I-TASSER results

I-TASSER results for job id Rv2143

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (352 residues)
MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENESLLATARHHDW
IARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGLLPPGCHQPVLVVGLVGQQPE
MRPMNPPSGFLRRTPTRRFRDRRDAGRVLADELASYRGRDRLLVLGLARGGVPVGWEVAS
ALGAELDVFLVRKLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAE
LQRRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIRATGPESIVVAVPVGPAT
ACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATPTTGAAT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENESLLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGLLPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLADELASYRGRDRLLVLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQRRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIRATGPESIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATPTTGAAT
Prediction	CCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEEHCCCHHHHHHHHHHHHHCCCEEEEEEEEHCCCCCHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCHHHHHHHHHCCCEEEEEEEHCCCCCCCCCEEEEHCCCCEEEHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHCCCCHHHHHHHHHHCCEEEHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
Conf.Score	9989999997645545679988999999987987589998589878999999999878874688987758888589999999976776554665468887665557765558899987545445666665456777677998899999999999997999859997789986456898888799857999886478986444667657998699879999998999999999999999999999999857888888899889998698556899999999999989978999986899689999999889899858998754588888657789999999999986657889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENESLLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGLLPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLADELASYRGRDRLLVLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQRRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIRATGPESIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATPTTGAAT
Prediction	8752211557514203240207303520672503100000015335004100500562510000000020436503520351165440321030013552235204432133212332342321432343124344442444442132003202623625200000024200200320152060100000033020431432100222440010004300630603362045115433540451264146744124064100000000000010021004103643043000000001261153035101200002014202000200640531315202500650465668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCCEEEEEEHCCCHHHHHHHHHHHHHCCCEEEEEEEEHCCCCCHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHCCCCCCCHHHHHHHHHCCCEEEEEEEHCCCCCCCCCEEEEHCCCCEEEHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHHHHHCCCEEEEEHCCCCHHHHHHHHHHCCEEEHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCC
MEAPPYAGDPTFERLRRSFQPADLLPELQAAGVHYTIAVEAADDPAENESLLATARHHDWIARVIGWVPLADPDEVTESSTHGRHRPDASWRRDLRCPGLLPPGCHQPVLVVGLVGQQPEMRPMNPPSGFLRRTPTRRFRDRRDAGRVLADELASYRGRDRLLVLGLARGGVPVGWEVASALGAELDVFLVRKLGVPQWRELAMGALASGGGVVMNDDVVSSLRITDQQVRAAIDSETAELQRRELAYRGGRPVVDPRARIVILVDDGIATGASMLAAVRTIRATGPESIVVAVPVGPATACRELAAEADDVVCATMPAAFEAVGQVYNDFHQVTDDEVRELLATPTTGAAT

1wd5A

0.44

0.26

0.58

1.45

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------RFRDRRHAGALLAEALAPL-GLEAPVVLGLPRGGVVVADEVARRLGGELDVVLVRKVGAPGNPEFALGAVGEGGELVLPY---ALRYADQSYLEREAARQRDVLRKRAERYRRVRPKAARKGRDVVLVDDGVATGAS-EAALSVVFQEGPRRVVVAVPVASPEAVERLKARA-EVVALSVPQDFAAVGAYYLDFGEVTDEDVEAILLEWAG----

1wd5A

0.44

0.26

0.58

2.14

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------RFRDRRHAGALLAEALAPL-GLEAPVVLGLPRGGVVVADEVARRLGGELDVVLVRKVGAPGNPEFALGAVGEGGELVLPY---ALRYADQSYLEREAARQRDVLRKRAERYRRVRPKAARKGRDVVLVDDGVATGAS-EAALSVVFQEGPRRVVVAVPVASPEAVERLKARA-EVVALSVPQDFAAVGAYYLDFGEVTDEDVEAILLEWAG----

3dahC

0.12

0.10

0.82

3.02

wdPPAS

----------------------------------GLMVFTGNAN---PALAQEVVKILGIPLGKAMVSRFSDGEIQVEIQENVRGKDVF-VLQSTCAPTNDNLMELMIMVDALKRASAGRITAAIPYFGYARQDRRPR-SARVAISAKVVANMLEIAGVERIITMDLH------ADQIQGFFDIPVDNIYATPILLGDLRPDLLVVSPDVGGVVRARALAKQLNCDLAIIDKR---------------RVMNIIGEVEGRTCVIMDDMVDTAGTLCKAAQVLKERGAKFAYATHPVLSGGAADRIAASLDELVVTDTIPLSAESLAC----PKIRALSSAGLLAETFSRIRR

