I-TASSER results

I-TASSER results for job id Rv2082

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (721 residues)
MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEANDLRNERSLLAVNQGR
TADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYLRDRLTEIAQSGNQQINQILA
GKGPIEAKVAAVNAVIEQSNAMADHVGATAMSNIIDATQRVFDETIGGDAHTWLRDHGVS
LDTPARPRPVTAEDMTSMTANSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMV
LSSSSTSSGPPTAPTPTSPFGTAPMPPGPPPPGTVSPPLPPSAPAVGVGGPSVPAAGMPP
AAAAATAPLSPQSLGQSFTTGMTTGTPAAAGAQALSAGALHAATEPLPPPAPPPTTPTVT
TPTVATATTAGIPHIPDSAPTPSPAPIAPPTTDNASAMTPIAPMVANGPPASPAPPAAAP
AGPLPAYGADLRPPVTTPPATPPTPTGPISGAAVTPSSPAAGGSLMSPVVNKSTAPATTQ
AQPSNPTPPLASATAAATTGAAAGDTSRRAAEQQRLRRILDTVARQEPGLSWAAGLRDNG
QTTLLVTDLASGWIPPHIRLPAHITLLEPAPRRRHATVTDLLGTTTVAAAHHPHGYLSQP
DPDTPALTGDRTARIAPTIDELGPTLVETVRRHDTLPPIAQAVVVAATRNYGVPDNETDL
LHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAINALIAGDQSGANYHLAWAIAAISTRRS
R

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEANDLRNERSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYLRDRLTEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATAMSNIIDATQRVFDETIGGDAHTWLRDHGVSLDTPARPRPVTAEDMTSMTANSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMVLSSSSTSSGPPTAPTPTSPFGTAPMPPGPPPPGTVSPPLPPSAPAVGVGGPSVPAAGMPPAAAAATAPLSPQSLGQSFTTGMTTGTPAAAGAQALSAGALHAATEPLPPPAPPPTTPTVTTPTVATATTAGIPHIPDSAPTPSPAPIAPPTTDNASAMTPIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPTPTGPISGAAVTPSSPAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASATAAATTGAAAGDTSRRAAEQQRLRRILDTVARQEPGLSWAAGLRDNGQTTLLVTDLASGWIPPHIRLPAHITLLEPAPRRRHATVTDLLGTTTVAAAHHPHGYLSQPDPDTPALTGDRTARIAPTIDELGPTLVETVRRHDTLPPIAQAVVVAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAINALIAGDQSGANYHLAWAIAAISTRRSR
Prediction	CCCCCCCCCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
Conf.Score	9888999887534546789998756778899999999999999999987887665566655778888777778888888777666776665555677888777777654555677787668888876666666544457888788888887777767777788888999988888889999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999998999999999999999887767777777788998777888999998765567899888998888898875678888888888877888877777789998888899999988888888778888777875444456788888567777655678877676568889999999999999877888888998889999998876587554445678999998655679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEANDLRNERSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYLRDRLTEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATAMSNIIDATQRVFDETIGGDAHTWLRDHGVSLDTPARPRPVTAEDMTSMTANSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMVLSSSSTSSGPPTAPTPTSPFGTAPMPPGPPPPGTVSPPLPPSAPAVGVGGPSVPAAGMPPAAAAATAPLSPQSLGQSFTTGMTTGTPAAAGAQALSAGALHAATEPLPPPAPPPTTPTVTTPTVATATTAGIPHIPDSAPTPSPAPIAPPTTDNASAMTPIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPTPTGPISGAAVTPSSPAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASATAAATTGAAAGDTSRRAAEQQRLRRILDTVARQEPGLSWAAGLRDNGQTTLLVTDLASGWIPPHIRLPAHITLLEPAPRRRHATVTDLLGTTTVAAAHHPHGYLSQPDPDTPALTGDRTARIAPTIDELGPTLVETVRRHDTLPPIAQAVVVAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAINALIAGDQSGANYHLAWAIAAISTRRSR
Prediction	7433125240000000010113542142013104411432453044134244333334032022004312410430241053043345324402401330343145235413530441246444254414422221432623143134422442252324225453434234323534143741322423446434444444344334434434244344444224424244244443222344434444243232442442434234433244443323343243443424314344234234444234144334343444443314225243323434434443344444334424344144434242232444433242434343243343245243221423523234242444414424244444351444423432241432444434414433442433424444344434443312222232222222322222234344442545304301421333401011011326523211000322200000002114202203144534424134112342431324233203524364224444442353341552123004104242402300210040024411114421300331044013300330241313000100000002011442420010000001000334468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720

