I-TASSER results

I-TASSER results for job id Rv2184c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (379 residues)
MVVSTDQAHSLGDVLGIAVPPTGQGDPVRVLAYDPEAGGGFLDALALDTLALLEGRWLHV
VETLDRRFPGSELSSIAPEELCALPGIQEVLGLHAVGELAAARRWDRIVVDCASTADALR
MLTLPATFGLYVERAWPRHRRLSIGADDGRSAVLAELLERIRASVERLSTLLTDGALVSA
HLVLTPERVVAAEAVRTLGSLALMGVRVEELLVNQLLVQDENYEYRSLPDHPAFHWYAER
IGEQRAVLDDLDATIGDVALVLVPHLAGEPIGPKALGGLLDSARRRQGSAPPGPLQPIVD
LESGSGLASIYRLRLALPQLDPGTLTLGRADDDLIVSAGGMRRRVRLASVLRRCTVLDAH
LRGGELTVRFRPNPEVWPT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVVSTDQAHSLGDVLGIAVPPTGQGDPVRVLAYDPEAGGGFLDALALDTLALLEGRWLHVVETLDRRFPGSELSSIAPEELCALPGIQEVLGLHAVGELAAARRWDRIVVDCASTADALRMLTLPATFGLYVERAWPRHRRLSIGADDGRSAVLAELLERIRASVERLSTLLTDGALVSAHLVLTPERVVAAEAVRTLGSLALMGVRVEELLVNQLLVQDENYEYRSLPDHPAFHWYAERIGEQRAVLDDLDATIGDVALVLVPHLAGEPIGPKALGGLLDSARRRQGSAPPGPLQPIVDLESGSGLASIYRLRLALPQLDPGTLTLGRADDDLIVSAGGMRRRVRLASVLRRCTVLDAHLRGGELTVRFRPNPEVWPT
Prediction	CEEEHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEHCCCEEEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHCCCCEEEEEEHCCCCCCCEEEEEEHCCEEEEEHCCEEEEEHCCHHHHCCCCCCEEEHCCEEEEEHCCCCCCCCC
Conf.Score	9567689989889879878888777776445788745568858999787899999999999999997557766678889987576689999999999999859987999959999689999875899999999998888888776577655468899999999999999999799965999986996889999999999999989986789996677888776555555566549999999999999999999848997789758888999999999999998656788888777666554455556878999999589993337888868889999979688886768885887544799799999998578888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVVSTDQAHSLGDVLGIAVPPTGQGDPVRVLAYDPEAGGGFLDALALDTLALLEGRWLHVVETLDRRFPGSELSSIAPEELCALPGIQEVLGLHAVGELAAARRWDRIVVDCASTADALRMLTLPATFGLYVERAWPRHRRLSIGADDGRSAVLAELLERIRASVERLSTLLTDGALVSAHLVLTPERVVAAEAVRTLGSLALMGVRVEELLVNQLLVQDENYEYRSLPDHPAFHWYAERIGEQRAVLDDLDATIGDVALVLVPHLAGEPIGPKALGGLLDSARRRQGSAPPGPLQPIVDLESGSGLASIYRLRLALPQLDPGTLTLGRADDDLIVSAGGMRRRVRLASVLRRCTVLDAHLRGGELTVRFRPNPEVWPT
Prediction	3300001022001004241364345222322424145115302000002432255105402520472044530440244012111001000003202510665500000000110210020030042023005302423431332354243540353055015205403510423720000000202510040033004104627040100000101244444433423443314004312520450054037204712212021134314226103400530463454642452434242452564622010102032145640412243210102035231103014203625134031565303020345574448
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEHCCCEEEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEHCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEHCCCCEEEEEEHCCCCCCCEEEEEEHCCEEEEEHCCEEEEEHCCHHHHCCCCCCEEEHCCEEEEEHCCCCCCCCC
MVVSTDQAHSLGDVLGIAVPPTGQGDPVRVLAYDPEAGGGFLDALALDTLALLEGRWLHVVETLDRRFPGSELSSIAPEELCALPGIQEVLGLHAVGELAAARRWDRIVVDCASTADALRMLTLPATFGLYVERAWPRHRRLSIGADDGRSAVLAELLERIRASVERLSTLLTDGALVSAHLVLTPERVVAAEAVRTLGSLALMGVRVEELLVNQLLVQDENYEYRSLPDHPAFHWYAERIGEQRAVLDDLDATIGDVALVLVPHLAGEPIGPKALGGLLDSARRRQGSAPPGPLQPIVDLESGSGLASIYRLRLALPQLDPGTLTLGRADDDLIVSAGGMRRRVRLASVLRRCTVLDAHLRGGELTVRFRPNPEVWPT

