I-TASSER results

I-TASSER results for job id Rv2165c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (396 residues)
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGP
TGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLD
RDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLD
RAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVR
RRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALD
ALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASV
AEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHHCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCC
Conf.Score	988777788887755688887888888777777776666666666667776556788888888745468999999977777777778888789997589985999999988998899995999999999999876599799997677899999999899877765689995899854468899887657889887788999999999999879999999999998785579999999999999799987899999999988946646789866899999999999999999999999999967797999997777689999999999867899999887778988867998588888999999978865678777755447888764554555679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS
Prediction	754525331352325212514334543533445455345545454454442443655644751301100041004102133454325343000000000101002100530470100000203400520362057244202001120330230046231420210000000020002104336100003461300000036342201100140436201500361041620430042005207743051043005002500234445564110110000000100500520350052025003640000000010000300141045236552156021426645240320152003024501761320100000001105555545645556568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHHHCCCCCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCC
MQTRAPWSLPEATLAYFPNARFVSSDRDLGAGAAPGIAASRSTACQTWGGITVADPGSGPTGFGHVPVLAQRCFELLTPALTRYYPDGSQAVLLDATIGAGGHAERFLEGLPGLRLIGLDRDPTALDVARSRLVRFADRLTLVHTRYDCLGAALAESGYAAVGSVDGILFDLGVSSMQLDRAERGFAYATDAPLDMRMDPTTPLTAADIVNTYDEAALADILRRYGEERFARRIAAGIVRRRAKTPFTSTAELVALLYQAIPAPARRVGGHPAKRTFQALRIAVNDELESLRTAVPAALDALAIGGRIAVLAYQSLEDRIVKRVFAEAVASATPAGLPVELPGHEPRFRSLTHGAERASVAEIERNPRSTPVRLRALQRVEHRAQSQQWATEKGDS

1m6yA

0.42

0.31

0.72

2.64

MUSTER

----------------------------------------------------------RKYSQRHIPV-VREVIEFLKPE--------DEKIILDCTVGEGGHSRAILEHCPGCRIIGIDVDSEVLRIAEEKLKEFSDRVSLFKVSYREADFLLKTLGIEKV----DGILDLGVSTYQLKGENRGFTFEREEPLDRDLE--SEVTAQKVLNELPEEELARIIFEYGEERFARRIARKIVENR---PLNTTLDLVKAVREALPYEIRRRKRHFATKTFQAIRIYVNRELENLKEFLKKAEDLLNPGGRIVVISFHSLEDRIVKETFRNS-----------------KKLRILTEKPVRPSEEEIRENPRARSGRLRAAERI----------------

1m6yA

0.42

0.31

0.72

4.63

dPPAS

----------------------------------------------------------RKYSQRHIPV-VREVIEFLKPED--------EKIILDCTVGEGGHSRAILEHCPGCRIIGIDVDSEVLRIAEEKLKEFSDRVSLFKVSYREADFLLKTLGIEKV----DGILDLGVSTYQLKGENRGFTFEREEPLDRDLE--SEVTAQKVLNELPEEELARIIFEYGEERFARRIARKIVENR---PLNTTLDLVKAVREALPYEIRRRKRHFATKTFQAIRIYVNRELENLKEFLKKAEDLLNPGGRIVVISFHSLEDRIVKETFRNS-----------------KKLRILTEKPVRPSEEEIRENPRARSGRLRAAERI----------------

1wg8A

0.45

0.32

0.71

5.14

wdPPAS

--------------------------------------------------------------MTHVPVLYQEALDLLAVRP--------GGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAALGV---ERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGLE-GPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

1wg8A

0.45

0.32

0.71

3.17

wMUSTER

---------------------------------------------------------------THVPVLYQEALDLLAVR--------PGGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAALGV---ERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGLE-GPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

1wg8A

0.45

0.32

0.71

4.25

wPPAS

--------------------------------------------------------------MTHVPVLYQEALDLLAVRP--------GGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAALGV---ERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGLE-GPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

1wg8A

0.46

0.32

0.71

8.43

dPPAS2

--------------------------------------------------------------MTHVPVLYQEALDLLAVRP--------GGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAALG---VERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGL-EGPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

1wg8A

0.45

0.32

0.71

3.91

PPAS

--------------------------------------------------------------MTHVPVLYQEALDLLAVRP--------GGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAAL---GVERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGLE-GPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

