I-TASSER results

I-TASSER results for job id Rv2190c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (385 residues)
MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALAKLNELSRQAEQTTEA
LHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMD
AILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQA
AAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPVPAVAAIAPGAPPAALPPG
APPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYAWGGAAPGGFDC
SGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVLTFYSDASHAGIYIGDGLMVH
SSTYGVPVRVVPMDSSGPIYDARRY

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPVPAVAAIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYAWGGAAPGGFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY
Prediction	CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHCCCCEEEEHCCCCCEEEEEHCCCEEEHCCCCCCCEEEEHCCCCCCEEEEHCC
Conf.Score	9988887765578999999999999986567777888889999999999999999999999999999999999999999999999999999999999999999999999998699858776776899999999999999999999999999999999999999999999999999999999999999999999999999999999985678888887655444455554555555555456777788888777888888888888888888699999999997798866899999998886799999999899999899999987976798879999799978999789999769989968999986899866789975578859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPVPAVAAIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYAWGGAAPGGFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY
Prediction	8546444312320100000000000011022333141442640453155025414513541450354155245415514641551454155045415512640452033104535242010002073033014114104403542453055145335514534541564355055235514532551453155145415514531551445433223344444434444443332323333244444444334343334223343343344322100210141001000000121301000000000033130401010110141035033720310000001240000000016311000135644020120233312100102
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHCCCCEEEEHCCCCCEEEEEHCCCEEEHCCCCCCCEEEEHCCCCCCEEEEHCC
MRLDQRWLIARVIMRSAIGFFASFTVSSGVLAANVLADPADDALAKLNELSRQAEQTTEALHSAQLDLNEKLAAQRAADQKLADNRTALDAARARLATFQTAVNKVAAATYMGGRTHGMDAILTAESPQLLIDRLSVQRVMAHQMSTQMARFKAAGEQAVKAEQAAAKSAADARSAAEQAAAVRANLQHKQSQLQVQIAVVKSQYVALTPEERTALADPGPVPAVAAIAPGAPPAALPPGAPPGDGPAPGVAPPPGGMPGLPFVQPDGAGGDRTAVVQAALTQVGAPYAWGGAAPGGFDCSGLVMWAFQQAGIALPHSSQALAHGGQPVALSDLQPGDVLTFYSDASHAGIYIGDGLMVHSSTYGVPVRVVPMDSSGPIYDARRY

4cgkA

0.14

0.12

0.84

1.38

MUSTER

----------------------------------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKNTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAP----WAGDYWG-----------------NGAQWATSAAAAGFRTG-STPQVGAIACWNDGGGHVAVVTATTQVSESNYAGNRTIGNHRGWFNPTEGFVTY

4fdyA

0.18

0.13

0.72

2.31

wdPPAS

--------------------------------------------------------------------------GVTVSPEVLAHRPLIEKYGKEYG-IEDYVSYILAIQVESGGTEDVQSSESLGLPPNSLSTEESIKQGVKYFSELLTSAEQQGVDIDSVIQSYNYGGGFLNYVRSHGKKYTYELAEQFSKEKSGGQKAD-----------------------------YPNPIAIPVNGGWRYNYGNQFYVQLVSQYLTDTSPTEFDDETVQVIDEALKYEGFPYVFGGASPTTSFDSGLIQWVYDKAGISLPRVAQDQYDATQEIS-EEAQAGDLIFFHSTVTHVAIYLEGNRFYHAGD---PIGYGDLSSQDHLIGARRV

4fdyA

0.18

0.13

0.72

1.87

wMUSTER

--------------------------------------------------------------------------GVTVSPEVLAHRPLIEKYGKEYG-IEDYVSYILAIQVEGGTAEDVQSSESLGLPPNSLSTEESIKQGVKYFSELLTSAEQQGVDIDSVIQSYNYGGGFLNYVRSH-----------------------------GKKYTYELAEQFSKEKSGGQKADYPNPIAIPVNGGWRYNYGNQFYVQLVSQYLTDTSPTEFDDETVQVIDEALKYEGFPYVFGGASPTTSFDSGLIQWVYDKAGISLPRVAQDQYDATQEIS-EEAQAGDLIFFHSYVTHVAIYLEGNRFYHAGD---PIGYGDLSSRDHLIGARRV

3pbiA

0.27

0.13

0.46

3.56

wPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------GQTLPALVSAGAPGDPLAVANASLQATAQATQTTLDLGRQFLGGLG-------------------------------------------INLGGPTGASRIPRANARQAVEYVIRRAGSQMGVPYSWGGGSLQGFDCSGLVRYAFAGVGVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGQHVTLYLGNGQMLEASGSAGKVTVSPVRKAGMTPFVTRY

4cgkA

0.14

0.12

0.85

2.33

PPAS

----------------------------------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGATSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRA----------KVRPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNWATSAAAAGFRTG-STPQVGAIACWNDGG-----Y-GHVAVVTAVESTTRIQVSESNYAGNRTIGNHR

