I-TASSER results

I-TASSER results for job id Rv2067c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (407 residues)
MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSHRILWPDREYRPDLDIL
IAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHGLANLELHLLPIEELATLG
RDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLYGKYGRIGVELLGSVFRDLGL
GQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSALVDTFLHGRQRSYTVEECVDLV
TSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLPEVKAWSVMERLETLNATHLFMACR
RDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTDMFWPGWRMAPSPAQLAFLQQVDGRRT
IREIAGCVARTGEPSGGSLADLEEFGRKLFQSLWRLDFVAVALPASG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSHRILWPDREYRPDLDILIAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHGLANLELHLLPIEELATLGRDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLYGKYGRIGVELLGSVFRDLGLGQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSALVDTFLHGRQRSYTVEECVDLVTSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLPEVKAWSVMERLETLNATHLFMACRRDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTDMFWPGWRMAPSPAQLAFLQQVDGRRTIREIAGCVARTGEPSGGSLADLEEFGRKLFQSLWRLDFVAVALPASG
Prediction	CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEHCCCCCHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEHCCHHHCCCCCCCCCEEEHCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCC
Conf.Score	98866899999999998689987455577777885666788899898655688999859998789869999999589988999979999999999999998999769998786669999998758998454676778999999999975899689999857876568999999999979998878999999999976788867777765556555555677765655567889999999999899476545765468677656675899999859999999999987787755899997688888788776677776556765456777665555788866678999999999966889899999999986667765688999999999999998673443589999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSHRILWPDREYRPDLDILIAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHGLANLELHLLPIEELATLGRDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLYGKYGRIGVELLGSVFRDLGLGQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSALVDTFLHGRQRSYTVEECVDLVTSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLPEVKAWSVMERLETLNATHLFMACRRDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTDMFWPGWRMAPSPAQLAFLQQVDGRRTIREIAGCVARTGEPSGGSLADLEEFGRKLFQSLWRLDFVAVALPASG
Prediction	75664541540262057331143245354144232420220201220154252446140110123022001101433602000010045005302520673615403111000240513662200100000010042033003000200223000000000422221031023004314233444114203400520365230241144133113100210101223422120410140046030300001322313124113534302520560443401310331335212010001237334451543442141032111023322142243422514030364024004303352203301520454444453225403510240041023001000222568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEHCCCCCHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCEEEEHCCHHHCCCCCCCCCEEEHCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHCCCCCC
MTDDHPRADIVSRQYHRWLYPHPIADLEAWTTANWEWFDPVHSHRILWPDREYRPDLDILIAGCGTNQAAIFAFTNRAAKVVAIDISRPALDHQQYLKDKHGLANLELHLLPIEELATLGRDFDLVVSTGVLHHLADPRAGMKELAHCLRRDGVVAAMLYGKYGRIGVELLGSVFRDLGLGQDDASIKLAKEAISLLPTYHPLRNYLTKARDLLSDSALVDTFLHGRQRSYTVEECVDLVTSAGLVFQGWFHKAPYYPHDFFVPNSEFYAAVNTLPEVKAWSVMERLETLNATHLFMACRRDRPKEQYTIDFSTVAALDYVPLMRTRCGVSGTDMFWPGWRMAPSPAQLAFLQQVDGRRTIREIAGCVARTGEPSGGSLADLEEFGRKLFQSLWRLDFVAVALPASG

5dooA

0.14

0.13

0.92

1.53

MUSTER

------------------PYPPFTFSYT--------YPPYLRTIGKLFGNPPLLETAKVLDIGCGIGVNLLNFAETPKSQSLGVDLSKTQIELGKKTISDAKINNVELKALSILDLDESYGKFDYIVCHGVYSWVSQQDKILEVLNKLLNPNGIAFVSYNTLPGWNMQNTIREMMMFHSESKLQQARLLLKFINDSLGSTTPYANFLRDEAKLISDSYVLHEYLGEINTGTYFHQFIEKAQKNHLNYLGDTSIAAMFIGNL---PTKAASKLQAIDIVCTEQYMDFITNRKFRSTLLCH-QNIPINR-KIEFDNLKDFYTTFNIRPISPENKIDLNNEQENISFSAIMKAILYVYANPIRLEQVAKEAFKKLGKYR--LQDFLATLEQHFITLIFQGYLKIFETKPH

