I-TASSER results

I-TASSER results for job id Rv2015c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (418 residues)
MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVAELDRDGLWGVTGARSV
AGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHY
AQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSADEQFSCWRIKLPHVEAAKFD
AALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAFLRLVEAGWDAEVARRPHGQHTT
VVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEAWFERDGQVIGCGRTTRQINRRLRR
ALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGATELANLVLVCPYHHRAHHRGLITITGP
ADNLTVADSAGRPLSAGSLARASTKPPPAVAPWPGPTGERADWWWYEPFQPQPPPISN

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVAELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSADEQFSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAFLRLVEAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEAWFERDGQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGATELANLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPPPAVAPWPGPTGERADWWWYEPFQPQPPPISN
Prediction	CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHCCCCCCEHCCCCCCCCHHHHHHHHHCCCEEEEHCCCCCHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9987778776677578999999999999999999999999999998875655446865599999999899999999999999998776799999998998699999888876568889999987656657888888776655556777766554433445677568987578665546654456667766555666666677888888854545567899876566676666556645568998677756545478999999999999985965676479885546886657888999999998588778999999875557766445789999988855665666444446985888579957997899988888888888899999889999998878877778888899999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVAELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSADEQFSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAFLRLVEAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEAWFERDGQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGATELANLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPPPAVAPWPGPTGERADWWWYEPFQPQPPPISN
Prediction	5624344425414414303301500340331120020200310220353411443404100100121140134202200310310340220130032231224203210520452324200420440213202200221222242443445543434444543212121302232102011102320231025234434344344341131222100001002212332213324123022202021221010021012002200320011020212142332003122322212210010000013000101032012010010332253130104001100330021224431323346521311114113133332333434121412235413251264313522536223588
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHCCCCCCEHCCCCCCCCHHHHHHHHHCCCEEEEHCCCCCHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MSSTATSGAAVVSPAERVEVLFEELAELAGQRNAIDGRIVEIVAELDRDGLWGVTGARSVAGLVAWKMGCSSGNAHTIATVARRLPEFPRCARGMREGRLSLDQVGVIAGRAGEGSDAHYAQLAGVATVNQLRTALKLEPRPEPEPDFRPEPRPSITRSADEQFSCWRIKLPHVEAAKFDAALQSHLDALIAEYKRDHDNSDGVSDQRPPLPGNVEAFLRLVEAGWDAEVARRPHGQHTTVVMHLDVQERAAGLHLGPLLSESERRYLLCDATFEAWFERDGQVIGCGRTTRQINRRLRRALEHRDRTCVVPGCGATRGLHAHHIRHWQDGGATELANLVLVCPYHHRAHHRGLITITGPADNLTVADSAGRPLSAGSLARASTKPPPAVAPWPGPTGERADWWWYEPFQPQPPPISN

4ogcA3

0.17

0.06

0.34

1.08

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGFTSRDKANRRRYNDNQEAKKIQRDYGK-----EGYISRGDIVRLDALELQGCCLY--CGTTIGCQLDHIVPQAGPGSNNRGNLVAVCERCNRSKSNTPFAVWAQKCG----IPHVGVKEAIGRVRGWRKQTPNTSSEDKEVIARLRRTQEDPE---------

5cwqA

0.10

0.06

0.56

1.15

dPPAS2

-EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.12

0.10

0.80

1.40

PPAS

--------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK----------------------------------------------------------------

4cg4A

0.06

0.05

0.86

1.25

Env-PPAS

--------------SEVALEHKKKIQKQLEHLKKLRKSGEEQRSYGEEKAVSFLKQTEALKQRVQRKLE--QVYYFLEQQEHFFVASLEDVGQMVGQIR--KAYDTRVSQDIALL-DALIGELEAKECQSEWELLQDIGDILHRAKTVPVPEKWTTPQEIKQKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVN-VILDAETAYPNLIFSDDLKSVRLGNKWERLP---DGPQRFDSCIIVLGSPSFLSGRRYWEVVGDKTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQA--SSVPPTRLLIKEPPYRVGSISNVTARSHIYTFASCSFSGPGTRDGGKNTAPLTICPVGGQGPDALEVLFQ-----------------------------------

