I-TASSER results

I-TASSER results for job id Rv2059

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (511 residues)
MATPVILVTGHEGTAAVTADLLGLLTDHGTATLRSVAPGSVRRADPRPRCHRREQRRRHR
ASMKSAIHPDHHPRRLPRCPVLRRDQVVLEMIVITMVGRPSGPGERKWDVWGSVARAVTG
GHVPVKSILTGAHADPHSYQASPADAAAIVDAELVIYNGGGYDPWVDQVLAGHPGVQAVD
AYSLLGAVGDDDAPNEHVFYDPNVAKAVAATIADRLADLDPSNSGNYRANAAEFSRGADA
IAISEHAIATTYPDAAVIATEPVVHYLLAAAGLKNRTPATFIAANENGNDPTPADMAAVL
DMIAGREVAALLVNPQTPTAATDELQVAARRAGVPITELTETLPSGTDRDQFCAADRPDR
RGRSLRADHADRGLSARGHRVGDLLPTALVCHRRSGGRGRPRRASARPGNCVRRTDGRGS
RPGCPDRRGTPRDVFADHPRRGGRPGRGCPGRRDRDLGGLRRGFRRRRHPAVAGAWSPGV
GVRGHHLVCDLPDLLVAPAAPLTSRSRFRPL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MATPVILVTGHEGTAAVTADLLGLLTDHGTATLRSVAPGSVRRADPRPRCHRREQRRRHRASMKSAIHPDHHPRRLPRCPVLRRDQVVLEMIVITMVGRPSGPGERKWDVWGSVARAVTGGHVPVKSILTGAHADPHSYQASPADAAAIVDAELVIYNGGGYDPWVDQVLAGHPGVQAVDAYSLLGAVGDDDAPNEHVFYDPNVAKAVAATIADRLADLDPSNSGNYRANAAEFSRGADAIAISEHAIATTYPDAAVIATEPVVHYLLAAAGLKNRTPATFIAANENGNDPTPADMAAVLDMIAGREVAALLVNPQTPTAATDELQVAARRAGVPITELTETLPSGTDRDQFCAADRPDRRGRSLRADHADRGLSARGHRVGDLLPTALVCHRRSGGRGRPRRASARPGNCVRRTDGRGSRPGCPDRRGTPRDVFADHPRRGGRPGRGCPGRRDRDLGGLRRGFRRRRHPAVAGAWSPGVGVRGHHLVCDLPDLLVAPAAPLTSRSRFRPL
Prediction	CCCCEEEEHCCCCCCEHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHCCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHCCCHHHCCCCCCCCCCCCCCCC
Conf.Score	9987799866887543567888887567754444457776657888755565555555555567765778887654567899999999999999996788887568865689999998598579999976899998878999999999985999999599856999999997899869986456776667889999876898999999999999999979677999999999999999999999999999789988999857599999998997875544444678899989999999999999989999998899998999999999999899589857888999999999999899999999985666545565477776667654555554688886433456789865567888889998888899764445788888999888988776665455666665567655566788765556566645745434577887776666789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MATPVILVTGHEGTAAVTADLLGLLTDHGTATLRSVAPGSVRRADPRPRCHRREQRRRHRASMKSAIHPDHHPRRLPRCPVLRRDQVVLEMIVITMVGRPSGPGERKWDVWGSVARAVTGGHVPVKSILTGAHADPHSYQASPADAAAIVDAELVIYNGGGYDPWVDQVLAGHPGVQAVDAYSLLGAVGDDDAPNEHVFYDPNVAKAVAATIADRLADLDPSNSGNYRANAAEFSRGADAIAISEHAIATTYPDAAVIATEPVVHYLLAAAGLKNRTPATFIAANENGNDPTPADMAAVLDMIAGREVAALLVNPQTPTAATDELQVAARRAGVPITELTETLPSGTDRDQFCAADRPDRRGRSLRADHADRGLSARGHRVGDLLPTALVCHRRSGGRGRPRRASARPGNCVRRTDGRGSRPGCPDRRGTPRDVFADHPRRGGRPGRGCPGRRDRDLGGLRRGFRRRRHPAVAGAWSPGVGVRGHHLVCDLPDLLVAPAAPLTSRSRFRPL
Prediction	7210000000231100000100000042022103201333343252433143355434452414311434444310200000321000000100000024545243202000100330034404031003436211141413161043045020000001301400430165165141030053251335634410000010610230042005201621372263035005402630550154036205715712000000001000520404311242113223565413152044005204747030000023244520520251056270412403332565541320020122410350155634554045452522201223444214413254015130553522443553245442454623234201520543344243133444431210341144342201010121010130110001012001010120344541456
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEHCCCCCCEHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHCCHHHHHHHHHCCEEHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEHCCCHHHCCCCCCCCCCCCCCCC
MATPVILVTGHEGTAAVTADLLGLLTDHGTATLRSVAPGSVRRADPRPRCHRREQRRRHRASMKSAIHPDHHPRRLPRCPVLRRDQVVLEMIVITMVGRPSGPGERKWDVWGSVARAVTGGHVPVKSILTGAHADPHSYQASPADAAAIVDAELVIYNGGGYDPWVDQVLAGHPGVQAVDAYSLLGAVGDDDAPNEHVFYDPNVAKAVAATIADRLADLDPSNSGNYRANAAEFSRGADAIAISEHAIATTYPDAAVIATEPVVHYLLAAAGLKNRTPATFIAANENGNDPTPADMAAVLDMIAGREVAALLVNPQTPTAATDELQVAARRAGVPITELTETLPSGTDRDQFCAADRPDRRGRSLRADHADRGLSARGHRVGDLLPTALVCHRRSGGRGRPRRASARPGNCVRRTDGRGSRPGCPDRRGTPRDVFADHPRRGGRPGRGCPGRRDRDLGGLRRGFRRRRHPAVAGAWSPGVGVRGHHLVCDLPDLLVAPAAPLTSRSRFRPL

