I-TASSER results

I-TASSER results for job id Rv2136c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (276 residues)
MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFA
RDIVRILSAWLHGLVVKAHRNTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVT
ALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLALVPGVSRSGSTISAGLFLGL
DRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAW
LLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHRNTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLALVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAWLLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT
Prediction	CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
Conf.Score	959999999998865554666547899999998589998645688888788999999999999999999999767887688555653456665345568877787655467764679999999999999999999756687454676557888899998759997667577877876699878999999999999998876554566557888988786899999999999999999999999998667556899999999999999997888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHRNTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLALVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAWLLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT
Prediction	451200110031033112122201001100030143720100000000331320000002320020022003102445433220100000003132000000001120444012010001011331221020131056525166030310000010001001012021300000012131424100100010012013001212024114544534411201000002202211100000002102530020001201210110031012131448
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHEEEEEEHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
MSWWQVIVLAAAQGLTEFLPVSSSGHLAIVSRIFFSGDAGASFTAVSQLGTEAAVVIYFARDIVRILSAWLHGLVVKAHRNTDYRLGWYVIIGTIPICILGLFFKDDIRSGVRNLWVVVTALVVFSGVIALAEYVGRQSRHIERLTWRDAVVVGIAQTLALVPGVSRSGSTISAGLFLGLDRELAARFGFLLAIPAVFASGLFSLPDAFHPVTEGMSATGPQLLVATLIAFVLGLTAVAWLLRFLVRHNMYWFVGYRVLVGTGMLVLLATGTVAAT

3wdoA2

0.11

0.08

0.71

1.28

dPPAS

------------------------------------------------------------RESGMVKGSFSKVLAEPRLLKLNFGIMCLHMLLMSTFVALPGQLADAGFPAAEHWKVYLATMLIAFGSVVPFIIYAEVKR-------KMKQVFVFCVGLIVV-------AEIVLWNAQTQFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTA-MGVYSTSQFLGVAIGGSLGGWIDGMFD----GQGVFLAGAMLAAVWLAVASTMKEPP

4bwzA2

0.16

0.09

0.55

2.15

dPPAS2

--------------------------------------------------------------------------------------------------------------RLKFLVAVLGVALPFLGGYLYGLEIG--------FETLPALFLGTALVA------TSVGITARVLQELGVSRIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGAPRGEVGLIVAALGAVNEE

4w6vA2

0.11

0.09

0.83

1.22

dPPAS

PVMIASLLVYVIAASV------TLYFIYLFAFAKMSRKDRARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTDRMVMGFEIPTVWFQSINALFIILLAPVFSWAP----SSITKFVIGILCAAAGFAVMMYAAQHVLSSGGAGVS---PLWLVMSILL--------LTLGELCLSPIGLATMTLLGQVMGLWFCASSLGNLAAGLIGGHVKADQLDMLPTLFARCSIALVICAAVLILLIVPIRRLM--------------------------

5x3xM

0.13

0.07

0.54

1.89

dPPAS2

-----------------------------------------------------------------------------------------------------------IMEGYLPVTHAIGWSLAAAPFVVAGALKIRKI-----VAERPEARMTLAAAGAFATGSCPTGTGLGAVVF-G------------PSVMAVLGVIVLLFQALLLAHG-GLTTLGANAFSMAIVGPWVAFGVYKLAGKAG--ASMAVAVFLAAFLGDLATYVTTSLQLALA

4zowA2

0.10

0.07

0.72

1.20

dPPAS

------------------------------------------------------------LSLKELGRDYKLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIITGEQLSSYEYGLLQVPIFGALIAGNLLLARLTSRRTVRSL-IIMGGWPIMIGLLV---------AAAATVISSHAYLWMTAGLSIYAFGIGLANAGLVRLTLFASDMSKGTV--SAAMGMLQMLIFTVGIEISKHAWLNGGN---GLFNLFNLVNGILWLSLMVIFLK---