4ke2A

0.13

0.06

0.47

1.10

dPPAS2

-MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAK--------------------------------AAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5lo9A

0.10

0.09

0.91

1.11

PPAS

DEALGAARLAGLEPAYLATQIERFRAVMSPWAERLTPVDIAAVSAYYGALAPASNARAPSDVDAAAGRALAETGDWPERDLPACVRCHGPGGVGAGAVPLALAQLQAWGTGRRHGEPMALMGAVAGRLDADEQRALAAYFATRPLARAEAASRFTPPSRDAL-------------PEGPLGEMVRLGARLFRHTNTDPRSAPHVGNDQTCAGCHLDNGR----RADASPMWAAWVAY------------PAYRGKNQRVDTMAERIQGCFRYSMNAQDSVSGQVPETNGLV---LDALQSYIFWLATGAPTGDTAMSGRGYPRLQPPAEGFDRTGAALYAEHCALCHGAEGEG----LLVDGEVVFPPLWGPRSYNWGAGMHRVDTAAAFIAANMPLLDTVR--NAHE-RPQDPRFDG

5cwiA

0.09

0.05

0.56

1.06

dPPAS2

-----------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEE---AVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNA-------------------------DIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER--------------------------------------------------------------------------------------------------------------------------------------

5hzdA

0.11

0.94

1.09

PPAS

LYSCDACPHAVFTTHAALLAHAEEHHADLLPDHARLRRIAQKLNPVWNRALNARTSWGKKIFHVAAQRDAGESKMQEAHRARAQLECVVRRWSSVAMGVWDGT-AVVDVDAMERGSWPPLEKNAVRSITELLRRVGFSFVNLEPISHARVPIIKHHASSPDVVARSIRFILNGPATREDRLLLEGSVRDAVGPTGVQQVWWNRTSDMMSATLES---TTAAVRAAMCSPALASASLRTKVQPAHDECRPELYNIDAFGIRNSTLLRKYLLSHPCARPG-GVNNSVNGYFTSYAINIMWIYYLVQKGYVPYVDPESLVNYTDFDPRYTPMIDPEITNTEREELYKAAGDMLVG--YSFEFDWGHNVISLNRPGITTKRMLGWHVEDVRHPTRYE--------------PYE----ENLN

5cwmA

0.11

0.06

0.51

1.05

dPPAS2

EAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPE------------VARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5hzdA

0.11

0.10

0.94

0.78

MUSTER

YSCDACPHAVFTTHAALLAHAEEHHADLLPDHARLRRIAQKLNPVWNRALNARRNTITSWGKKIFHVAAAGESKMQEAHRARAQLECVVRRWSSVAMGVWDGTAAVVDVDAMERGSWPPLEKNAVRSITELLRRVGFSFVNLEPISHARVPIIKHHASSPDVVARSIRFILNGPATREDRLLLEGSVRDAVGPTGVQQVWWNRTSDMMSATLESTTAAVRAAMC---SPALASASLRTKVQPAHDECRPELYNIDAFGIRNSTLLRKYLLSHPCARPGSGVNNSVNGYFTSYAINIMWIYYLVQKGYVPYVDSLVNYTDFDPRYTPMIDPEITLYKAAGDMLVGFFYF------YSFEFDWGHNVISLNRPGITTKRMLGWHVED-----------VRHPTRYELC-PYE----ENLN

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.66

Estimated TM-score = 0.41±0.14

Estimated RMSD = 13.4±4.1Å

Download Model 2

C-score=-4.22

Download Model 3

C-score=-3.84

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5hzdA	0.833	3.26	0.097	0.950
2	2b51A	0.633	4.51	0.064	0.821
3	2q0eA	0.498	4.14	0.088	0.615
4	3hiyA	0.432	4.57	0.056	0.548
5	5a2vA	0.426	4.46	0.068	0.538
6	4ep7A	0.417	4.46	0.046	0.526
7	4m5dA	0.412	5.37	0.044	0.572
8	4zrlA	0.408	4.43	0.038	0.521
9	3nybA	0.406	4.59	0.071	0.526
10	4xq7A	0.394	4.82	0.075	0.517

