I-TASSER results

I-TASSER results for job id Rv2205c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (358 residues)
MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDGGPGFVEVLGSRLGETR
RLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPPTPETALAAHSKGVGQLIA
AALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQLADVEVIAASDVEYPLLGPWG
TARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGVSAEPGAGAAGGIGAGLLAVGGR
YQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSLHGKVVGAIAAAARPLAIPVIVLAG
QVSLDKSALRSAGIMAALSIAEYAGSVRLALADAANQLMGLASQVAARLGNSGPSGYR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDGGPGFVEVLGSRLGETRRLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPPTPETALAAHSKGVGQLIAAALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQLADVEVIAASDVEYPLLGPWGTARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGVSAEPGAGAAGGIGAGLLAVGGRYQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSLHGKVVGAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMAALSIAEYAGSVRLALADAANQLMGLASQVAARLGNSGPSGYR
Prediction	CEEEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHCCCEEEEEEHCCCCCCEEEEEEHCCCCCEEEEHHHHHHCHCCCCCCCCHHHCHHCCCCCCHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEHCCHHHHHHHHHCHHHHHHHCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
Conf.Score	9799967899877879999999999887658898799868998998699999997995799997689998766799985898767755568876444789998555443478764899999999899899999767667767899999987656677876676799997799999987676655578889999999999999999999999985987555998765548999999999955667999999869799986599999689887444578866799999999989989999756789999999985676545678899899999999999999999999998557788899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDGGPGFVEVLGSRLGETRRLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPPTPETALAAHSKGVGQLIAAALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQLADVEVIAASDVEYPLLGPWGTARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGVSAEPGAGAAGGIGAGLLAVGGRYQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSLHGKVVGAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMAALSIAEYAGSVRLALADAANQLMGLASQVAARLGNSGPSGYR
Prediction	4200000011532130440040004103401150301100000414000000011444325140401144404020001474300000000001011064354361023010200010010014130300000000000000010003002416503520250200000002000202310211000134044720440250043005102721356036320000000000001002121210000002014026105402000002131130002210000003103724010000001112436202510041010006332303301440352035103400430256445538
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHCCCEEEEEEHCCCCCCEEEEEEHCCCCCEEEEHHHHHHCHCCCCCCCCHHHCHHCCCCCCHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEHCCHHHHHHHHHCHHHHHHHCCEEEHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
MRVLVAPDCYGDSLSAVEAAAAIATGWTRSRPGDSFIVAPQSDGGPGFVEVLGSRLGETRRLRVCGPLNTVVNAAWVFDPGSATAYLECAQACGLGLLGGPPTPETALAAHSKGVGQLIAAALRAGAARIVVGLGGSACTDGGKGMIAELGGLDAARRQLADVEVIAASDVEYPLLGPWGTARVFAPQKGADMATVAVLEGRLAAWAIELDAAAGRGVSAEPGAGAAGGIGAGLLAVGGRYQSGAAIIAEHTHFADDLADAELIVTGEGRFDEQSLHGKVVGAIAAAARPLAIPVIVLAGQVSLDKSALRSAGIMAALSIAEYAGSVRLALADAANQLMGLASQVAARLGNSGPSGYR

1to6A

0.31

0.30

0.96

2.60

MUSTER

MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSLLEEKCLQVTGSFGQKEVMRYFQKEQ--LALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGGTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLK----LKGAGAGGGIAGGLCAF-ASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTP-VGVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMP-----K

1to6A

0.30

0.29

0.96

8.66

dPPAS

MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSLDLEKCLQVTGSFGQKEVMRYFQ--KEQLALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGYTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLKL----KGAGAGGGIAGGLCAFAASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTP-VGVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMPKI----

1to6A

0.31

0.29

0.96

6.37

wdPPAS

MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSLLEEKCLQVTGSFGQKEVMRYFQK--EQLALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGYTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLK----LKGAGAGGGIAGGLCAF-ASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTPV-GVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMPKI----

1to6A

0.31

0.29

0.95

2.78

wMUSTER

-KIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSLLEEKCLQVTGSFGQKEVMRYFQK--EQLALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGGTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLK----LKGAGAGGGIAGGLCAF-ASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTP--GVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMP-----K

1to6A

0.31

0.29

0.96

3.53

wPPAS

MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSLLEEKCLQVTGSFGQKEVMRYFQK--EQLALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGSTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLKL----KGAGAGGGIAGGLCAF-ASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTP-VGVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMP-----K

1to6A

0.30

0.29

0.96

13.04

dPPAS2

MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSDLEEKCLQVTGSFGQKEVMRYFQ--KEQLALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGSTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLKL----KGAGAGGGIAGGLCAFAASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTP-VGVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMPKI----

1to6A

0.30

0.29

0.96

3.54

PPAS

MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSDLEEKCLQVTGSFGQKEVMRYFQ--KEQLALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGSTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLKL----KGAGAGGGIAGGLCAF-ASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTP-VGVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMPKI----