5dnkA

0.13

0.12

0.92

1.77

wMUSTER

---------------ESYPYAI----------TNPYHLSTLATLFGI--NAPEVENSKILELGCAAGGNLIPHAVLPNAHFVGVDLSKVQIDEANKNVRALGLKNIEFHHCSITDIDDSFGKFDYIICHGVISWVPKRDKIFKVCNRNLSTNGIAYISYNTLPGWNMVRTIRDMMLYHSFTNIRDRIAQSRLLLEFVKDSLEAEVLKTEAGLLAKDHYLRHDHLEEENAQFYFHEFMNEARKHNLQYLADCNISTMYLGNM---PPKVVEQLKAVDIVRTEQYMDFITNRRFRTTLLCHND--LKINRNINNDDIKKFNIIFNVIPEKPLKEVDLNNATENLQFSPYMKAILYTFSNPLSFKQVTSEANTK--LNNTKLNEIKNELLNNAMKLVLQGYISITNQKHR

5dooA1

0.13

0.09

0.69

1.71

dPPAS

------------------PYPPFTFSYTY-------PPYLRTIGKLFGLNPPLLETAKVLDIGCGIGVNLLNFAETPKSQSLGVDLSKTQIELGKKTISDAKINNVELKALSILDLDESYGKFDYIVCHGVYSWVSQQDKILEVLNKLLNPNGIAFVSYNTLPGWNMQNTIREMMMFHSESKLQQARLLLKFINDSLGNSTTFLRDEAKLISTYDDSYVLHEYLGEINTGTYFHQFIEKAQKNHLNYLGDTSIAAMFIGNL--PTKAASKLQAINDIVCTEQYMDFITNRKFRSTLLCHQNIPINRKI---------------------------------------------------------------------------------------------------

5dnkA

0.13

0.12

0.92

1.52

MUSTER

---------------ESYPYA------------ITNPYHLSTLATLFGINAPEVENSKILELGCAAGGNLIPHAVLPNAHFVGVDLSKVQIDEANKNVRALGLKNIEFHHCSITDIDDSFGKFDYIICHGVISWVPKRDKIFKVCNRNLSTNGIAYISYNTLPGWNMVRTIRDMMLYHSFTNIRDRIAQSRLLLEFVKDSLEAEVLKTEAGLLAKDHYLRHDHLEEENAQFYFHEFMNEARKHNLQYLADCNISTMYLGNM---PPKVVEQLKAVDIVRTEQYMDFITNRRFRTTLLCH--NDLKINRNINNDDIKKFNIIFNVIPEKPLKEVDLNNATENLQFSPYMKAILYTFSNPLSFKQVTSEANTK--LNNTKLNEIKNELLNNAMKLVLQGYISITNQKHR

5dnkA1

0.14

0.10

0.69

2.14

wdPPAS

-------------------------ESYPYAITNPYHLSTLATLFGI--NAPEVENSKILELGCAAGGNLIPHAVLPNAHFVGVDLSKVQIDEANKNVRALGLKNIEFHHCSITDIDDSFGKFDYIICHGVISWVPKRDKIFKVCNRNLSTNGIAYISYNTLPGWNMVRTIRDMMLYHSFTNIRDRIAQSRLLLEFVKDSLEVLKTEAGLLAKQTDHYLRHDHLEEENAQFYFHEFMNEARKHNLQYLADCNISTMYLGNMPPKVVEQLKAVN--DIVRTEQYMDFITNRRFRTTLLCHNDLKINRNI---------------------------------------------------------------------------------------------------

5dooA

0.14

0.13

0.92

1.75

wMUSTER

-------------------YPPFT--------FSYTYPPYLRTIGKLFGNPPLLETAKVLDIGCGIGVNLLNFAETPKSQSLGVDLSKTQIELGKKTISDAKINNVELKALSILDLDESYGKFDYIVCHGVYSWVSQQDKILEVLNKLLNPNGIAFVSYNTLPGWNMQNTIREMMMFHSESKLQQARLLLKFINDSLGSTTPYANFLRDEAKLISDSYVLHEYLGEINTGTYFHQFIEKAQKNHLNYLGDTSIAAMFIGNL---PTKAASKLQAIDIVCTEQYMDFITNRKFRSTLLCH-QNIPINR-KIEFDNLKDFYTTFNIRPISPENKIDLNNEQENISFSAIMKAILYVYANPIRLEQVAKEAFKKLGKYR--LQDFLATLEQHFITLIFQGYLKIFETKPH

5dnkA1

0.14

0.10

0.68

2.44

wPPAS

---------------ESYPYAI-----------NPYHLSTLATLFGI--NAPEVENSKILELGCAAGGNLIPHAVLPNAHFVGVDLSKVQIDEANKNVRALGLKNIEFHHCSITDIDDSFGKFDYIICHGVISWVPKRDKIFKVCNRNLSTNGIAYISYNTLPGWNMVRTIRDMMLYHSFTNIRDRIAQSRLLLEFVKDSAEVLKTEAGLLAKQTDHYLRHDHLEEENAQFYFHEFMNEARKHNLQYLADCNISTMYLGNMPPKVVEQLKAVN--DIVRTEQYMDFITNRRFRTTLLCHNDLKINRNI---------------------------------------------------------------------------------------------------