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	2d8rA	ZN	Rep, Mult	309,314,343,346
2	0.06	3	1y10A	CA	Rep, Mult	170,171,172,206,239
3	0.04	2	1q68A	ZN	Rep, Mult	309,314
4	0.04	2	2c6pA	UUU	Rep, Mult	297,300,301,304
5	0.04	2	3knvA	ZN	Rep, Mult	309,314,324,343
6	0.04	2	2b51A	UTP	Rep, Mult	149,285,286,287,288,290
7	0.04	2	4yzrA	HIS	Rep, Mult	124,128
8	0.04	2	2d9hA	ZN	Rep, Mult	309,314,323,324
9	0.02	1	4f6xA	MG	Rep, Mult	60,346
10	0.02	1	3e5uC	3C4	Rep, Mult	78,81,82
11	0.02	1	2xquC	CVM	Rep, Mult	75,78
12	0.02	1	2oycA	WO4	Rep, Mult	289,297,300
13	0.02	1	2q0fB	U5P	Rep, Mult	260,261,278,291,292,295
14	0.02	1	3wmnA	MQ8	Rep, Mult	81,85

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.066	2q0eA	0.498	4.14	0.088	0.615	2.7.7.52	NA
2	0.060	2vycA	0.347	6.57	0.045	0.548	4.1.1.19	NA
3	0.060	3fedA	0.349	7.23	0.053	0.603	3.4.17.21	303
4	0.060	3bicB	0.330	7.35	0.034	0.569	5.4.99.2	359
5	0.060	1d8cA	0.341	7.22	0.040	0.574	2.3.3.9	NA
6	0.060	3b8eC	0.335	6.95	0.026	0.548	3.6.3.9	301,358,376
7	0.060	1z8lA	0.370	6.28	0.032	0.565	3.4.17.21	NA
8	0.060	1kqfA	0.311	7.27	0.035	0.529	1.2.1.2	NA
9	0.060	1px5B	0.362	5.42	0.063	0.495	2.7.7.-	NA
10	0.060	1e6yA	0.344	6.87	0.042	0.562	2.8.4.1	303
11	0.060	2nomB	0.360	4.72	0.083	0.469	2.7.7.52	NA
12	0.060	1fdiA	0.344	7.53	0.043	0.601	1.2.1.2	NA
13	0.060	1y8bA	0.317	7.29	0.047	0.536	2.3.3.9	300
14	0.060	3l4uA	0.344	6.88	0.030	0.565	3.2.1.20,3.2.1.3	NA
15	0.060	1mo7A	0.175	5.71	0.063	0.249	3.6.3.9	NA
16	0.060	3b8eA	0.333	7.51	0.029	0.581	3.6.3.9	NA
17	0.060	1llwA	0.336	7.20	0.042	0.574	1.4.7.1	NA
18	0.060	2vdcA	0.356	7.10	0.047	0.591	1.4.1.13	NA
19	0.060	2cqsA	0.359	7.50	0.050	0.632	2.4.1.20	16
20	0.060	1dmrA	0.374	6.99	0.052	0.610	1.7.2.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.633	4.51	0.06	0.82	2b51A
1	0.07	0.498	4.14	0.09	0.61	2q0eA	GO:0000166 GO:0005524 GO:0005525 GO:0005739 GO:0046872
2	0.07	0.469	4.37	0.10	0.58	2q0cB	GO:0000166 GO:0005524 GO:0005525 GO:0005739 GO:0046872
3	0.06	0.449	4.66	0.06	0.57	3hj1B	GO:0005739 GO:0006351 GO:0050265
4	0.06	0.444	4.40	0.05	0.56	5jnbA	GO:0000166 GO:0004652 GO:0005524 GO:0005737 GO:0006397 GO:0006997 GO:0007275 GO:0009792 GO:0016740 GO:0031379 GO:0043186 GO:0043234 GO:0043631 GO:0046872 GO:0051302 GO:0051321
5	0.06	0.416	4.54	0.04	0.53	4e7xD	GO:0000166 GO:0000287 GO:0002134 GO:0003723 GO:0004652 GO:0005524 GO:0005737 GO:0005829 GO:0016740 GO:0016779 GO:0036450 GO:0046872 GO:0050265 GO:0071076