1wg8A

0.46

0.32

0.71

6.90

Env-PPAS

--------------------------------------------------------------MTHVPVLYQEALDLLAVRP--------GGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAALG---VERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGLE-GPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

1wg8A

0.46

0.32

0.71

2.64

MUSTER

--------------------------------------------------------------MTHVPVLYQEALDLLAVR--------PGGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAALG---VERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGLE-GPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

1wg8A

0.46

0.32

0.71

4.62

dPPAS

--------------------------------------------------------------MTHVPVLYQEALDLLAVRP--------GGVYVDATLGGAGHARGILER--GGRVIGLDQDPEAVARAKGLH---LPGLTVVQGNFRHLKRHLAALG---VERVDGILADLGVSSFHLDDPSRGFSYQKEGPLDMRMGL-EGPTAKEVVNRLPLEALARLLRELGEEPQAYRIARAIVAAREKAPIETTTQLAEIVRKAVG---FRRAGHPARKTFQALRIYVNDELNALKEFLEQAAEVLAPGGRLVVIAFHSLEDRVVKRFLRESG------------------LKVLTKKPLVPSEKEAAQNPRARSAKLRAAEKEA---------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.03

Estimated TM-score = 0.47±0.15

Estimated RMSD = 11.6±4.5Å

Download Model 2

C-score=-2.30

Download Model 3

C-score=-2.33

Download Model 4

C-score=-2.70

Download Model 5

C-score=-2.66

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1susA	0.399	3.79	0.107	0.477
2	1ri4A	0.387	3.27	0.118	0.450
3	1ej6A4	0.374	4.83	0.067	0.487
4	1pjcA	0.372	4.77	0.062	0.475
5	1w73A	0.369	4.66	0.064	0.477
6	1qaqA	0.369	3.71	0.066	0.437
7	1ipfA	0.367	4.37	0.083	0.462
8	1a4zA	0.366	6.45	0.027	0.568
9	1dkpA	0.365	6.22	0.074	0.561
10	1djnA	0.363	5.80	0.049	0.523

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.70	14	1m6yB	SAH	Rep, Mult	65,96,97,98,99,101,102,103,120,121,122,125,145,146,147,171,173,175,178,198
2	0.04	1	3tkaA	CTN	Rep, Mult	209,213,217,283
3	0.03	1	1o05B	NA	Rep, Mult	220,226,231
4	0.03	1	1o05C	NA	Rep, Mult	95,104,107,108,118,140

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1qanA	0.370	3.79	0.071	0.439	2.1.1.48	NA
2	0.060	1wnbA	0.358	6.52	0.044	0.561	1.2.1.19,1.2.1.8	287
3	0.060	1ipeB	0.369	4.42	0.083	0.465	1.1.1.236	105,173
4	0.060	1djnA	0.363	5.80	0.049	0.523	1.5.8.2,1.5.99.7	NA
5	0.060	1gnxA	0.348	6.65	0.069	0.553	3.2.1.21	NA
6	0.060	1susD	0.395	3.82	0.091	0.480	2.1.1.104	NA
7	0.060	2ix4A	0.336	6.10	0.061	0.505	2.3.1.41	NA
8	0.060	1pjbA	0.373	4.83	0.062	0.477	1.4.1.1	NA
9	0.060	1l2aE	0.346	7.33	0.049	0.601	3.2.1.4	173,367
10	0.060	1wndA	0.352	6.40	0.055	0.561	1.2.1.19	NA
11	0.060	1skaA	0.342	6.65	0.033	0.543	3.1.3.8	109
12	0.060	1ay4A	0.342	5.11	0.128	0.460	2.6.1.57	171
13	0.060	2tmdA	0.364	5.70	0.049	0.520	1.5.8.2	99
14	0.060	1p0fA	0.345	5.31	0.069	0.475	1.1.1.2	NA
15	0.060	2qnoA	0.338	7.54	0.071	0.604	3.2.1.4	148
16	0.060	1ri1A	0.387	3.28	0.118	0.450	2.1.1.56	120
17	0.060	1gu7A	0.343	5.40	0.099	0.477	1.3.1.38,1.3.1.10	NA
18	0.060	1qwoA	0.335	6.67	0.024	0.545	3.1.3.8	NA
19	0.060	1qhoA	0.358	6.98	0.038	0.604	3.2.1.133	127