5dooA

0.12

0.11

0.92

1.59

dPPAS

------------------PYPPFTFSYTY-------PPYLRTIGKLFGLNPPLLETAKVLDIGCGIGVNLLNFAETPKSQSLGVDLSKTQIELGKKTISDAKINNVELKALSILDLDESYGKFDYIVCHGVYSWVSQQDKILEVLNKLLNPNGIAFVSYNTLPGWNMQNTIREMMMFHSESKLQQARLLLKFINDSLGNSTTFLRDEAKLISTYDDSYVLHEYLGEINTGTYFHQFIEKAQKNHLNYLGDTSIAAMFIGN--LPTKAASKLQAINDIVCTEQYMDFITNRKFRSTLLCH--QNIPINRKIEFDNLKDFYTTFNIRPISPENKIDLNNEQENISFYAILYVYAENISNPIRLEQVAKEAFKKLGKYR--LQDFLATLEQHFITLIFQGYLKIFETKPH

5dooA1

0.13

0.09

0.69

3.36

dPPAS2

------------------PYPPFT-----FSYTYPPYLRTIGKLFGL--NPPLLETAKVLDIGCGIGVNLLNFAETPKSQSLGVDLSKTQIELGKKTISDAKINNVELKALSILDLDESYGKFDYIVCHGVYSWVSQQDKILEVLNKLLNPNGIAFVSYNTLPGWNMQNTIREMMMFHSESKLQQARLLLKFINDSLGNSTTFLRDEAKLISTYDDSYVLHEYLGEINTGTYFHQFIEKAQKNHLNYLGDTSIAAMFIGNL---PTKAASKLQAINIVCTEQYMDFITNRKFRSTLLCH-QNIPINRKI--------------------------------------------------------------------------------------------------

5dnkA

0.13

0.12

0.92

2.02

wdPPAS

-------------------------ESYPYAITNPYHLSTLATLFGI--NAPEVENSKILELGCAAGGNLIPHAVLPNAHFVGVDLSKVQIDEANKNVRALGLKNIEFHHCSITDIDDSFGKFDYIICHGVISWVPKRDKIFKVCNRNLSTNGIAYISYNTLPGWNMVRTIRDMMLYHSFTNIRDRIAQSRLLLEFVKDSLEVLKTEAGLLAKQTDHYLRHDHLEEENAQFYFHEFMNEARKHNLQYLADCNISTMYLGNMPPKVVEQLKAVN--DIVRTEQYMDFITNRRFRTTLLCHNDLKINRNINNDDIKKFNIIFNDLNNATENLQFFLNGNKESNLSTSPYMKAILYTF-NPLSFKQVTSEANTKLN--NTKLNEIKNELLNNAMKLVLQGYISITNQKHR

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 3 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.82

Estimated TM-score = 0.61±0.14

Estimated RMSD = 8.7±4.6Å

Download Model 2

C-score=-0.96

Download Model 3

C-score=-0.65

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5dooA	0.898	1.32	0.122	0.924
2	5dnkA	0.858	2.15	0.126	0.919
3	2zwaB	0.452	4.33	0.052	0.558
4	4krgA	0.451	5.02	0.082	0.585
5	1y8cA	0.447	3.43	0.126	0.509
6	1d2gA	0.443	3.69	0.114	0.516
7	2ckdA	0.437	4.47	0.089	0.545
8	3bgvC	0.436	3.49	0.097	0.504
9	4gekA	0.436	3.78	0.153	0.518
10	3p7eA	0.433	4.65	0.123	0.540

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.37	32	4qnuH	GEK	Rep, Mult	29,62,63,65,85,86,87,90,112,113,114,129,130,131,133,135,292
2	0.06	5	1d2hA	SAH	Rep, Mult	85,86,87,90,111,112,113,131,134
3	0.02	2	1jdbE	GLN	Rep, Mult	63,128,129,132,140,141,144
4	0.01	1	3ofkA	SAH	Rep, Mult	11,30,32,42,43,63,65,85,86,87,112,113,129,130,131,134
5	0.01	1	2o06A	MG	Rep, Mult	41,124,152,153