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Sec.Str
Seq

CCCCCCCCCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
MAGDLPPGRWSALLVGAWWPARPDAPMAGVTYWRKAAQLKRNEANDLRNERSLLAVNQGRTADDLLERYWRGEQRLATIAHQCEVKSDQSEQVADAVNYLRDRLTEIAQSGNQQINQILAGKGPIEAKVAAVNAVIEQSNAMADHVGATAMSNIIDATQRVFDETIGGDAHTWLRDHGVSLDTPARPRPVTAEDMTSMTANSPAGSPFGAAPSAPSHSTTTSGPPTAPTPTSPFGTAPMVLSSSSTSSGPPTAPTPTSPFGTAPMPPGPPPPGTVSPPLPPSAPAVGVGGPSVPAAGMPPAAAAATAPLSPQSLGQSFTTGMTTGTPAAAGAQALSAGALHAATEPLPPPAPPPTTPTVTTPTVATATTAGIPHIPDSAPTPSPAPIAPPTTDNASAMTPIAPMVANGPPASPAPPAAAPAGPLPAYGADLRPPVTTPPATPPTPTGPISGAAVTPSSPAAGGSLMSPVVNKSTAPATTQAQPSNPTPPLASATAAATTGAAAGDTSRRAAEQQRLRRILDTVARQEPGLSWAAGLRDNGQTTLLVTDLASGWIPPHIRLPAHITLLEPAPRRRHATVTDLLGTTTVAAAHHPHGYLSQPDPDTPALTGDRTARIAPTIDELGPTLVETVRRHDTLPPIAQAVVVAATRNYGVPDNETDLLHHKTTEIHQAVLTTYPNHDIATVVDWMLLAAINALIAGDQSGANYHLAWAIAAISTRRSR

5a1uG

0.09

0.97

1.71

MUSTER

NGEKLPGL--LMTIIRFVLPLQDHTIKKLLVFWEIVPKTTPDGRLLHEMRKDLQHPNEGSTLRFLCKKEAELLEPLMPAIRACLEHRHSRRNAVLAIYTIYRNFEHLIPDAPELIHDFLVNEKDASCKRNAFMMLIHADQDRALDYLSTCIDQVQTFGDILQLVIVELIYKVCHANPSERARFIRCIYNLLQSSSPAVKYEAAGTLVTLSSAPTAIKAAAQCYIDLIIKESDNNVKLIVLDRLVELKEHPAHERVLQDLVMDILRVLSTPDLEVRKKTLQLALDLVSSRNVEELVIVLKKEVIKTNNVSEHEDTDKYRQLLVRTLHSCSVRFPDMAANVIPVLMEFLSDSNEAAAADVLEIQRFDNLRMLIVEKMLEVFHAIKSVKIYRGACSTKEDIQSVMTERSLGEIPIVESEIKKEAGELKPEEEITVGPVQKLVTEMGTYATQSALSSSRPTKKEEDRPPFVAASLATTLTKIALRYVALVQEKKKQNSFVAEAMLLMATILHLGKSDPVYAEAYVHVNQYDIVLDVLVVNQTSDTLQNCTLELATLGDLKLVEKPSPLTLAPHDFANIKANVKVASTENGIIFGNIVYDVSGAASDRNCVV---LSDIHIDIMDYIQPATCTDAEFRQMWAEFE----NKVTVNTNMTD-LNDYLQHILKSTNMKCLT--PEKALSGYCGFM-LYAR---IFGEDALAN-------VSIEKPVHQ

3chnS

0.07

0.06

0.77

1.94

dPPAS

---------------------------------------------------------------------------------------------------------KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGSSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDALTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIR-----------------------------------------------------------