6	0.06	0.441	4.61	0.05	0.57	4ud5B	GO:0000166 GO:0000287 GO:0002134 GO:0003723 GO:0004652 GO:0005524 GO:0005737 GO:0005829 GO:0016740 GO:0016779 GO:0036450 GO:0046872 GO:0050265 GO:0071076
7	0.06	0.421	4.70	0.07	0.54	5a2vB	GO:0000287 GO:0002134 GO:0004652 GO:0005524 GO:0005739 GO:0006378 GO:0030145 GO:0042802 GO:0042803 GO:0043231 GO:0044822 GO:0071044
8	0.06	0.428	4.28	0.06	0.54	5jnbC	GO:0000166 GO:0004652 GO:0005524 GO:0005737 GO:0006397 GO:0006997 GO:0007275 GO:0009792 GO:0016740 GO:0031379 GO:0043186 GO:0043234 GO:0043631 GO:0046872 GO:0051302 GO:0051321
9	0.06	0.406	4.59	0.07	0.53	3nybA	GO:0004652 GO:0005634 GO:0005730 GO:0005829 GO:0006284 GO:0006400 GO:0007049 GO:0007067 GO:0016740 GO:0016779 GO:0031499 GO:0034459 GO:0034475 GO:0042138 GO:0043629 GO:0045910 GO:0046872 GO:0051301 GO:0051575 GO:0071031 GO:0071035 GO:0071036 GO:0071037 GO:0071038 GO:0071039 GO:0071040 GO:0071042 GO:0071044 GO:0071047 GO:0071050 GO:0071051
10	0.06	0.360	4.72	0.08	0.47	2nomB	GO:0000166 GO:0005524 GO:0005525 GO:0005739 GO:0046872
11	0.06	0.354	4.59	0.05	0.45	3pq1A	GO:0000166 GO:0000287 GO:0002134 GO:0003723 GO:0004652 GO:0005524 GO:0005737 GO:0005739 GO:0006351 GO:0006378 GO:0006397 GO:0016740 GO:0016779 GO:0030145 GO:0042802 GO:0042803 GO:0043231 GO:0044822 GO:0046872 GO:0071044
12	0.06	0.207	6.34	0.02	0.32	3szdB	GO:0006810 GO:0015288 GO:0016021 GO:0055085
13	0.06	0.182	6.29	0.03	0.28	2h56A	GO:0003824 GO:0006281 GO:0006284 GO:0008152 GO:0016798
14	0.06	0.170	4.59	0.04	0.22	3b8mA	GO:0009103 GO:0016020 GO:0016021
15	0.06	0.186	6.21	0.03	0.28	4fq5B	GO:0016853 GO:0050076
16	0.06	0.121	4.96	0.11	0.16	2jjzC	GO:0003779 GO:0005509 GO:0005737 GO:0005856 GO:0005884 GO:0005886 GO:0005925 GO:0015629 GO:0016020 GO:0032587 GO:0042995 GO:0043234 GO:0046872 GO:0051015 GO:0070062
17	0.06	0.134	3.80	0.05	0.16	1no5B	GO:0016779
18	0.06	0.103	4.74	0.05	0.14	3p8cF	GO:0003677 GO:0005737 GO:0005829 GO:0005856 GO:0006928 GO:0007010 GO:0008093 GO:0008154 GO:0016032 GO:0016477 GO:0016601 GO:0017124 GO:0018108 GO:0019900 GO:0030027 GO:0030175 GO:0031209 GO:0031625 GO:0032403 GO:0042995 GO:0048365 GO:0070064 GO:2000601

Consensus prediction of GO terms

Molecular Function	GO:0032550	GO:0043169	GO:0032559	GO:0035639
GO-Score	0.37	0.37	0.37	0.37
Biological Processes	GO:0006351	GO:0006997	GO:0051321	GO:0006397	GO:0051302	GO:0043631	GO:0009792
GO-Score	0.07	0.07	0.07	0.07	0.07	0.07	0.07
Cellular Component	GO:0043231	GO:0044444
GO-Score	0.37	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.