I-TASSER results

I-TASSER results for job id Rv2008c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (441 residues)
MDEIESLIGLRPTPLTWPVVIAGDFLGVWDPPPSLPGAANHEISAPTARISCMLIERRDA
AARLRRALHRAPVVLLTGPRQAGKTTLSRLVGKSAPECTFDAENPVDATRLADPMLALSG
LSGLITIDEAQRIPDLFPVLRVLVDRPVMPARFLILGSASPDLVGLASESLAGRVELVEL
SGLTVRDVGSSAADRLWLRGGLPPSFTARSNEDSAAWRDGYITTFLERDLAQLGVRIPAA
TMRRAWTMLAHYHGQLFSGAELARSLDVAQTTARRYLDALTDALVVRQLTPWFANIGKRQ
RRSPKIYIRDTGLLHRLLGIDDRLALERNPKLGASWEGFVLEQLAALLAPNPLYYWRTQQ
DAELDLYVELSGRPYGFEIKRTSTPSISRSMRSALVDLQLARLAIVYPGEHRFPLSDTVV
AVPADQILTTGSVDELLALLK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDEIESLIGLRPTPLTWPVVIAGDFLGVWDPPPSLPGAANHEISAPTARISCMLIERRDAAARLRRALHRAPVVLLTGPRQAGKTTLSRLVGKSAPECTFDAENPVDATRLADPMLALSGLSGLITIDEAQRIPDLFPVLRVLVDRPVMPARFLILGSASPDLVGLASESLAGRVELVELSGLTVRDVGSSAADRLWLRGGLPPSFTARSNEDSAAWRDGYITTFLERDLAQLGVRIPAATMRRAWTMLAHYHGQLFSGAELARSLDVAQTTARRYLDALTDALVVRQLTPWFANIGKRQRRSPKIYIRDTGLLHRLLGIDDRLALERNPKLGASWEGFVLEQLAALLAPNPLYYWRTQQDAELDLYVELSGRPYGFEIKRTSTPSISRSMRSALVDLQLARLAIVYPGEHRFPLSDTVVAVPADQILTTGSVDELLALLK
Prediction	CCHHHHHCCCCCCCCCCCEHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHCCCCCHHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHCCEEHCCCCCHHHHHHHHCHHHHHHCCCCCEEEHCHCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCHHHHCCCCCCCCCEEEEEEHCCCCHHHHHHHHHHHHHHHCCCCEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEHCCCCCCCCHHHHCCCCCEEEHCHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEEEEEHCCEEEEEEEHCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCEEHCCCEEEEEHHHHHHCCCCHHHHHHCC
Conf.Score	866776557788766554554666544447898755666677665544443344555899999999986898899995898769999999998476577679889999998588999977999599864434885999999999867899699998798678765665555546899996777888988877777777679935675699799999999999999999999985777689999999999998578888999999889989999999999999854365477888764554578867887789999998888878865676689999999999999985888568898589968999999899899999977999865689999998579985899959987577679889986888998698667887759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDEIESLIGLRPTPLTWPVVIAGDFLGVWDPPPSLPGAANHEISAPTARISCMLIERRDAAARLRRALHRAPVVLLTGPRQAGKTTLSRLVGKSAPECTFDAENPVDATRLADPMLALSGLSGLITIDEAQRIPDLFPVLRVLVDRPVMPARFLILGSASPDLVGLASESLAGRVELVELSGLTVRDVGSSAADRLWLRGGLPPSFTARSNEDSAAWRDGYITTFLERDLAQLGVRIPAATMRRAWTMLAHYHGQLFSGAELARSLDVAQTTARRYLDALTDALVVRQLTPWFANIGKRQRRSPKIYIRDTGLLHRLLGIDDRLALERNPKLGASWEGFVLEQLAALLAPNPLYYWRTQQDAELDLYVELSGRPYGFEIKRTSTPSISRSMRSALVDLQLARLAIVYPGEHRFPLSDTVVAVPADQILTTGSVDELLALLK
Prediction	764157436042321303113133042123431302430456144533301100022450163046117622000002043100000022105512200021431232330330231047363100000002044015102200232344000000010022025433422220011010101102201212132211320100002243452123004200310022002422524324102200310031114312243025314133500330030012001023222124423433343211000000000001202233204336102100000000000210232301102345310000002376300000001245354351034006616143000001264404264201000001003333053013107
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHCCCCCCCCCCCEHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHCCCCCHHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHCCEEHCCCCCHHHHHHHHCHHHHHHCCCCCEEEHCHCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCHHHHCCCCCCCCCEEEEEEHCCCCHHHHHHHHHHHHHHHCCCCEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEHCCCCCCCCHHHHCCCCCEEEHCHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCEEEEEEEHCCEEEEEEEHCCCCCCHHHHHHHHHHHCCCCCEEEEHCCCCCEEHCCCEEEEEHHHHHHCCCCHHHHHHCC
MDEIESLIGLRPTPLTWPVVIAGDFLGVWDPPPSLPGAANHEISAPTARISCMLIERRDAAARLRRALHRAPVVLLTGPRQAGKTTLSRLVGKSAPECTFDAENPVDATRLADPMLALSGLSGLITIDEAQRIPDLFPVLRVLVDRPVMPARFLILGSASPDLVGLASESLAGRVELVELSGLTVRDVGSSAADRLWLRGGLPPSFTARSNEDSAAWRDGYITTFLERDLAQLGVRIPAATMRRAWTMLAHYHGQLFSGAELARSLDVAQTTARRYLDALTDALVVRQLTPWFANIGKRQRRSPKIYIRDTGLLHRLLGIDDRLALERNPKLGASWEGFVLEQLAALLAPNPLYYWRTQQDAELDLYVELSGRPYGFEIKRTSTPSISRSMRSALVDLQLARLAIVYPGEHRFPLSDTVVAVPADQILTTGSVDELLALLK

