I-TASSER results

I-TASSER results for job id Rv2161c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (288 residues)
MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWPGGELPDWYRRCY
DPVVALAAAAAVTTRLRVGTGACLVAVHDPILLAKQIASLCAMSGERFVLGVGFGWNVEE
LADHGVPFADRIAVTVDKLAAMRALWAAEPVHYEGTHASVPPSWAWPKPAVAPPVLFGCR
PSARAFEVIARHGDGWQPIEGYGELLGALPMLHAAFERAGRDPATAQVCVYSSAGDPATL
HEYRRAGVAEVALALPSAGRDQVLAALDRSAPLVDAFAGDDREVKSHA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWPGGELPDWYRRCYDPVVALAAAAAVTTRLRVGTGACLVAVHDPILLAKQIASLCAMSGERFVLGVGFGWNVEELADHGVPFADRIAVTVDKLAAMRALWAAEPVHYEGTHASVPPSWAWPKPAVAPPVLFGCRPSARAFEVIARHGDGWQPIEGYGELLGALPMLHAAFERAGRDPATAQVCVYSSAGDPATLHEYRRAGVAEVALALPSAGRDQVLAALDRSAPLVDAFAGDDREVKSHA
Prediction	CCEEEEHCCCCCCCCHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHCCEEHCCCCCCCCCEEEHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
Conf.Score	957887568888877999999999989988997665556677888888888888888888999999999998895798664554676899999999999999869958999857998788887799976899999999999999985999567755689868564889999998599779987899999998985468999899999999999999998999554679998579998999999998998799976999858999999999999999858865654679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWPGGELPDWYRRCYDPVVALAAAAAVTTRLRVGTGACLVAVHDPILLAKQIASLCAMSGERFVLGVGFGWNVEELADHGVPFADRIAVTVDKLAAMRALWAAEPVHYEGTHASVPPSWAWPKPAVAPPVLFGCRPSARAFEVIARHGDGWQPIEGYGELLGALPMLHAAFERAGRDPATAQVCVYSSAGDPATLHEYRRAGVAEVALALPSAGRDQVLAALDRSAPLVDAFAGDDREVKSHA
Prediction	331012101343234132003102604010000000012224343323344244443211000000010021044020000000012210020010001003116330100000222440042141427401410220030022006654051514314056041213133411000001123300310031000000123163035005302510562424264020000023434520430151202200010353325401510440151055125455423668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEHCCCCCCCCHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHCCEEHCCCCCCCCCEEEHCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCC
MLVSLMQFVTDLTPPPQLVAVWAEERGFAGLYVPEKTHVPISRSTPWPGGELPDWYRRCYDPVVALAAAAAVTTRLRVGTGACLVAVHDPILLAKQIASLCAMSGERFVLGVGFGWNVEELADHGVPFADRIAVTVDKLAAMRALWAAEPVHYEGTHASVPPSWAWPKPAVAPPVLFGCRPSARAFEVIARHGDGWQPIEGYGELLGALPMLHAAFERAGRDPATAQVCVYSSAGDPATLHEYRRAGVAEVALALPSAGRDQVLAALDRSAPLVDAFAGDDREVKSHA

2b81C

0.22

0.20

0.93

2.28

MUSTER

LTLGVHIPIENYTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPATG----------QIYDIYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQQN--EWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQR-PADEVLDELGEEVLPHFPAL-------

2b81C

0.22

0.20

0.93

4.04

dPPAS

LTLGVHIPIENPTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPATGQIYD----------IYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQQN--EWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQRP-ADEVLDELGEEVLPHFPAL-------

2b81C

0.21

0.20

0.92

4.54

wdPPAS

LTLGVHIPIENPTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPAT----------GQIYDIYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQ--QNEWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQ-RPADEVLDELGEEVLPHF--------PA

2b81C

0.21

0.20

0.93

2.82

wMUSTER

LTLGVHIPIENYTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPAT----------GQIYDIYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQQN--EWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQRP-ADEVLDELGEEVLPHFPAL-------

