I-TASSER results

I-TASSER results for job id Rv2083

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (314 residues)
MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFGLSTNADLGGANADIEG
DDTDRRAHAADAARKFSANEANAAEQMQGVGAQGMAQMASGIGGALSGALGGVMGPLTQL
PQQAMQAGQGAMQPLMSAMQQAQGADGLAAVDGARLLDSIGGEPGLGSGAGGGDVGGGGA
GGTTPTGYLGPPPVPTSSPPTTPAGAPTKSATMPPPGGASPASAHMGAAGMPMVPPGAMG
ARGEGSGQEKPVEKRLTAPAVPNGQPVKGRLTVPPSAPTTKPTDGKPVVRRRILLPEHKD
FGRIAPDEKTDAGE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFGLSTNADLGGANADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGMAQMASGIGGALSGALGGVMGPLTQLPQQAMQAGQGAMQPLMSAMQQAQGADGLAAVDGARLLDSIGGEPGLGSGAGGGDVGGGGAGGTTPTGYLGPPPVPTSSPPTTPAGAPTKSATMPPPGGASPASAHMGAAGMPMVPPGAMGARGEGSGQEKPVEKRLTAPAVPNGQPVKGRLTVPPSAPTTKPTDGKPVVRRRILLPEHKDFGRIAPDEKTDAGE
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCC
Conf.Score	98778898888888889999999899989999898899888888889999999888888899988998899888899999988888889999999888888888888888888999888999999999888899998888898888889999988888889999999999988899999999999988999999999999999999998999999999999999999999999999888999999999999888888999999998888878999999999999998766655589988787778877777889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFGLSTNADLGGANADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGMAQMASGIGGALSGALGGVMGPLTQLPQQAMQAGQGAMQPLMSAMQQAQGADGLAAVDGARLLDSIGGEPGLGSGAGGGDVGGGGAGGTTPTGYLGPPPVPTSSPPTTPAGAPTKSATMPPPGGASPASAHMGAAGMPMVPPGAMGARGEGSGQEKPVEKRLTAPAVPNGQPVKGRLTVPPSAPTTKPTDGKPVVRRRILLPEHKDFGRIAPDEKTDAGE
Prediction	75415332642442444244443364433443343143433223342344335643634554474635335334524455563355254244533432343244344334323243344345534634543253434324434345335345444234434554524444434434434444432444332343446444443443445444444544444464543342234232333245365365653465414243155344143334332534336437343203220200555521432456546678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHCCCCCCCCCCCCCCCCCCCCC
MTSIESHPEQYWAAAGRPGPVPLALGPVHPGGPTLIDLLMALFGLSTNADLGGANADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVGAQGMAQMASGIGGALSGALGGVMGPLTQLPQQAMQAGQGAMQPLMSAMQQAQGADGLAAVDGARLLDSIGGEPGLGSGAGGGDVGGGGAGGTTPTGYLGPPPVPTSSPPTTPAGAPTKSATMPPPGGASPASAHMGAAGMPMVPPGAMGARGEGSGQEKPVEKRLTAPAVPNGQPVKGRLTVPPSAPTTKPTDGKPVVRRRILLPEHKDFGRIAPDEKTDAGE

3jacA1

0.18

0.98

1.67

MUSTER

------GGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

5gaoE

0.15

1.00

1.94

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKE

3jacA1

0.18

0.17

0.94

2.40

wdPPAS

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-----------------

1vt4I3

0.18

1.00

3.13

wMUSTER

GGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG

3jacA1

0.18

0.17

0.96

4.23

wPPAS

------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG----GGGGGGGGGG

3jacA1

0.18

0.17

0.94

4.10

dPPAS2

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-----------------

3jacA1

0.18

0.97

4.21

PPAS

------GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG--GGGGGGGGGGGGG

3jacA1

0.17

1.00

1.44

Env-PPAS

GGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGGG-GGGGGGGGGGGG

5gaoE

0.15

1.00

1.57

MUSTER

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQK

4nl6A

0.10

0.09

0.94

1.86

dPPAS

------MAMSSGGSGGGVPEQEDSVLFRRGTGQSDDSDIWDDTALIKAYDKAVASFKHALKNGDICETSGKPKTTPKRKPAKKNKSQKKNTAASLQQWKVGDKCSAIWSEDGCIYPATIASIDFKRETCVVVYTGYGNREEQNLSDLLSPICEVANNIEQNAQENENESQVSTDESENSRSPGNKSDNIKPKSAPWNSFLPPPPPMPGPRLGPGKPGLKFNGPPPPPPPPPPHLLSCWLPPFPSGPPIIPPPPPICPDSLDDADALGSMLISWYMSGYHTGYYMGFRQNQKEGRCSHSLN--------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.14