1xvlA

0.23

0.12

0.52

1.34

MUSTER

-------------------------------------------------------------------------------------------------GETKKKVLTTFTVLADMVQNVAGDKLVVESI-TRIGAEIHGYEPTPSDIVKAQDADLILYNGMNLERWFEQFLGNVKDVPSVVLTEGIEPIPYTDKPNPHAWMSPRNALVYVENIRQAFVELDPDNAKYYNANAAVYSEQLKAIDRQLGADLEQVPQRFLVSCEGAFSYLARDYGMEEI----YMWPINAEQQFTPKQVQTVIEEVKTNNVPTIFCESTVSDKGQKQVAQA---TGARFGGNLYVSTEEGPVPTFLDLLEYDARVITLLAG-TN--------------------------------------------------------------------------------------------------------------------------------------------

3hjtA

0.19

0.10

0.51

2.84

dPPAS

---------------------------------------------------------------------------------------------------QGMSVVTSFYPMYAMTKEVSGDLNDVRMI--QSGAGIHSFEPSVNDVAAIYDADLFVYHSHTLEAWARDLDP-KSKVNVFEASKPLTLDRVKGTLDPHTWTDPVLAGEEAVNIAKELGHLDPKHKDSYTKKAKAFKKEAEQLTEEYTQKFKKVRSKTFVTQHTAFSYLAKRFGLKQLG----ISGISPEQEPSPRQLKEIQDFVKEYNVKTIFAEDNVN---PKIAHAIAKSTGAKVKTLSPLEAAPSGNKTYLENLRANLEVLYQQLK-----------------------------------------------------------------------------------------------------------------------------------------------

1xvlA

0.22

0.12

0.52

3.41

wdPPAS

-----------------------------------------------------------------------------------------------GETEEKKKVLTTFTVLADMVQNVAGDKLVVESI-TRIGAEIHGYEPTPSDIVKAQDADLILYNGMNLERWFEQFLGNVKDVPSVVLTEGIEPIPYTDKPNPHAWMSPRNALVYVENIRQAFVELDPDNAKYYNANAAVYSEQLKAIDRQLGADLEQVPQRFLVSCEGAFSYLARDYGMEEIY----MWPINAEQQFTPKQVQTVIEEVKTNNVPTIFCESTVSDKGQKQVAQA---TGAGNLYVDSLSTEEGPVPTFLDLLEYDARVITLLAGTN---------------------------------------------------------------------------------------------------------------------------------------------

