I-TASSER results

I-TASSER results for job id Rv2017

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (346 residues)
MNGLGDVLAVARKARGLTQIELAELVGLTQPAINRYESGDRDPDQHIVAKLAEILGVTDD
LLIHGNRFRGALAVDAHMRRHKTTKASAWRQLEARLNLLRVHASFLFEEVAINSEQHVPA
FDPEFTAAEDAARLVRAQWRMPMGPVVNLTRWMEAAGCLVFEEDFATQRIDGLSQWVDDY
PVMLINANAAPDRKRLTLAHELGHLVLHSTNPTENMETEATAFAAEFLMPESEIRPELRR
LDLGKLLELKREWGVSMQALLARAYRMGLVSAEARTKLYKAMNARGWKTKEPGIESIVRE
KPSLPAHIGMTLRSRGFTDQQAAAIAGYANPADNPFRPEGGRLHAI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNGLGDVLAVARKARGLTQIELAELVGLTQPAINRYESGDRDPDQHIVAKLAEILGVTDDLLIHGNRFRGALAVDAHMRRHKTTKASAWRQLEARLNLLRVHASFLFEEVAINSEQHVPAFDPEFTAAEDAARLVRAQWRMPMGPVVNLTRWMEAAGCLVFEEDFATQRIDGLSQWVDDYPVMLINANAAPDRKRLTLAHELGHLVLHSTNPTENMETEATAFAAEFLMPESEIRPELRRLDLGKLLELKREWGVSMQALLARAYRMGLVSAEARTKLYKAMNARGWKTKEPGIESIVREKPSLPAHIGMTLRSRGFTDQQAAAIAGYANPADNPFRPEGGRLHAI
Prediction	CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCCEEEEEHCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCC
Conf.Score	9868999999999999999999999899999999999799999999999999998999777458988776667656777765555679999999999999999998877656666666665555566788999999987788876899999999989799996688876546899979956999869998778899999999999988899865899999999999859999999999869999999999998989999999999989999999999999999989855688877777778699999999999889999999999899875544544666775569
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNGLGDVLAVARKARGLTQIELAELVGLTQPAINRYESGDRDPDQHIVAKLAEILGVTDDLLIHGNRFRGALAVDAHMRRHKTTKASAWRQLEARLNLLRVHASFLFEEVAINSEQHVPAFDPEFTAAEDAARLVRAQWRMPMGPVVNLTRWMEAAGCLVFEEDFATQRIDGLSQWVDDYPVMLINANAAPDRKRLTLAHELGHLVLHSTNPTENMETEATAFAAEFLMPESEIRPELRRLDLGKLLELKREWGVSMQALLARAYRMGLVSAEARTKLYKAMNARGWKTKEPGIESIVREKPSLPAHIGMTLRSRGFTDQQAAAIAGYANPADNPFRPEGGRLHAI
Prediction	6541152024006626111530074161346202310546440426102300620702031204424254435344323224224422242032014103311422242032223222222222232222224222330222321032023114304120020403422212000226420000003433311100000000000000354545510310020000000026303620572315202300630400000002003303203472034004102644144624456615443140042004103754024630151051344224413555451366
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEEEHCCCCCCCCEEEEEHCCEEEEEHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHCCCCCCCCCC
MNGLGDVLAVARKARGLTQIELAELVGLTQPAINRYESGDRDPDQHIVAKLAEILGVTDDLLIHGNRFRGALAVDAHMRRHKTTKASAWRQLEARLNLLRVHASFLFEEVAINSEQHVPAFDPEFTAAEDAARLVRAQWRMPMGPVVNLTRWMEAAGCLVFEEDFATQRIDGLSQWVDDYPVMLINANAAPDRKRLTLAHELGHLVLHSTNPTENMETEATAFAAEFLMPESEIRPELRRLDLGKLLELKREWGVSMQALLARAYRMGLVSAEARTKLYKAMNARGWKTKEPGIESIVREKPSLPAHIGMTLRSRGFTDQQAAAIAGYANPADNPFRPEGGRLHAI

5jubA

0.12

0.10

0.84

1.00

MUSTER

LKSIGLRIKTERERQQMSREVLCLGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYEMKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFD-------------ILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRFSTNDLLVIDYY-----FFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTV-VDKALAVIEKSQLYSYKPSVFVLKAKYENKKEAAENYDKAIVFASVLEDS----------VLEESIKAGKLADGLG----------------------------