3igfB

0.23

0.18

0.79

1.69

MUSTER

LLAGLAE-PVLPLLLEQTLTP------------DPQQIAPNLEVVQFQSSVLLERNWEEVKKLEAQYTP--IIKEVYGQELVVLPG-DSALALNAIREYDASGKYDTIVYDGTGDAFTLRL-GLPESLSWYVRRFRQLFVNSDLGKQ---------PTNQVNNFLDKGKEALADPKRVAAFLVTTADPLEVVSVRYLWGSAQQIGLTIGGVIQV-----------------------------SSQTEGDLSAEFTPLSVTVVPDVTKGDWQIDALPNFVEQAEQAPKP--------------ITIDTHNRQVRLFLPGFDKKQVKLTQYGPEVTVEAGDQRRNIFLPPALSGRPITGAKFQNNYLIIS----------

3igfB

0.22

0.17

0.79

3.34

wdPPAS

LLAGLAE-PVLPLLLEQTLTPD------------PQQIAPNLEVVQFQSSVLLERNWEEVKKLEAQYTP--IIKEVYGQELVVLPG-DSALALNAIREYDASGKYDTIVYDGTGDAFTLRL-GLPESLSWYVRRFRQLFVNSDLGKQ---------PTNQVNNFLDKGKEALADPKRVAAFLVTTADPLEVVSVRYLWGSAQQIGLTIGGVIQVSSQTEGD-----------------------------LSAEFTPLSVTVVPDVTKGDWQIDALPNFVEQAEQAPKP--------------ITIDTHNRQVRLFLPGFDKKQVKLTQYGPEVTVEAGDQRRNIFLPPALSGRPITGAKFQNNYLIIS----------

3ug6A

0.22

0.15

0.69

2.19

dPPAS

VIVSTDPAHSLRDIFEQEFGHEPTKVKGY----------DNLYVVEIDPQKAMEEYKEKLKAQIEENPFLGEMLEDQLEMAALSPGTDESAAFDVFLKYMDSNEFDVVIFDTAPTGHTLRFLGMPEVMDKYMTKLIKLRKQMSGFMLPFDYDKMLEELEKMKERIVRARNILSDPERTAFRLVVIPEEMSILESERAMKALQKYGIPIDAVIVNQLIPEDVQ-----------CDFCRARRELQLKRLEMIKEKFGDKVIAYVPLLRTEAKGIETLKQIAKILY-----------------------------------------------------------------------------------------------

3igfB

0.23

0.18

0.79

2.10

wMUSTER

LLAGLAE-PVLPLLLEQTLTP------------DPQQIAPNLEVVQFQSSVLLERNWEEVKKLEAQYTP--IIKEVYGQELVVLPG-DSALALNAIREYDASGKYDTIVYDGTGDAFTLRL-GLPESLSWYVRRFRQLFVNSDLGKQ---------PTNQVNNFLDKGKEALADPKRVAAFLVTTADPLEVVSVRYLWGSAQQIGLTIGGVIQV-----------------------------SSQTEGDLSAEFTPLSVTVVPDVTKGDWQIDALPNFVEQAEQAPKP--------------ITIDTHNRQVRLFLPGFDKKQVKLTQYGPEVTVEAGDQRRNIFLPPALSGRPITGAKFQNNYLIIS----------

3igfB

0.23

0.18

0.79

3.68

wPPAS

LLAGLAE-PVLPLLLEQTLTP------------DPQQIAPNLEVVQFQSSVLLERNWEEVKKLEAQYTP--IIKEVYGQELVVLPG-DSALALNAIREYDASGKYDTIVYDGTGDAFTLRL-GLPESLSWYVRRFRQLFVNSDLGKQ---------PTNQVNNFLDKGKEALADPKRVAAFLVTTADPLEVVSVRYLWGSAQQIGLTIGGVIQV-----------------------------SSQTEGDLSAEFTPLSVTVVPDVTKGDWQIDALPNFVEQAEQAPKP--------------ITIDTHNRQVRLFLPGFDKKQVKLTQYGPEVTVEAGDQRRNIFLPPALSGRPITGAKFQNNYLIIS----------

