I-TASSER results

I-TASSER results for job id Rv2125

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (292 residues)
MTPSEGNAPLPELHNTVVVAAFEGWNDAGDAAGDAVAHLAASWQALPIVEIDDEAYYDYQ
VNRPVIRQVDGVTRELQWPAMRISHCRPPGSDRDVVLMCGVEPNMRWRTFCDELLAVIDK
LNVDTVVILGALLADTPHTRPVPVSGAAYSAASARQFGLQETRYEGPTGIAGVFQSACVG
AGIPAVTFWAAVPHYVSHPPNPKATIALLRRVEDVLDVEVPLADLPAQAEAWEREITETI
AEDHELAEYVQTLEQHGDAAVDMNEALGNIDGDALAAEFERYLRRRRPGFGR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTPSEGNAPLPELHNTVVVAAFEGWNDAGDAAGDAVAHLAASWQALPIVEIDDEAYYDYQVNRPVIRQVDGVTRELQWPAMRISHCRPPGSDRDVVLMCGVEPNMRWRTFCDELLAVIDKLNVDTVVILGALLADTPHTRPVPVSGAAYSAASARQFGLQETRYEGPTGIAGVFQSACVGAGIPAVTFWAAVPHYVSHPPNPKATIALLRRVEDVLDVEVPLADLPAQAEAWEREITETIAEDHELAEYVQTLEQHGDAAVDMNEALGNIDGDALAAEFERYLRRRRPGFGR
Prediction	CCCCCCCCCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCCCCCEEEEHCCEEEEEHCCCEEEEEEHCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCEEEEHCCCHHHHHHCCCCCCCHCCHCCHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
Conf.Score	9866567787667897899985886556599999999999997997899997676555667898599988978888678779999976899975899986899757999999999999998998899984656888876675689975898898755877665566457999999999998998799999867656789998999999999999989988989999999999999999999859999999999999987554566778899999999999999997899999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTPSEGNAPLPELHNTVVVAAFEGWNDAGDAAGDAVAHLAASWQALPIVEIDDEAYYDYQVNRPVIRQVDGVTRELQWPAMRISHCRPPGSDRDVVLMCGVEPNMRWRTFCDELLAVIDKLNVDTVVILGALLADTPHTRPVPVSGAAYSAASARQFGLQETRYEGPTGIAGVFQSACVGAGIPAVTFWAAVPHYVSHPPNPKATIALLRRVEDVLDVEVPLADLPAQAEAWEREITETIAEDHELAEYVQTLEQHGDAAVDMNEALGNIDGDALAAEFERYLRRRRPGFGR
Prediction	7555547442461530000000311220030031004101741724300202062012133421201035432441421401011033475620000000111433034004200400571604200000002152434343302010435521671624445120101000100310453604000000001100133711500230041027117060427504630551254045126627403510530064225445466745323044004201500473587858
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCCCCCEEEEHCCEEEEEHCCCEEEEEEHCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCEEEEHCCCHHHHHHCCCCCCCHCCHCCHHHHHHHHHHHHCCCEEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCC
MTPSEGNAPLPELHNTVVVAAFEGWNDAGDAAGDAVAHLAASWQALPIVEIDDEAYYDYQVNRPVIRQVDGVTRELQWPAMRISHCRPPGSDRDVVLMCGVEPNMRWRTFCDELLAVIDKLNVDTVVILGALLADTPHTRPVPVSGAAYSAASARQFGLQETRYEGPTGIAGVFQSACVGAGIPAVTFWAAVPHYVSHPPNPKATIALLRRVEDVLDVEVPLADLPAQAEAWEREITETIAEDHELAEYVQTLEQHGDAAVDMNEALGNIDGDALAAEFERYLRRRRPGFGR

2wamA

0.27

0.26

0.96

2.79

MUSTER

MYELEFPAPSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDAQE------NRSLGAEFERFLAQQAE----

2wamA

0.26

0.25

0.96

4.60

dPPAS

LEFPAPQLSSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDA------QENRSLGAEFERFLAQQAE----

2wamA

0.27

0.26

0.96

4.83

wdPPAS

MYELEFPASSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDA------QENRSLGAEFERFLAQQAE----

2wamA

0.27

0.26

0.96

3.33

wMUSTER

MYELEFPASSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDA------QENRSLGAEFERFLAQQAE----

2wamA

0.27

0.26

0.96

4.52

wPPAS

MYELEFPASSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDA------QENRSLGAEFERFLAQQAE----

2wamA

0.26

0.25

0.96

9.59

dPPAS2

LEFPAPQLSSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDA------QENRSLGAEFERFLAQQAE----

2wamA

0.27

0.26

0.96

4.11

PPAS

MYELEFPASSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDA------QENRSLGAEFERFLAQQAE----

