I-TASSER results

I-TASSER results for job id Rv2032

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (331 residues)
MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLDKDRVLYATDHSGREAL
LGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSPADFVTEGHRLRADAILLR
RTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRPELAAASKLTESLRLYDSSYH
AELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPVVANTDRRPEFGHDRSKVLVLST
YDNERASLLRCGEMLSAVLLDATMAGLATCTLTHITELHASRDLVAALIGQPATPQALVR
VGLAPEMEEPPPATPRRPIDEVFHVRAKDHR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLDKDRVLYATDHSGREALLGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSPADFVTEGHRLRADAILLRRTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRPELAAASKLTESLRLYDSSYHAELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPVVANTDRRPEFGHDRSKVLVLSTYDNERASLLRCGEMLSAVLLDATMAGLATCTLTHITELHASRDLVAALIGQPATPQALVRVGLAPEMEEPPPATPRRPIDEVFHVRAKDHR
Prediction	CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEHCCCCCCCCCCCCCCCCHHHHEEHCCCCCC
Conf.Score	9988899999999999999789877899879999599899997788777778975577899999999999999999899675898789999875899999768998865789999999866888888999999999999999985699699995889999999999999999885989999999976788888998866667777665554454466655555556654678869999869999999999999999999999998865544444566699999999997999968999998678888888998999997773664589999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLDKDRVLYATDHSGREALLGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSPADFVTEGHRLRADAILLRRTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRPELAAASKLTESLRLYDSSYHAELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPVVANTDRRPEFGHDRSKVLVLSTYDNERASLLRCGEMLSAVLLDATMAGLATCTLTHITELHASRDLVAALIGQPATPQALVRVGLAPEMEEPPPATPRRPIDEVFHVRAKDHR
Prediction	4576324461033004101300111101022032464212021145230220125312110000000000000021121322032034453421001020344543254343114203411122431555403750252036105443010100347104300400330231134253024002301434435210224112243343322122302334435334522441000000003533242004001000200110032200101001011245015302620647410000000010355663332021120420041346778
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEHCCEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEHCCCCCCCCCCCCCCCCHHHHEEHCCCCCC
MPDTMVTTDVIKSAVQLACRAPSLHNSQPWRWIAEDHTVALFLDKDRVLYATDHSGREALLGCGAVLDHFRVAMAAAGTTANVERFPNPNDPLHLASIDFSPADFVTEGHRLRADAILLRRTDRLPFAEPPDWDLVESQLRTTVTADTVRIDVIADDMRPELAAASKLTESLRLYDSSYHAELFWWTGAFETSEGIPHSSLVSAAESDRVTFGRDFPVVANTDRRPEFGHDRSKVLVLSTYDNERASLLRCGEMLSAVLLDATMAGLATCTLTHITELHASRDLVAALIGQPATPQALVRVGLAPEMEEPPPATPRRPIDEVFHVRAKDHR

2ymvA

0.54

0.53

0.98

2.91

MUSTER

-SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEVR---PR

2ymvA

0.54

0.53

0.98

3.90

dPPAS

-SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEVRPR---

2ymvA

0.54

0.53

0.98

5.71

wdPPAS

-SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEVRPR---

2ymvA

0.55

0.53

0.97

3.48

wMUSTER

--DTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEVR---PR

2ymvA

0.54

0.53

0.98

6.03

wPPAS

-SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEV---RPR

2ymvA

0.54

0.53

0.98

11.33

dPPAS2

-SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEVRPR---

2ymvA

0.54

0.53

0.98

4.97

PPAS

-SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSREA-VSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEVRPR---