5jubA

0.11

0.09

0.83

0.97

dPPAS

KDSIGLRIKTERERQQMSREVLCDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYEMKNRLIKFPDRIKSKLTLIEEVYEKFFEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKSLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIVFASVLE--DSVLEESIKAGKLADGLG----------------------------------------------------------

5jubA

0.11

0.09

0.81

1.47

wdPPAS

LKDIGLRIKTERERQQMSREVLCLGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYEMKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTFTSWEESPKVEEIYEDLFEQVKRKRKFSTNDLLVIDYYF---FHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSD---------FLTVV--DKALAVIEKSQLYSYKPSVFVLKA--KYELLH--------NKKEAAENYDKAIVF--------------EDSVLEESIKAGKLADGLG----------------------------

5fd4A

0.14

0.11

0.81

1.03

wMUSTER

MNDFGQRVRQLRESASMTREQFCDELELSVRQLTRIEAGASKPTFSKIQYIATRLGMGLYELMPDYVSLPERYSKLKFDVLRTPTYGNEDLAEKRDAMMTEIYDDYYDEL--------------PEEEKIAIDAIQSRIDTLESGKEILEDYFEQI----------------------------FRKRKYELNDLLIVRLHLEYVRLSSCDS--------EIFRQFLKI-IEHLHEQINIINSNDLFVLRDTL-LSCVNILGSKKYY-----EPIPKIFDSVDKIIQSTQD------FQKKPIVSVLKWKYALFVDKDRDEAEKHY----LDAVLFAKLIENEQKI

5jubA

0.10

0.08

0.79

1.56

wPPAS

LK-IGLRIKTERERQQMSREVLCLGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYEMKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFD-------------ILPEEELLTLDILENILSFTSWEESPKVEEIYEDL--------------------------VKRKRKFS-----TNDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLTDDVYNIVLFNDLAIAALKIFHNSFS-DFLTVVDKALAV--IEKSQLYSYKPSVFVLKAKKEN-------------KKEAAENYDK----AIVFASVLE---SVLEESIKA--GLG--

1b0nA

0.16

0.05

0.29

1.61

dPPAS2

--MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTPSIQFLEKVSAVLDVSVHTLLDEKHETLDSEWEVRDAMTSGVSKKQFREFLDYQKWRKSQ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5jubA

0.11

0.09

0.80

1.40

PPAS

LKSIGLRIKTERERQQMSREVLCLGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYEMKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFD-------------ILPEEELLTLDILENILSFTSWEESPKVEEIYEDL---------------------------VKRKRKFSTNDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDAIAALKIFHNSFSDFLTVVDKALAVIEKSQLYSYKPSVFVLKAKYELLHKENKKEAAEEDSVLEESIKAGKLADGLG----------------------------

3jxbC

0.25

0.05

0.19

1.77

Env-PPAS

QL-MGERIRARRKKLKIRQAALGKMVGVSNVAISQWERSETEPNGENLLALSKALQCSPDYLLKGD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5fd4A

0.12

0.10

0.83

0.95

MUSTER

MNDFGQRVRQLRESASMTREQFCDELELSVRQLTRIEAGASKPTFSKIQYIATRLGMGLYELMPDYVSLPERYSKLKFDVLRTPTYGNEDLAEKRDAMMTEIYDDYYDEL-------------PEEEKIAIDAIQSRIDTLESGTAGFGKEILEDYFEQIFRKRKYE------------------------LNDLLIVRLHLEYVRLSSCDS--------EIFRQFLKI-IEHLHEQINIINSNDLFVLRDTL-LSCVNILGSKKYYEPI-PKIFDSVDKIIQSTQD----------FQKKPIVSVLKWKYALFVDKDRDEAEKHYLDAVLFAKLIENREQKIEED