2qenA

0.16

0.10

0.59

1.10

wdPPAS

M--------FDLRPKTRR-----DIFD-----------------------------REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRELYAERGHITREELIKEGEFIVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEFLKRGFREVNGIPEYLRNGDFGRAMKRTLEVAKGLIMGELEELR--RRSPRYVDILRAIALG---YNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI--------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.10

0.60

0.69

MUSTER

M--------FDLRPKTRR-----DIFD-----------------------------REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRELYAREELIKLNDLGEELGEFVAFDEAQYLKELLALFAYAYDS-LPNLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEFLKRGFREVNGIPGWLVVFGVEYLRNFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI--------------------------------------------------------------------------------------------------------------------------

2fnaA

0.16

0.10

0.62

0.63

dPPAS

IEKLKGVLGLRRTGLNLPYIYL-DLRKFEERNYISYKDFLLELQKEINKL------VKRLPSLLKALKNIQGIVI-------------------GNEIKFNRLSFANLLESFEQAS---KDNVIIVLDEAQRGVNLLPALAYAYDNLKR--IKFISGSEGLLYDYDPESPLFGRFSTVELKPFSREEAIEFLRRGFQEADGIPIYLDNKNLDFAINQTLEYAKKLILKEFENFLHGREIARKRYLNIRTLGKWSDVKRALELEEGIEISDSEIYNYLTQLTKHSWIIK-------------EGEKYCPSEPLISLAFS---------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.10

0.59

0.88

wMUSTER

------ML-FDLRPKTRR-----DIFD-----------------------------REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRELYAREELIKLNDLGEELGEFVAFDEAQYLKELLALFAYAYDSL-PNLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEFLKRGFREVNGIPEYLRNGDFGRAMKRTLEVAKGLIMGELEELR--RRSPRYVDILRAIAL----YNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI--------------------------------------------------------------------------------------------------------------------------

2qenA

0.17

0.10

0.59

1.24

wPPAS

M-----L--FDLRPKTRR-----DIFD-----------------------------REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRELYAERGHITREELIKEGEFIVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEFLKRGFREVNGIPEYLRNGDFGRAMKRTLEVAKGLIMGELEELR--RRSPRYVDILRAIAL----YNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLR-I-------------------------------------------------------------------------------------------------------------------------