3igfB

0.23

0.18

0.79

3.11

PPAS

LAGLAEPV--LPLLLEQTLTP------------DPQQIAPNLEVVQFQSSVLLERNWEEVKKLEAQYTP--IIKEVYGQELVVLPG-DSALALNAIREYDASGKYDTIVYDGTGDAFTLRL-GLPESLSWYVRRFRQLFVNSDLGKQ---------PTNQVNNFLDKGKEALADPKRVAAFLVTTADPLEVVSVRYLWGSAQQIGLTIGGVIQV-----------------------------SSQTEGDLSAEFTPLSVTVVPDVTKGDWQIDALPNFVEQAEQAPKP--------------ITIDTHNRQVRLFLPGFDKKQVKLTQYGPEVTVEAGDQRRNIFLPPALSGRPITGAKFQNNYLIIS----------

3ug6A

0.22

0.15

0.69

5.40

dPPAS2

VIVSTDPAHSLRDIFEQEFGHEPTKVKGY----------DNLYVVEIDPQKAMEEYKEKLKAQIEENPFLGEMLEDQLEMAALSPGTDESAAFDVFLKYMDSNEFDVVIFDTAPTGHTLRFLGMPEVMDKYMTKLIKLRKQMSGFMLPFDYDKMLEELEKMKERIVRARNILSDPERTAFRLVVIPEEMSILESERAMKALQKYGIPIDAVIVNQLIPEDVQ-----------CDFCRARRELQLKRLEMIKEKFGDKVIAYVPLLRTEAKGIETLKQIAKILY-----------------------------------------------------------------------------------------------

3igfB

0.22

0.18

0.79

4.38

Env-PPAS

LAGLAEPV--LPLLLEQTL------------TPDPQQIAPNLEVVQFQSSVLLERNWEEVKKLEAQYTP--IIKEVYGQELVVLPG-DSALALNAIREYDASGKYDTIVYDGTGDAFTLRL-GLPESLSWYVRRFRQLFVNSDLGKQ---------PTNQVNNFLDKGKEALADPKRVAAFLVTTADPLEVVSVRYLWGSAQQIGLTIGGVIQV-----------------------------SSQTEGDLSAEFTPLSVTVVPDVTKGDWQIDALPNFVEQAEQAPKP--------------ITIDTHNRQVRLFLPGFDKKQVKLTQYGPEVTVEAGDQRRNIFLPPALSGRPITGAKFQNNYLIIS----------

3ug6A

0.22

0.15

0.69

1.59

MUSTER

VIVSTDPAHSLRDIFEQEFGHEPTKVKG----------YDNLYVVEIDPQKAMEEYKEKLKAQIEENPFLGEMLEDQLEMAALSPGTDESAAFDVFLKYMDSNEFDVVIFDTAPTGHTLRFLGMPEVMDKYMTKLIKLRKQMSGFMLPFDYDKMLEELEKMKERIVRARNILSDPERTAFRLVVIPEEMSILESERAMKALQKYGIPIDAVIVNQLIPEDVQ-----------CDFCRARRELQLKRLEMIKEKFGDKVIAYVPLLRTEAKGIETLKQIAKILY-----------------------------------------------------------------------------------------------

3igfB

0.22

0.17

0.79

2.11

dPPAS

VLLAGLAEPVLPLLLEQTLTPD------------PQQIAPNLEVVQFQSSVLLERNWEEVKKLEAQYTP--IIKEVYGQELVVLPG-DSALALNAIREYDASGKYDTIVYDGTGDAFTLRL-GLPESLSWYVRRFRQLFVNSDLGKQ---------PTNQVNNFLDKGKEALADPKRVAAFLVTTADPLEVVSVRYLWGSAQQIGLTIGGVIQVSSQTEGD-----------------------------LSAEFTPLSVTVVPDVTKGDWQIDALPNFVEQAEQAPKP--------------ITIDTHNRQVRLFLPGFDKKQVKLTQYGPEVTVEAGDQRRNIFLPPALSGRPITGAKFQNNYLIIS----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.25

Estimated TM-score = 0.68±0.12

Estimated RMSD = 7.2±4.2Å

Download Model 2

C-score=-2.48

Download Model 3

C-score=-1.53

Download Model 4

C-score=-3.60

Download Model 5

C-score=-2.64

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3igfB	0.745	1.91	0.226	0.794
2	3ug6A	0.559	3.56	0.209	0.662
3	3zq6A	0.536	3.10	0.223	0.615
4	2wooA	0.516	3.33	0.171	0.602
5	3h84A	0.511	3.49	0.200	0.602
6	1ii0B	0.479	4.70	0.113	0.612
7	4jcmA	0.446	5.81	0.054	0.662
8	1cygA	0.443	5.69	0.051	0.652
9	1qhoA	0.441	5.89	0.049	0.665
10	4a0fA	0.441	5.50	0.093	0.610