2wamA

0.27

0.26

0.96

5.00

Env-PPAS

MYELEFPASSSDGRGPVLVHALEGFSDAGHAIRLAAAHLKAALDTELVASFAIDELLDYRSRRPLMTFKTDHFTHSDDPELSLYALR-DSIGTPFLLLAGLEPDLKWERFITAVRLLAERLGVRQTIGLGTVPMAVPHTRPITMTAHSNNRELISDFQPSISEIQVPGSASNLLEYRMAQHGHEVVGFTVHVPHYLTQTDYPAAAQALLEQVAKTGSLQLPLAVLAEAAAEVQAKIDEQVQASAEVAQVVAALERQYDAFIDA------QENRSLGAEFERFLAQQAE----

2p90B

0.25

0.23

0.92

2.67

MUSTER

MYELEYPSPGQTAGGPTLIVALQGYADAGHAVESSSSHLMDALDHRLIASFNNDELIDYRSRRPVVVIEHNEVTSMDELNLGLHVVR-DNDNKPFLMLSGPEPDLRWGDFSNAVVDLVEKFGVENTICLYAAPMTVPHTRPTVVTAHGNSTDRLKDQVSLDTRMTVPGSASLMLEKLLKDKGKNVSGYTVHVPHYVSASPYPAATLKLLQSIADSADLNLPLLALERDAEKVHRQLMEQTEESSEIQRVVGALEQQYDSELERYRNRHP-----------------------

2p90B

0.24

0.22

0.92

4.44

dPPAS

LEYPSPEVSGQTAGGPTLIVALQGYADAGHAVESSSSHLMDALDHRLIASFNNDELIDYRSRRPVVVIEHNEVTSMDELNLGLHVVR-DNDNKPFLMLSGPEPDLRWGDFSNAVVDLVEKFGVENTICLYAAPMTVPHTRPTVVTAHGNSTDRLKDQVSLDTRMTVPGSASLMLEKLLKDKGKNVSGYTVHVPHYVSASPYPAATLKLLQSIADSADLNLPLLALERDAEKVHRQLMEQTEESSEIQRVVGALEQQYDSELERYRNRHP-----------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.30

Estimated TM-score = 0.89±0.07

Estimated RMSD = 3.5±2.4Å

Download Model 2

C-score=-3.18

Download Model 3

C-score=-4.28

Download Model 4

C-score=-3.79

Download Model 5

C-score=-4.44

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2wamA	0.939	0.99	0.270	0.959
2	2p90B	0.855	1.84	0.246	0.914
3	3e35A	0.797	2.13	0.229	0.866
4	3mnfA	0.706	2.29	0.548	0.770
5	3vr0A	0.651	3.00	0.139	0.760
6	3gaaA	0.593	3.37	0.139	0.702
7	3wz2A	0.590	3.11	0.128	0.692
8	5cxqA	0.509	3.34	0.098	0.616
9	3e0qC	0.504	3.83	0.074	0.630
10	1yqqA	0.502	4.09	0.117	0.640

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	6	3ut6B	PO4	Rep, Mult	22,23,129,130,131,205
2	0.07	4	1v2hE	GUN	Rep, Mult	16,17,96,124,125
3	0.05	3	1ampA	ZN	Rep, Mult	27,102,198
4	0.05	3	3djfC	BC3	Rep, Mult	31,140,141,191,192,193,206,230
5	0.03	2	4zfzA	ZN	Rep, Mult	245,248
6	0.02	1	3uxmC	MG	Rep, Mult	102,235
7	0.02	1	1nquA	RDL	Rep, Mult	187,188
8	0.02	1	2oyyB	HEM	Rep, Mult	225,229
9	0.02	1	2anuA	ZN	Rep, Mult	245,256
10	0.02	1	4mchA	61N	Rep, Mult	38,42,205,206
11	0.02	1	3hq9B	BU3	Rep, Mult	276,280
12	0.02	1	3jsxE	FAD	Rep, Mult	61,77,79
13	0.02	1	3se1A	MG	Rep, Mult	259,262
14	0.02	1	5da5O	CA	Rep, Mult	243,245
15	0.02	1	2f1oD	FAD	Rep, Mult	77,79
16	0.02	1	1jm0D	MN	Rep, Mult	230,233
17	0.02	1	2hawA	MG	Rep, Mult	27,214

