I-TASSER results

I-TASSER results for job id Rv2047c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (854 residues)
MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIRDATAVESAMT
GADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTSSGHQPRVEQMLADCGLEW
VAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRLLVRALLDTVIDSGP
VNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAELELLHSAPLMDVTLLRDRWGFQ
PAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGA
NGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQRE
IAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQRPPSE
SSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLS
LILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVA
AARRDPVVIRLLAEPGERLDKLAVEAPEFHSAVLAELTLIGHRGPAEVEMAATSYADNPE
LLVRMVAKTLRAVPAPQPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLR
EYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVFSGSW
EPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEILVAEVTDVGYTAAF
CYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELA
SEDGPALPGSDLSR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIRDATAVESAMTGADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTSSGHQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEAPEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAPQPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR
Prediction	CEEEEHCCCCHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCCEEEHCCCCCHHHHHHHHHCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHCCCEEEEEEEEEHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCCHHHHHHHHCCCCEEHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCEEEHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCCCCCCCCCCEEEEEEHCCCEEEEEEEEHCCCHHHHCCCCEEEEHCCCCCCHHHHHHHHCEEEEHCCCCCHHHHHHHHHHCCCEEEHCCCHHHHCCCCEEEEEHCCCCEEEEEHCCCCCCCCCCCCCCCC
Conf.Score	97999957865789999999998995999986888778887589985788889999998587579986567788644558999999999999899759998466579999999996997799874456668867899998766875568888876444489999999999858888886799778887799999999867755656876655567677764588865454678888767666555554555456666666666544444444566667776667777765444457777788887788888756765554554678899746778999999999998876467766565466677776566567753589999998588767777777776655455666777667777766467899999999889999999998889999999999999985566555558999999999999999999999999999999999999999766666776588865456889999999999978899999986857999998758899999999999989988874888578766794999999999998677776645677788999999999999876554679999999999999999999999899888664564469999999865999999999999999858998577588876554444568886689998657589999999877667657899699977899975688877336888589764588999998789789856867884799979999889869999865667766678878889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIRDATAVESAMTGADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTSSGHQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEAPEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAPQPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR
Prediction	21000010021000000313163401000000113521211010000001215003300300000000000133232000300310020016040300000001001000100160300000000000002100000210021000000215000000000000200000013442331000001321000000000031110000000000000000001000000000000111001011111121011001111111012121121111111112011121122121101111212121112321243111111010110011000000000001001000000011010342133421220000000000000000220021022233421323342133212214224343323344212301320330231133013215413510440152043045132540442324202410330141012001000000000100020034113421123322302103123002300420373540241044445304401650540151035004400000010000010113320420141034205424455555433523334114301410431121110000000000200130033026441054320000011000100024032003402511431261200001023222222213444243213010002220201010032651650452000001100000000032000000022020000000000110000000440143044423010105402011132635635634556368
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840