1xvlA

0.22

0.12

0.52

1.60

wMUSTER

-----------------------------------------------------------------------------------------------GETEEKKKVLTTFTVLADMVQNVAGDKLVVESI-TRIGAEIHGYEPTPSDIVKAQDADLILYNGMNLERWFEQFLGNVKDVPSVVLTEGIEPIPYTDKPNPHAWMSPRNALVYVENIRQAFVELDPDNAKYYNANAAVYSEQLKAIDRQLGADLEQVPQRFLVSCEGAFSYLARDYGMEEI----YMWPINAEQQFTPKQVQTVIEEVKTNNVPTIFCESTVSDKGQKQVAQA---TGARFGGNLYVSTEEGPVPTFLDLLEYDARVITLLAG-TN--------------------------------------------------------------------------------------------------------------------------------------------

1xvlA

0.22

0.12

0.52

2.24

wPPAS

-----------------------------------------------------------------------------------------------GETEEKKKVLTTFTVLADMVQNVAGDKLVVESI-TRIGAEIHGYEPTPSDIVKAQDADLILYNGMNLERWFEQFLGNVKDVPSVVLTEGIEPIPYTDKPNPHAWMSPRNALVYVENIRQAFVELDPDNAKYYNANAAVYSEQLKAIDRQLGADLEQVPQRFLVSCEGAFSYLARDYGMEEIY----MWPINAEQQFTPKQVQTVIEEVKTNNVPTIFCESTVSDKGQKQVAQAT---GAGNLYVDSLSTEEGPVPTFLDLLEYDARVITLLAG-TN--------------------------------------------------------------------------------------------------------------------------------------------

2ps3A

0.16

0.08

0.50

4.25

dPPAS2

------------------------------------------------------------------------------------------------------AVVASLKPVGFIASAIADGVTETEVL-LPDGASEHDYSLRPSDVKRLQNADLVVWVGPEMEAFMQKPVSKLPGAKQVTIAQLEDLMKSHGDFNMHLWLSPEIARATAVAIHGKLVELMPQSRAKLDANLKDFEAQLASTETQVGNELAPLKGKGYFVFHDAYGYFEKQFGLTPLG----HFTVNPEIQPGAQRLHEIRTQLVEQKATCVFAEPQFRPAVVESVAR---GTSVRMGTLDTNIKLGKTSYSEFLSQLANQYASCLKGD-----------------------------------------------------------------------------------------------------------------------------------------------

4cl2A

0.17

0.09

0.51

2.07

PPAS

----------------------------------------------------------------------------------------------------KKVVLSSFSIIGDITQNIAKDLVTVTTLV-EAGNDSHSYQVTSADAIKIQNADLILCNGLHLEETYMKYFTNLKGTKIITVTDGINPIGVSEEPNPHAWMSLTNAMIYIENIRKALTALDPSNAKKYELNAREYSEKIRNSILPLKTRIEKVDKRWFVTSEGCLVYLAEDFGFKSL-------YLWPINSRSPSMMRHAINQMRSHKIKFIFSESTNSDQPAKQVAYETNASYGGVLYVDSLSKPDGPAPTYLDLLRFSLTKIVDTLF-----------------------------------------------------------------------------------------------------------------------------------------------

4cl2A

0.17

0.09

0.51

3.69

Env-PPAS

----------------------------------------------------------------------------------------------------KKVVLSSFSIIGDITQNIAKDLVTVTTLV-EAGNDSHSYQVTSADAIKIQNADLILCNGLHLEETYMKYFTNLKGTKIITVTDGINPIGVSEEPNPHAWMSLTNAMIYIENIRKALTALDPSNAKKYELNAREYSEKIRNSILPLKTRIEKVDKRWFVTSEGCLVYLAEDFGFKSL-------YLWPINSRSPSMMRHAINQMRSHKIKFIFSESTNSDQPAKQVAYETNASYGGVLYVDSLSKPDGPAPTYLDLLRFSLTKIVDTLF-----------------------------------------------------------------------------------------------------------------------------------------------

