I-TASSER results

I-TASSER results for job id Rv2148c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (258 residues)
MAADLSAYPDRESELTHALAAMRSRLAAAAEAAGRNVGEIELLPITKFFPATDVAILFRL
GCRSVGESREQEASAKMAELNRLLAAAELGHSGGVHWHMVGRIQRNKAGSLARWAHTAHS
VDSSRLVTALDRAVVAALAEHRRGERLRVYVQVSLDGDGSRGGVDSTTPGAVDRICAQVQ
ESEGLELVGLMGIPPLDWDPDEAFDRLQSEHNRVRAMFPHAIGLSAGMSNDLEVAVKHGS
TCVRVGTALLGPRRLRSP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MAADLSAYPDRESELTHALAAMRSRLAAAAEAAGRNVGEIELLPITKFFPATDVAILFRLGCRSVGESREQEASAKMAELNRLLAAAELGHSGGVHWHMVGRIQRNKAGSLARWAHTAHSVDSSRLVTALDRAVVAALAEHRRGERLRVYVQVSLDGDGSRGGVDSTTPGAVDRICAQVQESEGLELVGLMGIPPLDWDPDEAFDRLQSEHNRVRAMFPHAIGLSAGMSNDLEVAVKHGSTCVRVGTALLGPRRLRSP
Prediction	CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCHHHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHCCCEEEHCCCCCCCCCCCCC
Conf.Score	998888896899999999999999999999998999576589997578999999999998995553557999999999999975555556789986887575457899999987877886585999999999999866545458886589999689998778998557899999999999699986868855799999999999999999999999899997887679975999999899889864444688899999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MAADLSAYPDRESELTHALAAMRSRLAAAAEAAGRNVGEIELLPITKFFPATDVAILFRLGCRSVGESREQEASAKMAELNRLLAAAELGHSGGVHWHMVGRIQRNKAGSLARWAHTAHSVDSSRLVTALDRAVVAALAEHRRGERLRVYVQVSLDGDGSRGGVDSTTPGAVDRICAQVQESEGLELVGLMGIPPLDWDPDEAFDRLQSEHNRVRAMFPHAIGLSAGMSNDLEVAVKHGSTCVRVGTALLGPRRLRSP
Prediction	756625446513530351055026204500762735373020000035231620230171413200212012035016404733444544643503001013203310230062030000011240042025214544555646430300000101546343414363043025005203715604020000001346424500530350053037414713200000130033004230220001110025153768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHCCCCHHHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHCCCEEEHCCCCCCCCCCCCC
MAADLSAYPDRESELTHALAAMRSRLAAAAEAAGRNVGEIELLPITKFFPATDVAILFRLGCRSVGESREQEASAKMAELNRLLAAAELGHSGGVHWHMVGRIQRNKAGSLARWAHTAHSVDSSRLVTALDRAVVAALAEHRRGERLRVYVQVSLDGDGSRGGVDSTTPGAVDRICAQVQESEGLELVGLMGIPPLDWDPDEAFDRLQSEHNRVRAMFPHAIGLSAGMSNDLEVAVKHGSTCVRVGTALLGPRRLRSP

3r79A

0.30

0.26

0.85

3.03

MUSTER

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEKTS--------DIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLC-IPPAEENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

3r79A

0.29

0.25

0.85

4.28

dPPAS

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEK--------TSDIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLCIP-PAEENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

3r79A

0.29

0.25

0.85

4.86

wdPPAS

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEK--------TSDIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLCIPPA-EENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

3r79A

0.29

0.25

0.85

3.80

wMUSTER

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEKT--------SDIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLCIPP-AEENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

3r79A

0.29

0.25

0.85

4.80

wPPAS

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEK--------TSDIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLCIPPA-EENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

3r79A

0.29

0.25

0.85

9.46

dPPAS2

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEK--------TSDIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLCIP-PAEENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

3r79A

0.30

0.26

0.85

4.29

PPAS

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEK--------TSDIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLC-IPPAEENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