1to6A

0.30

0.29

0.96

7.04

Env-PPAS

MKIVIAPDSFKESLTAQQVAEAIKRGFQQSIADVECLLCPVGDGGEGTVDAIRHSDLEEKCLQVTGSFGQKEVMRYFQ--KEQLALFEVADLVGLGKI--PLEKRNPLQIQTRGIGELIRHLISQEIKEIYIGVGGTASNDGGIGIAAGLGSTENRYKIPEDVHIRILADVVSPLCGHQGATYTFGKQKGLDSTMFEVVDQAIQDFYEKVSPATLKL----KGAGAGGGIAGGLCAFAASIVSGIDTCLDLIDFDKKVSDVDLVIVGEGRLDRQSLAGKAPIGVAKRTP-VGVPVVAICGSLVEDLPSLPFENIQAAFSILEKSEPLEDSLKNASLYLEHTASNIGHLLNMPKI----

3cwcB

0.35

0.34

0.95

2.52

MUSTER

AKIVIAPDSYKESLSALEVATAIEQGFREIWPDADYLKLPLADGGEGTVEAVEATAGRIVHVEVTGPLGHRVNAFYGLSGDARSAFIE-AAASGLEQV--PPAQRDPLKTTSWGTGELIRHALDAGVEHIIIGIGGSATNDGG-AGVQALGAISGLDKRLSACHIEVACDVTNPLTGKEGASAVFGPQKGAT-PEIERLDTALTRYAHLIARDLHVDVLDLAGGGAAGGGAALYAFCGAQLRRGIEIVTDALHLEACLADADLVITGEGRIDSQTIHGKVPIGVANIAKRYNKPVIGIAGSLT-------AHGLDAVFSVIYTICTLE-DALKNASENVRTARNVAATLK----AGQQ

3cwcB

0.35

0.33

0.96

8.32

dPPAS

AKIVIAPDSYKESLSALEVATAIEQGFREIWPDADYLKLPLADGGEGTVEAVEATAGRIVHVEVTGPLGHRVNAFYGLSGDARSAFIEAA-ASGLEQV--PPAQRDPLKTTSWGTGELIRHALDAGVEHIIIGIGGSATNDGG-AGVQALGAISGLDKRLSACHIEVACDVTNPLTGKEGASAVFGPQKGATP-EIERLDTALTRYAHLIARDLHVDVLDLAGGGAAGGGAALYAFCGAQLRRGIEIVTDALHLEACLADADLVITGEGRIDSQTIHGKVPIGVANIAKRYNKPVIGIAGSLTA-------HGLDAVFSVIYTICTLEDALKNASENVRTARNVAATLKAGQQL----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.67

Estimated TM-score = 0.95±0.05

Estimated RMSD = 3.2±2.3Å

Download Model 2

C-score=1.74

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1to6A	0.941	1.17	0.304	0.964
2	3cwcB	0.758	3.88	0.342	0.933
3	3kc2A	0.453	5.99	0.059	0.676
4	4bqeA	0.443	6.73	0.061	0.749
5	2amvA	0.442	6.65	0.044	0.740
6	3hltA	0.441	5.06	0.099	0.612
7	4l22A	0.440	6.57	0.055	0.732
8	2aw3A	0.438	6.74	0.087	0.743
9	2c4mC	0.438	6.61	0.038	0.726
10	1zjjB	0.435	5.21	0.113	0.612

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	6	1zjjA	MG	Rep, Mult	8,10,270
2	0.05	3	1l7xA	700	Rep, Mult	181,184,199,203
3	0.05	3	1rd4C	L08	Rep, Mult	3,5,22,35,263,265,294,296,297,298,316,317,318,341,344,346
4	0.04	2	1gfzA	CFF	Rep, Mult	17,42,44,48
5	0.04	2	3m0kA	MN	Rep, Mult	136,141,170,172
6	0.04	2	5m7oA	MG	Rep, Mult	7,8,16,267,320
7	0.02	1	1zdmB	XE	Rep, Mult	6,7,19,266,267,298
8	0.02	1	3cejB	AVF	Rep, Mult	319,320,321,337
9	0.02	1	1to60	III	Rep, Mult	1,262,294,296,301,302,304,309,315,316,317,318,319,321,322,323,324,327,344,347,348,349
10	0.02	1	1kgzB	MN	Rep, Mult	66,112,273
11	0.02	1	3mboC	MG	Rep, Mult	268,278
12	0.02	1	3qqsA	MG	Rep, Mult	272,273
13	0.02	1	3mboE	MG	Rep, Mult	268,271
14	0.02	1	1bk5B	CO	Rep, Mult	114,170
15	0.02	1	1exvB	700	Rep, Mult	182,202,206
16	0.02	1	1o5qA	MG	Rep, Mult	170,240