5gaoE

0.19

0.09

0.47

1.79

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4bedB

0.11

0.98

1.77

wMUSTER

TKRDINRDRLFQGSTKTHHNWFIEQALLALEQYCDFEVQFEIMHNGVHTWGGKEPYGIGHQTDRIWAIWQSLQRFRGLSGSEANCAVNLMKTPEDTFDYQK-SIRGIDHIVRNRQEHFAGFLLEGFGTSATVDFQVCRTAGDCEDAGYFTVLGGEKEMPWAFDRLYKYDITETLDKMNLRHDEIFQIEVTITSYDGTVLDSGLIPTPSIIYDPAHHDISSHHLSLNK-TLSERADTSADGFAAIASFHGLPAKCNDSHNNEVACCIHGMPRHGSSVAVPYWDWTKPIHNIPHLFTDKEYYDVWRNKVMPNPFARGYVPSHDTYTVRDVQEGLFHLTSTGEHSALLNQALLALEQHDYCDFAVQVGGPQVYSLSSLHYASYDPEKRGLPSDRADCAVSLQNMRPFHYEINHNQFTKKHAVPNDNLEIGGMNLHEIEKVRVFAGFLLHGIRTSADVQFQICKTSEDGGTKEMAWAYNRLITPEDVFHPSEPFFIKVSVTAVNGTVLPASILHAPTIIYEPGLDHHEDHHSSSMAGHGVRKEINTLTTADHGPNGGNPPMCPMPDGKNYSCCTHGMATHGARVGLPYWDGTTAFTALPTFVTDEEDNPFHHGHIDYLGVDTTRSPRDKLFNDPERGSESFFYRQVLLALEQTDFC---QFEVQFEITHNAIHSWTGGLTPYGTLEYTTYDPLFWLHHANTD------RIWAIWQALQEYRGLPY

5gaoE

0.18

0.08

0.47

2.72

wPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.16

0.07

0.47

3.05

dPPAS2

------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.16

0.07

0.47

2.74

PPAS

------------------------------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1elvA

0.07

0.02

0.34

0.61

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LDCGIPESIENGKVEDPESTLFGSVIRYTCEEPYYYMEGGGEYHCAGNGSWVNEVLGPELPKCVPVCGVPRE-PFIIGGSDADIKNFPWQVFFDNPWHVVEGNREPTMYVGSTSVQKMLTPEHVFIHPGWKLLAVPEGRTNFDNDKDPVKMGPTVSPICLPGTSSDYNLMDGDLGLISGRTEKRDRAV----RLKARLPVAPLRKCKEVAYV----FTPNMICAGGEKFAVQDPNDKKNYVDWIMKTMQE-NS-

5a1uE

0.09

0.08

0.99

1.71

MUSTER

QGEHLGTTEATEAFFAMTKLFQSNDPTLTIKEMSCIAEDVIIVTSSLTK-TGKEDNYRGPAVRALCQTDSTMLQAVERYMKQAIVDKVPSSSALVSSLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLYHVRKNDRLAVSKMISKFTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRSFMSEISDEFKVVVVQAISALCQKYPRKHAVEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDCEFTVLATRQEGPKTNNPSKYIRFIYNRVVLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEEQKQKALNAGYILNGLTVSIPGLEKALQQYTLEPSQPEKVAATRQEIFQEQLAAVPEFQGLGPLFKSSPEPVALTESETEYVIRCTKHTFSDHLVFQFDCTNTLNDQTLENVTVQMEPTEAYEVLSYVPARSLPYNQPGTCYTLVALPTEDPTAVACTFSCVMKFTVKDCDPNTGEIDEEGYEVLEDLEVTVADHIQKVMKVGDEFEKEETFTLSTIKTLEEAVGNI---VKFLGMHPCERSDKVPENKNTHTLLLAGV--FRGGHDILVRSRLL-LLDTVTMQRSS

3cm9S

0.07

0.06

0.77

1.94

dPPAS

---------------------------------------------------------------------------------------------------------KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGSSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDALTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIR-----------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.89

Estimated TM-score = 0.60±0.14

Estimated RMSD = 10.2±4.6Å

Download Model 2

C-score=-1.03

Download Model 3

C-score=-3.18

Download Model 4

C-score=-3.55

Download Model 5

C-score=-3.78

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5a1uG	0.924	2.52	0.080	0.974
2	3a6pA	0.435	7.01	0.040	0.619
3	1w63C	0.400	6.09	0.043	0.535
4	3icqT	0.396	7.09	0.031	0.571
5	4fgvA	0.394	7.87	0.033	0.613
6	5ganJ	0.392	7.45	0.041	0.591
7	3m1iC	0.387	7.32	0.042	0.560
8	1qbkB	0.386	6.99	0.045	0.542
9	1u6gC	0.384	6.27	0.050	0.512
10	2jktA	0.383	6.65	0.042	0.539