1wd5A

0.44

0.26

0.58

1.68

wMUSTER

------------------------------------------------------------------------------------------------------------------------------------------FRDRRHAGALLAEALAPL-GLEAPVVLGLPRGGVVVADEVARRLGGELDVVLVRKVGAPGNPEFALGAVGEGGELVLPY---ALRYADQSYLEREAARQRDVLRKRAERYRRVRPKAARKGRDVVLVDDGVATGAS-EAALSVVFQEGPRRVVVAVPVASPEAVERLKARA-EVVALSVPQDFAAVGAYYLDFGEVTDEDVEAILLEWAG----

3lpnA

0.14

0.11

0.77

2.63

wPPAS

---------------------------------MKIIALRSS---------LKLAAR---IAEELK-TEPVM----PDERRFPDGELYLRYDEDLTGHNIFIIGNTHSTLSAIQDYRTKSVNIIAPYYGYARQHQRYKN--GEPISSQILTEIYSSY-SNSIATVDIHDE------KTLSYSKVKFSDLHANDAIVRYYKDVDYVVSPDDGGLARVADISAKLGKKHFFIEK--KRIDDRTVEMKV------PNVDVNGKKLLIVDDIISTGGTIAKSSGLLREKGASKIYVSA-LFVNGSENKILQNADEIHVTDTVE------------SKFSDISVYQEVCNYIRDI--

1wd5A

0.44

0.26

0.58

5.05

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------RFRDRRHAGALLAEALAPL-GLEAPVVLGLPRGGVVVADEVARRLGGELDVVLVRKVGAPGNPEFALGAVGEGGELVLPY---ALRYADQSYLEREAARQRDVLRKRAERYRRVRPKAARKGRDVVLVDDGVATGAS-EAALSVVFQEGPRRVVVAVPVASPEAVERLKARA-EVVALSVPQDFAAVGAYYLDFGEVTDEDVEAILLEWAG----

1wd5A

0.44

0.26

0.58

2.33

PPAS

-----------------------------------------------------------------------------------------------------------------------------------------RFRDRRHAGALLAEALAPLGL-EAPVVLGLPRGGVVVADEVARRLGGELDVVLVRKVGAPGNPEFALGAVGEGGELVLPY---ALRYADQSYLEREAARQRDVLRKRAERYRRVRPKAARKGRDVVLVDDGVATGAS-EAALSVVFQEGPRRVVVAVPVASPEAVERLKARA-EVVALSVPQDFAAVGAYYLDFGEVTDEDVEAILLEWAG----

1wd5A

0.44

0.26

0.58

4.33

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------RFRDRRHAGALLAEALAPLGL-EAPVVLGLPRGGVVVADEVARRLGGELDVVLVRKVGAPGNPEFALGAVGEGGELVLPY---ALRYADQSYLEREAARQRDVLRKRAERYRRVRPKAARKGRDVVLVDDGVATGAS-EAALSVVFQEGPRRVVVAVPVASPEAVERLKARA-EVVALSVPQDFAAVGAYYLDFGEVTDEDVEAILLEWAG----

3lpnA

0.13

0.10

0.77

1.31

MUSTER

-------------------------------------------------MKIIALRSSLKLAARIA--ELKTEPVMPDERRFPDGELYLRYDEDLTGHNIFIIGNTHSTLSAIQDYRTKSVNIIAPYYGYARQHQRY--KNGEPISSQILTEIYSSY-SNSIATVDIHDE------KTLSYSKVKFSDLHANDAIVRYYVDVDYVVSPDDGGLARVADISAKLGKKHFFIEK--KRIDDRTVEMK------VPNVDVNGKKLLIVDDIISTGGTIAKSSGLLREKGASKIYVSAVLFVNGSENKILQNADEIHVTDTVES---------KFSDIS---VYQEVCNYIRDI--

3lpnA

0.13

0.10

0.77

1.62

dPPAS

-------------------------------------------------MKIIALRSSLKLAARIA-EELKTEPVMPDERRFPDGELYLRYDEDLTGHNIFIIGNTHSTLSAIQDYRTKSVNIIAPYYGYARQHQRYKN--GEPISSQILTEIYSSY-SNSIATVDIHDE------KTLSYSKVKFSDLHANDAIVRYNVDVDYVVSPDDGGLARVADISAKLGKKHFFIEK--KRIDDRTVEMKV------PNVDVNGKKLLIVDDIISTGGTIAKSSGLLREKGASKIYVSAVLFVNGSENKILQNADEIHVTDTVES------------KFSDISVYQEVCNYIRDI--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.64