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.11	0.414	2.75	0.17	0.46	3eeyA	GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
1	0.06	0.419	3.54	0.13	0.49	2hnkB	GO:0008168 GO:0008171 GO:0016740 GO:0032259
2	0.06	0.409	3.48	0.13	0.48	3duwA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
3	0.06	0.410	4.28	0.10	0.51	4ckcD	GO:0000166 GO:0003723 GO:0003824 GO:0004482 GO:0004484 GO:0004651 GO:0005525 GO:0006351 GO:0006353 GO:0006355 GO:0006370 GO:0006397 GO:0008152 GO:0008168 GO:0016740 GO:0016779 GO:0016787 GO:0019012 GO:0032259 GO:0036265 GO:0046872 GO:0050355 GO:0098507
4	0.06	0.399	3.79	0.11	0.48	1suiA	GO:0008168 GO:0008171 GO:0009699 GO:0009809 GO:0016740 GO:0032259 GO:0042409 GO:0046872
5	0.06	0.397	4.09	0.10	0.49	3bkxA	GO:0008168 GO:0016740 GO:0032259
6	0.06	0.401	3.80	0.09	0.48	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
7	0.06	0.406	3.67	0.15	0.48	3tr6A	GO:0008168 GO:0008171 GO:0016740 GO:0032259
8	0.06	0.407	3.58	0.13	0.47	4pcaA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
9	0.06	0.389	4.28	0.10	0.48	3vc1D	GO:0008152 GO:0008168 GO:0008169 GO:0008757 GO:0016740 GO:0032259 GO:0042214
10	0.06	0.412	3.28	0.11	0.47	4p7kA	GO:0000287 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006584 GO:0007565 GO:0007612 GO:0007614 GO:0008168 GO:0008171 GO:0008210 GO:0009712 GO:0014070 GO:0016020 GO:0016021 GO:0016036 GO:0016206 GO:0016740 GO:0030424 GO:0030425 GO:0032259 GO:0032496 GO:0032502 GO:0035814 GO:0042135 GO:0042417 GO:0042420 GO:0042493 GO:0043197 GO:0044297 GO:0045211 GO:0045963 GO:0046498 GO:0046500 GO:0046872 GO:0048265 GO:0048609 GO:0048662 GO:0050668 GO:0051930 GO:0070062
11	0.06	0.404	3.39	0.14	0.47	2avdA	GO:0005739 GO:0008168 GO:0008171 GO:0016020 GO:0016021 GO:0016740 GO:0032259
12	0.06	0.407	2.72	0.12	0.45	4xucA	GO:0000287 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006584 GO:0007565 GO:0007612 GO:0007614 GO:0008168 GO:0008171 GO:0008210 GO:0009712 GO:0014070 GO:0016020 GO:0016021 GO:0016036 GO:0016206 GO:0016740 GO:0030424 GO:0030425 GO:0032259 GO:0032496 GO:0032502 GO:0035814 GO:0042135 GO:0042417 GO:0042420 GO:0042493 GO:0043197 GO:0044297 GO:0045211 GO:0045963 GO:0046872 GO:0048265 GO:0048609 GO:0048662 GO:0050668 GO:0051930 GO:0070062
13	0.06	0.404	3.49	0.15	0.47	3cbgA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872
14	0.06	0.401	3.81	0.13	0.48	4ymgB	GO:0008171 GO:0032259 GO:0046872 GO:0051536 GO:0051539
15	0.06	0.405	3.56	0.11	0.47	3c3yA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0042409 GO:0046872
16	0.06	0.405	3.65	0.09	0.48	3bgvB	GO:0003723 GO:0004482 GO:0005634 GO:0005654 GO:0005730 GO:0005845 GO:0006366 GO:0006370 GO:0006397 GO:0008168 GO:0016740 GO:0032259 GO:0036265 GO:0043235
17	0.06	0.409	3.68	0.15	0.48	3tfwA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
18	0.06	0.399	3.44	0.08	0.46	4iv8A	GO:0000234 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0008168
GO-Score	0.45	0.32
Biological Processes	GO:0032259
GO-Score	0.32
Cellular Component	GO:0019012
GO-Score	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.