I-TASSER results

I-TASSER results for job id Rv2159c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (344 residues)
MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEGLLTAGWATLRETLLV
GQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAILAGTAPAAGDPNAPYV
AWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLDETFLPGGPRAQQLMRRA
GGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIATAFAALSHHLDTAPHLPPP
TRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRLALLTGLAPHQVTDDDVAAA
RSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQNPTG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEGLLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAILAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLDETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIATAFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRLALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQNPTG
Prediction	CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
Conf.Score	99876567889766898999999999999899978899876999999999999999998589999999999999999989987689999999997899799999987878888799999999999767777899999899999999999999999999875788889988765456788888887765678899987656778899998876678997579999999999987655999999999999997689999998765768886598665657899999987554589999999876689869999999999999999999876577777877778889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEGLLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAILAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLDETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIATAFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRLALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQNPTG
Prediction	75534305314475046303500530274132013002010221510310032023114546034401100000003204030000001220342444522332234445433441230142034134564452504351001000000100220120100234431232342452033200310233234444113104104736327414104432100100120011243154035501510352056141632416442045105714574311000000001012303471044034444313100100010001003201320434464524565568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MKFVNHIEPVAPRRAGGAVAEVYAEARREFGRLPEPLAMLSPDEGLLTAGWATLRETLLVGQVPRGRKEAVAAAVAASLRCPWCVDAHTTMLYAAGQTDTAAAILAGTAPAAGDPNAPYVAWAAGTGTPAGPPAPFGPDVAAEYLGTAVQFHFIARLVLVLLDETFLPGGPRAQQLMRRAGGLVFARKVRAEHRPGRSTRRLEPRTLPDDLAWATPSEPIATAFAALSHHLDTAPHLPPPTRQVVRRVVGSWHGEPMPMSSRWTNEHTAELPADLHAPTRLALLTGLAPHQVTDDDVAAARSLLDTDAALVGALAWAAFTAARRIGTWIGAAAEGQVSRQNPTG

2prrK

0.15

0.08

0.50

1.10

dPPAS

AHPISRYPVPELAALPDDIRQRILEVQDKAGFVPNVFLTLAHRPDEFRAFFAYHDALLKDGGLT-KGEREIVVATSAANQCLYCVVAHGAILRIYEKKLVADQVAVNYLKADIPPRQRALDFALKVCKEALREHGFTDEDAWDIAAITAFFGLSNRANTIGRPNDEFFLGRVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5dj4A

0.15

0.13

0.88

1.20

wMUSTER

--------------------GL--EALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHR----APEKLRKLSEINKLLAIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDPPESRFELEKSESMLCFVEDPTFGYEDFTRRGAQAPPQDYTWEDHYPEGGQLLDEKFQAAYSAMHVTSVLRRAIWNYIHCVFGRYDDYDYGEVNQLL------ERNLKVYIKTVACYPEKTTRRMYNLFRHFRHSEKVHVNLLLLEARMQAALLYALRA------ITR---T-

2prrK

0.16

0.08

0.49

1.89

wdPPAS

AHPISRYPVPELAALPDDIRQRILEVQDKAGFVPNVFLTLAHRPDEFRAFFAYHDALLKDGGLT-KGEREIVVATSAANQCLYCVVAHGAILRIYEKKPLVADQVAVNLKADIPPRQRALDFALKVCFEALREHGFTDEDAWDIAAITAFFGLSNRANTIGRPNDEVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5dj4A

0.14

0.13

0.89

0.93

MUSTER

--------------------GL--EALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLHTGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHR----APEKLRKLSEINKLLAHRALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILPEGDPPESRFELEKSESMLCFVEDPTFGYEDFTRRGAQAPPTDYTWEDHGYSYPEGGQLLDEKFQAAYSLTSVLRRAIWNYIHCVFGIRY--DDYDYGEVNQLLE---RNLKVYIKTVACYPEKTTRRMYNLFRHFRHSEKVHVNLLLLEARMQAALLYALRAITRYMT--------

