I-TASSER results

I-TASSER results for job id Rv2172c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (301 residues)
MTLNTIALELVPPNLEGGKERAIEDARKVVQYSAASGLDGRIRHVMMPGMIAEDDDRPIP
MQPKLDVLDFWSIIKPELAGVHGLCTQVTAFMDEPSLHRRLVDLSDAGMEGIVFVGVPRT
MQDGEGSGVAPTDALSLYRQLVANRGVIVIPTRDGEQGRLNFKCSRGATYGMTQLLYSDA
IVGFLREFARTTEHRPEILLSFGFVPKVETRIGLINWLIQDPGNAAVADEQAFVQKLAGS
EPARRRRLMVDLYKRVLDGVADLGFPLSIHLEATYGVSAAAFETFAEMLAYWSPAEPGKP
D

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTLNTIALELVPPNLEGGKERAIEDARKVVQYSAASGLDGRIRHVMMPGMIAEDDDRPIPMQPKLDVLDFWSIIKPELAGVHGLCTQVTAFMDEPSLHRRLVDLSDAGMEGIVFVGVPRTMQDGEGSGVAPTDALSLYRQLVANRGVIVIPTRDGEQGRLNFKCSRGATYGMTQLLYSDAIVGFLREFARTTEHRPEILLSFGFVPKVETRIGLINWLIQDPGNAAVADEQAFVQKLAGSEPARRRRLMVDLYKRVLDGVADLGFPLSIHLEATYGVSAAAFETFAEMLAYWSPAEPGKPD
Prediction	CCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEHCCCCHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHHHHCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
Conf.Score	9987589998678999999999999999999997589977899985688788888888765444689999999998757888578876567999999999999999899669998568898888888877999999985766667868875777556569999998997676644568899999999999989999789977667775689999999985789988889999999985998899999999999999999987598689999855577758999999999857888888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTLNTIALELVPPNLEGGKERAIEDARKVVQYSAASGLDGRIRHVMMPGMIAEDDDRPIPMQPKLDVLDFWSIIKPELAGVHGLCTQVTAFMDEPSLHRRLVDLSDAGMEGIVFVGVPRTMQDGEGSGVAPTDALSLYRQLVANRGVIVIPTRDGEQGRLNFKCSRGATYGMTQLLYSDAIVGFLREFARTTEHRPEILLSFGFVPKVETRIGLINWLIQDPGNAAVADEQAFVQKLAGSEPARRRRLMVDLYKRVLDGVADLGFPLSIHLEATYGVSAAAFETFAEMLAYWSPAEPGKPD
Prediction	6514200000000537453630350054005205715020100000132455377612140354230230053036605624100000004234740350056047341410000000344652644414314213524741350000000013554441341043304000000012540150024006627250300000010343523030040026335224026325423432754254115102400420062037240000000102222334004100300420226555568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEHCCCCHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHHHHCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCC
MTLNTIALELVPPNLEGGKERAIEDARKVVQYSAASGLDGRIRHVMMPGMIAEDDDRPIPMQPKLDVLDFWSIIKPELAGVHGLCTQVTAFMDEPSLHRRLVDLSDAGMEGIVFVGVPRTMQDGEGSGVAPTDALSLYRQLVANRGVIVIPTRDGEQGRLNFKCSRGATYGMTQLLYSDAIVGFLREFARTTEHRPEILLSFGFVPKVETRIGLINWLIQDPGNAAVADEQAFVQKLAGSEPARRRRLMVDLYKRVLDGVADLGFPLSIHLEATYGVSAAAFETFAEMLAYWSPAEPGKPD

