAG------EFNDSHKEAIRESRVLPTKFLAELVAESTQCTTISASAVGFYGHRGDEILTEESESGDDFLAEVCRDWEHATAPASDAGKRVAFIRTGVALSGRGG----LPLLKTLFSGGKFGDGTSWFSWIAIDDLTDIYYRAIVDAQISGPINAVAPNPVSNAD---------------------TKILATQGAEELALASQRTAPAALENLSHTFRYTDIGAAIAHELGYEQ

4b4oA

0.34

0.33

0.95

3.86

dPPAS

----RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPG--RITWD----ELAASGLPSCDAAVNLAGENILNRRWNETFQKEVLGSRLETTQLLAKAITKAPPKAWVLVTGVAYYQPSLTAEYDEDSPGGFDFFSNLVTKWEAAAR-LPGDSTRQVVVRSGVVLGRGGGAGH--LLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

4b4oA

0.33

0.31

0.95

3.87

wdPPAS

----RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPG--RITWD----ELAASGLPSCDAAVNLAGENILNRRWNETFQKEVLGSRLETTQLLAKAITKAPPKAWVLVTGVAYYQPSLTAEYDEDSPGGDFDFFSNLVTKWEAAARLPGDSTRQVVVRSGVVLGRGGGA--GHLLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

3oh8A

0.37

0.33

0.89

2.93

wMUSTER

GSPLTVAITGSRGLVGRALTAQLQTGGHEVIQLVRKEPK-PGKRFWDPLNP--ASDLLDGADVLVHLAG------EFNDSHKEAIRESRVLPTKFLAELVAESTQCTTISASAVGFYGHRGDEILTEESESGDDFLAEVCRDWEHATAPASDAGKRVAFIRTGVALSGRGG----LPLLKTLFSGGKFGDGTSWFSWIAIDDLTDIYYRAIVDAQISGPINAVAPNPVSNAD---------------------TKILATQGAEELALASQRTAPAALENLSHTFRYTDIGAAIAHELGYEQ

4b4oA

0.34

0.33

0.95

3.73

wPPAS

----RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPG--RITWD----ELAASGLPSCDAAVNLAGENILNRRWNETFQKEVLGSRLETTQLLAKAITKAPPKAWVLVTGVAYYQPSLTAEYDEDSPGGFDFFSNLVTKWEAAAR-LPGDSTRQVVVRSGVVLGRGGGAG--HLLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

4b4oA

0.34

0.33

0.95

7.45

dPPAS2

----RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPG--RITWD----ELAASGLPSCDAAVNLAGENILNRRWNETFQKEVLGSRLETTQLLAKAITKAPPKAWVLVTGVAYYQPSLTAEYDEDSPGGFDFFSNLVTKWEAAAR-LPGDSTRQVVVRSGVVLGRGGGAGH--LLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

4b4oA

0.34

0.33

0.95

3.56

PPAS

----RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPG--RITWD----ELAASGLPSCDAAVNLAGENILNRRWNETFQKEVLGSRLETTQLLAKAITKAPPKAWVLVTGVAYYQPSLTAEYDEDSPGGFDFFSNLVTKWEAAAR-LPGDSTRQVVVRSGVVLGRGGGAG--HLLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

4b4oA

0.34

0.33

0.95

4.34

Env-PPAS

----RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPG--RITWD----ELAASGLPSCDAAVNLAGENILNRRWNETFQKEVLGSRLETTQLLAKAITKAPPKAWVLVTGVAYYQPSLTAEYDEDSPGGFDFFSNLVTKWEAAAR-LPGDSTRQVVVRSGVVLGRGGGAG--HLLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

4b4oA

0.34

0.33

0.95

2.38

MUSTER

----RVLVGGGTGFIGTALTQLLNARGHEVTLVSRKPGPG--RITWD----ELAASGLPSCDAAVNLAGENILNRRWNETFQKEVLGSRLETTQLLAKAITKAPPKAWVLVTGVAYYQPSLTAEYDEDSPGGFDFFSNLVTKWEAAAR-LPGDSTRQVVVRSGVVLGRGGGAGH--LLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

4b4oA2

0.32

0.20

0.62

2.54

dPPAS

-------------------------------------------------------------------------------------------------------------LVTGVAYYQPSLTAEYDEDSPGGDFDFFSNLVTKWEAAARLPGDSTRQVVVRSGVVLGRGGGAGH--LLPFRLGLGGPIGSGHQFFPWIHIGDLAGILTHALEANHVHGVLNGVAPSSATNAEFAQTFGAALGRRAFIPLPSAVVQAVFGRQ-RAILLEGQKVIPRRTLATGYQYSFPELGAALKEIAENL-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.30

Estimated TM-score = 0.89±0.07

Estimated RMSD = 3.6±2.5Å

Download Model 2

C-score=-4.01

Download Model 3

C-score=-5.00

Download Model 4

C-score=-4.40

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4b4oA	0.935	0.85	0.339	0.950
2	1sb8A	0.825	2.98	0.153	0.957
3	4zrmA	0.824	2.78	0.130	0.944
4	1gy8C	0.824	3.00	0.149	0.957
5	4lisA	0.821	2.97	0.181	0.954
6	2p5uA	0.820	2.80	0.159	0.940
7	1wvgA	0.820	2.80	0.120	0.944
8	5l9aA	0.820	2.82	0.140	0.950
9	3enkA	0.819	3.02	0.160	0.957
10	2c5aA	0.818	2.86	0.161	0.950