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1yw6A	0.459	4.48	0.076	0.627	3.5.1.96	26,79,187
2	0.060	1vhjB	0.473	3.38	0.099	0.579	2.4.2.1	NA
3	0.060	3eueA	0.474	3.86	0.101	0.599	2.4.2.3	NA
4	0.060	1t8rA	0.463	4.07	0.081	0.593	3.2.2.4	NA
5	0.060	1jdvC	0.468	3.44	0.089	0.579	2.4.2.28	NA
6	0.060	1tcuC	0.504	3.82	0.079	0.630	2.4.2.1	NA
7	0.060	1v4nB	0.457	4.01	0.073	0.579	2.4.2.28	NA
8	0.060	1a9oA	0.499	3.91	0.126	0.630	2.4.2.1	38
9	0.060	1yqqA	0.502	4.09	0.117	0.640	2.4.2.1	NA
10	0.060	1qe5B	0.483	3.87	0.066	0.616	2.4.2.1	NA
11	0.060	1jpvA	0.467	3.48	0.089	0.579	2.4.2.28	100
12	0.060	1k3fA	0.466	3.64	0.093	0.586	2.4.2.3	NA
13	0.060	2a8yA	0.460	3.98	0.080	0.582	2.4.2.28	NA
14	0.060	1nc3A	0.463	3.42	0.113	0.558	3.2.2.9	NA
15	0.060	3bl6A	0.457	3.38	0.143	0.551	3.2.2.16	NA
16	0.060	2iscD	0.471	3.42	0.075	0.579	2.4.2.1	NA
17	0.060	3dp9C	0.456	3.44	0.130	0.551	3.2.2.9	NA
18	0.060	2qttA	0.454	3.98	0.125	0.579	3.2.2.16	32
19	0.060	3e0qC	0.504	3.83	0.074	0.630	2.4.2.1	100

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.49	0.939	0.99	0.27	0.96	2wamA	GO:0005886 GO:0006367 GO:0070207
1	0.43	0.855	1.84	0.25	0.91	2p90B	GO:0006367
2	0.39	0.804	2.13	0.23	0.87	3e35A	GO:0006367
3	0.06	0.396	5.78	0.06	0.62	4goxA	GO:0003824 GO:0008152 GO:0016740 GO:0031177
4	0.06	0.325	6.18	0.05	0.52	2ap1A	GO:0000166 GO:0005524 GO:0005975 GO:0006044 GO:0008270 GO:0009254 GO:0016301 GO:0016310 GO:0016740 GO:0045127 GO:0046835 GO:0046872
5	0.06	0.348	5.51	0.04	0.53	2decA	GO:0005975 GO:0030246
6	0.06	0.360	6.42	0.05	0.61	4fuqC	GO:0000166 GO:0003824 GO:0005524 GO:0008152 GO:0016874
7	0.06	0.299	5.45	0.04	0.46	1narA	GO:0004553 GO:0005975
8	0.06	0.341	6.26	0.08	0.58	1iwpA	GO:0003824 GO:0008152 GO:0016829 GO:0016836 GO:0031419 GO:0046405 GO:0050215
9	0.06	0.303	4.42	0.07	0.41	3ewiB	GO:0005634 GO:0005829 GO:0006054 GO:0006055 GO:0008781 GO:0016020 GO:0016740 GO:0016779
10	0.06	0.300	6.51	0.04	0.51	3ezuA
11	0.06	0.279	6.25	0.06	0.47	3istA	GO:0006807 GO:0008152 GO:0008360 GO:0008881 GO:0009252 GO:0016853 GO:0016855 GO:0036361 GO:0071555
12	0.06	0.289	5.07	0.08	0.41	4o6oD	GO:0003677 GO:0006281 GO:0006310 GO:0006974 GO:0046872
13	0.06	0.275	6.09	0.04	0.44	5ee7A	GO:0003796 GO:0003824 GO:0004871 GO:0004888 GO:0004930 GO:0004967 GO:0005085 GO:0005768 GO:0005886 GO:0005887 GO:0006091 GO:0006887 GO:0007165 GO:0007166 GO:0007186 GO:0007188 GO:0007189 GO:0007584 GO:0008152 GO:0008217 GO:0009253 GO:0009755 GO:0016020 GO:0016021 GO:0016787 GO:0016798 GO:0016998 GO:0017046 GO:0019076 GO:0019835 GO:0030430 GO:0042593 GO:0042594 GO:0042742 GO:0043547 GO:0070873 GO:0071377
14	0.06	0.318	4.78	0.08	0.44	2ohoA	GO:0006807 GO:0008152 GO:0008360 GO:0008881 GO:0009252 GO:0016853 GO:0016855 GO:0036361 GO:0071555
15	0.06	0.239	5.74	0.07	0.37	4uucA	GO:0005622 GO:0016567 GO:0035556
16	0.06	0.215	5.37	0.05	0.32	4v6iBs	GO:0000027 GO:0002181 GO:0003735 GO:0005622 GO:0005737 GO:0005840 GO:0022625 GO:0030529 GO:0030687 GO:0042254 GO:0070180
17	0.06	0.212	6.68	0.07	0.38	4djmD	GO:0030288 GO:0042597 GO:0043711 GO:0061077 GO:0071555
18	0.06	0.224	5.61	0.05	0.35	4stdA	GO:0006582 GO:0016829 GO:0030411 GO:0042438 GO:0043581

Consensus prediction of GO terms

Molecular Function	GO:0008270	GO:0045127	GO:0005524	GO:0031177
GO-Score	0.06	0.06	0.06	0.06
Biological Processes	GO:0006367	GO:0070207
GO-Score	0.82	0.49
Cellular Component	GO:0005886
GO-Score	0.49

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.