2qenA

0.16

0.10

0.60

1.23

dPPAS2

-------MLFDLRPKTRR----EDIFD-----------------------------REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDISPFQKFQSKFKNDLGEELGEFIVAFDEAQYLKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEFLKRGFREVNGIPGWLVVFGVEYLRNFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI--------------------------------------------------------------------------------------------------------------------------

2qenA

0.16

0.10

0.60

1.14

PPAS

M--------FDLRPKTRR-----DIFD-----------------------------REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDCRELYAERGHITREELIKEGEFIVAFDEAQYGKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEFLKRGFREVNGIPGWLVVFGVEYLRNFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI--------------------------------------------------------------------------------------------------------------------------

3u5zB

0.13

0.09

0.69

1.11

Env-PPAS

-----SMITVNEKEHILPSTID-ECIL-----------------------------PAFDKETFKSITSKGKIIILHSPPGTGKTTVAKALCHDVNFVNGSDCKIDFVRGPLTNFASAASFDGRIVIDEFDRSAESQRHLRSFMEAYSSNCSIIITANN----IDGIIKPLQSRCRVITFGQPT-DEDKIEMMKQMIRR----------LTEICKHEGIAIADMKVVAALVKKNFPD----FRKTIGELDSYSSKGVLDAGILSLVTNDRGAIDDVLESLKNKDV--------KQLRALAPK----YAADYSWFVGKL-AEEIYSRVTPQSIIRMYEIVGENNQYHGIAANTELHL-------AYLFIQ-----LACEMQWK-----------------------------------------------------------

1fnnA

0.14

0.11

0.79

0.67

MUSTER

-----AIVV-DDSVFS-PSYVPKRLPH------------REQQLQQL---------DILLGNWLRNPGHHYPRATLLGRPGTGKTVTLRKLWELYRFVYINGFIYRNFTAIIGEIARSLNIPFP------RGLSEFLALLVEHLRERDLYMFLVLDDSTFIRLGQEADKLGAFRIALVIV-NDAVLNNLDPSTRGIMGK--YVIRFSPYTKDQIFDILLDRAKAGLAEGSYS----------EDILQMIADITGAQTPL-------DTNRGDARLAIDILYRSAY-----------AAQQNGRKHIAPEDVRKSSKEVLFGIEEVLIGLPLHEKLFLLAIVRSLKIS------------HTPYITFAEESYKIVC----EYGERPRVHSQLWSYLNDLREKG--IVETRQNT-----TLISIG------TEPLDTLEAVIT

2qenA

0.16

0.10

0.60

0.62

dPPAS

-------MLFDLRPKTRR----EDIFD-----------------------------REEESRKLEESLENYPLTLLLGIRRVGKSSLLRAFLNERPGILIDISPFQKFQSKFKNDLGEELGEFIVAFDEAQGGKELLALFAYAYDSLP-NLKIILTGSEVGLLHDDYESPLYGRAGEVLVKPFDKDTSVEFLKRGFREVNGIPGWLVVFGVEYLRNFGRAMKRTLEVAKGLIMGELEELRRRSPRYVDILRAIAGYNRWSLIRDYLAIPEPRLYALLENLKKMNWIVE-------------EDNTYKIADPVVATVLRI--------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.20

Estimated TM-score = 0.45±0.15

Estimated RMSD = 12.3±4.4Å

Download Model 2

C-score=-1.39

Download Model 3

C-score=-2.27

Download Model 4

C-score=-3.36

Download Model 5

C-score=-2.95

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2qenA	0.560	1.91	0.138	0.590
2	2fnaA	0.532	2.37	0.168	0.578
3	1vt4I	0.513	4.47	0.089	0.635
4	3iytA	0.486	4.57	0.072	0.610
5	2a5yB2	0.471	4.48	0.089	0.592
6	1w5tB	0.465	4.15	0.161	0.578
7	2qbyA	0.422	4.41	0.113	0.524
8	3cf1B	0.412	5.40	0.066	0.567
9	4kxfK	0.412	5.76	0.078	0.576
10	1fnnA	0.411	4.62	0.132	0.508