4xcmA

0.27

0.12

0.43

2.89

Env-PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ATYTVAPGDTLYSIARRYGTTVEELRLNGLESFLLQPGQV-----LKLPPPPPEPEALDPESPLLRAVLRYLGVPYKYGANSPLALDCSAFVAQVYAELGVALPRTTKEQYQAFPPVE--APRPGDLVFFSFEVDHVGIYLGRGVFAHASSYGSRVVIESLEARKVYRGARRV

4fdyA

0.17

0.12

0.71

1.26

MUSTER

--------------------------------------------------------------------------GVTVSPEVLAHRPLIEKYGKEYG---EDYVSYILAIQVGGTAEDVQSSESLGLPPNSLSTEESIKQGVKYFSELLTSAEQQGVDIDSVIQSYNYGGGFLNYVRSH-----------------------------GKKYTYELAEQFSKEKSGGQKADYPNPIAIPVNGGWRYNYGNQFYVQLVSQYLTDTSPTEFDDETVQVIDEALKYEGFPYVFGGASPTTSFDSGLIQWVYDKAGISLPRVAQDQYDATQEIS-EEAQAGDLIFFHTYVTHVAIYLEGNRFYHAG---DPIGYGDLSSRDHLIGARRV

4cgkA

0.13

0.11

0.82

1.09

dPPAS

----------------------------------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAPWAGD------------------------YWGNGAQWATSAAAAGFRTGST-PQVGAIACWNDGGY------GHVAVVTAVESTTRIQVSESNYAGNRTIGNHR

4cgkA

0.14

0.12

0.85

1.83

wMUSTER

----------------------------------------SNLTAQQQEAQKQVDQIQEQVSAIQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVSYINTIVNSKSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRA----------KVRPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNWATSAAAAGFRTG-STPQVGAIACWNDGG-----Y-GHVAVVTAVESTTRIQVSESNYAGRTIGNHRG

3pbiA

0.23

0.11

0.47

2.16

wdPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GQWDPTLPALVSAGAPGDPLAVANASLQATAQATQTTLDLGRQFLGGL----------------------GINLGGPTGASRIPRANARQAVEYVIRRAGSQMGVPYSWGGGSLQGFDCSGLVRYAFAGVGVLIPRFSGDQYNAGRHVPPAEAKRGDLIFYGPGGQHVTLYLGNGQMLEASGSAGKVTVSPVRKAGMTPFVTRI

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.06

Estimated TM-score = 0.37±0.13

Estimated RMSD = 14.2±3.8Å

Download Model 2

C-score=-3.77

Download Model 3

C-score=-4.19

Download Model 4

C-score=-4.09

Download Model 5

C-score=-4.33

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4cgkA	0.674	3.67	0.122	0.795
2	1ciiA	0.426	6.46	0.072	0.667
3	4ut1A	0.385	5.83	0.071	0.566
4	4k0eA	0.384	7.17	0.037	0.654
5	2ch7A	0.376	3.21	0.085	0.434
6	3psfA	0.375	6.40	0.037	0.582
7	1w27A	0.374	5.44	0.070	0.538
8	1y2mB	0.372	5.44	0.093	0.535
9	3vuoA	0.368	6.70	0.031	0.610
10	1vw1A	0.368	4.90	0.037	0.473

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	2e42B	NUC	Rep, Mult	150,151,154,155,157,158,159,161
2	0.04	2	2qveA	247	Rep, Mult	327,340,350
3	0.04	2	3p93A	KDG	Rep, Mult	288,290
4	0.04	2	3sjqD	PHU	Rep, Mult	87,90,91
5	0.02	1	3h41A	UUU	Rep, Mult	162,197,290,291,299,300,301,318,319,347
6	0.02	1	4f8hA	LMD	Rep, Mult	94,97
7	0.02	1	3athC	AKG	Rep, Mult	291,352
8	0.02	1	1yklG	DHB	Rep, Mult	285,287
9	0.02	1	3e1nE	UNK	Rep, Mult	60,190
10	0.02	1	1l5gB	III	Rep, Mult	288,310,311,312,314,315
11	0.02	1	1bviD	CA	Rep, Mult	297,299
12	0.02	1	1m1xB	UUU	Rep, Mult	289,290,291,292,293,307,312
13	0.02	1	2c9qA	CU	Rep, Mult	340,348
14	0.02	1	4zxqA	CA	Rep, Mult	145,148
15	0.02	1	1utzA	PF3	Rep, Mult	360,361
16	0.02	1	2vdoB	III	Rep, Mult	304,307,308,368,369
17	0.02	1	2iunB	CA	Rep, Mult	291,299
18	0.02	1	3cp0A	ZN	Rep, Mult	348,355
19	0.02	1	3c9iA	CA	Rep, Mult	148,151
20	0.02	1	2ll8A	PNS	Rep, Mult	299,301