Estimated TM-score = 0.52±0.15

Estimated RMSD = 10.3±4.6Å

Download Model 2

C-score=-2.45

Download Model 3

C-score=-2.46

Download Model 4

C-score=-2.24

Download Model 5

C-score=-4.16

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4s2uA	0.697	2.81	0.137	0.787
2	2c4kA	0.696	2.66	0.138	0.784
3	3dahC	0.693	2.92	0.123	0.787
4	2hcrB	0.693	2.75	0.112	0.784
5	1dkrB	0.690	2.94	0.132	0.787
6	3lpnA	0.682	2.86	0.129	0.764
7	4twbA	0.672	2.47	0.126	0.742
8	1u9yA	0.658	2.57	0.124	0.730
9	1xdwA	0.496	4.42	0.086	0.659
10	3x2eA	0.494	5.17	0.061	0.702

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.25	10	3lpnA	SO4	Rep, Mult	132,270,271,272,274
2	0.24	12	1dkuB	ABM	Rep, Mult	132,133,135,137,168
3	0.04	2	1dkuB	AP2	Rep, Mult	136,137,138,141,142
4	0.02	1	3dahC	PO4	Rep, Mult	94,96
5	0.02	1	3mbiA	ADP	Rep, Mult	132,133,139,168,232,234

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.276	3dahC	0.693	2.92	0.123	0.787	2.7.6.1	211
2	0.118	1dkrB	0.690	2.94	0.132	0.787	2.7.6.1	NA
3	0.060	1gdhA	0.470	4.60	0.090	0.636	1.1.1.29	NA
4	0.060	2j6iA	0.474	5.32	0.098	0.679	1.2.1.2	299,302
5	0.060	1dxhA	0.464	5.72	0.076	0.707	2.1.3.3	266
6	0.060	2nadA	0.459	5.49	0.083	0.676	1.2.1.2	NA
7	0.060	2gsdA	0.458	5.59	0.075	0.682	1.2.1.43	NA
8	0.060	1u9zC	0.658	2.55	0.124	0.730	2.7.6.1	NA
9	0.060	1edzA	0.464	5.55	0.072	0.676	1.5.1.15	NA
10	0.060	3d64B	0.489	5.49	0.068	0.722	3.3.1.1	192,268
11	0.060	1acmA	0.467	5.90	0.086	0.716	2.1.3.2	NA
12	0.060	2dldA	0.482	4.61	0.095	0.653	1.1.1.28	NA
13	0.060	1j49A	0.490	4.45	0.083	0.651	1.1.1.28	NA
14	0.060	1at1A	0.469	5.90	0.090	0.719	2.1.3.2	NA
15	0.060	2h06B	0.694	2.73	0.112	0.784	2.7.6.1	NA
16	0.060	1a7aA	0.467	5.72	0.062	0.705	3.3.1.1	NA
17	0.060	3gg9A	0.490	4.90	0.091	0.682	1.1.1.95	NA
18	0.060	3csuA	0.462	5.57	0.108	0.685	2.1.3.2	NA
19	0.060	3e2pA	0.472	5.74	0.076	0.710	2.1.3.2	NA
20	0.060	1v8bA	0.476	5.57	0.072	0.705	3.3.1.1	NA
21	0.060	3h9uC	0.470	5.75	0.079	0.707	3.3.1.1	235