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.19	9	3ug6A	ADP	Rep, Mult	187,189
2	0.18	9	3ug7A	ADP	Rep, Mult	214,215,263,264,265,266
3	0.04	2	3ug6B	MG	Rep, Mult	6,10
4	0.04	2	3zq6B	UUU	Rep, Mult	6,114,214,263
5	0.02	1	1ofdB	F3S	Rep, Mult	11,19,20,21,22,35,44
6	0.02	1	1lm1A	F3S	Rep, Mult	90,91,92,95,96,97,124,125
7	0.02	1	3h84A	NA	Rep, Mult	3,4,5,110,111,112
8	0.02	1	1llwA	F3S	Rep, Mult	15,16,17,18,19,36,45

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3gbdA	0.395	6.66	0.049	0.660	5.4.99.11	NA
2	0.060	1cp2B	0.406	3.42	0.124	0.483	1.18.6.1	6,194
3	0.060	3eifA	0.415	6.37	0.076	0.654	3.4.21.110	NA
4	0.060	2ad5B	0.379	4.83	0.063	0.507	6.3.4.2	NA
5	0.060	1m53A	0.395	6.47	0.042	0.649	5.4.99.12	NA
6	0.060	1s1mB	0.376	4.95	0.056	0.507	6.3.4.2	NA
7	0.060	1wzaA	0.387	6.60	0.038	0.641	3.2.1.1	210
8	0.060	1ofdA	0.399	6.87	0.091	0.667	1.4.7.1	NA
9	0.060	1r64A	0.388	5.95	0.047	0.583	3.4.21.61	NA
10	0.060	1eg7A	0.385	6.17	0.075	0.599	6.3.4.3	NA
11	0.060	1e6zB	0.389	5.87	0.039	0.583	3.2.1.14	NA
12	0.060	1cygA	0.443	5.69	0.051	0.652	2.4.1.19	94,193
13	0.060	1veoA	0.385	6.12	0.066	0.591	3.2.1.2	NA
14	0.060	3czkA	0.382	6.02	0.076	0.588	3.2.1.48	NA
15	0.060	3a5vA	0.392	5.92	0.060	0.586	3.2.1.22	NA
16	0.060	1llwA	0.407	6.66	0.082	0.675	1.4.7.1	NA
17	0.060	3do6A	0.411	5.38	0.066	0.578	6.3.4.3	NA
18	0.060	1p8jA	0.386	6.15	0.066	0.594	3.4.21.75	NA
19	0.060	1b23P	0.387	6.23	0.082	0.607	3.6.5.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.750	1.91	0.23	0.80	3igfB	GO:0005524 GO:0016887
1	0.21	0.546	3.27	0.22	0.63	3zq6D	GO:0000166 GO:0005524 GO:0015446 GO:0016787 GO:0016887 GO:0046685 GO:0098655 GO:0098656
2	0.20	0.539	2.94	0.23	0.61	4xtrA	GO:0000166 GO:0000750 GO:0005085 GO:0005524 GO:0005737 GO:0005783 GO:0005794 GO:0006620 GO:0006810 GO:0006890 GO:0009408 GO:0010038 GO:0016192 GO:0016787 GO:0016887 GO:0042802 GO:0043529 GO:0043547 GO:0045048 GO:0046685 GO:0046872 GO:0051082 GO:1990507
3	0.18	0.544	3.30	0.20	0.63	3sjaB	GO:0000166 GO:0000750 GO:0005085 GO:0005524 GO:0005737 GO:0005783 GO:0005794 GO:0006620 GO:0006810 GO:0006890 GO:0009408 GO:0010038 GO:0016192 GO:0016787 GO:0016887 GO:0042802 GO:0043529 GO:0043547 GO:0045048 GO:0046685 GO:0046872 GO:0051082 GO:1990507
4	0.17	0.511	3.49	0.20	0.60	3h84A	GO:0000166 GO:0000750 GO:0005085 GO:0005524 GO:0005737 GO:0005783 GO:0005794 GO:0006620 GO:0006810 GO:0006890 GO:0009408 GO:0010038 GO:0016192 GO:0016787 GO:0016887 GO:0042802 GO:0043529 GO:0043547 GO:0045048 GO:0046685 GO:0046872 GO:0051082 GO:1990507
5	0.07	0.558	3.27	0.20	0.65	3ug7A	GO:0000166 GO:0005524 GO:0015446 GO:0016787 GO:0016887 GO:0042802 GO:0046685 GO:0098655 GO:0098656
6	0.07	0.539	3.07	0.21	0.61	3zq6B	GO:0000166 GO:0005524 GO:0015446 GO:0016787 GO:0016887 GO:0046685 GO:0098655 GO:0098656
