I-TASSER results

I-TASSER results for job id Rv2024c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (515 residues)
MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAVWWWIDWPERRGRTDT
GIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTGFTNRVIISTTDRWGRN
AEDALADQLVPVQRIGMAEIAESPIDWDIAWPADDLQVNLTPAKRHELRPHQQQAIDAVF
RGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGSARILLLVPSISLLSQTLREWTA
QSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVLLHEMAHRRRAQGLTVVFCTY
QSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESNFVRVHDGQYLKAARRLYMTA
TPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQG
VIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMRRAVAFAKDIKTS
KQVAELFPKVVEAYRELVDDGPGLACLNSSRRIQA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAVWWWIDWPERRGRTDTGIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEIAESPIDWDIAWPADDLQVNLTPAKRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGSARILLLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVLLHEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESNFVRVHDGQYLKAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMRRAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACLNSSRRIQA
Prediction	CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEHCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHCCCCHHHHHHHHCCCCCCCEHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCEHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEHCCCHHHHHHCCCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCHCCCCHHHHCCCCCCEEEHCCCHHHCCCEEEEEEHHHHHHHCCCCCCEEEEEHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCC
Conf.Score	97899999999987885666678999999999857899999886544554554568887557899998489874555544347887666788899999878754456758996798645677776688876444358999988888888766555555656666788889999999999999998898599996789988999999999999985988779999667999999999999977788765444456545555456665566765555689999999856667787689997544445567767898887599996887776665455577899999887657776699976766444676455545566567766775447856898769999988986797899997555544455555555556787646899999999999999999987478876479999689999999999999999999987577755666477887659
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAVWWWIDWPERRGRTDTGIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEIAESPIDWDIAWPADDLQVNLTPAKRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGSARILLLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVLLHEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESNFVRVHDGQYLKAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMRRAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACLNSSRRIQA
Prediction	54204400520372554441032003001200320240262044012022015454442100100022165441012201111663504353043012113443032100001044024202422242324122010220251123143223345251423446423023102300420151056344100000001010000000001201532642100000002420151025104623544131001022342444464242452423122313201430354444641411011133045345365052621000000000102044244414520340143420430100000000102445335434444231131434610131002020330053410020301204154433454045414544551436304401521340024203420555440100000022161044006204610550463265644253343454268
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEHCCCCCEEEEEEEHCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHCCCCHHHHHHHHCCCCCCCEHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHCHHHHHHHHHHHHHHHCCCCCCCCEHCCCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEHCCCHHHHHHCCCCCCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEHCCCCCHCCCCHHHHCCCCCCEEEHCCCHHHCCCEEEEEEHHHHHHHCCCCCCEEEEEHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCC
MGSVHDVIEAFRKAPSNAERGTKFEQLMVRYFELDPTMAQQYDAVWWWIDWPERRGRTDTGIDLVARERDTGNYTAIQCKFYEPTHTLAKGDIDSFFTASGKTGFTNRVIISTTDRWGRNAEDALADQLVPVQRIGMAEIAESPIDWDIAWPADDLQVNLTPAKRHELRPHQQQAIDAVFRGFAVGNDRGKLIMACGTGKTFTALKIAERIAADNGGSARILLLVPSISLLSQTLREWTAQSELDVRAFAVCSDTKVSRSAEDYHVHDVPIPVTTDARVLLHEMAHRRRAQGLTVVFCTYQSLPTVAKAQRLGVDEFDLVMCDEAHRTTGVTLAGDDESNFVRVHDGQYLKAARRLYMTATPRIFTESIKDRADQHSAELVSMDDELTFGPEFHRLSFGEAVERGLLTDYKVMVLTVDQGVIAPRLQQELSGVSGELMLDDASKIVGCWNGLAKRSGTGIVAGEPPMRRAVAFAKDIKTSKQVAELFPKVVEAYRELVDDGPGLACLNSSRRIQA