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ahpA	0.446	6.68	0.077	0.751	2.4.1.1	NA
2	0.060	2qr5A	0.416	6.25	0.080	0.659	3.4.19.1	NA
3	0.060	2azdB	0.442	6.67	0.061	0.746	2.4.1.1	270
4	0.060	2epoA	0.411	6.24	0.071	0.659	3.2.1.52	NA
5	0.060	1e3xA	0.403	6.89	0.026	0.693	3.2.1.1	129
6	0.060	1djnA	0.419	6.84	0.053	0.718	1.5.8.2,1.5.99.7	170
7	0.060	2tmdA	0.420	6.84	0.053	0.721	1.5.8.2	333
8	0.060	2c4mC	0.438	6.61	0.038	0.726	2.4.1.1	NA
9	0.060	2bs9E	0.406	6.62	0.060	0.684	3.2.1.37	NA
10	0.060	1ps9A	0.405	6.25	0.053	0.648	1.3.1.34	NA
11	0.060	1qbaA	0.418	6.99	0.049	0.737	3.2.1.52	NA
12	0.060	2epoB	0.354	7.01	0.050	0.615	3.2.1.52	NA
13	0.060	1to6B	0.927	1.43	0.304	0.964	2.7.1.31	95,136,171,185,270,279
14	0.060	2cftA	0.431	5.13	0.089	0.598	3.1.3.74	NA
15	0.060	2bfgA	0.415	6.65	0.066	0.701	3.2.1.37	NA
16	0.060	2pbgA	0.415	6.68	0.066	0.679	3.2.1.85	NA
17	0.060	2r4uA	0.410	6.39	0.068	0.654	2.4.1.21	88
18	0.060	3gpbA	0.446	6.45	0.063	0.721	2.4.1.1	NA
19	0.060	1c7sA	0.416	6.81	0.062	0.718	3.2.1.52	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.46	0.771	3.80	0.34	0.94	3cwcB	GO:0008887 GO:0016301 GO:0016310 GO:0016740 GO:0031388
1	0.44	0.941	1.17	0.30	0.96	1to6A	GO:0000166 GO:0005524 GO:0008887 GO:0016301 GO:0016310 GO:0016740 GO:0031388
2	0.07	0.451	5.97	0.06	0.68	3kc2B	GO:0046474
3	0.07	0.438	5.03	0.09	0.60	4bx2A	GO:0000287 GO:0004647 GO:0004721 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0006470 GO:0007088 GO:0008152 GO:0015629 GO:0016020 GO:0016787 GO:0016791 GO:0030027 GO:0030496 GO:0030836 GO:0031072 GO:0031247 GO:0031258 GO:0032154 GO:0032361 GO:0032465 GO:0032587 GO:0033883 GO:0042803 GO:0042995 GO:0046872 GO:0070062 GO:0070938 GO:0071318
4	0.07	0.441	5.06	0.10	0.61	3hltA	GO:0016311 GO:0016791 GO:0019899 GO:0046872 GO:0070062
5	0.07	0.452	5.96	0.05	0.68	3rf6B	GO:0046474
6	0.07	0.437	5.29	0.08	0.61	4bkmA	GO:0000121 GO:0000287 GO:0004647 GO:0004721 GO:0004725 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005975 GO:0006114 GO:0006470 GO:0006650 GO:0007088 GO:0008152 GO:0008967 GO:0015629 GO:0016020 GO:0016311 GO:0016787 GO:0016791 GO:0030027 GO:0030496 GO:0030836 GO:0031072 GO:0031247 GO:0031258 GO:0032154 GO:0032361 GO:0032465 GO:0032587 GO:0033883 GO:0035335 GO:0042803 GO:0042995 GO:0043136 GO:0045721 GO:0046872 GO:0070062 GO:0070938 GO:0071318 GO:0098519
7	0.07	0.440	4.79	0.09	0.60	2ho4B	GO:0016311 GO:0016791 GO:0019899 GO:0046872 GO:0070062
8	0.07	0.435	5.21	0.11	0.61	1zjjB	GO:0046872
9	0.06	0.421	5.09	0.13	0.59	2c4nA	GO:0000287 GO:0005829 GO:0005975 GO:0008253 GO:0016311 GO:0016787 GO:0046050 GO:0046872
10	0.06	0.430	4.99	0.10	0.59	3eprA	GO:0016787
11	0.06	0.423	5.01	0.15	0.58	1ydfA	GO:0016787
12	0.06	0.429	5.09	0.09	0.59	1vjrA	GO:0016311 GO:0016791 GO:0046872
13	0.06	0.415	5.64	0.08	0.61	2hx1A	GO:0046872
14	0.06	0.425	5.08	0.08	0.59	1yv9A	GO:0016787
15	0.06	0.423	5.08	0.10	0.59	3pdwA	GO:0016311 GO:0016787 GO:0016791 GO:0046872
16	0.06	0.426	5.20	0.13	0.60	1wviA
17	0.06	0.422	5.21	0.14	0.59	1ys9A
18	0.06	0.356	6.14	0.06	0.56	5hbrA	GO:0048037

Consensus prediction of GO terms

Molecular Function	GO:0008887	GO:0005524
GO-Score	0.70	0.44
Biological Processes	GO:0031388
GO-Score	0.70
Cellular Component	GO:0070062	GO:0032587	GO:0030496	GO:0005829	GO:0070938	GO:0032154	GO:0005911	GO:0031258	GO:0015629
GO-Score	0.13	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.