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Sec.Str
Seq

CEEEEHCCCCHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCCEEEHCCCCCHHHHHHHHHCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCHHHHHHHHHHHCCCEEEEEEEEEHCCCCHHHHHHHHHCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCCHHHHHHHHCCCCEEHCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCEEEHCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCEEEEHCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHCCCCCCCCCCCCCCCCCCEEEEEEHCCCEEEEEEEEHCCCHHHHCCCCEEEEHCCCCCCHHHHHHHHCEEEEHCCCCCHHHHHHHHHHCCCEEEHCCCHHHHCCCCEEEEEHCCCCEEEEEHCCCCCCCCCCCCCCCC
MRIAVTGASGVLGRGLTARLLSQGHEVVGIARHRPDSWPSSADFIAADIRDATAVESAMTGADVVAHCAWVRGRNDHINIDGTANVLKAMAETGTGRIVFTSSGHQPRVEQMLADCGLEWVAVRCALIFGRNVDNWVQRLFALPVLPAGYADRVVQVVHSDDAQRLLVRALLDTVIDSGPVNLAAPGELTFRRIAAALGRPMVPIGSPVLRRVTSFAELELLHSAPLMDVTLLRDRWGFQPAWNAEECLEDFTLAVRGRIGLGKRTFSLPWRLANIQDLPAVDSPADDGVAPRLAGPEGANGEFDTPIDPRFPTYLATNLSEALPGPFSPSSASVTVRGLRAGGVGIAERLRPSGVIQREIAMRTVAVFAHRLYGAITSAHFMAATVPFAKPATIVSNSGFFGPSMASLPIFGAQRPPSESSRARRWLRTLRNIGVFGVNLVGLSAGSPRDTDAYVADVDRLERLAFDNLATHDDRRLLSLILLARDHVVHGWVLASGSFMLCAAFNVLLRGLCGRDTAPAAGPELVSARSVEAVQRLVAAARRDPVVIRLLAEPGERLDKLAVEAPEFHSAVLAELTLIGHRGPAEVEMAATSYADNPELLVRMVAKTLRAVPAPQPPTPVIPLRAKPVALLAARQLRDREVRRDRMVRAIWVLRALLREYGRRLTEAGVFDTPDDVFYLLVDEIDALPADVSGLVARRRAEQRRLAGIVPPTVFSGSWEPSPSSAAALAAGDTLRGVGVCGGRVRGRVRIVRPETIDDLQPGEILVAEVTDVGYTAAFCYAAAVVTELGGPMSHAAVVAREFGFPCVVDAQGATRFLPPGALVEVDGATGEIHVVELASEDGPALPGSDLSR

5fbtA

0.16

0.13

0.81

2.05

MUSTER

-KVLLVGGKGNLGAC----SNIEGVHV-CLTTEAYKEFTQL--------LQRLAIREISETIRTLIQHTQIPSEIASYDAT---------------------LQHISCWASLFTEVQL-------AVVIQQISPEA--------ILFTADPITSNRKSLSIDASFGLG---ESGLVSADSYTVRENTITNKIIATKKLAETRILEKSQQTKQTLTDQQIIQL----AKLGRKIEAYFG--------------------------------------KPQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQTDAK-----------------PLGLSFYLTTPATYT----------AGGRLFVDITQSLSAKVSR---DVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRS----------IPDSSSVFELVRNSENSIKHLKQSIET---KSGSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGEKNVADKLSESAPNNITS-QGLELLDVADVIRPYPAVRAYLETKNPDFNELLEGGAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTGYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILEEK-ADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGG-LTHGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

5fbtA

0.16

0.13

0.78

1.88

dPPAS

---------------------------------------------------------------------------------------------------------------------------KPYVLVGGKGNLGACSNIEGVHVPAGEFTQLLQRLAIREISETIRTLIQPSEIASYDATPFAVLLQHISCWASLFTEVQLAVVIQQISPEASLFTADPITSNRKSLSIDASFGLGESGLVSRENTITNKIIATKKLAETRILEKSQQTKQTLTKPQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQTDAK-----------------PLGLSFYLTTPATY----------TAGGRLFVDITQSLSAKVSRDVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRSI----------------PDSSSVFELVRNSENSIKHLKQSIETKSGSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGEKNVADKLSESAPNNITS-QGLELLDVADVIRPYPAVRAYLEQTKNPDFNELATLAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTDYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILEE-KADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGGL-THGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

5fbtA

0.15

0.12

0.81

4.67

wdPPAS

-KVL-VGGKG----NLGACSNIEGVHV-CLTKEFTQLLQRLAIREISETIRTLIQHTQIPS-------EIASYDAT------PFAVLLQHISC-------WASLFTEVQ---------------LAVVIQ-QISPEASGILF-----TADPITSNRKSLSIDASFGLGE---SGLVSADSYTVRENTITN-----KIIATKK-------------------------------------LAETRILEKSQQTKQTLTDQQIIQLAKLGRKIEAYFGKPQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQT---DAKPLGLSFYLT------------------------TPATYTAGGRLFVDIAKVSRDVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRSIPD------------------SSSVFELVRNSENSIKHLKQSIETKS-------GSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGVADKLSESAPNNITSQGLELLDVADVIRPYPAVRAYLETKNPDFNELATGGAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTDYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILE-EKADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGG-LTHGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