3ijdA

0.14

0.12

0.88

1.84

MUSTER

RESGIITYGITPPKKNNTEEKIKEISQKHIERISGLDIDGLVIYDLQ--------------IETIDPQIYSENYLKDL-KIPKIIYRCVGKYTPDEFRRLTRPVSGQDA-FSVFVGAASVL-------LKLSDAYKIRQDPDLLLGGVAIPERHMEHLRIIDKINKGCKYFITQAVYNVEAAKDFLSDYYYYSKMVPIIFTLTPCGS----TKTLEFMKW--LGISIPRWLENDLMNCEDILNKSVSLSKSIFNELMEFCLEKGIPIGCNIES-VSVRKVEIEASIALAKDIKYIM-----

3ijdA

0.13

0.11

0.88

2.72

dPPAS

RESGIITYGITPPKKNNTEEKIKEISQKHIERISGLDIDGLVIYDLQ-------------FIETIDPQIYSENYLKDL-KIPKIIYRCVGKYTPDEFRRLTRPVSGQDA-FSVFVGAASVLLK-----LSDAYKIRQDVNPDLLLGGVAIPERHMEHLRIIDKINKGCKYFITQAVYNVEAAKDFLSDYYYYSKMVPIIFTLTPCGS----TKTLEFMKW--LGISIPRWLENDLMNCEDILNKSVSLSKSIFNELMEFCLEKGIPIGCNIESVSVRIEASIALAKDIKYIM---------

1v93A

0.16

0.14

0.88

3.68

wdPPAS

MKGPLFSFEFFPPKDPEGEEALFRTLEELKA-----RPA---FVSITYGAMGSTRER---------SVAWAQRIQSL--GLNPLAHLTVAGQSRKEVAEVLHRFVESGVENLLALGDPPRGERVPEGFRYAAELVALIREDRVSVGGAAYPEGHPDLRHFKAKVEAGLDFAITQLFFNNAHYFGFLERARRAGIGIPILPGIMPVTSYRQLRRFTEVC------ASIPGPLLAKLERHQDDPKAVLEIGVEHAVRQVAELLEAGVE-GVHFYT-LNKSPATRMVLERL---LRPA------

1v93A

0.16

0.14

0.89

2.37

wMUSTER

RRGPLFSFEFFPPKDPEGEEALFRTLEELKAF----RPA---FVSITYGAMGSTRER---------SVAWAQRIQSL--GLNPLAHLTVAGQSRKEVAEVLHRFVESGVENLLALGDPPRGERHPEGFRYAAELVALIREDRVSVGGAAYPEGHPDLRHFKAKVEAGLDFAITQLFFNNAHYFGFLERARRAGIGIPILPGIMPVTSYRQLRRFTEVCG-----ASIPGPLLAKLERHQDDPKAVLEIGVEHAVRQVAELLEAGVE-GVHFYT-LNKSPATRMVLERL---LRPA------

1v93A

0.16

0.14

0.88

3.48

wPPAS

MKGPLFSFEFFPPKDPEGEEALFRTLEELKA-----RPA---FVSITYGAMGSTRER---------SVAWAQRIQSL--GLNPLAHLTVAGQSRKEVAEVLHRFVESGVENLLALGDPPRGERVPEGFRYAAELVALIREDRVSVGGAAYPEGHPDLRHFKAKVEAGLDFAITQLFFNNAHYFGFLERARRAGIGIPILPGIMPVTSYRQLRRFTEVC------ASIPGPLLAKLERHQDDPKAVLEIGVEHAVRQVAELLEAGVE-GVHFYT-LNKSPATRMVLERL---LRPA------

3ijdA

0.13

0.12

0.88

8.08

dPPAS2

RESGIITYGITPPKKNNTEEKIKEISQKHIERISGLDIDGLVIYDLQ-------------FIETIDPQIYSENYLKDL-KIPKIIYRCVGKYTPDEFRRLTRPVSGQDA-FSVFVGAASVLLK-----LSDAYKIRQDVNPDLLLGGVAIPERHMEHLRIIDKINKGCKYFITQAVYNVEAAKDFLSDYYYYSKMVPIIFTLTPCGS----TKTLEFMKW--LGISIPRWLENDLMNCEDILNKSVSLSKSIFNELMEFCLEKGIPIGCNIES-VSVREASIALAKDIKYIM---------