4xqkA

0.38

0.37

0.96

2.41

MUSTER

-------KQTFDDLINQINTGTLFEKLTLAYLKNEPTYKALYQNVWLLSEVP---ESYGIPVDLVAEQKNGD-LVAIQAKFY--TNKVGKSEINSFVAELGKSYYQRGLIVSTMDDWNSNARETIDQNEKGIEIIGLSDLRNSQIDWSQFNF--ERPENVVVKKPKKLRDYQQTAKENALAHFK-ENDRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRMGFGQAVSRDILTDYKVMVLAVDEAAIQKDMQRTLADPENGLNIDDVGRIVGIWNGMMRRNGYNSPYDGAPLERAIAFTRTIEESKKVSSQFEEVVNEYISIDGQMNALQKGEVLDWLAN

4xqkA5

0.45

0.19

0.43

1.70

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LRDYQQTAKENALAHFK-ENDRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRM-----------------------------------------------------------------------------------------------------------------------

4xqkA5

0.45

0.19

0.43

2.61

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LRDYQQTAKENALAHFK-ENDRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRM-----------------------------------------------------------------------------------------------------------------------

4xqkA

0.38

0.37

0.96

2.98

wMUSTER

-------KQTFDDLINQINTGTLFEKLTLAYLKNEPTYKALYQNVWLLSEVPESY---GIPVDLVAEQKNGD-LVAIQAKFYTN--KVGKSEINSFVAELGKSYYQRGLIVSTMDDWNSNARETIDQNEKGIEIIGLSDLRNSQIDWSQFNF--ERPENVVVKKPKKLRDYQQTAKENALAHFKEN-DRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRMGFGQAVSRDILTDYKVMVLAVDEAAIQKDMQRTLADPENGLNIDDVGRIVGIWNGMMRRNGYNSPYDGAPLERAIAFTRTIEESKKVSSQFEEVVNEYISIDGQMNALQKGEVLDWLAN

4xqkA5

0.45

0.19

0.43

2.89

wPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LRDYQQTAKENALAHFKEN-DRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRM-----------------------------------------------------------------------------------------------------------------------

4xqkA5

0.45

0.19

0.43

4.47

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LRDYQQTAKENALAHFK-ENDRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRM-----------------------------------------------------------------------------------------------------------------------

4xqkA5

0.45

0.19

0.43

2.31

PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LRDYQQTAKENALAHFK-ENDRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRM-----------------------------------------------------------------------------------------------------------------------

4xqkA5

0.45

0.19

0.43

3.65

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------LRDYQQTAKENALAHFK-ENDRGQLIMAPGTGKTFTSLKISEALSKDKDGPFKVLYLVPSIQLLTQTLRGWNNDTELTMTSMAVTST-------EDIKASDIGYPATTSSKKILQNWHDFPKQTDMLVVFSTYQSIEVIGEAQKEGFPEFDFIISDEAHRTTGAHEAAKEASAFSKVHSNNNVKGLKRMYQTATPKIYGESAKKNAKDKSILLSSMDDESKYGEVFFRM-----------------------------------------------------------------------------------------------------------------------

2w00B

0.14

0.12

0.90

1.43

MUSTER

LANVREQLQNLNGVVFNDSEWRRFTEQYLDNPSDGILDKTRKIHIDYICDFIFDDERLDK-RYDVTILVNGLPLVQIELKKRGVAIREAFNQIHSLFKYLQLFVISNGTYFANTTKRDKNSFDFTNWAKSDNTLIKLKDFTATCFQKHTLLNVLVNYSVFDSSQTLLVRPYQIAATERILWKIKSSESGGYIWHTTGSGKTLTSFKAARLATE-LDFIDKVFFVVDRKDLDYQTKEYQRFSPDS--------------------------VNGSENTAGLKRNLD----KDDNKIIVTTIQKLNNLKAESDLPYNQQVVFIFDECHRSQFGEAQKNLKKKF---------KRYYQFGFTGTPIFPENALGSE-----------TTASVFGRELHSYVITDAIRDEKVLKFKVDYNDVRPQFKSLETEKKLSAAENQFLHPRIQEITQYILNNFRQKTHRTFPGSK--GFNALAVSSVDAAKAYYATFKRLQEEAANKSATYKPLRIATIFSFAAI