Estimated TM-score = 0.36±0.12

Estimated RMSD = 13.9±3.9Å

Download Model 2

C-score=-2.82

Download Model 3

C-score=-3.58

Download Model 4

C-score=-3.46

Download Model 5

C-score=-4.33

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3jacA1	0.689	3.76	0.151	0.838
2	3hz3A	0.389	6.43	0.046	0.659
3	4w6vA	0.381	6.34	0.060	0.624
4	2yevA	0.380	6.15	0.066	0.608
5	4wgkA	0.373	6.65	0.043	0.653
6	2uv9D	0.369	6.57	0.060	0.634
7	4ikvA	0.369	6.42	0.054	0.605
8	4q65A	0.369	6.41	0.049	0.602
9	4zhjA	0.368	6.41	0.057	0.624
10	2h3wA	0.368	6.34	0.046	0.596

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	2ckjC	FES	Rep, Mult	84,85,89,91,103,106,107
2	0.04	2	2ckjA	FES	Rep, Mult	81,82,83,84,86,88,91,93
3	0.04	2	3wubA	ZN	Rep, Mult	64,68
4	0.04	2	4il6H	CLA	Rep, Mult	35,39,42
5	0.04	2	1vdfB	CL	Rep, Mult	35,38
6	0.04	2	2ckjB	FES	Rep, Mult	162,164,166,167,169
7	0.02	1	1yklG	DHB	Rep, Mult	190,191
8	0.02	1	1c9uB	CA	Rep, Mult	190,191,289
9	0.02	1	1fbmD	RTL	Rep, Mult	28,35
10	0.02	1	2vqgA	ZN	Rep, Mult	57,61
11	0.02	1	3vh7E	MG	Rep, Mult	26,29
12	0.02	1	1cq1A	CA	Rep, Mult	180,190,191
13	0.02	1	3ucpA	MG	Rep, Mult	160,163,166
14	0.02	1	1yo8A	CA	Rep, Mult	244,246,253,255
15	0.02	1	3l36A	DTR	Rep, Mult	43,44
16	0.02	1	1aklA	CA	Rep, Mult	203,204,205,207,217,218,219,222
17	0.02	1	1satA	CA	Rep, Mult	259,260,261,263,284
18	0.02	1	3zvwC	MG	Rep, Mult	251,252
19	0.02	1	2z8xA	CA	Rep, Mult	169,170,171,178,179,180,183