2b81C

0.22

0.20

0.92

3.99

wPPAS

LTLGVHIPIENPTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPATG----------QIYDIYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQ--QNEWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQ-RPADEVLDELGEEVLPH---------PA

2b81C

0.22

0.20

0.93

6.23

dPPAS2

LTLGVHIPIENPTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPATGQ----------IYDIYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQQN--EWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQRP-ADEVLDELGEEVLPHFPAL-------

2b81C

0.22

0.20

0.92

3.23

PPAS

LTLGVHIPIENYTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPATG----------QIYDIYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQQN--EWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQ-RPADEVLDELGEEVLPH---------PA

2b81C

0.21

0.20

0.92

4.49

Env-PPAS

LTLGVHIPIENYTEKQVELVQKAEQYGFTGVWLRDVLLQDPDFGDPAT----------GQIYDIYLTYLASKTEKIAFGTSATVLSLRHPLRVAKEIATLDQLFPERI-LGVSSGDRRADFKALGVSHETRGEKFREAFAYLEEILYKNFPSIQSTLGEVHGANLVPKPSKRVPTFITGFSQQN--EWFAEHGDGWYYPRSPVHQAGAIGQWRELVEDYHPDVFKPFIQPHLDLSEIELLDIYKSIGVNHLFLALFDGQ-RPADEVLDELGEEVLPHF--------PA

1rhcA

0.19

0.18

0.95

2.16

MUSTER

MKIGYFASLEQYRPDALEQAIRAEKVGFDSVWVDDHFHPWY------------HDNAQSAQAWAWMGAALQATKKVFISTCITCPIMRNPAIVAQTFATLRQMYPGRVGVAVGAGEAMNEVPVTGPSVPVRQDMTVEAVKVMRMLWESDPVTFKGDYFTLDKAFLYTKPDDEVPLYFSGMG-PKGAKLAGMYGDHLMTVAASTLKNVTIPKFEEGAREAGKDPSKMEHAMLIWYSVDPDYDKAVEALRFWAGCLVPSYDPKEVQLHANLVCDTIKENYTDAEEMIKEI

1z69A

0.21

0.19

0.92

3.60

dPPAS

MKFGIEFVPSDPALKIAYYAKLSEQQGFDHVWITDHYN--------------------NRDVYSTLTVLALNTNSIKIGPGVTNSYTRNPAITASSIASIAEISGGRAVLGLGPGD-KATFDAMGIAWKKPLATTKEAIQAIRDFISGKKVSMDGEMIKFAGAKLAFKAG-NIPIYMGAQG-PKMLELAGEIADGVLINAHPKDFEVAVEQIKKGAEKAGRDPSEVDVTAYACDKDPVKAVNAAKVVVAFIVAGSPDLVLERHGIPVEAKSQIGAAIAKGDFGALMGG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.78

Estimated TM-score = 0.82±0.08

Estimated RMSD = 4.5±3.0Å

Download Model 2

C-score=-2.11

Download Model 3

C-score=-2.38

Download Model 4

C-score=-1.84

Download Model 5

C-score=-3.60

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2b81C	0.892	1.35	0.221	0.927
2	3fgcA	0.829	2.33	0.174	0.920
3	3sdoA	0.822	2.70	0.179	0.941
4	1yw1A	0.820	2.52	0.160	0.924
5	3b9nB	0.819	3.03	0.133	0.951
6	2i7gB	0.817	2.54	0.170	0.920
7	5dqpA1	0.817	2.91	0.168	0.941
8	1rhcA	0.815	2.40	0.175	0.913
9	3raoA	0.807	2.66	0.225	0.903
10	3fgcD	0.806	2.49	0.129	0.913