5fbtA

0.16

0.13

0.82

2.67

wMUSTER

-KVLLVGGKGNLGAC----SNIEGVHV-CLTTEAYKEFTQL--------LQRLAIREISETIRTLIQHTQIPSEIASY-----FAVLLQHISC-------WASLFTEVQ---------------LAVVIQQISPE------ASGILFTADPITSNRKSLSIDASFGLG---ESGLVSADSYTVRENTITN-----KIIATKK-------------------------------------LAETRILEKSQQTKQTLTDQQIIQLAKLGRKIEAYFGKPQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQT---DAKPLGLSFYLT--------------TPATYT----------AGGRLFVDITQSLSAKVSR---DVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRSIP----------DSSSVFELVRNSENSIKHLKQSIET---KSGSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGE-KNVADKLSESAPNNITSQGLELLDVADVIRPYPAVRAYLETKNPDFNELLEGGAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTGYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILE-EKADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGG-LTHGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

5fbtA

0.16

0.13

0.80

4.89

wPPAS

-KVLV-GGKGNLGAC----SNIEGVHV-CLTTEAYKEF---------QLLQRLAIREISETITLIQHTQIPSEIASYDAT--PFAVLLQHISC-------WASLFTEVQ---------------LAVVIQ-QISPEASGILFT-----ADPITSNRKSLSIDASFGLGE---SGLVSADSYTVRENTITN-----KIIATKKLARILEKSQQTLTDQQIIQL----AKLGRKIEAYFG--------------------------------------KPQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQT---DAKPLGLSFYLT------------------------TPATYTAGGRLFVDIAKVSRDVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRSIPD------------------SSSVFELVRNSENSIKHLKQSIETKS-------GSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGVADKLSESAPNNITSQGLELLDVADVIRPYPAVRAYLEQKNPDFNELATGGAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTDYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILE-EKADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGG-LTHGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

5fbtA

0.17

0.12

0.73

3.50

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------LGACSNIEGVHVPAGFCLTTEQRLAIREISETIRTLIQHTQIPSEIASYDA-----TPFAVLLQHISCWASLFTEVQLARENTITNKIIATKKLAETRILEKSQQTKQTLTKPQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQTDAK-----------------PLGLSFYLTTPATY----------TAGGRLFVDITQSLSAKVSRDVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRSI-------------PDSSSVFELVRNSENSIKHLKQSIET---KSGSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGEKNVADKLSESAPNNITS-QGLELLDVADVIRPYPAVRAYLEQTKNPDFNELATLAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTDYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILEE-KADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGGL-THGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

5fbtA

0.17

0.14

0.82

3.77

PPAS

ISEALVGGKGNLGAC----SNIEGVHV------PA-----------GFCLTTEAYKEFTQLLQ--------RLAIREISETIRTLIQHTQIPSEIASYDATPFAVLLQHISCWASLFTEV---QLAVVIQQISPEA--------ADPITSNRKS----LSIDASFGLG---ESGLVSADSYTVRENTITNKIIATKKLAETRILEKSQQTKQTLTDQQIIQL----AKLGRKIEAYFG--------------------------------------KPQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQT---DAKPLGLSFYLT------------------------TPATYTAGGRLFVDITQSLSAKVSRDVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRSI-------------PDSSSVFELVRNSENSIKHLKQSIET---KSGSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGEKNVADKLSESAPNNIT-SQGLELLDVADVIRPYPAVRAYLEQTKNPDFNTLEGGAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTGYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILE-EKADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGG-LTHGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