3ijdA

0.13

0.11

0.88

2.77

PPAS

RESGIITYGITPPKKNNTEEKIKEISQKHIERISGLDIDGLVIYDLQ-------------FIETIDPQIYSENYLKDL-KIPKIIYRCVGKYTPDEFRRLTRPVSGQDA-FSVFVGAASVLLK-----LSDAYKIRQDVNPDLLLGGVAIPERHMEHLRIIDKINKGCKYFITQAVYNVEAAKDFLSDYYYYSKMVPIIFTLTPCGS----TKTLEFMKW--LGISIPRWLENDLMNCEDILNKSVSLSKSIFNELMEFCLEKGIPIGCNIESVSVRIEASIALAKDIKYIM---------

3ijdA

0.13

0.11

0.88

4.29

Env-PPAS

RESGIITYGITPPKKNNTEEKIKEISQKHIERISGLDIDGLVIYDLQ-------------FIETIDPQIYSENYLKDL-KIPKIIYRCVGKYTPDEFRRLTRPVSGQDA-FSVFVGAASVLLK-----LSDAYKIRQDVNPDLLLGGVAIPERHMEHLRIIDKINKGCKYFITQAVYNVEAAKDFLSDYYYYSKMVPIIFTLTPCGS----TKTLEFMKW--LGISIPRWLENDLMNCEDILNKSVSLSKSIFNELMEFCLEKGIPIGCNIESVSVRIEASIALAKDIKYIM---------

1v93A

0.16

0.14

0.89

1.83

MUSTER

MKGPLFSFEFFPPKDPEGEEALFRTLEELKAF----RPA---FVSITYGAMGSTRER---------SVAWAQRIQSL--GLNPLAHLTVAGQSRKEVAEVLHRFVESGVENLLALGDPPRGERHPEGFRYAAELVALIREDRVSVGGAAYPEGHPDLRHFKAKVEAGLDFAITQLFFNNAHYFGFLERARRAGIGIPILPGIMPVTSYRQLRRFTEVCG-----ASIPGPLLAKLERHQDDPKAVLEIGVEHAVRQVAELLEAGVE-GVHFYT-LNKSPATRMVLERL---LRPA------

1v93A

0.14

0.13

0.89

2.56

dPPAS

RRGPLFSFEFFPPKD----PEGEEALFRTLEELKAFRPAFVSITYGAMGSTR--------------ERSVAWAQRIQSLGLNPLAHLTVAGQSRKEVAEVLHRFVESGVENLLALGDPPRGERVFRPHPELVALIRERYGDRVSVGGAAYPEGHPDLRHFKAKVEAGLDFAITQLFFNNAHYFGFLERARRAGIGIPILPGIMPVTSYRQLRRFTEVCG-----ASIPGPLLAKLERHQDDPKAVLEIGVEHAVRQVAELLEAGVE-GVHFYT-LNKSPATRMVLERLG--LRPA------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.21

Estimated TM-score = 0.74±0.11

Estimated RMSD = 5.8±3.6Å

Download Model 2

C-score=-0.78

Download Model 3

C-score=-0.53

Download Model 4

C-score=-2.91

Download Model 5

C-score=-1.34

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ijdA	0.801	2.23	0.128	0.884
2	1v93A	0.783	2.51	0.133	0.877
3	1zp3B	0.765	2.48	0.119	0.861
4	2c8nA	0.689	4.08	0.045	0.890
5	3clwA	0.687	4.14	0.078	0.887
6	2y2wA	0.683	4.15	0.073	0.890
7	1kfwA	0.683	4.45	0.097	0.904
8	3s2cA	0.683	4.09	0.062	0.890
9	3ahyA	0.681	3.76	0.060	0.854
10	2dgaA	0.679	3.77	0.068	0.847