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jC	0.342	6.19	0.016	0.564	1.17.3.2,1.17.1.4	NA
2	0.060	1q16A	0.369	7.16	0.063	0.685	1.7.99.4	NA
3	0.060	3lxuX	0.339	6.71	0.036	0.589	3.4.14.10	NA
4	0.060	2np0A	0.359	6.27	0.055	0.592	3.4.24.69	NA
5	0.060	1fo4A	0.351	6.36	0.018	0.586	1.17.1.4	NA
6	0.060	2fy3A	0.345	6.55	0.051	0.586	2.3.1.6	NA
7	0.060	3cskA	0.340	6.76	0.042	0.589	3.4.14.4	NA
8	0.060	2occN	0.326	5.39	0.038	0.478	1.9.3.1	147,153
9	0.060	1jqnA	0.340	6.55	0.018	0.586	4.1.1.31	NA
10	0.060	1t3tA	0.343	6.56	0.036	0.583	6.3.5.3	55,59
11	0.060	2vuaA	0.272	6.17	0.034	0.440	3.4.24.69	NA
12	0.060	2uv8G	0.348	6.74	0.037	0.605	2.3.1.86	NA
13	0.060	3ikmD	0.336	6.48	0.051	0.570	2.7.7.7	150
14	0.060	1m56A	0.336	5.67	0.047	0.510	1.9.3.1	NA
15	0.060	3hhsA	0.346	6.42	0.027	0.580	1.14.18.1	NA
16	0.060	2axqA	0.338	6.79	0.054	0.599	1.5.1.10	NA
17	0.060	1occA	0.334	5.65	0.050	0.500	1.9.3.1	59
18	0.060	1gthA	0.361	7.20	0.040	0.681	1.3.1.2	NA
19	0.060	1t7nA	0.366	6.07	0.041	0.586	2.3.1.7	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.345	7.30	0.03	0.65	3aibC	GO:0005576 GO:0005975 GO:0009250 GO:0016740 GO:0016757 GO:0046527 GO:0047849
1	0.06	0.332	7.11	0.03	0.61	4aygA	GO:0005975 GO:0009250 GO:0016740 GO:0016757 GO:0046527 GO:0046872 GO:0047849
2	0.06	0.303	6.26	0.04	0.50	5d3qB	GO:0000166 GO:0001917 GO:0002031 GO:0003924 GO:0005525 GO:0005737 GO:0005794 GO:0005856 GO:0005874 GO:0005886 GO:0006897 GO:0006898 GO:0007032 GO:0007605 GO:0008021 GO:0008022 GO:0008344 GO:0016787 GO:0019901 GO:0030117 GO:0031623 GO:0031749 GO:0032403 GO:0042802 GO:0043196 GO:0043209 GO:0043234 GO:0044822 GO:0045202 GO:0046983 GO:0048013 GO:0050998 GO:0051262 GO:0051932 GO:0070062 GO:0072583 GO:1901998 GO:1903423
3	0.06	0.370	6.79	0.04	0.66	4amcA	GO:0005975 GO:0009250 GO:0016740 GO:0016757 GO:0046527 GO:0046872 GO:0047849
4	0.06	0.261	7.00	0.04	0.47	5do8B	GO:0003824 GO:0005975
5	0.06	0.319	7.26	0.04	0.61	3ttoA	GO:0005975 GO:0009250 GO:0016740 GO:0016757 GO:0046527 GO:0046872 GO:0047849
6	0.06	0.266	6.08	0.05	0.42	3k1dA	GO:0003824 GO:0003844 GO:0004553 GO:0005886 GO:0005975 GO:0005977 GO:0005978 GO:0009250 GO:0016740 GO:0016757 GO:0040007 GO:0043169 GO:0045227
7	0.06	0.275	6.76	0.04	0.47	2h0vA	GO:0008127 GO:0016491 GO:0046872 GO:0051213 GO:0055114
8	0.06	0.281	6.37	0.04	0.47	3ueqA	GO:0003824 GO:0005576 GO:0005975 GO:0016740 GO:0016757 GO:0047669
9	0.06	0.230	6.55	0.04	0.39	2bibA	GO:0046872
10	0.06	0.237	6.89	0.03	0.43	5e70B	GO:0003824 GO:0003844 GO:0004553 GO:0005975 GO:0005977 GO:0005978 GO:0016740 GO:0016757 GO:0043169
11	0.06	0.270	6.49	0.06	0.46	1jdaA	GO:0003824 GO:0005576 GO:0005975 GO:0005983 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0033910 GO:0043169 GO:0046872 GO:2001070
12	0.06	0.283	6.81	0.04	0.49	5e70C	GO:0003824 GO:0003844 GO:0004553 GO:0005975 GO:0005977 GO:0005978 GO:0016740 GO:0016757 GO:0043169
13	0.06	0.230	6.21	0.01	0.39	5a2aA	GO:0003824 GO:0004556 GO:0005975 GO:0008152 GO:0016020 GO:0016021 GO:0016787 GO:0016798
14	0.06	0.269	6.55	0.04	0.44	3bsgA	GO:0003824 GO:0004556 GO:0005509 GO:0005576 GO:0005615 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0043169 GO:0046872
15	0.06	0.232	7.22	0.04	0.44	3bh4A	GO:0003824 GO:0004553 GO:0004556 GO:0005509 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046872
16	0.06	0.224	7.19	0.02	0.41	1hvxA	GO:0003824 GO:0004553 GO:0004556 GO:0005509 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046872
17	0.06	0.255	6.99	0.06	0.47	4h8vA	GO:0003824 GO:0005975 GO:0046872
18	0.06	0.250	6.90	0.05	0.45	4z7cA	GO:0000166 GO:0004163 GO:0005524 GO:0005829 GO:0006629 GO:0008299 GO:0016829 GO:0016831 GO:0019287

Consensus prediction of GO terms

Molecular Function	GO:0016758
GO-Score	0.36
Biological Processes	GO:0033692	GO:0006073
GO-Score	0.36	0.36
Cellular Component	GO:0008021	GO:0005794	GO:0043196	GO:0005874	GO:0005886	GO:0030117	GO:0001917	GO:0070062	GO:0043209
GO-Score	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.