5fbtA

0.16

0.14

0.83

3.40

Env-PPAS

ISEALVGGKGNLGAC----SNIEGVHV-------PAGF-----CLTTEAYKE--FTQLLQRLAI-----------REISETIRTLIQHTQIPSEIASYDATPFAVLLQHISCWASLFTEV---QLAVVIQQIS-PEASGILFT-ADPITSNRKSL-SI---DASFGLG---ESGLVSADSYTVRENTITNKIIATKKLAETRILEKSQQTKQTLTDQQIIQL----AKLGRKIEAYFGK--------------------------------------PQDIEWCLAEGAFYIVQSRPITTLYPIPEVNEPGNRVYISVAHQQTD---AKPLGLSFYLT------------------------TPATYTAGGRLFVDITQSLSAKVSRDVNSLGQSDPLIKDALLTVINKKGFLPPLPTVRSI-------------PDSSSVFELVRNSENSIKHLKQSIET---KSGSDLFDFIVEDLEELKRVLFNPTSIDAIAGDASAWLNEHIYQWLGEKNVADKLSESAPNNIT-SQGLELLDVADVIRPYPAVRAYLETKNPDFNELAEGGAETKKALEDYLQKYG-RCAGEIDLTKTRWIENPLTLIPLILSNIKNFDSSASPDGEQKAETKEKIDILRHFIGYREY-PKYGINRYFIYKLALLRAGEQLVKDGILQEHEDIYFLYFEELREVVRTGYELINARKRDFATFEKLTPPRILTSDGEINGEYKRENLPKDAILGLPVSSGTVEGRARVILE-EKADLEDGDILVTAYTDPSWTPAFVSIKGLVTEVGG-LTHGAVIAREYGLPAVVGVENATTIIKDGQQIRINGTEGYIEILD----------------

4c0oA

0.10

0.09

0.92

1.16

MUSTER

-------GAKP-----LQLVYQA---VQALYHDPDPSGKERASFWLGELQSVHAWEISDQ--------LLQIRQDVESCYFAAQTMKMKIQTSFYE----LPTDSHASLRDSLLTH---------IQNLKDLSPVIVTQLALAIADLALQMPSW-------GCVQTLVEKYSNDVTSLPFL------LEILTVLPEEVHSRSLRIGDLAFYSSTVVSLLMTCVEKAGTDEKMLMKVFRCLGSWFNLGVLDSNFMANNKLLALLFEVLQQDKTSSNLHEAASDCVCSALYAI---ENVETNLPLAMQLFQGVLTLETAYHMAVAREDLDKVLNYCRIFTELCETFLEKIVCTPGQGLGDLRTLELLLICAGHPQYEVVEISFNFWYRLGTNDEVIHGIFKAYIQRLLHALLEPDHEGVPEETDDFGEFRMRVSDLVKDLIFLIGSMECFAQLYSTWEVTEAVLFIMAAKSVDPENNPTLVEVLEGVVRHTAVRYTSIELVGEMSEVVDRNPQFLDPVLGYLMKGEKPLASAAAKAIHNICSVCRDHNGLLEIARSSPEAAVGLLKGTALVLARLLDKITEC---LSELCSVQVMALKSDPTVFLDRLAVIFRHTNPIVH---PCQKVIQEIWPVLSETLNKHRADNRIVERCCRCLRFAVRCVGAALLQP-LVTQMVNVY-HQHSCFLYLGSILVDEYGMEEGCRQGLLDM--QALCIPTFQLLEQQNGLQNHPDTVDDL-ATRFIQRSPVTLLRSQVVIPILQWAIASTTLDHRDLRDLIHTGVAVMNQLGQQLVSQLLHTCCFCLPP--TLPDVAEVLW--EIMQVDRPT-FCRWLENSLKGLPTVTHKQLTD

2jl1A

0.16

0.05

0.31

0.87

dPPAS

FSIAVTGATGQLGGLVIQHLLKPASQIIAIVRNVEKAADQGVEVRHGDYNQPESLQKAFAGVSKLLFISGP-HYDNTLLIVQHANVVKAARDAGVKHIAYTGYAFHLATEYAIRTTNIPYTFLRNALYTDFFVNEGLRASTESGAIVTNAGSGIVNSVTRNELALAAATVLTEEGHENKTYNLVSNQPWTFDELAQILSKKVVHQPVSFE----EEKNFLVNAGVPEPFTEITAAIYDAISKGEASKTSDDLQKLIGSLTPLKETVKQALKM------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.58

