I-TASSER results

I-TASSER results for job id Rv2004c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (498 residues)
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRER
ACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGAL
DAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMV
DEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDA
AFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKP
EAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRL
RDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACAR
RLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTA
GPRERSVGQAYHIWRSAI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI
Prediction	CCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCCEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCEEEEEHCCCCCCCCEEEEEEHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCCCCCCCCEEEHCCEEEEEEEHCCCCCHCHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCEEEHCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHHHCCCEEEEEEHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEHCCCCCHHHHHHHHHHHHHHHC
Conf.Score	986556888888888888877999876689999779588876577888889999999999999999997567857753578977799997646788665795789999999899989999999999999999788888887788999999999999999999868889999999999999999999999999999989878758888877679989978898754579764434478999999999999897899999999999998998667899999999999999999986578887999999999999999875788769999768998766999999998699799636999999799866677666777778999999999999999999999899799966889999999999999998998999999889999999999957899889999999999866899887576689999999999999999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI
Prediction	744226544223222765430310000000000004100000101611000010152024003401400230034000000102247442120001011035631033006535132510320041003003403414534310103101410330041036106531336004301500340055035004402652200100000000000015530000000000440000000000000000013221420031002100420414302300000000000010000002133534422430210020011101212000000001113110000100074160000000100210251412432434143311244003200310141034006341000000011234004101500562603000120302250024105504743340234004203632451642230104242340042015103716
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCCEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCEEEEEHCCCCCCCCEEEEEEHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHCCCCCCCCCEEEHCCEEEEEEEHCCCCCHCHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCEEEHCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHHHCCCEEEEEEHCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCEEHCCCCCHHHHHHHHHHHHHHHC
MDSPTNDGTCDAHPVTDEPFIDVRETHTAVVVLAGDRAFKAKKPVVTDFCDFRTAEQRERACIREFELNSRLAAQSYLGIAHLSDPSGGHAEPVVVMRRYRDKQRLASMVTAGLPVEGALDAIAEVLARFHQRAQRNRCIDTQGEVGAVARRWHENLAELRHHADKVVSGDVIRRIEHMVDEFVSGREVLFAGRIKEGCIVDGHADLLADDIFLVDGEPALLDCLEFEDELRYLDRIDDAAFLAMDLEFLGRKDLGDYFLAGYAVRSGDTAPASLRDFYIAYRAVVRAKVECVRFSQGKPEAAADAVRHLIIATQHLQHATVRLALVGGNPGTGKSTLARGVAELVGAQVISTDDVRRRLRDCGVITGEPGVLDSGLYSRANVVAVYQEALRKARLLLGSGHSVILDGTWGDPQMRACARRLAADTHSAIVEFRCSATVDVMADRIVARAGGNSDATAEIAAALAARQADWDTGHRIDTAGPRERSVGQAYHIWRSAI

1yj5B

0.15

0.10

0.70

1.29

wPPAS

------RKS--------SLGWESLKK--LLVFTASG---KPQGKV---AFDLGT-------------LITTRSGKVF---------PTSPSDWRI----YP--------------------EIPKKLQELAAE----------G---KL------N----QGIGRGKLP---AEVFKGKVEAVLEKLG---------FQVLVAHAGLN--------GWDHLQ--EQANEGIP-IS--VEDSVFVGDAAGRLANWAPGRKKKDFSCADRL--ALNVLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLG----------------------------SWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFRETDPSHAPVSDVFSYRKQFEPPTLALEIPLQEHLDPALQRLYRQFSEG-

1ko5A

0.16

0.05

0.34

1.20

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTNHDHHIYVLMGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMASGE-------PLNDDDRKPWLQALNDAAFAMQRTNKVSLIVCSALKKHYRDLLRE----GNPNLSFIYLKGDFDVIESRLKARKGHFFK--TQMLVTQFETLQEPGADLVVDIDQPLEGVVASTIEVIKKG-

1yj5B

0.15

0.10

0.69

1.09

PPAS

----------RKSSLG-------WESLKKLLVFTASGVKPQGKVA---AFDLGT-------------LITTRSGKVFP---------TSPSDWRIL---YP--------------------EIPKKLQELAAE----GIGRGKLPAEVFKGKVEAVLEKLQVLVATHAGL-----------------WDHLQEQANEGI----PISV--EDSVFVDAAGRLANWA---PGRKKKDFSCADRLFALNV----------------------------LPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLG----------------------------SWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFRETDPSHAPVSDVFSYRKQFEPPTLALEIPFRLQ-EHLDPALQRLYRQFS

1ko5A

0.14

0.05

0.34

1.57

wdPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTNHDHHIYVLMGVSGSGKSAVASEVAHQLHAAFLDGDFLH-------PRRNIEKMASGEPLNDDDRKPWLQALNDAAFAMQRTNKVSLIVCSALKKHYRDLLRE----GNPNLSFIYLKGDFDVIESRLKARKGHFFK--TQMLVTQFETLQEPGADLVVDIDQPLEGVVASTIEVIKKG-

1yj5B

0.14

0.11

0.74

2.05

Env-PPAS

----------------RKSSLG-WESLKKLLVFTASGVKPQGKVA---AFDLGT-------------LITTRSGKVFP---------TSPSDWRILY--PEIPKKLQELAAEGY-----------KLVIFTNQGIGRGKLP-------------------------------AEVFKGKVEAVLEKLGVPFQ-------VLVAHAGLNRKPVSGWD-----HLQEQANEGIP-IS-VEDS-VFVGDAAGRLANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLG----------------------------SWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFRETDPSHAPVSDVFSYRKQFEPPTLALEIPFRLQ-EHLDPALQRLYRQFS