2prrK

0.16

0.08

0.49

2.01

wPPAS

PAHISRYPVPELAALPDDIRQRILEVQDKAGFVPNVFLTLAHRPDEFRAFFAYHDALLKDGGLT-KGEREIVVATSAANQCLYCVVAHGAILRIYEKKPLVADQVAVNLKADIPPRQRALDFALKVCFEALREHGFTDEDAWDIAAITAFFGLSNRANTIGRPNDEVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2prrK

0.16

0.08

0.49

2.59

dPPAS2

AHPISRYPVPELAALPDDIRQRILEVQDKAGFVPNVFLTLAHRPDEFRAFFAYHDALLKDGGLT-KGEREIVVATSAANQCLYCVVAHGAILRIYEKKLVADQVAVNYLKADIPPRQRALDFALKVCKEALREHGFTDEDAWDIAAITAFFGLSNRANTIGRPNGRVP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2prrK

0.16

0.08

0.48

1.46

PPAS

AHPISRYPVPELAALPDDIRQRILEVQDKAGFVPNVFLTLAHRPDEFRAFFAYHDALLKDGGLT-KGEREIVVATSAANQCLYCVVAHGAILRIYEKKLVADQVAVNYLKADIPPRQRALDFALKVCKEALREHGFTDEDAWDIAAITAFFGLSNRANTIGRPND-VP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2prrK

0.15

0.08

0.50

2.64

Env-PPAS

AHPISRYPVPELAALPDDIRQRILEVQDKAGFVPNVFLTLAHRPDEFRAFFAYHDALLKDGGLT-KGEREIVVATSAANQCLYCVVAHGAILRIYEKKLVADQVAVNYLKADIPPRQRALDFALKVCFEALREHGFTDEDAWDIAAITAFFGLSNRANTIGRPNDEFFLGRVP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2oyoA

0.16

0.08

0.50

0.88

MUSTER

-DRISSLPVPDATQVPEGVRKLWAKAEANIGFVPNVFRAQAVNGEQFLAWWNYFNLLLNKGYLTNAERELVAVVVSGVNRCLYCAVSHGAALREFLGDPQKADAVAVNHADLTEREQALAAYAEKLTRHPAEAVGLDDHQI--ELVQVIGFNLTNRVSSAL-GFVPNPEYYRQAR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3lvyA

0.13

0.06

0.49

1.06

dPPAS

----SKFTIHTIETAPERVKETLRTVKKDNGYIPNLIGLLANAPTALETYRTVGEINRRNS-LTPTEREVVQITAAVTNGCAFCVAGHTAFSIKQIQADLLEALRNATPIDDDPKLDTLAKFTIAVINTKGRVGGYTPENALDVVLGVSLASLCNYANNADTPINPELQQYVKG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.58

Estimated TM-score = 0.42±0.14

Estimated RMSD = 12.6±4.3Å

Download Model 2

C-score=-3.93

Download Model 3

C-score=-3.73

Download Model 4

C-score=-3.71

Download Model 5

C-score=-4.93

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5dj4A	0.708	3.36	0.112	0.846
2	2oyoA	0.454	2.32	0.169	0.500
3	2prrK	0.452	2.23	0.152	0.494
4	2dqmA	0.444	6.40	0.026	0.730
5	3lvyA	0.443	2.28	0.125	0.488
6	3ebgA	0.442	6.33	0.050	0.715
7	4kx7A	0.436	6.00	0.051	0.680
8	2pfxA	0.430	2.38	0.146	0.477
9	3c1lB	0.425	2.60	0.170	0.480
10	4wz9A	0.421	6.23	0.041	0.686