7	0.07	0.516	3.33	0.17	0.60	2wooA	GO:0000166 GO:0005524 GO:0005634 GO:0005737 GO:0005783 GO:0005829 GO:0006810 GO:0006890 GO:0016787 GO:0016887 GO:0043529 GO:0045048 GO:0046872
8	0.07	0.508	3.44	0.22	0.60	3a36A	GO:0000166 GO:0000750 GO:0005085 GO:0005524 GO:0005737 GO:0005783 GO:0005794 GO:0006620 GO:0006810 GO:0006890 GO:0009408 GO:0010038 GO:0016192 GO:0016787 GO:0016887 GO:0042802 GO:0043529 GO:0043547 GO:0045048 GO:0046685 GO:0046872 GO:0051082 GO:1990507
9	0.07	0.479	4.70	0.11	0.61	1ii0B	GO:0000166 GO:0005524 GO:0015446 GO:0016787 GO:0016887 GO:0046685 GO:0071722 GO:0098655 GO:0098656
10	0.07	0.466	2.78	0.23	0.52	3iqxA	GO:0000166 GO:0005524 GO:0005737 GO:0005783 GO:0006810 GO:0016787 GO:0016887 GO:0045048 GO:0046872
11	0.07	0.476	3.78	0.20	0.58	3ibgA	GO:0000166 GO:0005524 GO:0005634 GO:0005737 GO:0005783 GO:0005829 GO:0006810 GO:0016787 GO:0016887 GO:0045048 GO:0046872
12	0.07	0.467	3.02	0.23	0.53	3sjbA	GO:0000166 GO:0000750 GO:0005085 GO:0005524 GO:0005737 GO:0005783 GO:0005794 GO:0006620 GO:0006810 GO:0006890 GO:0009408 GO:0010038 GO:0016192 GO:0016787 GO:0016887 GO:0042802 GO:0043529 GO:0043547 GO:0045048 GO:0046685 GO:0046872 GO:0051082 GO:1990507
13	0.06	0.386	3.72	0.13	0.47	3kb1A	GO:0000166 GO:0005524 GO:0016787 GO:0016887 GO:0046872 GO:0051536
14	0.06	0.382	2.30	0.23	0.42	3io3A	GO:0000166 GO:0000750 GO:0005085 GO:0005524 GO:0005634 GO:0005737 GO:0005783 GO:0005829 GO:0006620 GO:0006810 GO:0006890 GO:0009408 GO:0010038 GO:0016787 GO:0016887 GO:0042802 GO:0043529 GO:0043547 GO:0045048 GO:0046872 GO:0051082 GO:1990507
15	0.06	0.310	6.86	0.05	0.52	3ja84	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0043596 GO:0097373 GO:1990163
16	0.06	0.235	6.30	0.05	0.36	3jc54	GO:0000166 GO:0000727 GO:0003677 GO:0003678 GO:0003688 GO:0003697 GO:0004003 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005656 GO:0005737 GO:0006260 GO:0006267 GO:0006268 GO:0006270 GO:0006271 GO:0007049 GO:0016787 GO:0017116 GO:0031261 GO:0031298 GO:0033260 GO:0042555 GO:0043140 GO:0043142 GO:0043596 GO:0097373 GO:1990163
17	0.06	0.262	7.68	0.07	0.49	3i0zA	GO:0005975 GO:0016853 GO:0030246
18	0.06	0.227	6.76	0.06	0.38	2w7yA

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0042802	GO:0005085	GO:0046872	GO:0051082	GO:0008490	GO:0043225	GO:0019829
GO-Score	0.73	0.46	0.46	0.46	0.46	0.41	0.41	0.41
Biological Processes	GO:0046685	GO:1990507	GO:0045048	GO:0043547	GO:0006620	GO:0006890	GO:0000750	GO:0010038	GO:0009408	GO:0006812	GO:0034220	GO:0006820
GO-Score	0.57	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.41	0.41	0.41
Cellular Component	GO:0005794	GO:0043529
GO-Score	0.46	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.