5fd4A

0.12

0.10

0.82

0.89

dPPAS

MNDFGQRVRQLRESASMTREQFCDELELSVRQLTRIEAGASKPTFSKIQYIATRLGMGLYELMPDYVSLPERYSKLKFDVLRTPTYGNEDLAEKRDAMMTEIYDDYYDELPEQSRIDTLESGTAGFGKEILEDYFEQIFRKRKYELNDLLIVRLHLEYVRLSSCDSEIFRQFLKIIEHLHEQIIINSNDLFVLRDTLLSCVNILGSKKYYEPIPKIFDSVDKIIQSTKKPIVSVLKWKYALFVDKDRDEAEKH---YLDAVLFAKLIE--NRELEQKIEEDWRVDNQ-----------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.88

Estimated TM-score = 0.39±0.13

Estimated RMSD = 13.5±4.0Å

Download Model 2

C-score=-2.93

Download Model 3

C-score=-3.79

Download Model 4

C-score=-4.07

Download Model 5

C-score=-4.47

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5fd4A	0.740	2.80	0.104	0.832
2	1w6jA	0.532	5.77	0.062	0.798
3	3sqcA	0.530	5.70	0.057	0.801
4	2eabA	0.525	5.76	0.075	0.806
5	4k6jA	0.524	5.41	0.043	0.760
6	4ufcA	0.515	5.76	0.072	0.789
7	5jubA	0.515	4.09	0.079	0.656
8	3msvA	0.509	4.95	0.092	0.697
9	3h7lA	0.505	4.63	0.063	0.682
10	5bv9A	0.500	5.78	0.029	0.754

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	5	3dnvB	NUC	Rep, Mult	12,18,19,30,31,34,38
2	0.09	4	1i1iP	ZN	Rep, Mult	200,204,217
3	0.07	3	3prqX	CLA	Rep, Mult	221,228
4	0.05	2	5jubA	III	Rep, Mult	81,83,84,85,99,135,202,203,251,252,255,259,299,303,306,310,345
5	0.05	2	5d3eI	III	Rep, Mult	134,139,195,202,203,255,256,259,307
6	0.02	1	1gzmB	C8E	Rep, Mult	198,234
7	0.02	1	3m1cA	XYL	Rep, Mult	4,51,55
8	0.02	1	3wmn2	BCL	Rep, Mult	234,238
9	0.02	1	1ocoB	HEA	Rep, Mult	228,229
10	0.02	1	3dtkA	ZN	Rep, Mult	201,204
11	0.02	1	4zfzA	ZN	Rep, Mult	214,217

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1fmiA	0.452	5.13	0.062	0.639	3.2.1.113	130
2	0.060	1r76A	0.443	5.72	0.053	0.668	4.2.2.2	133
3	0.060	1g87B	0.475	5.41	0.032	0.691	3.2.1.4	NA
4	0.060	2qnoA	0.475	5.65	0.052	0.711	3.2.1.4	NA
5	0.060	1ut9A	0.486	5.72	0.040	0.731	3.2.1.4	NA
6	0.060	2sqcA	0.530	5.73	0.070	0.806	5.4.99.17	130,200
7	0.060	1hn0A	0.497	6.23	0.052	0.792	4.2.2.20	200
8	0.060	1js4A	0.476	5.47	0.049	0.688	3.2.1.4	NA
9	0.060	1l2aE	0.493	5.79	0.054	0.746	3.2.1.4	125
10	0.060	1j0mA	0.435	5.65	0.047	0.659	4.2.2.12	NA
11	0.060	1fp3A	0.458	5.20	0.038	0.647	5.1.3.8	195
12	0.060	1hcuB	0.437	5.25	0.067	0.633	3.2.1.113	NA
13	0.060	2f6dA	0.446	5.10	0.053	0.642	3.2.1.3	NA
14	0.060	1ksdA	0.458	5.44	0.063	0.676	3.2.1.4	220,224
15	0.060	1w6jA	0.532	5.77	0.062	0.798	5.4.99.7	125
16	0.060	2jg0A	0.456	6.28	0.033	0.749	3.2.1.28	NA
17	0.060	1ia7A	0.458	5.42	0.035	0.676	3.2.1.4	NA
18	0.060	1dl2A	0.449	5.33	0.034	0.662	3.2.1.113	NA
19	0.060	1ayxA	0.473	5.86	0.039	0.717	3.2.1.3	53