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1q05A	CU1	Rep, Mult	81,84
2	0.08	4	3bz1H	CLA	Rep, Mult	151,154
3	0.06	3	2ckjA	FES	Rep, Mult	14,15,16,20,38,41,42
4	0.06	3	4toeV	FE2	Rep, Mult	139,140,143
5	0.04	2	1fiqA	FES	Rep, Mult	66,67,70,93,94,95,96,99,101
6	0.04	2	3oceC	CO	Rep, Mult	147,150
7	0.04	2	1v54B	HEA	Rep, Mult	85,155,158,159
8	0.02	1	1gkiA	ADP	Rep, Mult	55,339
9	0.02	1	2hr0B	THC	Rep, Mult	84,87,134,202
10	0.02	1	1ne9A	MG	Rep, Mult	126,128
11	0.02	1	3fecA	ZN	Rep, Mult	88,114,164
12	0.02	1	2nrzB	MN	Rep, Mult	76,152

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3ebgA	0.442	6.33	0.050	0.715	3.4.11.-	NA
2	0.060	2bhrA	0.347	6.56	0.066	0.579	3.4.21.91	76
3	0.060	2w00B	0.378	6.52	0.050	0.631	3.1.21.3	37,166
4	0.060	1q16A	0.382	6.77	0.050	0.660	1.7.99.4	NA
5	0.060	1ofdA	0.387	6.78	0.043	0.660	1.4.7.1	119
6	0.060	3igyB	0.378	6.25	0.034	0.608	5.4.2.1	NA
7	0.060	2ckjA	0.340	6.66	0.061	0.579	1.17.1.4,1.17.3.2	NA
8	0.060	3b9jC	0.323	6.50	0.054	0.541	1.17.3.2,1.17.1.4	NA
9	0.060	2vdcF	0.392	6.57	0.036	0.651	1.4.1.13	NA
10	0.060	1fo4A	0.367	6.57	0.036	0.613	1.17.1.4	NA
11	0.060	1z1wA	0.409	6.30	0.033	0.645	3.4.11.-	NA
12	0.060	1bgvA	0.319	6.80	0.044	0.546	1.4.1.2	114
13	0.060	3b9jJ	0.247	6.53	0.042	0.407	1.17.1.4,1.17.3.2	58,60,130,140,146
14	0.060	1ct9A	0.377	6.22	0.078	0.596	6.3.5.4	NA
15	0.060	2d4eC	0.374	6.75	0.056	0.645	1.2.1.60	NA
16	0.060	1z01A	0.378	6.00	0.069	0.587	1.14.13.61	NA
17	0.060	1lrwC	0.380	6.31	0.073	0.611	1.1.99.8	NA
18	0.060	2vdcA	0.384	6.83	0.049	0.657	1.4.1.13	NA
19	0.060	2e1qA	0.395	6.77	0.026	0.671	1.17.3.2,1.17.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.18	0.697	3.48	0.11	0.84	5cufC	GO:0001932 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0006635 GO:0006914 GO:0007005 GO:0009749 GO:0016239 GO:0016684 GO:0030308 GO:0030330 GO:0031588 GO:0031932 GO:0032042 GO:0032542 GO:0032868 GO:0034599 GO:0036091 GO:0042593 GO:0043491 GO:0046323 GO:0061700 GO:0070328 GO:0070728 GO:0071230 GO:0071233 GO:0072593 GO:0090526 GO:0098869 GO:1900182 GO:1901031 GO:1902010 GO:1904262 GO:1990316 GO:2000479
1	0.15	0.458	2.27	0.16	0.50	2oyoA	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
2	0.13	0.440	2.63	0.14	0.50	3c1lB	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
3	0.12	0.466	2.24	0.14	0.51	2prrD	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
4	0.10	0.453	2.40	0.14	0.50	2pfxA	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
5	0.09	0.447	2.36	0.12	0.49	3lvyA	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
6	0.08	0.442	6.33	0.05	0.72	3ebgA	GO:0004177 GO:0005737 GO:0005829 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
7	0.07	0.444	6.38	0.03	0.73	4xo4A	GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016787 GO:0042277 GO:0042802 GO:0043171 GO:0046872 GO:0070006
8	0.06	0.432	6.60	0.05	0.72	4qpeA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787 GO:0046872
9	0.06	0.414	6.57	0.03	0.70	5dllA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787