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1im8A	0.415	3.77	0.126	0.494	2.1.1.-	87,140
2	0.060	2iipA	0.392	3.72	0.107	0.469	2.1.1.1	63,65,91
3	0.060	2vz8B	0.412	6.22	0.062	0.626	2.3.1.85	NA
4	0.060	1bxrA	0.417	6.72	0.065	0.683	6.3.5.5	NA
5	0.060	1xj5A	0.406	4.58	0.071	0.516	2.5.1.16	NA
6	0.060	1mjfA	0.398	4.49	0.058	0.501	2.5.1.16	63
7	0.060	1uirB	0.406	4.48	0.089	0.511	2.5.1.16	85
8	0.060	2jfdA	0.274	7.25	0.046	0.464	2.3.1.85	31
9	0.060	2e5wA	0.403	4.57	0.066	0.511	2.5.1.16	63,86
10	0.060	1tw2B	0.407	4.10	0.130	0.491	2.1.1.-	NA
11	0.060	2vdwG	0.431	3.52	0.098	0.499	2.7.7.50	34
12	0.060	1kyzE	0.394	4.29	0.125	0.484	2.1.1.68	66
13	0.060	2j5nB	0.393	6.10	0.083	0.597	1.5.1.12	83
14	0.060	3eppB	0.437	3.78	0.107	0.511	2.1.1.56	64,86,131
15	0.060	1ej6A	0.413	5.52	0.052	0.558	2.7.7.50	63,65,86,89,111
16	0.060	2opbB	0.389	3.74	0.074	0.467	2.1.1.28	21,63,65,85,116
17	0.060	2vz9B	0.519	5.45	0.125	0.708	2.3.1.85	NA
18	0.060	2ytzA	0.415	5.75	0.073	0.587	2.1.1.32	23,85
19	0.060	2i62C	0.390	3.84	0.100	0.472	2.1.1.1	20,63,65,91

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.14	0.408	3.40	0.13	0.47	3l8dA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
1	0.13	0.390	2.84	0.10	0.43	3h2bB	GO:0008168 GO:0016740 GO:0032259
2	0.09	0.398	2.92	0.15	0.45	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
3	0.09	0.409	3.46	0.13	0.48	3g5lA
4	0.08	0.398	3.80	0.13	0.47	3kkzA	GO:0046872 GO:0051536 GO:0051539
5	0.07	0.400	3.86	0.10	0.47	1ve3B	GO:0046872 GO:0051536 GO:0051539
6	0.07	0.467	4.93	0.08	0.59	4krgA	GO:0008152 GO:0008168 GO:0032259
7	0.07	0.452	4.33	0.05	0.56	2zwaB	GO:0005737 GO:0005739 GO:0005829 GO:0006400 GO:0008033 GO:0008168 GO:0008175 GO:0008757 GO:0016740 GO:0030488 GO:0031591 GO:0032259
8	0.06	0.428	3.40	0.14	0.49	3d2lC	GO:0008168 GO:0016740 GO:0032259
9	0.06	0.421	3.83	0.12	0.50	4ineA	GO:0000773 GO:0005737 GO:0006656 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0080101
10	0.06	0.400	3.32	0.14	0.46	4qdkA	GO:0005737 GO:0008168 GO:0008757 GO:0015979 GO:0015995 GO:0016740 GO:0032259 GO:0036068 GO:0046406
11	0.06	0.414	3.56	0.12	0.48	4mwzB	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
12	0.06	0.408	3.29	0.12	0.47	3bkwA	GO:0008152 GO:0008168 GO:0032259
13	0.06	0.330	6.32	0.09	0.51	3o7wA	GO:0003880 GO:0005829 GO:0006464 GO:0006479 GO:0006481 GO:0008168 GO:0008276 GO:0008757 GO:0010906 GO:0016740 GO:0018423 GO:0031333 GO:0032259 GO:0042981 GO:0090266
14	0.06	0.397	3.68	0.11	0.47	5cvdA	GO:0005634 GO:0005654 GO:0005737 GO:0006480 GO:0007051 GO:0007059 GO:0008168 GO:0008276 GO:0016740 GO:0018011 GO:0018012 GO:0018016 GO:0032259 GO:0035572 GO:0035573 GO:0071885
15	0.06	0.389	3.65	0.11	0.46	1xtpA	GO:0005737 GO:0006480 GO:0008168
16	0.06	0.381	3.16	0.12	0.43	3ccfB	GO:0008152 GO:0008168 GO:0016740 GO:0030798 GO:0032259
17	0.06	0.379	3.50	0.11	0.44	3egeA	GO:0008152 GO:0008168 GO:0032259
18	0.06	0.430	4.40	0.07	0.53	1rjdC	GO:0005829 GO:0006481 GO:0008168 GO:0010506 GO:0016740 GO:0018423 GO:0032259 GO:0043623

Consensus prediction of GO terms

Molecular Function	GO:0008168
GO-Score	0.32
Biological Processes	GO:0032259
GO-Score	0.32
Cellular Component	GO:0005737
GO-Score	0.09

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.