2ymvA

0.54

0.53

0.98

7.80

Env-PPAS

-SDTRLDVATLANAVQLAARAPSLHNTQPWRLIAEDGELKLFLDPSRVVRSTDRSSRE-AVSCGVLLDHLRVALAAAGWDTEVQRFPNPNDRDHLATLSFRPLQFVTEGHRKRADAILARRTDRLPS--AYVDWDAFETLLRARLGDGPVHDTLGEDVREEVAEAAALTESLRLYDAAYHSELAWWTTPFATEDGIPQTALISAEESERVAVSRDFPVAPHSSRRPALNNDAATIVVLSTDGYSREDALDAGEGLSKVLLECTS-GLATCPVTHVTELHTSRDIIGRLIVRDACPQVLVRIGLAPALDEVPPPTPRRPVDAFLEVRPR---

3gr3A

0.14

0.09

0.63

0.84

MUSTER

------------------------------------------------------------------------------------------------------------APIDIFQSILSRKSIRA-FTDQPVTQETIREILKLAARQPWQVIVLTGKILQKVGQELSQLVLSGIKGERE----YHYYPRQWREPYLSRRRKVGLDLYKSLGIQKGDQEKLHQKAKNFLFYGAPVGLLFTIDHDE-GSWLDLGF---QTILAARGFGLDTCAQA---AFADYHKQIRSLLSVPDRHIICGALGYRDNAPENNFETEREPIDNFVHFIKSYP-

3gr3A

0.14

0.08

0.62

0.98

dPPAS

------------------------------------------------------------------------------------------------------------APIDIFQSILSRKSIRA-FTDQPVTQETIREILKLAARQPWQVIVLTGKILQKVGQELSQLVLSGIKGER--------EYHYYPRQWREPYLSRRRKVGLDLYKSLGIQKGDQEKLKNFLFYGAPVGLLFTIDHDE-GSWLDLGFQT---ILAARGFGLDTCAQA---AFADYHKQIRSLLSVPDRHIICGALGYRDNAPENNFETEREPIDNFVHFIKSYP-

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.89

Estimated TM-score = 0.98±0.05

Estimated RMSD = 2.6±1.9Å

Download Model 2

C-score=-2.02

Download Model 3

C-score=-5.00

Download Model 4

C-score=-4.67

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1vfrA	0.418	3.10	0.093	0.486
2	1ffvB3	0.354	6.52	0.052	0.574
3	1jroB	0.340	6.24	0.073	0.541
4	1x6lA2	0.335	6.73	0.051	0.583
5	1a4zA	0.333	6.45	0.048	0.556
6	1faeA	0.333	6.70	0.039	0.553
7	1nj1A	0.331	5.43	0.026	0.471
8	1gonA	0.328	6.83	0.049	0.565
9	1uuvA	0.326	6.41	0.046	0.523
10	1gqiA	0.326	7.10	0.036	0.592

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.43	12	3gh8A	FMN	Rep, Mult	120,121,122,124,270,271,272,273,316
2	0.07	3	1v5yA	FMN	Rep, Mult	22,23,24,26
3	0.05	2	2onmC	NA	Rep, Mult	14,15,20,68,117
4	0.02	1	3rj8A	ZN	Rep, Mult	69,223
5	0.02	1	3gh8C	UUU	Rep, Mult	120,121,122,124,170,174,186,189,222,226,270,271,272,273,316
6	0.02	1	1nzxB	NAD	Rep, Mult	11,12,14,70,71,74,75,98,100