5ivwV

0.17

0.11

0.66

1.27

dPPAS

-------------------------------------------------------------------------------------------------------IPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAVNPDINIDLKPTAVLRPYQEKSLRKMFGNG--RARSGVIVLPCGAGKSLVGVTAACTVR------KRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSD------------------------------AKDKPIGCSVAISTYSMLGHTTKMEWLKTQEWGLMILDEVHTIPAKM--------FRRVLTIV--QAHCKLGLTATLVREDDKIVDL-------------NFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPE-----FYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRN--DKIIVFADNVFALKEYAIRLNKPY-----IYGPTSQGERMQILQNFKH

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.95

Estimated TM-score = 0.59±0.14

Estimated RMSD = 9.6±4.6Å

Download Model 2

C-score=0.37

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2w00B	0.791	3.26	0.128	0.893
2	4xqkA	0.510	4.45	0.262	0.616
3	5b7iA	0.499	5.91	0.111	0.685
4	1z3iX	0.498	5.17	0.124	0.639
5	2eyqA	0.478	5.31	0.094	0.629
6	4pj3A	0.477	5.68	0.070	0.643
7	4bgdA2	0.473	3.79	0.110	0.559
8	3h1tA	0.470	3.91	0.171	0.548
9	4f91B	0.470	4.24	0.099	0.573
10	5jc3A	0.467	4.37	0.129	0.569

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.29	10	2w74B	ATP	Rep, Mult	166,167,168,169,172,196,197,198,199,200,201,202
2	0.12	4	4bebB	MG	Rep, Mult	200,201,323,324
3	0.06	2	3jv2B	III	Rep, Mult	176,202,205,207,209,210
4	0.03	1	2xb2X	III	Rep, Mult	193,194,199,204,207,392,393