3r79A

0.30

0.26

0.85

6.91

Env-PPAS

-------------EIEARLEDVRQRIADVAEKSGRKAADVALVAVSKTFDAEAIQPVIDAGQRVFGENRVQEAQGKWPALKEKT--------SDIELHLIGPLQSNKAADAVALFDVVESIDREKIARALSEECARQ------GRSLRFYVQVNTGLEPQKAGI---DPRETVAFVAFCRDELKLPVEGLC-IPPAEENPGPHFALLAKLAGQCG-------LEKLSGSGDFETAVEFGATSVRVGSAIFGSRAENLY

1w8gA

0.33

0.29

0.86

2.86

MUSTER

-------------DIAHNLAQVRDKISAAATRCGRSPEEITLLAVSKTKPASAIAEAIDAGQRQFGENYVQEGVDKIRHFQEL-------GVTGLEWHFIGPLQSNKSRLVAEHFDWCHTIDRLRIATRLNDQR------PAELPPLNVLIQINISDENSKSGIQ---LAELDELAAAVAELPRLRLRGLMAIPAPESEQFEVARQMAVAFAGLKTRYPHIDTLSLGMSDDMEAAIAAGSTMVRIGTAIFGA------

1w8gA

0.33

0.29

0.86

4.05

dPPAS

-------------DIAHNLAQVRDKISAAATRCGRSPEEITLLAVSKTKPASAIAEAIDAGQRQFGENYVQEGVDKIRHFQEL-------GVTGLEWHFIGPLQSNKSRLVAEHFDWCHTIDRLRIATRLNDQR------PAELPPLNVLIQINISDENSKSGIQ---LAELDELAAAVAELPRLRLRGLMAIPAPESEYVRQFEVARQMAVAFAGLKPHIDTLSLGMSDDMEAAIAAGSTMVRIGTAIFGA------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.32

Estimated TM-score = 0.90±0.06

Estimated RMSD = 3.2±2.3Å

Download Model 2

C-score=-3.33

Download Model 3

C-score=-3.56

Download Model 4

C-score=-4.00

Download Model 5

C-score=-4.49

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3r79A	0.822	1.24	0.295	0.853
2	3cpgA	0.822	2.45	0.321	0.907
3	1w8gA	0.812	1.64	0.329	0.861
4	1b54A	0.806	1.92	0.252	0.876
5	3n2oA	0.749	2.83	0.097	0.884
6	3nzqA	0.748	2.91	0.119	0.884
7	4y2wA	0.730	2.63	0.125	0.837
8	4v15A	0.724	2.92	0.173	0.849
9	4lusA	0.723	2.67	0.117	0.833
10	4bf5A	0.722	3.29	0.140	0.880

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.88	26	4v15A	PLP	Rep, Mult	45,47,68,161,193,227,228,229,244,245,246,247
2	0.02	1	4y2wA	PO4	Rep, Mult	228,229,244,246,247
3	0.02	1	2oo0B	N2P	Rep, Mult	207,226,236,237,239