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.69	39	2bkaA	NDP	Rep, Mult	10,12,13,14,15,35,36,48,67,68,69,88,111,112,113,136,140,162,163,165
2	0.03	3	1y1pA	AMP	Rep, Mult	10,12,13,14,35,68,69,71,171
3	0.03	3	4aljE	GLU	Rep, Mult	4,62,106,154,156,211,212
4	0.02	2	1gy80	III	Rep, Mult	81,82,83,86,87,91,94,95,97,98,101,146,148,150

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.293	3m2pA	0.802	2.92	0.151	0.920	5.1.3.7	117
2	0.281	1kc0A	0.804	2.73	0.140	0.924	1.1.1.133	162,165
3	0.270	2x6tG	0.813	2.84	0.124	0.937	5.1.3.20	10,13,15,111
4	0.236	1he4A	0.519	2.90	0.146	0.595	1.3.1.24,1.5.1.30	10,21,67
5	0.208	2zcvA	0.727	2.98	0.154	0.861	1.6.5.2	NA
6	0.204	1r66A	0.804	2.99	0.172	0.944	4.2.1.46	NA
7	0.189	2z1mA	0.811	3.19	0.138	0.964	4.2.1.47	NA
8	0.179	1t2aA	0.814	3.17	0.138	0.964	4.2.1.47	NA
9	0.176	2ggsA	0.785	2.69	0.141	0.897	1.1.1.133	NA
10	0.172	1db3A	0.785	3.25	0.160	0.934	4.2.1.47	NA
11	0.171	1eq2D	0.812	2.88	0.124	0.937	5.1.3.20	112
12	0.155	3enkA	0.819	3.02	0.160	0.957	5.1.3.2	NA
13	0.150	1i3kA	0.824	2.81	0.171	0.950	5.1.3.2	NA
14	0.150	1orrA	0.813	2.93	0.126	0.947	5.1.3.10	112
15	0.148	1bsvA	0.789	3.05	0.136	0.927	1.1.1.271	112
16	0.144	2c20A	0.799	3.23	0.143	0.950	5.1.3.2	165,173
17	0.137	2c29F	0.774	3.30	0.168	0.914	1.1.1.219	NA
18	0.135	1udpB	0.813	2.99	0.186	0.947	5.1.3.2	NA
19	0.077	2fwmX	0.533	2.91	0.102	0.611	1.3.1.28	112
20	0.060	1a9yA	0.815	2.96	0.186	0.947	5.1.3.2	113
21	0.060	1rpnC	0.815	3.04	0.136	0.954	4.2.1.47	NA
22	0.060	1y1pA	0.779	3.35	0.125	0.924	1.1.1.2	10
23	0.060	1kbzA	0.805	2.71	0.140	0.924	1.1.1.133	NA
24	0.060	1gy8C	0.824	3.00	0.149	0.957	5.1.3.2	112
25	0.060	2p5uA	0.820	2.80	0.159	0.940	5.1.3.2	NA
26	0.060	1keuA	0.814	2.99	0.154	0.950	4.2.1.46	NA
27	0.060	1eq2A	0.718	3.06	0.150	0.837	5.1.3.20	NA
28	0.060	2c59A	0.817	2.86	0.161	0.950	5.1.3.18	112
29	0.060	2yy7A	0.813	2.92	0.122	0.950	1.1.1.103	112
30	0.060	1sb8A	0.825	2.98	0.153	0.957	5.1.3.7	112
31	0.060	1kerB	0.813	2.95	0.115	0.954	4.2.1.46	NA
32	0.060	1kewA	0.816	2.97	0.150	0.950	4.2.1.46	10,13,15,67,75
33	0.060	1ujmA	0.766	3.46	0.119	0.917	1.1.1.2	93
34	0.060	1rkxC	0.795	3.05	0.133	0.927	4.2.1.45	NA
35	0.060	1n7gB	0.817	2.92	0.157	0.950	4.2.1.47	NA
36	0.060	2blnA	0.399	4.75	0.060	0.535	2.1.1.2	66
37	0.060	1i24A	0.820	3.02	0.177	0.957	3.13.1.1	NA
38	0.060	2hunA	0.810	2.86	0.142	0.937	4.2.1.46	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.55	0.947	0.88	0.34	0.96	4b4oA	GO:0005634 GO:0016491 GO:0055114
1	0.42	0.815	2.36	0.38	0.89	3oh8A	GO:0003824 GO:0050662
2	0.32	0.803	3.08	0.18	0.94	3vpsA	GO:0000166 GO:0003824 GO:0050662
3	0.29	0.820	2.80	0.16	0.94	2p5uA	GO:0000166 GO:0003824 GO:0050662
4	0.29	0.812	2.89	0.15	0.95	3wmxA	GO:0000166 GO:0003824 GO:0016853 GO:0046872 GO:0050662
5	0.29	0.785	3.28	0.15	0.95	3aw9A	GO:0000166 GO:0003824 GO:0016491 GO:0050662 GO:0055114
6	0.28	0.816	3.29	0.14	0.98	1z7eD	GO:0003824 GO:0006629 GO:0008152 GO:0009058 GO:0009103 GO:0009245 GO:0016491 GO:0016616 GO:0016740 GO:0016742 GO:0033320 GO:0046493 GO:0046677 GO:0048040 GO:0050662 GO:0055114 GO:0070403 GO:0099618 GO:0099619