4m58A

0.17

0.09

0.54

1.88

dPPAS2

-----------------------------------------------------------------------------------------------------------IPEGYLSPQTCAVMGAAMVPVLTVAAKKVNKS-----FDKKDVPAMAIGSAFAFIPGGTAIGATLLATTL-G------------PWAASISLTLALFIQALLFGDG-GILALGANSFNMAFIAPFVGYGIYRLMLSLKL--NKVLSSAIGGYVGINAAALATAIELGLQ

4bwzA2

0.14

0.08

0.58

1.17

dPPAS

-------------------------------------------------------------------------------------------------------RLKDILAVGKEAFLVAVLGVALPFLGGYLYGLEI------GFETLPALFLGTALVA------TSVGITARVLQELGVLRIILGAAVIDDVLGLIVLACVNGVAETGQELSALASPVVLVAGTVVTVIAILGKVLGGFLGALTQGVRSALTVGCGAPRGEVGLIVAALGLKAGA

4o9uB1

0.14

0.07

0.49

1.46

dPPAS2

------------------------------------------------------------------------------------------------------------------MDLIQAAYFVVAILFIVGLKRMAHPT-----TAKSGIVWAGWGMVL---------AVLATFFWPGMG-------NFALILLALLLGSVVAWWAAVR-----VAMTDMPQMVAIYNGMGGGAAATIAAVELLKGAFENTGLMALAILGGLIGSVAFTGSLIAF

5i20A

0.11

0.09

0.85

1.14

dPPAS

--------------------SRSSATLIGFTAILLW----STLALATSSPFLLTALTFTIGGAVGIAAGLARGVSVLRQPWPVWVHGIGLVAYLWPLLIVLFSAFLP-GERLRPAHVAGALMGLAGTVVLLGA-------RAGGFGFAPEYVPGYLAAAA---------CAVIWSVYSVASRRFARVTEVVAGFCLATAALSALCHILFEPSVWPVGSEWLAVVALGIGPVGIAFYTWDIGMKRGDVRLLGVLSYAAPVLSTLLLVVAGFAAPSGA

5awwG

0.14

0.03

0.23

1.45

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDLLYTLVILFYLGVAGLLVYLVLVQEPKQGAGDLMGGGGLYRLTVILGVVFAALALVIGLWPR-----------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.37

Estimated TM-score = 0.26±0.08

Estimated RMSD = 17.0±2.8Å

Download Model 2

C-score=-3.98

Download Model 3

C-score=-4.46

Download Model 4

C-score=-4.97

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4zowA	0.698	4.04	0.078	0.859
2	4ldsA	0.622	4.59	0.047	0.833
3	4gbyA	0.609	4.47	0.073	0.812
4	4j05A	0.609	4.36	0.071	0.808
5	4pypA	0.605	4.21	0.050	0.793
6	3wdoA	0.603	4.43	0.066	0.819
7	1pw4A	0.602	4.81	0.054	0.844
8	5aymA	0.601	4.32	0.085	0.793
9	4ybqA	0.599	4.22	0.054	0.793
10	4w6vA	0.597	4.44	0.086	0.797