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	3cmvC	ANP	Rep, Mult	336,337,338,339,342,343,344
2	0.06	3	4elxB	PEG	Rep, Mult	315,316,319
3	0.06	3	1vrgB	BCT	Rep, Mult	290,291,292,293
4	0.04	2	2hzcA	ZN	Rep, Mult	91,95
5	0.04	2	1qozB	NAG	Rep, Mult	676,677,694
6	0.02	1	3kvnA	C8E	Rep, Mult	318,322
7	0.02	1	4eyaB	NUC	Rep, Mult	678,680
8	0.02	1	2vn4A	MAN	Rep, Mult	183,184
9	0.02	1	3hm5A	CA	Rep, Mult	41,46
10	0.02	1	2bptA	III	Rep, Mult	77,78,81,82,110,111,112,113,114,119,141,142
11	0.02	1	2ikfA	MG	Rep, Mult	680,686
12	0.02	1	3cmvE	ANP	Rep, Mult	257,259,260,261,262,287,293
13	0.02	1	1id3H	MN	Rep, Mult	213,214
14	0.02	1	4kegA	MG	Rep, Mult	259,260
15	0.02	1	3htwA	MG	Rep, Mult	48,61
16	0.02	1	2o011	CLA	Rep, Mult	699,700
17	0.02	1	1r4vA	ZN	Rep, Mult	628,655