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1nx9A	0.323	6.65	0.018	0.562	3.1.1.43	295
2	0.060	1o01C	0.314	6.67	0.050	0.532	1.2.1.3	NA
3	0.060	1lgrA	0.333	5.92	0.037	0.514	6.3.1.2	209
4	0.060	1gz7A	0.321	7.08	0.045	0.589	3.1.1.3	NA
5	0.060	1fziA	0.330	6.16	0.014	0.532	1.14.13.25	NA
6	0.060	1zumI	0.302	6.95	0.032	0.535	1.2.1.3	NA
7	0.060	1gnxA	0.330	6.90	0.049	0.571	3.2.1.21	NA
8	0.060	1htoA	0.309	6.84	0.040	0.538	6.3.1.2	NA
9	0.060	1ffuB	0.305	7.10	0.046	0.553	1.2.99.2	NA
10	0.060	1nj6A	0.331	5.40	0.031	0.468	6.1.1.15	140,253
11	0.060	1h1lB	0.318	6.89	0.052	0.559	1.18.6.1	NA
12	0.060	1v5yA	0.418	3.10	0.093	0.486	1.6.99.-	NA
13	0.060	2qnoA	0.318	6.73	0.034	0.544	3.2.1.4	NA
14	0.060	1kc7A	0.323	6.71	0.035	0.559	2.7.9.1	NA
15	0.060	2lgsA	0.333	6.06	0.037	0.520	6.3.1.2	62,69
16	0.060	1lpsA	0.314	7.35	0.046	0.589	3.1.1.3	22
17	0.060	1pl7A	0.322	7.10	0.033	0.580	1.1.1.14	NA
18	0.060	1kblA	0.327	6.45	0.036	0.544	2.7.9.1	NA
19	0.060	1qh1B	0.325	6.72	0.047	0.559	1.18.6.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.452	2.97	0.14	0.51	3gfaA	GO:0000166 GO:0016491 GO:0055114
1	0.21	0.413	3.20	0.19	0.47	3e39A	GO:0000166 GO:0016491 GO:0055114
2	0.19	0.411	3.40	0.14	0.49	1ds7A	GO:0004155 GO:0005829 GO:0010181 GO:0016020 GO:0016491 GO:0018545 GO:0042802 GO:0046256 GO:0055114
3	0.19	0.410	2.88	0.14	0.47	3m5kA	GO:0000166 GO:0016491 GO:0055114
4	0.19	0.410	3.33	0.16	0.48	1kqbA	GO:0016491 GO:0055114
5	0.18	0.455	3.45	0.16	0.53	3eo8A	GO:0000166 GO:0016491 GO:0055114
6	0.17	0.478	3.46	0.12	0.57	4ttcA	GO:0004447 GO:0005886 GO:0006590 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
7	0.16	0.481	3.42	0.11	0.57	3tnzA	GO:0004447 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
8	0.12	0.434	3.14	0.13	0.50	4ttbA	GO:0004447 GO:0005886 GO:0006590 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
9	0.11	0.441	2.94	0.16	0.50	4dn2A	GO:0000166 GO:0016491 GO:0055114
10	0.11	0.477	3.72	0.15	0.58	2wzvB	GO:0000166 GO:0010181 GO:0016491 GO:0042802 GO:0042803 GO:0050661 GO:0055114 GO:2001039
11	0.11	0.420	3.15	0.16	0.49	2hayD	GO:0000166 GO:0016491 GO:0055114
12	0.10	0.459	3.72	0.10	0.56	2isjA	GO:0000166 GO:0009236 GO:0016491 GO:0016705 GO:0055114
13	0.10	0.444	2.92	0.14	0.51	3ek3A	GO:0000166 GO:0016491 GO:0055114
14	0.09	0.433	2.81	0.12	0.49	4bn9A	GO:0000166 GO:0016491 GO:0055114
15	0.07	0.409	3.25	0.13	0.48	3qdlA	GO:0016491 GO:0046677 GO:0055114
16	0.06	0.432	3.01	0.14	0.50	3gb5A	GO:0004447 GO:0016020 GO:0016021 GO:0016491 GO:0055114 GO:0098869
17	0.06	0.417	2.55	0.13	0.46	1zchA	GO:0009636 GO:0016491 GO:0019439 GO:0052873 GO:0052874 GO:0055114
18	0.06	0.414	3.03	0.16	0.47	3ge5A	GO:0000166 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0032553	GO:0016657	GO:0048037	GO:0005515	GO:0016646
GO-Score	0.39	0.39	0.39	0.39	0.39
Biological Processes	GO:0055114	GO:0018974	GO:0046260
GO-Score	0.67	0.39	0.39
Cellular Component	GO:0044444
GO-Score	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.