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2hyiI	0.431	4.41	0.148	0.528	3.6.4.13	198,201,233
2	0.060	3kx2B	0.443	4.66	0.084	0.555	3.6.4.13	224
3	0.060	1uaaA	0.395	4.64	0.074	0.489	3.6.4.12	NA
4	0.060	1z0hB	0.255	7.18	0.039	0.406	3.4.24.69	338
5	0.060	2gtqA	0.381	7.53	0.036	0.633	3.4.11.2	NA
6	0.060	2wwyA	0.415	4.73	0.121	0.530	3.6.4.12	226
7	0.060	1t3tA	0.371	7.31	0.056	0.600	6.3.5.3	NA
8	0.060	1clqA	0.366	7.76	0.056	0.625	2.7.7.7	190
9	0.060	2jlzB	0.368	3.90	0.145	0.435	3.4.21.91	220,222,359
10	0.060	2vuaA	0.250	7.09	0.043	0.392	3.4.24.69	NA
11	0.060	3i62A	0.465	4.83	0.114	0.583	3.6.4.13	173,198,201
12	0.060	3iayA	0.367	7.78	0.043	0.625	2.7.7.7	205
13	0.060	2epoB	0.372	7.25	0.053	0.600	3.2.1.52	323,324
14	0.060	2is4B	0.389	5.70	0.070	0.538	3.6.1.-	NA
15	0.060	1hv8A	0.386	4.95	0.115	0.497	3.6.4.13	201,230
16	0.060	2olsA	0.367	7.06	0.090	0.579	2.7.9.2	NA
17	0.060	3crvA	0.428	4.44	0.093	0.530	3.6.4.12	199,207
18	0.060	3l9oA	0.401	4.69	0.089	0.499	3.6.4.13	195,200,231,324,326,361
19	0.060	2dqmA	0.379	7.99	0.034	0.660	3.4.11.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.25	0.443	5.19	0.09	0.57	3mwyW	GO:0000124 GO:0000166 GO:0000182 GO:0000790 GO:0001178 GO:0003677 GO:0004386 GO:0005524 GO:0005634 GO:0006351 GO:0006355 GO:0006363 GO:0006368 GO:0006369 GO:0008094 GO:0016568 GO:0016584 GO:0016787 GO:0030874 GO:0031490 GO:0034728 GO:0035064 GO:0042766 GO:0043044 GO:0044212 GO:0046695 GO:0060303 GO:0070615 GO:0071441 GO:0071894 GO:1900050 GO:1902275 GO:2000104 GO:2000616
1	0.21	0.449	3.99	0.38	0.53	5ffjB	GO:0000166 GO:0003676 GO:0003677 GO:0004518 GO:0004519 GO:0005524 GO:0006306 GO:0008168 GO:0008170 GO:0016787 GO:0032259 GO:0090305
2	0.18	0.277	7.72	0.04	0.46	1t5lA	GO:0000166 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009381 GO:0009432 GO:0016787 GO:0090305
3	0.17	0.441	5.04	0.15	0.57	1wp9A	GO:0000166 GO:0003676 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0006259 GO:0006281 GO:0046872 GO:0090305
4	0.16	0.390	4.98	0.09	0.50	3tbkA	GO:0000166 GO:0002230 GO:0002376 GO:0003677 GO:0003690 GO:0003723 GO:0003725 GO:0003727 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005923 GO:0008270 GO:0009597 GO:0009615 GO:0010628 GO:0015629 GO:0016020 GO:0016787 GO:0016817 GO:0030054 GO:0030334 GO:0032480 GO:0032587 GO:0032725 GO:0032727 GO:0032728 GO:0032755 GO:0032757 GO:0039529 GO:0042802 GO:0042993 GO:0042995 GO:0043330 GO:0045087 GO:0045944 GO:0046872 GO:0051607
5	0.16	0.799	3.22	0.12	0.90	4xjxB	GO:0000166 GO:0003677 GO:0004519 GO:0005524 GO:0006304 GO:0009035 GO:0009307 GO:0016787 GO:0090305
6	0.09	0.416	4.53	0.13	0.51	1c4oA	GO:0000166 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009381 GO:0009432 GO:0016787 GO:0090305
7	0.07	0.477	3.90	0.18	0.56	3h1tA	GO:0000166 GO:0003677 GO:0003824 GO:0005524 GO:0006304 GO:0016787
8	0.07	0.459	5.18	0.07	0.59	2wjyA	GO:0000166 GO:0000184 GO:0000294 GO:0000723 GO:0000784 GO:0000785 GO:0000932 GO:0000956 GO:0003677 GO:0003682 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006260 GO:0006281 GO:0006406 GO:0006449 GO:0008270 GO:0009048 GO:0016787 GO:0032201 GO:0035145 GO:0042162 GO:0044530 GO:0044822 GO:0046872 GO:0061014 GO:0061158 GO:0071044 GO:0071222 GO:0071347
9	0.07	0.458	4.57	0.10	0.56	5f9fI	GO:0000166 GO:0002230 GO:0002376 GO:0003676 GO:0003690 GO:0003723 GO:0003725 GO:0003727 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005923 GO:0008270 GO:0009597 GO:0009615 GO:0010628 GO:0015629 GO:0016020 GO:0016032 GO:0016787 GO:0016817 GO:0030054 GO:0030334 GO:0032480 GO:0032587 GO:0032725 GO:0032727 GO:0032728 GO:0032755 GO:0032757 GO:0034344 GO:0039528 GO:0039529 GO:0042802 GO:0042993 GO:0042995 GO:0043330 GO:0045087 GO:0045944 GO:0046872 GO:0051091 GO:0051607
10	0.07	0.466	4.39	0.10	0.56	5f9hG	GO:0000166 GO:0002230 GO:0002376 GO:0003676 GO:0003690 GO:0003723 GO:0003725 GO:0003727 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005923 GO:0008270 GO:0009597 GO:0009615 GO:0010628 GO:0015629 GO:0016020 GO:0016032 GO:0016787 GO:0016817 GO:0030054 GO:0030334 GO:0032480 GO:0032587 GO:0032725 GO:0032727 GO:0032728 GO:0032755 GO:0032757 GO:0034344 GO:0039528 GO:0039529 GO:0042802 GO:0042993 GO:0042995 GO:0043330 GO:0045087 GO:0045944 GO:0046872 GO:0051091 GO:0051607
11	0.07	0.457	4.55	0.10	0.56	4a36A	GO:0000166 GO:0003677 GO:0005524 GO:0005737 GO:0016787 GO:0016817 GO:0046872
12	0.06	0.436	4.99	0.11	0.56	2ykgA	GO:0000166 GO:0002230 GO:0002376 GO:0003676 GO:0003690 GO:0003723 GO:0003725 GO:0003727 GO:0004386 GO:0005524 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005923 GO:0008270 GO:0009597 GO:0009615 GO:0010628 GO:0015629 GO:0016020 GO:0016032 GO:0016787 GO:0016817 GO:0030054 GO:0030334 GO:0032480 GO:0032587 GO:0032725 GO:0032727 GO:0032728 GO:0032755 GO:0032757 GO:0034344 GO:0039528 GO:0039529 GO:0042802 GO:0042993 GO:0042995 GO:0043330 GO:0045087 GO:0045944 GO:0046872 GO:0051091 GO:0051607
13	0.06	0.437	5.40	0.06	0.58	2xzlA	GO:0000166 GO:0000184 GO:0000956 GO:0003677 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005844 GO:0006310 GO:0006449 GO:0006452 GO:0008270 GO:0008298 GO:0016567 GO:0016787 GO:0016887 GO:0030466 GO:0043024 GO:0046872 GO:0070478
14	0.06	0.405	5.71	0.13	0.54	2d7dA	GO:0000166 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009381 GO:0009432 GO:0016787 GO:0090305
15	0.06	0.412	5.14	0.08	0.53	4a2wA	GO:0000166 GO:0003677 GO:0005524 GO:0005737 GO:0016787 GO:0016817 GO:0046872
16	0.06	0.396	4.86	0.14	0.50	4kbfA	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0016787
17	0.06	0.317	7.57	0.03	0.53	5ffjA	GO:0000166 GO:0003676 GO:0003677 GO:0004518 GO:0004519 GO:0005524 GO:0006306 GO:0008168 GO:0008170 GO:0016787 GO:0032259 GO:0090305
18	0.06	0.428	4.44	0.09	0.53	3crvA	GO:0000166 GO:0003676 GO:0003677 GO:0004003 GO:0004386 GO:0005524 GO:0006139 GO:0006281 GO:0006351 GO:0006974 GO:0008026 GO:0016787 GO:0016818 GO:0032508 GO:0043139 GO:0046872 GO:0051536 GO:0051539