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.34	10	3fgcA	FMN	Rep, Mult	34,35,81,82,84,113,114,115,116,178,179,180,182,185,199
2	0.10	4	1luc0	III	Rep, Mult	13,14,37,38,39,60,62,64,65,67,68,70,71,72,87,89,91,92,95,96,99,102,103,122,123,124,163,164,166,167,168
3	0.04	1	1ezwA	MG	Rep, Mult	70,73,74
4	0.03	1	3b4yA	FLC	Rep, Mult	40,116,199,233,253,260,261,287
5	0.03	1	1uh3A	UUU	Rep, Mult	189,208,211,212,215
6	0.03	1	2v3eA	NND	Rep, Mult	142,144,158
7	0.03	1	3gxfB	PO4	Rep, Mult	21,25,73,74,76

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.244	1xkjA	0.799	2.52	0.130	0.910	1.14.14.3	28,100
2	0.169	1tqxA	0.588	3.30	0.053	0.715	5.1.3.1	NA
3	0.159	1xbzB	0.575	3.29	0.085	0.694	4.1.1.85	93
4	0.156	1rpxA	0.583	3.47	0.086	0.715	5.1.3.1	NA
5	0.147	3exrA	0.586	3.23	0.074	0.705	4.1.1.85	NA
6	0.141	1rhcA	0.815	2.40	0.175	0.913	1.1.99.5	116
7	0.128	3ct7A	0.574	3.74	0.105	0.722	5.1.3.-	NA
8	0.117	2v81A	0.539	3.59	0.118	0.677	4.1.2.21	NA
9	0.082	1h1yB	0.579	3.33	0.084	0.705	5.1.3.1	31
10	0.082	2fliC	0.589	3.35	0.078	0.715	5.1.3.1	NA
11	0.081	1h1yA	0.578	3.42	0.083	0.708	5.1.3.1	NA
12	0.080	3inpA	0.584	3.53	0.063	0.719	5.1.3.1	NA
13	0.079	3f4wA	0.569	3.47	0.124	0.701	4.1.2.-	NA
14	0.073	1nsjA	0.528	3.51	0.074	0.656	5.3.1.24	NA
15	0.073	1tqjC	0.584	3.31	0.110	0.708	5.1.3.1	NA
16	0.073	2czfA	0.562	3.16	0.114	0.667	4.1.1.23	NA
17	0.071	3cu2B	0.589	3.40	0.052	0.719	5.1.3.1	NA
18	0.070	1v5xA	0.523	3.49	0.143	0.646	5.3.1.24	NA
19	0.067	2cz5A	0.551	3.46	0.114	0.670	4.1.1.23	NA
20	0.067	1vqtA	0.507	3.14	0.096	0.608	4.1.1.23	89
21	0.060	1wcgA	0.627	4.06	0.055	0.826	3.2.1.147	NA
22	0.060	3a47A	0.627	4.20	0.051	0.830	3.2.1.10	NA
23	0.060	2e3zA	0.627	3.97	0.063	0.819	3.2.1.21	NA
24	0.060	3m07A	0.621	4.20	0.078	0.819	3.2.1.141	NA
25	0.060	1lucA	0.830	2.33	0.170	0.920	1.14.14.3	NA
26	0.060	1ezwA	0.774	2.73	0.184	0.885	1.5.99.11	178
27	0.060	1nqkA	0.792	2.20	0.209	0.875	1.14.14.5	115,131,178,187
28	0.060	2ekcB	0.620	3.79	0.075	0.785	4.2.1.20	NA
29	0.060	2bfgA	0.617	4.09	0.054	0.812	3.2.1.37	86
30	0.060	1wzaA	0.619	4.27	0.049	0.826	3.2.1.1	NA
31	0.060	1izjA	0.626	4.30	0.065	0.833	3.2.1.135,3.2.1.1	NA
32	0.060	1fhlA	0.625	4.12	0.071	0.819	3.2.1.89	NA
33	0.060	1m53A	0.615	4.31	0.031	0.823	5.4.99.12	NA
34	0.060	2jf6B	0.625	3.96	0.052	0.809	3.2.1.105	NA
35	0.060	2djxA	0.614	4.45	0.081	0.826	1.3.3.1	NA