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.219	3ct7A	0.571	3.16	0.098	0.702	5.1.3.-	98,119
2	0.207	2fliC	0.575	3.20	0.103	0.705	5.1.3.1	98,119
3	0.198	1h1yB	0.564	3.07	0.115	0.686	5.1.3.1	NA
4	0.148	1xbzB	0.566	3.33	0.075	0.709	4.1.1.85	111
5	0.120	3exrA	0.573	3.32	0.075	0.709	4.1.1.85	NA
6	0.114	1j2wA	0.546	3.52	0.108	0.702	4.1.2.4	NA
7	0.095	2yw3E	0.540	3.06	0.145	0.655	4.1.2.14	NA
8	0.093	1vlwB	0.554	3.03	0.109	0.667	4.1.3.16	NA
9	0.088	3cu2B	0.597	3.42	0.065	0.729	5.1.3.1	NA
10	0.083	2c0aB	0.552	3.11	0.097	0.667	4.1.2.14,4.1.3.16	154,229
11	0.082	2v81A	0.542	3.33	0.128	0.674	4.1.2.21	NA
12	0.067	3inpA	0.581	3.01	0.098	0.698	5.1.3.1	NA
13	0.067	2cz5A	0.549	3.55	0.082	0.698	4.1.1.23	NA
14	0.067	1rpxA	0.582	3.32	0.089	0.709	5.1.3.1	NA
15	0.067	2czfA	0.551	3.48	0.105	0.690	4.1.1.23	115,193
16	0.067	1wbhB	0.552	3.11	0.097	0.667	4.1.3.16,4.1.2.14	NA
17	0.067	1vqtA	0.509	4.05	0.102	0.678	4.1.1.23	NA
18	0.066	1h1yA	0.565	3.06	0.126	0.686	5.1.3.1	NA
19	0.066	3f4wA	0.555	3.45	0.115	0.702	4.1.2.-	227
20	0.066	1tqjC	0.580	3.06	0.087	0.698	5.1.3.1	NA
21	0.060	2nv9B	0.683	2.98	0.073	0.814	4.1.1.19	NA
22	0.060	3gnrA	0.618	4.30	0.070	0.841	3.2.1.21	2
23	0.060	1od0B	0.620	4.37	0.081	0.845	3.2.1.21	NA
24	0.060	3n2oA	0.749	2.83	0.097	0.884	4.1.1.19	68
25	0.060	1cbgA	0.620	4.31	0.052	0.845	3.2.1.21	NA
26	0.060	3hz3A	0.631	4.49	0.092	0.876	2.4.1.5	NA
27	0.060	2qghA	0.711	3.04	0.088	0.849	4.1.1.20	NA
28	0.060	1xfcA	0.707	2.89	0.174	0.830	5.1.1.1	47,161
29	0.060	3f4vA	0.543	4.57	0.063	0.779	3.2.1.21	NA
30	0.060	1rcqA	0.671	2.81	0.134	0.787	5.1.1.1	47
31	0.060	1tufA	0.719	3.27	0.115	0.880	4.1.1.20	NA
32	0.060	3n2bA	0.716	2.94	0.120	0.845	4.1.1.20	47,193,246,248
33	0.060	3bg3A	0.618	3.97	0.046	0.810	6.4.1.1	NA
34	0.060	2j66A	0.688	3.20	0.093	0.845	4.1.1.20	NA
35	0.060	3kw3B	0.680	3.05	0.120	0.814	5.1.1.1	NA
36	0.060	1epvA	0.682	3.15	0.132	0.826	5.1.1.1	47,161
37	0.060	2pbgA	0.627	4.20	0.051	0.841	3.2.1.85	NA
38	0.060	2vd8A	0.685	3.30	0.122	0.837	5.1.1.1	161
39	0.060	1bgaA	0.550	4.22	0.037	0.760	3.2.1.21	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.48	0.819	1.73	0.29	0.87	3sy1A	GO:0005829 GO:0030170
1	0.46	0.806	1.92	0.25	0.88	1b54A	GO:0005622 GO:0030170
2	0.26	0.681	2.86	0.15	0.80	3co8A	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0018113 GO:0030170
3	0.26	0.722	3.29	0.14	0.88	4bf5A	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
4	0.20	0.713	3.03	0.09	0.85	3c5qA	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
5	0.17	0.520	3.69	0.06	0.67	4a3qA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
6	0.14	0.748	2.91	0.12	0.88	3nzqA	GO:0003824 GO:0006527 GO:0006596 GO:0008295 GO:0008792 GO:0009446 GO:0016829 GO:0016831 GO:0033388 GO:0042597 GO:0046872
7	0.13	0.749	2.83	0.10	0.88	3n2oA	GO:0003824 GO:0006527 GO:0006596 GO:0008295 GO:0008792 GO:0016829 GO:0016831 GO:0046872
8	0.12	0.709	3.22	0.14	0.85	1hkvA	GO:0003824 GO:0005618 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170 GO:0040007
9	0.12	0.716	2.94	0.12	0.84	3n2bA	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
10	0.11	0.714	3.36	0.11	0.88	1twiA	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