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0004386	GO:0043566	GO:0000975	GO:0042623	GO:0042393	GO:1990837	GO:0003682	GO:0016741	GO:0004520	GO:0003723	GO:0046914
GO-Score	0.66	0.57	0.51	0.51	0.51	0.51	0.51	0.51	0.41	0.36	0.32	0.32
Biological Processes	GO:0006353	GO:0001174	GO:0060260	GO:0065008	GO:0090329	GO:0035067	GO:1900049	GO:0033523	GO:0071440	GO:2000615	GO:0006360	GO:0006354	GO:0008156	GO:0031497	GO:0090305	GO:0006305	GO:0043414	GO:0044728	GO:0031668	GO:0006281	GO:0001818	GO:0032675	GO:0039528	GO:2000145	GO:0032647	GO:0042307	GO:0032677	GO:0016477	GO:0042990	GO:0043331	GO:0045893	GO:0032645	GO:0050691	GO:0032481	GO:0032648
GO-Score	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.46	0.41	0.41	0.41	0.36	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32	0.32
Cellular Component	GO:0070461	GO:0000790	GO:0044452	GO:0043296	GO:0001726	GO:0031256	GO:0005856	GO:0070160	GO:0044444	GO:0031253
GO-Score	0.51	0.51	0.51	0.32	0.32	0.32	0.32	0.32	0.32	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.