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.37	22	1zptB	NAD	Rep, Mult	9,11,44,46,174,175,214,272,274
2	0.16	8	3ijdA	C2F	Rep, Mult	11,44,45,46,115,116,117,150,163,174,218,272
3	0.06	4	3ijdB	C2F	Rep, Mult	11,12,14,21,25,28,32,62,64,210,214,274
4	0.03	2	1zp4A	C2F	Rep, Mult	9,117,174,212,216,225,272,277
5	0.01	1	1zrqC	NAD	Rep, Mult	9,11,47,48,49,52,174,175,214,272,275

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.350	1tqxA	0.540	3.65	0.087	0.674	5.1.3.1	165
2	0.338	3ijdA	0.801	2.23	0.128	0.884	1.5.1.20	115,150,177,217,223
3	0.325	1v93A	0.783	2.51	0.133	0.877	1.5.1.20	9
4	0.207	2yw3E	0.514	3.36	0.100	0.631	4.1.2.14	9
5	0.152	1xbzB	0.550	3.71	0.073	0.681	4.1.1.85	NA
6	0.136	2c0aB	0.520	3.41	0.113	0.641	4.1.2.14,4.1.3.16	116,203
7	0.109	1vlwB	0.531	3.28	0.108	0.641	4.1.3.16	NA
8	0.104	1nsjA	0.538	3.02	0.120	0.638	5.3.1.24	NA
9	0.104	1mxsA	0.527	3.38	0.087	0.644	4.1.2.14	NA
10	0.081	1v5xA	0.525	3.14	0.106	0.625	5.3.1.24	NA
11	0.077	2v81A	0.532	3.26	0.091	0.644	4.1.2.21	NA
12	0.077	2fliC	0.547	3.56	0.078	0.678	5.1.3.1	NA
13	0.071	2cz5A	0.538	3.39	0.111	0.658	4.1.1.23	NA
14	0.071	2czfA	0.537	3.54	0.116	0.661	4.1.1.23	NA
15	0.067	1wbhB	0.520	3.41	0.113	0.641	4.1.3.16,4.1.2.14	NA
16	0.067	2h6rB	0.518	3.70	0.096	0.648	5.3.1.1	NA
17	0.067	1h1yB	0.535	3.76	0.091	0.674	5.1.3.1	NA
18	0.067	1h1yA	0.534	3.85	0.101	0.678	5.1.3.1	NA
19	0.067	1vqtA	0.479	3.71	0.097	0.608	4.1.1.23	NA
20	0.067	3f4wA	0.547	3.52	0.129	0.671	4.1.2.-	150,269
21	0.064	1bgaA	0.670	3.77	0.060	0.831	3.2.1.21	258
22	0.060	1zp3B	0.765	2.48	0.119	0.861	1.5.1.20,1.7.99.5	9
23	0.060	1v03A	0.673	4.06	0.064	0.854	3.2.1.21	NA
24	0.060	1r8lB	0.676	4.39	0.066	0.887	3.2.1.89	NA
25	0.060	1dwaM	0.668	3.83	0.073	0.837	3.2.1.147	NA
26	0.060	3gnrA	0.665	3.91	0.071	0.844	3.2.1.21	NA
27	0.060	2jieA	0.668	3.80	0.095	0.834	3.2.1.21	272
28	0.060	1lucA	0.664	3.90	0.068	0.854	1.14.14.3	NA
29	0.060	2dgaA	0.679	3.77	0.068	0.847	3.2.1.21	41
30	0.060	1e1eB	0.669	4.08	0.084	0.861	3.2.1.21	41
31	0.060	1ezwA	0.668	3.92	0.079	0.837	1.5.99.11	135
32	0.060	1np2A	0.672	3.69	0.065	0.834	3.2.1.21	41
33	0.060	1gnxA	0.669	3.88	0.083	0.841	3.2.1.21	NA
34	0.060	1od0B	0.669	3.90	0.075	0.841	3.2.1.21	NA
35	0.060	2zoxA	0.592	4.59	0.053	0.787	3.2.1.21	171
36	0.060	1tr1D	0.671	3.93	0.052	0.841	3.2.1.21	NA
37	0.060	1c7sA	0.664	4.05	0.072	0.847	3.2.1.52	NA
38	0.060	3fgcA	0.666	3.96	0.072	0.857	1.14.14.3	NA