4cl2A

0.17

0.09

0.51

1.33

MUSTER

----------------------------------------------------------------------------------------------------KKVVLSSFSIIGDITQNIAKDLVTVTTLV-EAGNDSHSYQVTSADAIKIQNADLILCNGLHLEETYMKYFTNLKGTKIITVTDGINPIGVSEEPNPHAWMSLTNAMIYIENIRKALTALDPSNAKKYELNAREYSEKIRNSILPLKTRIEKVDKRWFVTSEGCLVYLAEDFGFKSL-------YLWPINSRSPSMMRHAINQMRSHKIKFIFSESTNSDQPAKQVAYETNASYGGVLYVDSLSKPDGPAPTYLDLLRFSLTKIVDTLF-----------------------------------------------------------------------------------------------------------------------------------------------

2ps3A

0.16

0.08

0.50

2.84

dPPAS

------------------------------------------------------------------------------------------------------AVVASLKPVGFIASAIADGVTETEVL-LPDGASEHDYSLRPSDVKRLQNADLVVWVGPEMEAFMQKPVSKLPGAKQVTIAQLEDLMKSHGDFNMHLWLSPEIARATAVAIHGKLVELMPQSRAKLDANLKDFEAQLASTETQVGNELAPLKGKGYFVFHDAYGYFEKQFGLTPLG----HFTVNPEIQPGAQRLHEIRTQLVEQKATCVFAEPQFRPAVVESVAR---GTSVRMGTLDTNIKLGKTSYSEFLSQLANQYASCLKGD-----------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 3 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.57

Estimated TM-score = 0.32±0.11

Estimated RMSD = 16.4±3.0Å

Download Model 2

C-score=-4.29

Download Model 3

C-score=-2.80

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1xvlA	0.498	2.10	0.212	0.526
2	3hjtA	0.495	1.29	0.181	0.507
3	1k0fA	0.487	2.13	0.158	0.519
4	1pszA	0.486	2.31	0.156	0.519
5	3cx3A	0.483	1.75	0.171	0.503
6	3mfqA	0.481	2.02	0.150	0.509
7	4oxqA	0.477	2.34	0.173	0.509
8	5hx7A	0.472	2.31	0.187	0.503
9	4cl2A	0.468	2.30	0.171	0.503
10	1pq4B	0.466	2.12	0.202	0.495

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.50	28	3hh8A	FE	Rep, Mult	137,197,261,286,343
2	0.02	1	1a9x1	III	Rep, Mult	143,144,146,147,170,171
3	0.02	1	3u7qB	IMD	Rep, Mult	127,128,148,149,152
4	0.02	1	3u7qD	IMD	Rep, Mult	278,279,280,298,302
5	0.02	1	1xvlC	MN	Rep, Mult	137,197,261,326
6	0.02	1	3u7qD	IMD	Rep, Mult	315,318,319,322