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1eulA	0.335	5.74	0.041	0.493	3.6.3.8	267
2	0.060	1fziA	0.335	5.79	0.036	0.478	1.14.13.25	NA
3	0.060	1pj6A	0.324	7.16	0.049	0.558	1.5.3.10	NA
4	0.060	3e04D	0.330	5.42	0.047	0.462	4.2.1.2	NA
5	0.060	3ffzA	0.356	6.47	0.030	0.553	3.4.24.69	NA
6	0.060	2fenD	0.319	5.52	0.053	0.457	5.5.1.2	NA
7	0.060	2vuaA	0.226	6.92	0.051	0.377	3.4.24.69	352
8	0.060	1b8fA	0.321	5.36	0.058	0.444	4.3.1.3	NA
9	0.060	1mhsA	0.342	7.06	0.062	0.577	3.6.3.6	NA
10	0.060	1ti2A	0.321	6.51	0.049	0.519	1.97.1.2	NA
11	0.060	3lssB	0.321	5.08	0.038	0.431	6.1.1.11	NA
12	0.060	1p4rA	0.337	6.92	0.052	0.582	2.1.2.3,3.5.4.10	NA
13	0.060	1w27A	0.374	5.44	0.070	0.538	4.3.1.24	NA
14	0.060	1ffyA	0.340	7.24	0.077	0.590	6.1.1.5	296
15	0.060	2gq3A	0.324	6.33	0.041	0.512	2.3.3.9	299
16	0.060	3g61A	0.343	5.92	0.044	0.496	3.6.3.44	350
17	0.060	1ti6A	0.320	6.58	0.045	0.522	1.97.1.2	NA
18	0.060	2vumB	0.270	7.30	0.031	0.473	2.7.7.6	NA
19	0.060	2j0mA	0.220	6.78	0.026	0.366	2.7.10.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.426	6.46	0.07	0.67	1ciiA	GO:0005886 GO:0016020 GO:0016021 GO:0019835 GO:0042742 GO:0050829
1	0.06	0.263	7.45	0.05	0.47	3nogA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
2	0.06	0.356	7.27	0.09	0.62	2v50D	GO:0005215 GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0016020 GO:0016021 GO:0046677
3	0.06	0.395	7.11	0.06	0.66	3w9iF	GO:0005215 GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0016020 GO:0016021 GO:0046677
4	0.06	0.311	6.32	0.05	0.48	2d4yA	GO:0005198 GO:0005576 GO:0009288 GO:0009424 GO:0044780 GO:0071973
5	0.06	0.385	5.83	0.07	0.57	4ut1A	GO:0005198 GO:0009424 GO:0044780
6	0.06	0.384	7.17	0.04	0.65	4k0eA	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
7	0.06	0.317	6.98	0.05	0.54	4k0eC	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
8	0.06	0.272	7.08	0.04	0.46	1rh1A	GO:0005886 GO:0009405 GO:0016020 GO:0016021 GO:0019835 GO:0042742 GO:0050829
9	0.06	0.385	6.98	0.04	0.64	3d9bA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
10	0.06	0.263	7.11	0.05	0.45	2wssA	GO:0000166 GO:0005524 GO:0005739 GO:0005743 GO:0005753 GO:0005886 GO:0006754 GO:0006810 GO:0006811 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016820 GO:0033178 GO:0045261 GO:0046034 GO:0046933 GO:0046961
11	0.06	0.345	7.16	0.06	0.59	4dnrA	GO:0005215 GO:0005375 GO:0005507 GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0006825 GO:0006878 GO:0008324 GO:0010272 GO:0010273 GO:0015080 GO:0015673 GO:0015679 GO:0016020 GO:0016021 GO:0046688 GO:0060003 GO:1902601
12	0.06	0.307	7.43	0.07	0.56	4k0eB	GO:0005215 GO:0006810 GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
13	0.06	0.269	6.97	0.05	0.45	2ad5B	GO:0000166 GO:0003883 GO:0005524 GO:0005829 GO:0006221 GO:0006241 GO:0006541 GO:0016874 GO:0042802 GO:0044210
14	0.06	0.285	6.88	0.02	0.48	4mt1A	GO:0005215 GO:0006810 GO:0016020 GO:0016021
15	0.06	0.255	6.60	0.04	0.41	3i6sA	GO:0004252 GO:0005618 GO:0006508 GO:0008233 GO:0008236 GO:0016787
16	0.06	0.289	7.00	0.05	0.49	3fewX	GO:0016020 GO:0016021 GO:0019835 GO:0050829
17	0.06	0.297	5.94	0.04	0.45	5en5C	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015307 GO:0016020 GO:0016021 GO:0042493 GO:0042802 GO:0046618
18	0.06	0.203	5.31	0.06	0.28	3lidA	GO:0000155 GO:0000160 GO:0005622 GO:0023014

Consensus prediction of GO terms

Molecular Function	GO:0022857	GO:0090484
GO-Score	0.36	0.36
Biological Processes	GO:0055085	GO:0015893
GO-Score	0.36	0.36
Cellular Component	GO:0071944	GO:0031224
GO-Score	0.47	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.