7	0.28	0.814	2.99	0.15	0.95	1keuA	GO:0008460 GO:0009103 GO:0009225 GO:0009243 GO:0016829 GO:0019305 GO:0045226 GO:0070404
8	0.28	0.813	2.84	0.12	0.94	2x6tG	GO:0003824 GO:0005829 GO:0005975 GO:0008712 GO:0009103 GO:0009244 GO:0016020 GO:0016853 GO:0050661 GO:0050662 GO:0070401 GO:0097171
9	0.28	0.825	2.98	0.15	0.96	1sb8A	GO:0000166 GO:0003824 GO:0005975 GO:0016857 GO:0050662
10	0.27	0.817	2.92	0.16	0.95	1n7gB	GO:0000166 GO:0005525 GO:0005829 GO:0008446 GO:0009826 GO:0016829 GO:0019673 GO:0042351
11	0.27	0.824	2.79	0.13	0.94	4zrnA	GO:0003824 GO:0003978 GO:0005975 GO:0016853 GO:0016857 GO:0050662
12	0.27	0.824	2.81	0.17	0.95	1i3kA	GO:0003974 GO:0003978 GO:0005829 GO:0005975 GO:0006012 GO:0016853 GO:0016857 GO:0019388 GO:0042803 GO:0070062
13	0.27	0.824	3.00	0.15	0.96	1gy8C	GO:0000166 GO:0003824 GO:0003978 GO:0006012 GO:0016853 GO:0050662
14	0.27	0.804	3.02	0.16	0.93	1bxkB	GO:0008460 GO:0009103 GO:0009225 GO:0009246 GO:0016829 GO:0045226
15	0.26	0.813	2.95	0.12	0.95	1kerB	GO:0000166 GO:0008460 GO:0009225 GO:0016829
16	0.25	0.819	3.02	0.16	0.96	3enkA	GO:0000166 GO:0003978 GO:0006012 GO:0016853
17	0.25	0.801	2.95	0.19	0.93	2b69A	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403
18	0.25	0.708	2.98	0.21	0.82	4lk3B	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403
19	0.25	0.802	3.35	0.13	0.95	3wj7A	GO:0003824 GO:0050662
20	0.25	0.636	3.13	0.15	0.75	3ay3A	GO:0003824 GO:0050662
21	0.24	0.703	3.55	0.14	0.87	3i5mA	GO:0000166
22	0.24	0.503	3.32	0.14	0.60	3dhnA
23	0.24	0.804	2.99	0.17	0.94	1r66A	GO:0000166 GO:0008460 GO:0009225 GO:0016491 GO:0016829 GO:0055114
24	0.23	0.815	2.96	0.19	0.95	1a9yA	GO:0003978 GO:0005737 GO:0005829 GO:0005975 GO:0006012 GO:0009242 GO:0016853 GO:0016857 GO:0033499 GO:0042802 GO:0070403
25	0.22	0.580	3.38	0.13	0.69	1uznA	GO:0004316 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0016491 GO:0018454 GO:0046459 GO:0055114 GO:0071768 GO:0102132
26	0.19	0.821	2.97	0.18	0.95	4lisA	GO:0000166 GO:0003978 GO:0005622 GO:0005737 GO:0006012 GO:0016853
27	0.18	0.567	3.58	0.17	0.69	4jp2A	GO:0000166
28	0.17	0.803	3.27	0.15	0.95	4twrA	GO:0000166 GO:0003824 GO:0003978 GO:0006012 GO:0016853 GO:0046872 GO:0050662
29	0.17	0.813	2.93	0.13	0.95	1orrA	GO:0009103 GO:0016853 GO:0047732
30	0.17	0.529	2.99	0.14	0.61	1uzmB	GO:0004316 GO:0005886 GO:0006629 GO:0006631 GO:0006633 GO:0016491 GO:0018454 GO:0046459 GO:0055114 GO:0071768 GO:0102132
31	0.16	0.525	2.65	0.16	0.59	3h2sA	GO:0000166
32	0.16	0.455	2.39	0.24	0.50	4m55E	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403
33	0.14	0.704	3.58	0.13	0.85	3hfsB	GO:0003824 GO:0050662

Consensus prediction of GO terms

Molecular Function	GO:0050662	GO:0000166	GO:0043169	GO:0016491
GO-Score	0.80	0.66	0.58	0.56
Biological Processes	GO:0055114
GO-Score	0.56
Cellular Component	GO:0005634
GO-Score	0.56

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.