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.23	17	4lzzT	08T	Rep, Mult	25,80,81,82,83,84,85,86,128,129,158,420,421
2	0.17	11	3u60E	MG	Rep, Mult	85,128,129
3	0.09	7	5t0gE	ATP	Rep, Mult	26,79,82,83,84,85,86,191,420
4	0.01	1	3u5zL	MG	Rep, Mult	85,129,243
5	0.01	1	3shfA	GBL	Rep, Mult	250,307,314,319

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1moqA	0.259	6.72	0.060	0.410	2.6.1.16	280
2	0.060	1yrlC	0.353	6.63	0.063	0.551	1.1.1.86	415
3	0.060	1yq2A	0.360	7.31	0.068	0.603	3.2.1.23	179
4	0.060	1qbaA	0.360	7.12	0.036	0.596	3.2.1.52	NA
5	0.060	3b9eA	0.355	7.24	0.035	0.599	3.2.1.14	128
6	0.060	3fr8B	0.364	6.13	0.052	0.540	1.1.1.86	NA
7	0.060	2pdaA	0.374	7.26	0.038	0.630	1.2.7.1	76
8	0.060	1ixsB	0.369	4.68	0.132	0.474	3.6.4.12	NA
9	0.060	1c7sA	0.364	7.17	0.045	0.601	3.2.1.52	129
10	0.060	2w00B	0.396	6.61	0.044	0.612	3.1.21.3	NA
11	0.060	1in5A	0.398	4.96	0.150	0.517	3.6.4.12	NA
12	0.060	2vdcF	0.352	7.23	0.047	0.578	1.4.1.13	NA
13	0.060	1hcuB	0.357	6.78	0.066	0.565	3.2.1.113	NA
14	0.060	2cqsA	0.331	7.59	0.063	0.585	2.4.1.20	NA
15	0.060	1b0pA	0.379	7.30	0.054	0.637	1.2.7.1	NA
16	0.060	2pflA	0.345	7.19	0.072	0.571	2.3.1.54	289
17	0.060	1mosA	0.254	6.97	0.069	0.419	2.6.1.16	NA
18	0.060	2vf4X	0.258	6.67	0.074	0.410	2.6.1.16	NA
19	0.060	1ea0A	0.344	7.19	0.060	0.574	1.4.1.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.560	1.91	0.14	0.59	2qenA	GO:0000166 GO:0005524
1	0.07	0.539	2.40	0.17	0.58	2fnaA	GO:0000166 GO:0005524
2	0.07	0.503	4.96	0.08	0.65	4v4lA	GO:0002921 GO:0005524 GO:0006915 GO:0006919 GO:0007291 GO:0007423 GO:0008635 GO:0008656 GO:0010332 GO:0012501 GO:0021556 GO:0033353 GO:0034352 GO:0035006 GO:0035070 GO:0035071 GO:0042594 GO:0043065 GO:0043293 GO:0043531 GO:0046668 GO:0046672 GO:0048813 GO:0050700 GO:0051260 GO:0051291 GO:0070050 GO:0070328 GO:0097190 GO:0097199 GO:1901053
3	0.07	0.486	4.78	0.06	0.63	3j2tA	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007399 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043065 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0072432 GO:0097190 GO:0097193 GO:1902510 GO:2001235
4	0.07	0.471	4.73	0.09	0.60	4m9sB	GO:0000166 GO:0005524 GO:0005634 GO:0005739 GO:0005829 GO:0006915 GO:0008361 GO:0008635 GO:0008656 GO:0009792 GO:0010954 GO:0016020 GO:0016505 GO:0030155 GO:0042981 GO:0043065 GO:0043066 GO:0043281 GO:0043531 GO:0048471 GO:0048598 GO:0051432 GO:0051434 GO:0061133 GO:1902742 GO:2001056
5	0.06	0.422	4.41	0.11	0.52	2qbyA	GO:0000166 GO:0003677 GO:0005524 GO:0006260