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	4jreD	GYP	Rep, Mult	87,234,237,238,256,257,260,261
2	0.04	2	4jr9A	GYP	Rep, Mult	87,230,233,234,259,260,263
3	0.04	2	1o5qA	MG	Rep, Mult	38,113
4	0.02	1	3ehbB	HEA	Rep, Mult	90,199
5	0.02	1	1s4eB	MG	Rep, Mult	22,24
6	0.02	1	4zp2A	LDA	Rep, Mult	94,97,231
7	0.02	1	1e3mB	QNA	Rep, Mult	160,162,166
8	0.02	1	3wu2h	CLA	Rep, Mult	118,122
9	0.02	1	3rkoN	LFA	Rep, Mult	189,192,193,196
10	0.02	1	3rkoN	LFA	Rep, Mult	97,98,101,122,123
11	0.02	1	1q19B	MG	Rep, Mult	22,229
12	0.02	1	2r9rB	PGW	Rep, Mult	42,43
13	0.02	1	1vykA	ZN	Rep, Mult	171,175,255
14	0.02	1	3bjeA	R1P	Rep, Mult	26,80
15	0.02	1	1mz9A	VDY	Rep, Mult	224,227,238
16	0.02	1	3tijA	DMU	Rep, Mult	231,238
17	0.02	1	2iidA	UUU	Rep, Mult	80,81,84
18	0.02	1	4fe1B	CLA	Rep, Mult	240,244,248
19	0.02	1	2abmA	POQ	Rep, Mult	92,244
20	0.02	1	1wdc2	III	Rep, Mult	39,41,42,43,44,45,46,47,48,49,50,51,52,53,54,56,57,59,60,62,63