36	0.060	1hjqA	0.628	3.87	0.081	0.806	3.2.1.89	NA
37	0.060	3f4vA	0.622	4.05	0.052	0.812	3.2.1.21	NA
38	0.060	2d0gA	0.625	4.32	0.069	0.833	3.2.1.135	NA
39	0.060	3c8nA	0.782	2.69	0.178	0.899	1.-.-.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.43	0.907	1.28	0.22	0.94	2b81C	GO:0004497 GO:0005886 GO:0016491 GO:0016705 GO:0055114
1	0.40	0.827	2.50	0.18	0.93	2i7gB	GO:0004497 GO:0016705 GO:0055114
2	0.39	0.829	2.53	0.23	0.92	3raoB	GO:0016705 GO:0055114
3	0.36	0.830	2.33	0.17	0.92	1lucA	GO:0004497 GO:0008218 GO:0016491 GO:0016705 GO:0047646 GO:0055114
4	0.34	0.799	2.89	0.18	0.92	5aecA	GO:0004497 GO:0016491 GO:0016705 GO:0055114
5	0.32	0.758	2.44	0.20	0.85	1f07A	GO:0005737 GO:0006730 GO:0015948 GO:0016491 GO:0016705 GO:0018537 GO:0019386 GO:0055114
6	0.30	0.826	2.46	0.16	0.93	1yw1A	GO:0004497 GO:0016491 GO:0016705 GO:0055114
7	0.29	0.803	2.49	0.13	0.91	3fgcD	GO:0004497 GO:0008218 GO:0016491 GO:0016705 GO:0047646 GO:0055114
8	0.29	0.829	2.33	0.17	0.92	3fgcA	GO:0004497 GO:0008218 GO:0016491 GO:0016705 GO:0047646 GO:0055114
9	0.28	0.792	2.20	0.21	0.88	1nqkA	GO:0004497 GO:0008726 GO:0009408 GO:0016491 GO:0016705 GO:0042802 GO:0046306 GO:0055114
10	0.27	0.761	2.90	0.18	0.88	4us5C	GO:0004497 GO:0016705 GO:0055114
11	0.25	0.815	2.40	0.17	0.91	1rhcA	GO:0016705 GO:0055114
12	0.25	0.817	2.91	0.17	0.94	5dqpA	GO:0004497 GO:0016705 GO:0055114
13	0.22	0.822	2.70	0.18	0.94	3sdoA	GO:0004497 GO:0016491 GO:0016705 GO:0055114
14	0.21	0.799	2.64	0.17	0.91	3c8nA	GO:0004497 GO:0005618 GO:0005829 GO:0005886 GO:0005975 GO:0016491 GO:0016614 GO:0016705 GO:0045454 GO:0052749 GO:0055114 GO:0070967
15	0.18	0.819	3.03	0.13	0.95	3b9nB	GO:0000166 GO:0004497 GO:0016705 GO:0055114
16	0.17	0.823	2.71	0.18	0.94	3sdoB	GO:0004497 GO:0016491 GO:0016705 GO:0055114
17	0.16	0.774	2.73	0.18	0.89	1ezwA	GO:0005737 GO:0006730 GO:0015948 GO:0016491 GO:0016705 GO:0018537 GO:0019386 GO:0055114
18	0.16	0.772	2.52	0.21	0.87	1z69A	GO:0005737 GO:0006730 GO:0015948 GO:0016491 GO:0016705 GO:0018537 GO:0019386 GO:0055114
19	0.07	0.499	4.27	0.10	0.67	2yswA	GO:0003824 GO:0003855 GO:0008652 GO:0009073 GO:0009423 GO:0016829

Consensus prediction of GO terms

Molecular Function	GO:0047646
GO-Score	0.36
Biological Processes	GO:0055114	GO:0008218
GO-Score	0.91	0.36
Cellular Component	GO:0005886
GO-Score	0.43

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.