6	0.06	0.377	5.26	0.07	0.49	1z6tB	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007399 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043065 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0072432 GO:0097190 GO:0097193 GO:1902510 GO:2001235
7	0.06	0.325	5.60	0.05	0.46	3sfzA	GO:0000166 GO:0001666 GO:0001843 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006915 GO:0006919 GO:0007275 GO:0007420 GO:0007568 GO:0007584 GO:0008635 GO:0008656 GO:0010659 GO:0030154 GO:0030900 GO:0031072 GO:0034349 GO:0042802 GO:0042981 GO:0043293 GO:0043531 GO:0051260 GO:0051402 GO:0070059 GO:0070062 GO:0071560 GO:0097190 GO:1902510 GO:2001235
8	0.06	0.300	7.53	0.03	0.52	4xfvA	GO:0002098 GO:0005634 GO:0005654 GO:0005737 GO:0006351 GO:0006355 GO:0006357 GO:0006810 GO:0008017 GO:0015031 GO:0032447 GO:0033588
9	0.06	0.299	7.33	0.04	0.51	4ci8A	GO:0000226 GO:0002244 GO:0005509 GO:0005737 GO:0005829 GO:0005856 GO:0005874 GO:0005875 GO:0007052 GO:0007405 GO:0007420 GO:0008017 GO:0015631 GO:0048471 GO:0097431 GO:1990023
10	0.06	0.283	7.57	0.05	0.50	3eifA	GO:0004252 GO:0005618 GO:0006508 GO:0008233 GO:0008236 GO:0016020 GO:0016787
11	0.06	0.289	7.44	0.03	0.50	1nr0A	GO:0003779 GO:0005737 GO:0005856 GO:0016528 GO:0030016 GO:0030240 GO:0030836 GO:0030837 GO:0040011 GO:0040012 GO:0042643 GO:0051015 GO:0071689
12	0.06	0.277	7.17	0.05	0.46	5cxbA	GO:0000463 GO:0000466 GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0030687 GO:0042254 GO:0042273 GO:0043021
13	0.06	0.271	7.03	0.04	0.44	4nsxA	GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0030529 GO:0031167 GO:0032040 GO:0034388 GO:0042254 GO:0042274
14	0.06	0.276	7.47	0.03	0.47	1pguB	GO:0003779 GO:0005737 GO:0005856 GO:0005884 GO:0006970 GO:0030042 GO:0030479 GO:0032466 GO:0051016
15	0.06	0.296	5.76	0.07	0.42	4ofxA	GO:0004122 GO:0004124 GO:0005737 GO:0006535 GO:0016829 GO:0030170
16	0.06	0.276	7.26	0.04	0.46	2ymuA	GO:0016020 GO:0016021
17	0.06	0.275	7.47	0.03	0.47	4o9dB	GO:0000122 GO:0000781 GO:0005634 GO:0005737 GO:0005829 GO:0006348 GO:0006351 GO:0006355 GO:0016568 GO:0030466 GO:0030702 GO:0031048 GO:0031494 GO:0031618 GO:0031934 GO:0034507 GO:0034613 GO:0035391 GO:0043494 GO:0045132 GO:0045141 GO:0051572 GO:0051574 GO:1990141
18	0.06	0.269	7.49	0.04	0.46	3wj9B	GO:0002183 GO:0003743 GO:0005737 GO:0005829 GO:0006412 GO:0006413 GO:0006417 GO:0022627

Consensus prediction of GO terms

Molecular Function	GO:0032550	GO:0035639	GO:0032559	GO:0043028	GO:0016505
GO-Score	0.58	0.58	0.58	0.37	0.37
Biological Processes	GO:0006919
GO-Score	0.37
Cellular Component	GO:0043293	GO:0005634	GO:0070062	GO:0048471	GO:0016020	GO:0005739
GO-Score	0.13	0.13	0.07	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.