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1kc7A	0.408	5.99	0.064	0.681	2.7.9.1	NA
2	0.060	2p0mB	0.393	4.40	0.070	0.536	1.13.11.33	NA
3	0.060	1qxoC	0.416	6.23	0.046	0.721	4.2.3.5	NA
4	0.060	1u8vA	0.401	6.02	0.053	0.674	5.3.3.3	NA
5	0.060	2cseW	0.399	5.91	0.068	0.663	3.6.4.13	NA
6	0.060	3b9jJ	0.321	5.61	0.086	0.496	1.17.1.4,1.17.3.2	156
7	0.060	1ue8A	0.404	5.42	0.050	0.616	1.14.-.-	82
8	0.060	1g8kA	0.400	6.54	0.051	0.721	1.20.98.1	NA
9	0.060	1kqfA	0.410	6.32	0.053	0.717	1.2.1.2	NA
10	0.060	1fo4A	0.435	6.40	0.050	0.754	1.17.1.4	NA
11	0.060	1qmgA	0.416	6.04	0.045	0.696	1.1.1.86	NA
12	0.060	1yrlA	0.409	5.94	0.079	0.670	1.1.1.86	NA
13	0.060	3fr8B	0.409	6.15	0.063	0.696	1.1.1.86	NA
14	0.060	2iukB	0.403	5.74	0.015	0.616	1.13.11.12	NA
15	0.060	2yyjA	0.402	6.16	0.041	0.677	1.14.13.3	NA
16	0.060	1ti2A	0.391	6.82	0.049	0.725	1.97.1.2	NA
17	0.060	1fl2A	0.286	6.90	0.062	0.533	1.8.1.-	NA
18	0.060	2wm4A	0.397	5.20	0.054	0.587	1.14.-.-	82
19	0.060	2e1qA	0.428	6.28	0.035	0.754	1.17.3.2,1.17.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.12	0.698	3.96	0.08	0.86	4zp0A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006855 GO:0015238 GO:0015385 GO:0015386 GO:0016020 GO:0016021 GO:0030641 GO:0035725 GO:0046677 GO:0055085 GO:0071805
1	0.07	0.622	4.59	0.05	0.83	4ldsA	GO:0005215 GO:0006810 GO:0016020 GO:0016021 GO:0022857 GO:0022891 GO:0055085
2	0.07	0.609	4.36	0.07	0.81	4j05A	GO:0005215 GO:0016020 GO:0016021 GO:0022857 GO:0055085
3	0.07	0.579	4.76	0.05	0.80	4q65A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0006857 GO:0015031 GO:0015197 GO:0015333 GO:0015833 GO:0015992 GO:0016020 GO:0016021 GO:0042936 GO:0042938
4	0.07	0.556	4.63	0.07	0.77	2gfpA	GO:0005886 GO:0006810 GO:0006855 GO:0015238 GO:0015893 GO:0016020 GO:0016021 GO:0055085
5	0.07	0.577	4.02	0.07	0.73	4ja4A	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015293 GO:0015519 GO:0015753 GO:0016020 GO:0016021 GO:0022857 GO:0022891 GO:0055085
6	0.07	0.606	4.20	0.05	0.79	5eqgA	GO:0000139 GO:0001939 GO:0005215 GO:0005355 GO:0005622 GO:0005737 GO:0005829 GO:0005886 GO:0005887 GO:0005901 GO:0005911 GO:0005989 GO:0006461 GO:0006810 GO:0006970 GO:0008643 GO:0015758 GO:0016020 GO:0016021 GO:0016323 GO:0016324 GO:0019852 GO:0019900 GO:0022857 GO:0022891 GO:0030496 GO:0030864 GO:0031982 GO:0033300 GO:0042149 GO:0042470 GO:0042802 GO:0042908 GO:0042910 GO:0043621 GO:0045121 GO:0050796 GO:0055056 GO:0055085 GO:0070062 GO:0070837 GO:0072562 GO:1904659
7	0.07	0.609	4.47	0.07	0.81	4gbyA	GO:0005215 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015293 GO:0015519 GO:0015753 GO:0016020 GO:0016021 GO:0022857 GO:0022891 GO:0055085
8	0.07	0.505	3.72	0.08	0.65	4yb9D	GO:0003044 GO:0005215 GO:0005353 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0009750 GO:0015755 GO:0016020 GO:0016021 GO:0016324 GO:0022857 GO:0022891 GO:0042383 GO:0055085 GO:0070061 GO:0071332 GO:1990539
9	0.07	0.598	4.33	0.07	0.79	4zw9A	GO:0005215 GO:0005355 GO:0005536 GO:0005886 GO:0005887 GO:0005975 GO:0006810 GO:0008643 GO:0015758 GO:0016020 GO:0016021 GO:0019852 GO:0022857 GO:0022891 GO:0033300 GO:0055056 GO:0055085 GO:0070062 GO:0070837 GO:1904659
10	0.07	0.598	4.15	0.05	0.79	4ybqB	GO:0003044 GO:0005215 GO:0005353 GO:0005355 GO:0005886 GO:0005887 GO:0006810 GO:0008643 GO:0015755 GO:0015758 GO:0016020 GO:0016021 GO:0016324 GO:0022857 GO:0022891 GO:0042383 GO:0055085 GO:0070061 GO:0071332 GO:1904659 GO:1990539
11	0.06	0.306	6.81	0.05	0.57	3fhdA	GO:0003677 GO:0004518 GO:0004527 GO:0046872 GO:0090305
12	0.06	0.287	6.26	0.06	0.50	1z6aA	GO:0004386 GO:0005524
13	0.06	0.303	5.10	0.06	0.43	1q90B	GO:0005506 GO:0009055 GO:0009507 GO:0009535 GO:0009536 GO:0009579 GO:0015979 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0045158 GO:0046872 GO:0055114
14	0.06	0.258	6.80	0.05	0.48	2rirE	GO:0016491 GO:0030435 GO:0055114
15	0.06	0.207	5.62	0.07	0.33	3fb3B	GO:0004343 GO:0006044 GO:0006048 GO:0008080 GO:0016740 GO:0020015
16	0.06	0.239	6.55	0.07	0.43	4prsB	GO:0004970 GO:0016020 GO:0035235
17	0.06	0.291	6.62	0.03	0.52	1mwuB	GO:0008658 GO:0046677
18	0.06	0.192	4.81	0.06	0.28	2jxnA	GO:0003677 GO:0010421

Consensus prediction of GO terms

Molecular Function	GO:0022857	GO:0090484
GO-Score	0.36	0.36
Biological Processes	GO:0044763	GO:0015893
GO-Score	0.57	0.36
Cellular Component	GO:0031226	GO:0016021
GO-Score	0.36	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.