10	0.06	0.413	6.55	0.05	0.69	2yd0A	GO:0001525 GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005138 GO:0005151 GO:0005164 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005829 GO:0005886 GO:0006508 GO:0006509 GO:0008217 GO:0008233 GO:0008235 GO:0008237 GO:0008270 GO:0009617 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0043231 GO:0045088 GO:0045444 GO:0045766 GO:0046872 GO:0070006 GO:0070062
11	0.06	0.415	6.49	0.03	0.68	5c97A	GO:0000209 GO:0002480 GO:0004177 GO:0005576 GO:0005622 GO:0005765 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0007165 GO:0007267 GO:0007565 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0030163 GO:0030659 GO:0031905 GO:0042277 GO:0043171 GO:0046872 GO:0048471 GO:0060395 GO:0061024 GO:0070006
12	0.06	0.350	6.96	0.06	0.62	4wz9B	GO:0005737 GO:0005886 GO:0006508 GO:0008237 GO:0008270 GO:0042277 GO:0043171 GO:0070006
13	0.06	0.428	6.15	0.05	0.68	5ab0C	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
14	0.06	0.436	6.00	0.05	0.68	4kx7A	GO:0001525 GO:0002003 GO:0002005 GO:0003081 GO:0004177 GO:0005765 GO:0005886 GO:0005887 GO:0005903 GO:0006508 GO:0007267 GO:0008233 GO:0008237 GO:0008270 GO:0008283 GO:0009897 GO:0016020 GO:0016021 GO:0016324 GO:0016477 GO:0016787 GO:0031410 GO:0032835 GO:0042277 GO:0043171 GO:0045177 GO:0046872 GO:0070006 GO:0070062
15	0.06	0.427	6.37	0.04	0.69	4fyrA	GO:0001525 GO:0001618 GO:0004177 GO:0004872 GO:0005615 GO:0005737 GO:0005765 GO:0005793 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0006725 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0009897 GO:0012506 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0031983 GO:0035814 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006 GO:0070062
16	0.06	0.429	6.63	0.06	0.72	5ab0A	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
17	0.06	0.338	6.45	0.04	0.55	3b7rL	GO:0004177 GO:0004301 GO:0004463 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006508 GO:0006691 GO:0008233 GO:0008237 GO:0008270 GO:0010043 GO:0016787 GO:0019370 GO:0042277 GO:0043171 GO:0043434 GO:0044822 GO:0046872 GO:0060509 GO:0070006 GO:0070062
18	0.06	0.302	6.90	0.04	0.51	2xpyA	GO:0004177 GO:0004301 GO:0004463 GO:0005634 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0030163 GO:0042277 GO:0043171 GO:0044255 GO:0046872 GO:0070006

Consensus prediction of GO terms

Molecular Function	GO:0051920	GO:0004601	GO:0016667	GO:0016597
GO-Score	0.41	0.41	0.36	0.36
Biological Processes	GO:0098869	GO:0043619	GO:1900180	GO:0072331	GO:0019395	GO:0036490	GO:0006111	GO:0016241	GO:0032007	GO:0032055	GO:1903432	GO:0043434	GO:0010508	GO:0055090	GO:1902882	GO:1901522	GO:0000002	GO:0009062	GO:0045926	GO:0015758	GO:0006259	GO:0001678	GO:0009746	GO:0043201	GO:0042770	GO:0071230	GO:0001558	GO:0000302	GO:0036003	GO:1903829	GO:0071900
GO-Score	0.52	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36	0.36
Cellular Component	GO:0038201	GO:0044444	GO:0043231	GO:0035859	GO:1902554
GO-Score	0.36	0.36	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.