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1m34A	0.422	6.09	0.067	0.597	1.18.6.1	NA
2	0.060	1fp4B	0.420	5.61	0.040	0.554	1.18.6.1	NA
3	0.060	1ofdA	0.346	7.75	0.034	0.591	1.4.7.1	NA
4	0.060	2pmgB	0.343	6.50	0.065	0.509	5.4.2.2	136,320
5	0.060	1t3tA	0.392	7.49	0.078	0.636	6.3.5.3	324
6	0.060	2w00B	0.371	7.01	0.045	0.573	3.1.21.3	357
7	0.060	2vdcF	0.382	7.88	0.050	0.648	1.4.1.13	115
8	0.060	2d1rA	0.358	7.26	0.065	0.579	1.13.12.7	NA
9	0.060	1mioB	0.411	5.31	0.065	0.534	1.18.6.1	319
10	0.060	3gpbA	0.353	6.25	0.033	0.505	2.4.1.1	NA
11	0.060	2qllA	0.347	6.30	0.040	0.505	2.4.1.1	NA
12	0.060	1qh8A	0.420	6.10	0.085	0.601	1.18.6.1	204,212
13	0.060	1fa9A	0.347	6.28	0.033	0.499	2.4.1.1	NA
14	0.060	1h1lB	0.418	5.38	0.066	0.546	1.18.6.1	NA
15	0.060	1l5hA	0.401	5.41	0.091	0.536	1.18.6.1	NA
16	0.060	2jfgA	0.362	6.42	0.070	0.530	6.3.2.9	NA
17	0.060	2cseW	0.359	7.35	0.048	0.571	3.6.4.13	NA
18	0.060	1kfqB	0.361	6.78	0.042	0.550	5.4.2.2	237
19	0.060	2vdcA	0.407	7.16	0.059	0.642	1.4.1.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.16	0.461	2.80	0.16	0.50	2o1eA	GO:0005886 GO:0006810 GO:0006811 GO:0006829 GO:0007155 GO:0010043 GO:0016020 GO:0030001 GO:0046872
1	0.15	0.468	2.31	0.17	0.50	5afsA	GO:0006810 GO:0007155 GO:0030001 GO:0046872
2	0.14	0.478	2.07	0.19	0.50	4xrvB	GO:0006810 GO:0007155 GO:0030001 GO:0046872
3	0.12	0.492	1.67	0.17	0.51	3cx3A	GO:0005886 GO:0006810 GO:0007155 GO:0010043 GO:0030001 GO:0046872
4	0.11	0.484	2.22	0.19	0.51	5i4kA	GO:0005886 GO:0006810 GO:0007155 GO:0010043 GO:0016020 GO:0030001 GO:0046872
5	0.10	0.432	2.04	0.24	0.46	4irmC	GO:0005886 GO:0006810 GO:0007155 GO:0010043 GO:0030001 GO:0046872
6	0.08	0.479	2.25	0.17	0.51	4k3vB	GO:0006810 GO:0007155 GO:0030001 GO:0046872
7	0.08	0.451	3.03	0.16	0.50	2xy4A	GO:0005886 GO:0010043 GO:0030001 GO:0046872
8	0.07	0.487	2.13	0.16	0.52	1k0fA	GO:0006810 GO:0006811 GO:0006829 GO:0007155 GO:0030001 GO:0042597 GO:0046872
9	0.07	0.498	2.10	0.21	0.53	1xvlA	GO:0005886 GO:0006810 GO:0007155 GO:0010043 GO:0030001 GO:0046872
10	0.07	0.494	1.35	0.18	0.51	4h0fA	GO:0006810 GO:0007155 GO:0030001 GO:0046872
11	0.07	0.486	2.31	0.16	0.52	1pszA	GO:0005886 GO:0006810 GO:0007155 GO:0016020 GO:0030001 GO:0046872
12	0.07	0.481	2.02	0.15	0.51	3mfqA	GO:0006810 GO:0007155 GO:0030001 GO:0046872
13	0.07	0.485	2.19	0.16	0.51	3hh8A	GO:0005886 GO:0006810 GO:0006811 GO:0006825 GO:0006829 GO:0007155 GO:0016020 GO:0030001 GO:0046872 GO:0055072
14	0.07	0.477	2.34	0.17	0.51	4oxqA	GO:0006810 GO:0007155 GO:0030001 GO:0046872
15	0.07	0.466	2.12	0.20	0.50	1pq4B	GO:0005886 GO:0010043 GO:0030001 GO:0046872
16	0.06	0.445	2.33	0.17	0.47	4k3vA	GO:0006810 GO:0007155 GO:0030001 GO:0046872
17	0.06	0.290	7.01	0.06	0.45	4whbA	GO:0016787 GO:0016810
18	0.06	0.246	6.25	0.07	0.35	4gcmB	GO:0004791 GO:0005737 GO:0016491 GO:0019430 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0046872
GO-Score	0.52
Biological Processes	GO:0007155	GO:0010043	GO:0070838	GO:0000041
GO-Score	0.52	0.34	0.32	0.32
Cellular Component	GO:0005886
GO-Score	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.