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jJ	0.148	6.83	0.030	0.214	1.17.1.4,1.17.3.2	330
2	0.060	2vz8A	0.292	8.81	0.031	0.491	2.3.1.85	NA
3	0.060	3ecqB	0.294	8.92	0.043	0.505	3.2.1.97	NA
4	0.060	2vdcA	0.281	8.00	0.032	0.434	1.4.1.13	NA
5	0.060	3b9jI	0.110	5.41	0.094	0.140	1.17.1.4,1.17.3.2	237
6	0.060	1xc6A	0.256	8.33	0.036	0.413	3.2.1.23	266
7	0.060	2vdcF	0.278	8.19	0.030	0.438	1.4.1.13	NA
8	0.060	1ygpA	0.281	8.46	0.046	0.461	2.4.1.1	335
9	0.060	2pdaA	0.282	7.91	0.033	0.437	1.2.7.1	261,499
10	0.060	1vbgA	0.273	8.24	0.054	0.438	2.7.9.1	NA
11	0.060	2pffB	0.285	8.51	0.038	0.467	2.3.1.86	287
12	0.060	2qf7B	0.282	8.04	0.035	0.440	6.4.1.1	NA
13	0.060	2zxqA	0.298	8.66	0.052	0.503	3.2.1.97	223
14	0.060	2qllA	0.269	8.00	0.042	0.423	2.4.1.1	NA
15	0.060	2vz8B	0.276	8.48	0.036	0.449	2.3.1.85	NA
16	0.060	1t3tA	0.281	8.41	0.021	0.461	6.3.5.3	NA
17	0.060	3gpbA	0.276	8.49	0.045	0.454	2.4.1.1	NA
18	0.060	1e1yA	0.275	8.30	0.047	0.447	2.4.1.1	NA
19	0.060	3dsxA	0.232	5.58	0.034	0.301	2.5.1.60	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.924	2.52	0.08	0.97	5a1uG	GO:0000139 GO:0005198 GO:0005737 GO:0005793 GO:0005794 GO:0005798 GO:0005886 GO:0006810 GO:0006886 GO:0006891 GO:0015031 GO:0016020 GO:0016192 GO:0030117 GO:0030126 GO:0030137 GO:0030663 GO:0031410 GO:0043231
1	0.07	0.396	7.09	0.03	0.57	3icqT	GO:0000049 GO:0003723 GO:0005525 GO:0005634 GO:0005635 GO:0005643 GO:0005737 GO:0005829 GO:0006409 GO:0006605 GO:0006810 GO:0008033 GO:0008536 GO:0015932 GO:0016363 GO:0071528
2	0.07	0.435	7.01	0.04	0.62	3a6pA	GO:0000049 GO:0003723 GO:0003729 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0031047 GO:0035281 GO:0042565 GO:0044822 GO:0070883 GO:0090631 GO:1900370
3	0.06	0.382	6.76	0.04	0.54	2jkrA	GO:0005886 GO:0005905 GO:0006810 GO:0006886 GO:0006897 GO:0008289 GO:0008565 GO:0015031 GO:0016020 GO:0016023 GO:0016192 GO:0019901 GO:0030117 GO:0030131 GO:0030141 GO:0032403 GO:1902036
4	0.06	0.400	6.09	0.04	0.54	1w63A	GO:0005737 GO:0005794 GO:0005802 GO:0005829 GO:0006810 GO:0006886 GO:0008565 GO:0015031 GO:0016020 GO:0016192 GO:0017137 GO:0019894 GO:0030117 GO:0030131 GO:0030136 GO:0030665 GO:0030742 GO:0031410 GO:0035646 GO:0043231 GO:0043323 GO:0045954 GO:0048471 GO:0055037 GO:0090160
5	0.06	0.355	8.12	0.04	0.56	5difC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
6	0.06	0.374	6.83	0.05	0.54	4uqiB	GO:0003279 GO:0003281 GO:0005048 GO:0005802 GO:0005829 GO:0005886 GO:0005905 GO:0006810 GO:0006886 GO:0006897 GO:0007018 GO:0007507 GO:0008565 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030117 GO:0030118 GO:0030122 GO:0030131 GO:0030276 GO:0030666 GO:0030669 GO:0032403 GO:0035615 GO:0035904 GO:0036020 GO:0042059 GO:0043231 GO:0048013 GO:0048268 GO:0050690 GO:0060071 GO:0060976 GO:0072583
7	0.06	0.339	6.38	0.05	0.46	5a1uE	GO:0000139 GO:0005198 GO:0005737 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0015031 GO:0016020 GO:0016192 GO:0030117 GO:0030126 GO:0030663 GO:0031410
8	0.06	0.378	7.50	0.04	0.56	4bsmA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
9	0.06	0.359	7.76	0.04	0.55	3gjxA	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005487 GO:0005634 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0046825 GO:0051028
10	0.06	0.383	7.25	0.03	0.55	3wyfC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
11	0.06	0.357	7.81	0.03	0.55	3gb8A	GO:0000055 GO:0000056 GO:0000122 GO:0000776 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005642 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006611 GO:0006810 GO:0006886 GO:0007062 GO:0008536 GO:0008565 GO:0010824 GO:0015030 GO:0015031 GO:0016020 GO:0016032 GO:0019904 GO:0030529 GO:0031965 GO:0034504 GO:0042176 GO:0042493 GO:0043231 GO:0043488 GO:0046825 GO:0051028 GO:0075733
12	0.06	0.276	8.10	0.06	0.44	2iw3B	GO:0000166 GO:0001933 GO:0003723 GO:0003746 GO:0005524 GO:0005737 GO:0005840 GO:0006412 GO:0006414 GO:0006415 GO:0006469 GO:0010494 GO:0016887 GO:0019843 GO:0022626 GO:0042788
13	0.06	0.267	7.85	0.02	0.41	5dfzC	GO:0000166 GO:0000329 GO:0000407 GO:0004672 GO:0005524 GO:0005643 GO:0005768 GO:0005777 GO:0005794 GO:0006468 GO:0006810 GO:0006914 GO:0010008 GO:0015031 GO:0016020 GO:0016301 GO:0016303 GO:0016310 GO:0016740 GO:0030242 GO:0032968 GO:0034271 GO:0034272 GO:0036092 GO:0046854 GO:0048015 GO:0071561
14	0.06	0.194	3.77	0.11	0.22	3ltjA
15	0.06	0.171	5.43	0.04	0.22	4lctB	GO:0000338 GO:0005634 GO:0005737 GO:0005829 GO:0006461 GO:0006972 GO:0007275 GO:0008180 GO:0009585 GO:0009646 GO:0009651 GO:0009793 GO:0010017 GO:0010387 GO:0010388
16	0.06	0.163	6.46	0.09	0.23	2y7dD	GO:0003824 GO:0016740 GO:0019475 GO:0046872
17	0.06	0.160	7.42	0.03	0.24	4e0vB	GO:0001716 GO:0005576 GO:0006915 GO:0016491 GO:0019835 GO:0042742 GO:0044179 GO:0055114
18	0.06	0.149	6.20	0.04	0.20	3j6bL	GO:0000002 GO:0003735 GO:0005622 GO:0005739 GO:0005762 GO:0005840 GO:0006412 GO:0030529 GO:0032543

Consensus prediction of GO terms

Molecular Function	GO:0022892	GO:0005198
GO-Score	0.36	0.31
Biological Processes	GO:0006886	GO:0006891
GO-Score	0.44	0.31
Cellular Component	GO:0005886	GO:0005793	GO:0030126	GO:0000139
GO-Score	0.36	0.31	0.31	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.