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.532	5.77	0.06	0.80	1w6jA	GO:0000250 GO:0005783 GO:0005789 GO:0005811 GO:0006629 GO:0006694 GO:0006695 GO:0016020 GO:0016853 GO:0016866 GO:0031647
1	0.07	0.530	5.73	0.07	0.81	2sqcA	GO:0005886 GO:0016020 GO:0016829 GO:0016853 GO:0016866 GO:0019746 GO:0051007
2	0.07	0.499	5.69	0.06	0.73	5bp8A	GO:0003824
3	0.07	0.503	5.87	0.05	0.78	2rdyA	GO:0003824 GO:0004560
4	0.06	0.443	5.72	0.05	0.67	1r76A	GO:0016829
5	0.06	0.424	6.14	0.05	0.66	2pn5A	GO:0004866 GO:0005576 GO:0005615 GO:0010951
6	0.06	0.424	6.04	0.05	0.66	4lnvB	GO:0004866 GO:0005576 GO:0005615 GO:0010951
7	0.06	0.418	5.77	0.04	0.64	1dceB	GO:0003824 GO:0004659 GO:0004663 GO:0005968 GO:0008270 GO:0016740 GO:0017137 GO:0018344 GO:0046872
8	0.06	0.515	5.73	0.07	0.79	4ufcB	GO:0003824 GO:0004560
9	0.06	0.525	5.76	0.07	0.81	2eabA	GO:0003824 GO:0016020 GO:0016021 GO:0046872
10	0.06	0.333	6.26	0.08	0.52	3awjA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
11	0.06	0.300	6.62	0.06	0.50	3d12A	GO:0004308 GO:0016020 GO:0016021 GO:0016032 GO:0019012 GO:0019031 GO:0019058 GO:0019062 GO:0020002 GO:0033644 GO:0046718 GO:0046789 GO:0055036 GO:0075509 GO:0075512
12	0.06	0.287	5.60	0.04	0.44	13gsA	GO:0000302 GO:0002674 GO:0004364 GO:0005615 GO:0005622 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006469 GO:0006749 GO:0006805 GO:0007417 GO:0008144 GO:0008152 GO:0008432 GO:0009636 GO:0009890 GO:0010804 GO:0014003 GO:0016740 GO:0019207 GO:0031100 GO:0031667 GO:0031982 GO:0032355 GO:0032691 GO:0032720 GO:0032869 GO:0032872 GO:0032873 GO:0032930 GO:0033591 GO:0035726 GO:0035730 GO:0035731 GO:0035732 GO:0043066 GO:0043124 GO:0043200 GO:0043295 GO:0043407 GO:0043409 GO:0043508 GO:0045471 GO:0046689 GO:0048147 GO:0051771 GO:0070026 GO:0070062 GO:0070372 GO:0070373 GO:0070664 GO:0071222 GO:0071364 GO:0071385 GO:0071460 GO:0071638 GO:0097057 GO:1901687 GO:2001237
13	0.06	0.298	6.54	0.06	0.49	2x9mA	GO:0004308 GO:0016020 GO:0016021 GO:0016032 GO:0019012 GO:0019031 GO:0019058 GO:0019062 GO:0020002 GO:0033644 GO:0046718 GO:0046789 GO:0055036
14	0.06	0.272	6.61	0.06	0.46	4ic6A	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0009507 GO:0009534 GO:0009536 GO:0009543 GO:0009579 GO:0010206 GO:0016787 GO:0031977
15	0.06	0.276	6.92	0.04	0.48	4gl4A	GO:0004022 GO:0005737 GO:0006069 GO:0008270 GO:0016491 GO:0046872 GO:0051903 GO:0055114
16	0.06	0.267	5.87	0.04	0.41	1dbtA	GO:0003824 GO:0004590 GO:0005829 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
17	0.06	0.235	6.97	0.04	0.41	3p0sA	GO:0019079
18	0.06	0.284	6.70	0.04	0.47	3b1nB	GO:0000166 GO:0016301 GO:0016310 GO:0016740 GO:0016773

Consensus prediction of GO terms

Molecular Function	GO:0016829	GO:0000250	GO:0051007	GO:0004560
GO-Score	0.13	0.07	0.07	0.07
Biological Processes	GO:0019746	GO:0006695	GO:0031647
GO-Score	0.07	0.07	0.07
Cellular Component	GO:0005789	GO:0005811	GO:0005886
GO-Score	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.