Estimated TM-score = 0.64±0.13

Estimated RMSD = 9.9±4.6Å

Download Model 2

C-score=-2.79

Download Model 3

C-score=-1.24

Download Model 4

C-score=-2.57

Download Model 5

C-score=-3.90

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5fbtA	0.794	2.43	0.161	0.831
2	5a22A	0.321	8.74	0.042	0.518
3	2pffA	0.318	9.25	0.055	0.526
4	4f91B	0.317	8.61	0.030	0.502
5	1vbgA	0.315	7.41	0.070	0.447
6	3cmuA	0.314	8.98	0.034	0.510
7	3a6pA	0.314	8.56	0.031	0.496
8	3hmjA	0.314	8.73	0.051	0.501
9	5dotA	0.310	8.87	0.040	0.501
10	2fhfA	0.310	8.64	0.034	0.495

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	3shdE	MN	Rep, Mult	802,803
2	0.05	3	1ofdB	F3S	Rep, Mult	793,794,795,798,799,800,801,808
3	0.05	3	3cmvA	MG	Rep, Mult	772,795,810
4	0.03	2	3shdA	MN	Rep, Mult	789,803
5	0.03	2	2jfrA	MG	Rep, Mult	828,829
6	0.03	2	4xk8g	CLA	Rep, Mult	444,448
7	0.03	2	4rkuL	CLA	Rep, Mult	655,659
8	0.02	1	3cmvE	ANP	Rep, Mult	764,766,767,786,801,829
9	0.02	1	5fbtA	5WQ	Rep, Mult	318,336,339,353,354,355,375,391,395,485,486
10	0.02	1	1vbhA	PEP	Rep, Mult	767,787,788,789,808,809
11	0.02	1	4z10D	RCO	Rep, Mult	455,459
12	0.02	1	1lm1A	F3S	Rep, Mult	799,800,801,802,805,806,808,830
13	0.02	1	4uc9A	ASP	Rep, Mult	455,477
14	0.02	1	5fbuA	5WP	Rep, Mult	316,318,321,322,336,339,353,354,375,395,485,486,641,645,796
15	0.02	1	4dr5F	MG	Rep, Mult	607,611
16	0.02	1	1ofdA	F3S	Rep, Mult	659,678,679,680,681,682,683,685
17	0.02	1	3a6pA	III	Rep, Mult	542,580,602