11	0.11	0.698	3.00	0.13	0.83	3n2bB	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
12	0.11	0.711	3.13	0.14	0.86	3vabA	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
13	0.11	0.700	2.98	0.11	0.84	4xg1B	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
14	0.09	0.680	3.25	0.09	0.83	4xg1A	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
15	0.09	0.706	3.00	0.11	0.83	3oo2A	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
16	0.09	0.660	3.34	0.10	0.81	1knwA	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
17	0.09	0.683	3.21	0.14	0.83	2p3eB	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
18	0.08	0.683	2.98	0.07	0.81	2nv9B	GO:0003824 GO:0006596
19	0.08	0.525	4.80	0.05	0.76	1f3tB	GO:0003824 GO:0004586 GO:0006596 GO:0016829 GO:0016831 GO:0033387
20	0.07	0.644	3.09	0.12	0.77	4ilsA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
21	0.07	0.711	2.97	0.15	0.85	4dzaA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
22	0.07	0.723	2.67	0.12	0.83	4lusA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
23	0.07	0.707	2.89	0.17	0.83	1xfcA	GO:0003824 GO:0006522 GO:0008784 GO:0009252 GO:0016853 GO:0030170 GO:0030632 GO:0040007
24	0.07	0.690	2.95	0.13	0.82	2dy3D	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
25	0.07	0.723	2.67	0.11	0.83	4luyA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
26	0.07	0.713	2.89	0.12	0.84	1vfsA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
27	0.07	0.730	2.63	0.12	0.84	4y2wA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
28	0.07	0.680	2.81	0.14	0.79	4wr3A	GO:0003824 GO:0006522 GO:0008360 GO:0008784 GO:0009252 GO:0016853 GO:0030170 GO:0030632 GO:0071555
29	0.07	0.717	3.09	0.15	0.86	4fs9A	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
30	0.07	0.698	2.82	0.12	0.82	4eclA	GO:0003824 GO:0006522 GO:0008784 GO:0016020 GO:0016021 GO:0016747 GO:0016853 GO:0016855 GO:0030170 GO:0046677
31	0.07	0.680	3.05	0.12	0.81	3kw3B	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
32	0.07	0.674	2.97	0.13	0.80	3s46A	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
33	0.07	0.699	2.96	0.14	0.83	3e5pB	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
34	0.07	0.688	3.20	0.09	0.84	2j66A	GO:0003824 GO:0008836 GO:0009089 GO:0016829 GO:0016831 GO:0017000 GO:0042803
35	0.07	0.669	2.90	0.14	0.79	2odoA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
36	0.07	0.686	3.20	0.11	0.83	3ha1A	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
37	0.07	0.681	3.04	0.12	0.82	1sftA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
38	0.07	0.661	3.23	0.12	0.81	3hurA	GO:0003824 GO:0006522 GO:0008784 GO:0016853 GO:0030170 GO:0030632
39	0.07	0.549	4.84	0.04	0.79	3nzpB	GO:0003824 GO:0006527 GO:0008295 GO:0008792 GO:0016829 GO:0016831
40	0.07	0.667	3.01	0.11	0.80	4aibA	GO:0003824 GO:0004586 GO:0005737 GO:0006596 GO:0016829 GO:0033387
41	0.07	0.495	4.36	0.07	0.69	4fokA	GO:0000166 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0030170	GO:0008784	GO:0016830
GO-Score	0.88	0.45	0.40
Biological Processes	GO:0046145	GO:0046436	GO:0009085	GO:0046451
GO-Score	0.51	0.51	0.40	0.40
Cellular Component	GO:0005829
GO-Score	0.48

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.