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.28	0.693	2.92	0.12	0.79	3dahC	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0044249 GO:0046872
1	0.28	0.697	2.81	0.14	0.79	4s2uA	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0005829 GO:0006015 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0042301 GO:0044249 GO:0046872
2	0.26	0.658	2.57	0.12	0.73	1u9yA	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009116 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0046872
3	0.25	0.681	2.52	0.15	0.76	2ji4A	GO:0000287 GO:0002189 GO:0004749 GO:0004857 GO:0006139 GO:0009165 GO:0043086 GO:0043234 GO:0060348
4	0.24	0.684	2.83	0.13	0.77	3mbiA	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009116 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0046872
5	0.23	0.672	2.47	0.13	0.74	4twbA	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009116 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0046872
6	0.20	0.696	2.81	0.11	0.79	4lygB	GO:0000166 GO:0000287 GO:0002189 GO:0004749 GO:0005524 GO:0005829 GO:0006015 GO:0006144 GO:0006164 GO:0006167 GO:0006221 GO:0007399 GO:0009156 GO:0009165 GO:0016208 GO:0016301 GO:0016310 GO:0016740 GO:0019003 GO:0019693 GO:0030246 GO:0031100 GO:0034418 GO:0042803 GO:0043234 GO:0043531 GO:0044249 GO:0046101 GO:0046872
7	0.18	0.696	2.66	0.14	0.78	2c4kA	GO:0000287 GO:0002189 GO:0004749 GO:0004857 GO:0006139 GO:0009165 GO:0019900 GO:0030234 GO:0033673 GO:0043234
8	0.14	0.358	3.95	0.17	0.44	1oreA	GO:0002055 GO:0003999 GO:0005654 GO:0005737 GO:0005829 GO:0006166 GO:0006168 GO:0007595 GO:0007625 GO:0009116 GO:0016208 GO:0016740 GO:0016757 GO:0032869 GO:0043101 GO:0044209 GO:0046083 GO:0070062
9	0.09	0.690	2.94	0.13	0.79	1dkrB	GO:0000166 GO:0000287 GO:0004749 GO:0005524 GO:0005737 GO:0006015 GO:0009156 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0044249 GO:0046872
10	0.09	0.374	4.14	0.11	0.47	1jlrA	GO:0000166 GO:0003824 GO:0004845 GO:0005525 GO:0008152 GO:0016740 GO:0016757 GO:0044206
11	0.06	0.372	4.16	0.12	0.47	1mzvA	GO:0000166 GO:0003999 GO:0009116 GO:0016740 GO:0016757
12	0.06	0.366	4.28	0.10	0.46	4rv4B	GO:0000287 GO:0004588 GO:0006221 GO:0009116 GO:0016740 GO:0016757 GO:0044205
13	0.06	0.350	4.65	0.08	0.46	2wnsB	GO:0003824 GO:0004588 GO:0004590 GO:0005634 GO:0005737 GO:0005829 GO:0006207 GO:0006221 GO:0006222 GO:0007565 GO:0007595 GO:0008152 GO:0009116 GO:0016740 GO:0016757 GO:0016829 GO:0016831 GO:0035690 GO:0044205 GO:0046134
14	0.06	0.352	3.89	0.14	0.43	4lzaB	GO:0003999 GO:0005737 GO:0006166 GO:0006168 GO:0009116 GO:0016740 GO:0016757 GO:0044209
15	0.06	0.345	4.13	0.07	0.43	4pawA	GO:0000287 GO:0004588 GO:0006221 GO:0009116 GO:0016740 GO:0016757 GO:0019856 GO:0044205
16	0.06	0.343	3.57	0.12	0.41	1o5oA	GO:0000166 GO:0000287 GO:0003824 GO:0004845 GO:0004849 GO:0005525 GO:0005829 GO:0006206 GO:0006223 GO:0008152 GO:0008655 GO:0016740 GO:0016757 GO:0043097 GO:0044206
17	0.06	0.344	4.04	0.11	0.42	1i5eA	GO:0000166 GO:0000287 GO:0003824 GO:0004845 GO:0005525 GO:0006223 GO:0008152 GO:0008655 GO:0016740 GO:0016757 GO:0044206
18	0.06	0.325	4.16	0.12	0.41	2vfaB	GO:0000166 GO:0000287 GO:0000310 GO:0001975 GO:0004422 GO:0005737 GO:0005829 GO:0006164 GO:0006166 GO:0006168 GO:0006178 GO:0007625 GO:0007626 GO:0009116 GO:0016740 GO:0016757 GO:0019835 GO:0021756 GO:0021895 GO:0021954 GO:0032263 GO:0032264 GO:0032265 GO:0042417 GO:0042802 GO:0042803 GO:0043101 GO:0043103 GO:0045964 GO:0046038 GO:0046040 GO:0046083 GO:0046100 GO:0046651 GO:0046872 GO:0048813 GO:0051289 GO:0052657 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0004749	GO:0000287	GO:0016301	GO:0005524	GO:0043168	GO:0030234
GO-Score	0.79	0.79	0.71	0.71	0.57	0.50
Biological Processes	GO:0009165	GO:0016310	GO:0006015	GO:0009156	GO:0044092	GO:0001501	GO:0050790	GO:0048513	GO:0009116
GO-Score	0.79	0.71	0.71	0.71	0.50	0.50	0.50	0.50	0.44
Cellular Component	GO:0044444	GO:0061695
GO-Score	0.57	0.50

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.