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1b0pA	0.275	8.95	0.025	0.447	1.2.7.1	NA
2	0.060	2pdaA	0.287	9.18	0.047	0.477	1.2.7.1	318,332
3	0.060	1ofdA	0.331	9.01	0.053	0.540	1.4.7.1	NA
4	0.060	2fhbA	0.316	8.56	0.041	0.498	3.2.1.41	NA
5	0.060	2pffB	0.279	8.71	0.041	0.443	2.3.1.86	NA
6	0.060	2e1qA	0.302	9.08	0.049	0.501	1.17.3.2,1.17.1.4	NA
7	0.060	1ob2A	0.156	7.28	0.033	0.225	3.6.1.48	NA
8	0.060	2vdcA	0.300	9.41	0.033	0.508	1.4.1.13	NA
9	0.060	1llwA	0.307	9.01	0.034	0.502	1.4.7.1	NA
10	0.060	1yq2A	0.281	8.32	0.060	0.434	3.2.1.23	NA
11	0.060	3ebgA	0.287	8.08	0.044	0.431	3.4.11.-	765
12	0.060	2dqmA	0.284	8.85	0.043	0.456	3.4.11.2	765
13	0.060	3hmjA	0.314	8.73	0.051	0.501	2.3.1.86	NA
14	0.060	2zxqA	0.281	8.63	0.036	0.444	3.2.1.97	596
15	0.060	3b9jC	0.238	9.12	0.074	0.395	1.17.3.2,1.17.1.4	NA
16	0.060	1hn0A	0.284	8.74	0.045	0.454	4.2.2.20	817
17	0.060	1k32A	0.301	8.73	0.042	0.480	3.4.21.-	NA
18	0.060	1kblA	0.302	7.99	0.037	0.444	2.7.9.1	NA
19	0.060	2ckjA	0.304	8.77	0.044	0.491	1.17.1.4,1.17.3.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.266	8.57	0.03	0.42	2x0sA	GO:0003824 GO:0005524 GO:0006090 GO:0016301 GO:0016310 GO:0016772 GO:0020015 GO:0046872 GO:0050242
1	0.06	0.315	7.41	0.07	0.45	1vbgA	GO:0000166 GO:0003824 GO:0005524 GO:0005737 GO:0006090 GO:0009507 GO:0009536 GO:0015979 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872 GO:0050242
2	0.06	0.302	7.99	0.04	0.44	1kblA	GO:0000166 GO:0003824 GO:0005524 GO:0006090 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872 GO:0050242
3	0.06	0.280	6.23	0.06	0.35	2olsA	GO:0000166 GO:0003824 GO:0005524 GO:0006090 GO:0006094 GO:0008986 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
4	0.06	0.206	8.50	0.06	0.33	2kx9A	GO:0000287 GO:0003824 GO:0005737 GO:0005829 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0019197 GO:0046872
5	0.06	0.219	8.04	0.05	0.34	3ictA	GO:0000166 GO:0003756 GO:0005623 GO:0016491 GO:0045454 GO:0050451 GO:0050660 GO:0050661 GO:0055114
6	0.06	0.192	6.97	0.05	0.26	2wqdA	GO:0003824 GO:0005737 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
7	0.06	0.196	7.95	0.05	0.30	3hx6A	GO:0005509 GO:0005737 GO:0005829 GO:0009289 GO:0016020 GO:0046872
8	0.06	0.186	7.66	0.04	0.28	3tcmA	GO:0003824 GO:0004021 GO:0008483 GO:0009058 GO:0016740 GO:0030170 GO:0042853
9	0.06	0.157	7.06	0.04	0.22	1sezA	GO:0004729 GO:0005739 GO:0006779 GO:0006782 GO:0006783 GO:0016491 GO:0055114
10	0.06	0.179	7.60	0.08	0.26	2cb1A	GO:0003824 GO:0016829 GO:0030170
11	0.06	0.167	7.09	0.06	0.24	1qzzA	GO:0008168 GO:0008171 GO:0016829 GO:0016831 GO:0017000 GO:0032259
12	0.06	0.179	8.25	0.06	0.28	2e28A	GO:0000166 GO:0000287 GO:0003824 GO:0004743 GO:0005524 GO:0006096 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0030955 GO:0046872
13	0.06	0.178	8.26	0.04	0.28	3t05A	GO:0000166 GO:0000287 GO:0003824 GO:0004743 GO:0005524 GO:0006096 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0030955 GO:0046872
14	0.06	0.142	6.34	0.03	0.19	4cnjA	GO:0000166 GO:0016491 GO:0055114
15	0.06	0.145	6.90	0.06	0.20	4pmxA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493 GO:0046872
16	0.06	0.154	6.49	0.08	0.21	2ip2A	GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259
17	0.06	0.142	6.69	0.03	0.19	4hnnF	GO:0003824 GO:0008152 GO:0008840 GO:0009089 GO:0016829
18	0.06	0.145	6.75	0.05	0.20	1a0iA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0006260 GO:0006281 GO:0006310 GO:0006974 GO:0016874 GO:0046872 GO:0051103

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0032559	GO:0035639	GO:0032550	GO:0016781
GO-Score	0.56	0.46	0.46	0.46	0.36
Biological Processes	GO:0006796	GO:0032787
GO-Score	0.56	0.46
Cellular Component	GO:0020015	GO:0009507	GO:0019197	GO:0005829
GO-Score	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.