39	0.060	1gonA	0.669	3.84	0.087	0.837	3.2.1.21	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.801	2.23	0.13	0.88	3ijdA	GO:0004489 GO:0006555 GO:0016491 GO:0035999 GO:0055114
1	0.26	0.773	2.48	0.13	0.87	3aptA	GO:0000166 GO:0004489 GO:0005829 GO:0006555 GO:0009086 GO:0016491 GO:0035999 GO:0055114
2	0.25	0.765	2.48	0.12	0.86	1zp3B	GO:0004489 GO:0005829 GO:0006555 GO:0006730 GO:0008652 GO:0009086 GO:0016491 GO:0035999 GO:0046654 GO:0051289 GO:0055114 GO:0071949
3	0.19	0.682	4.09	0.06	0.89	3ug4C	GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046373 GO:0046556
4	0.14	0.689	4.08	0.04	0.89	2c8nA	GO:0005737 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031222 GO:0046373 GO:0046556
5	0.10	0.688	4.16	0.07	0.89	1pz2A	GO:0005737 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031222 GO:0046373 GO:0046556
6	0.10	0.684	4.21	0.07	0.89	2y2wE	GO:0005975 GO:0046373 GO:0046556
7	0.07	0.641	4.08	0.07	0.82	4m29A	GO:0004553 GO:0005975
8	0.07	0.637	3.95	0.09	0.81	2bfgA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0009044 GO:0016787 GO:0016798 GO:0045493
9	0.07	0.642	4.07	0.07	0.82	4ekjA	GO:0004553 GO:0005975
10	0.07	0.557	3.78	0.07	0.70	4oecA	GO:0006629 GO:0008081 GO:0008889 GO:0046872
11	0.07	0.569	4.46	0.04	0.75	3uyiA	GO:0009820 GO:0016491 GO:0055114
12	0.07	0.685	4.14	0.05	0.88	2vrkA	GO:0008152 GO:0016787 GO:0016798 GO:0046373 GO:0046556
13	0.07	0.538	5.26	0.08	0.79	4aioA	GO:0003824 GO:0004553 GO:0005975 GO:0046872 GO:0051060
14	0.06	0.421	4.01	0.09	0.55	2c71A	GO:0000272 GO:0003824 GO:0004553 GO:0005975 GO:0016810 GO:0030246 GO:0045493
15	0.06	0.519	4.29	0.09	0.70	3ritA	GO:0000287 GO:0003824 GO:0006518 GO:0008152 GO:0009063 GO:0016853 GO:0016854 GO:0018850 GO:0019614 GO:0046872
16	0.06	0.323	5.35	0.10	0.48	3zx4B	GO:0005737 GO:0016311 GO:0046872 GO:0050531 GO:0051479
17	0.06	0.307	6.29	0.04	0.51	2d3tC	GO:0003824 GO:0003988 GO:0005737 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0016042 GO:0016740 GO:0016746 GO:0016747
18	0.06	0.298	7.00	0.04	0.54	3im1A	GO:0000166 GO:0000388 GO:0003676 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005681 GO:0005682 GO:0006397 GO:0008380 GO:0016787 GO:0046540

Consensus prediction of GO terms

Molecular Function	GO:0004489	GO:0050660	GO:0046556
GO-Score	0.64	0.49	0.31
Biological Processes	GO:0055114	GO:0035999	GO:0009396	GO:0051260	GO:0051262	GO:0009086	GO:0046373
GO-Score	0.64	0.64	0.49	0.49	0.49	0.44	0.31
Cellular Component	GO:0005829
GO-Score	0.44

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.