1ko5A

0.16

0.05

0.34

2.70

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTNHDHHIYVLMGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMASGE-------PLNDDDRKPWLQALNDAAFAMQRTNKVSLIVCSALKKHYRDLLRE----GNPNLSFIYLKGDFDVIESRLKARKGHFFK--TQMLVTQFETLQEPGADLVVDIDQPLEGVVASTIEVIKKG-

4orkA

0.13

0.07

0.57

1.04

PPAS

AMKYLIE-HYFDN--FKVDSIEIIGSYDSVAYLVNEYIFKTKFS-----TNKKKGYAKEKAIYNFLNTNLETNVKI--NIEYSYISDEL---SILGYKEIKGTFLTPEIYSTMSEENLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLEEYILLRETIYNDLTD-IEKDYIESFMERLNAT----------TVFEGKKCLCHNDFSCNHLLLDGNN-RLTGIIDF-GDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMY-----NIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

1ko5A

0.17

0.06

0.34

1.14

PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TTNHDHHIYVLMGVSGSGKSAVASEVAHQLHAAFLDGDFLHPRRNIEKMASGEP-------LNDDDRKPWLQALNDAAFAMQRTNKVSLIVCSALKKHYRDLLRE----GNPNLSFIYLKGDFDVIESRLKARKGHFFK--TQMLVTQFETLQEPGADLVVDIDQPLEGVVASTIEVIKKG-

1yj5B

0.15

0.10

0.69

0.78

MUSTER

--------------RKSSLGWESLKK---LLVFTASGVKPQGKVA---AFDLGTL---------------------------ITTRSGSPSDWRIL---YPIPKKLQELAAEGKLPAEVFKGKVEAVLEKLG-VPFATHAGLNRKPVSGWDHLQEQANE-----GIPISVEDS--------------------------------------VFVGDAAGRLANWA---PGRKKKDFSCADRLFALNV----------------------------LPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLGS----------------------------WQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFRETDPSHAPVSDVFSYRKQFEPPLEILEIPFRLQ-EHLDPALQRLYRQFS

1yj5B

0.15

0.10

0.67

0.90

wMUSTER

---------------KSSLGWESLKK---LLVFTASGVKPQGKVA---AFDLGTL---------------------------ITTRSGSPSDWRIL---YPIPKKLQELAAEGKLPAEVFKGKVEAVLEKLG-VPFATHAGLNSGWDHLQEQANE---------GIPISVEDS-------------------------------GDAAGRLANWAPGR-------DFS------CADRLFALNV-------------------------------LPFATPEEFFLKWPAARFELPAFDPRTISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLGS----------------------------WQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFRETDPSHAPVSDVFSYRKQFEPPTLALEIPFRLQ-EHLDPALQRLYRQFS

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.07

Estimated TM-score = 0.47±0.15

Estimated RMSD = 12.3±4.4Å

Download Model 2

C-score=-1.94

Download Model 3

C-score=-2.11

Download Model 4

C-score=-2.91

Download Model 5

C-score=-2.60

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1yj5B	0.656	2.83	0.127	0.719
2	1t3tA2	0.400	7.56	0.057	0.665
3	3ppcA	0.394	6.95	0.059	0.623
4	4ztxA	0.391	6.93	0.061	0.617
5	1xr2B	0.386	7.19	0.051	0.628
6	4bedA	0.383	7.01	0.028	0.602
7	3iz3A	0.382	7.16	0.070	0.617
8	3ttoA	0.374	6.62	0.054	0.564
9	4xc6A	0.374	7.39	0.052	0.615
10	2nq5A	0.372	6.47	0.052	0.548

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.41	20	3a4lA	ANP	Rep, Mult	331,332,333,334,335,336,337,445,449,479
2	0.06	3	1qhxA	MG	Rep, Mult	335,336,354,407
3	0.02	1	3todA	III	Rep, Mult	242,270,273,275
4	0.02	1	3zvnA	QNA	Rep, Mult	353,354,387,409,418,456,460,467

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2pdaA	0.348	7.10	0.034	0.558	1.2.7.1	336
2	0.060	2x42A	0.352	6.86	0.061	0.548	3.2.1.21	NA
3	0.060	3bq5A	0.383	7.01	0.044	0.615	2.1.1.14	NA
4	0.060	1ecfB	0.359	7.12	0.063	0.568	2.4.2.14	330,332
5	0.060	1gph1	0.347	6.87	0.066	0.540	2.4.2.14	347
6	0.060	2fugU	0.304	7.65	0.077	0.514	1.6.99.5	207
7	0.060	1ps9A	0.345	7.25	0.030	0.554	1.3.1.34	204
8	0.060	1ii0B	0.347	7.34	0.073	0.562	3.6.3.16	332,335
9	0.060	1e1cA	0.361	7.06	0.052	0.566	5.4.99.2	NA
10	0.060	2ecfA	0.364	6.19	0.078	0.526	3.4.14.5	336
11	0.060	1h16A	0.346	7.59	0.041	0.578	2.3.1.54	NA
12	0.060	1u22A	0.341	7.15	0.043	0.544	2.1.1.14	NA
13	0.060	2tmdA	0.354	6.81	0.059	0.546	1.5.8.2	329,332
14	0.060	1r1jA	0.334	7.37	0.032	0.544	3.4.24.11	355,405
15	0.060	1yj5B	0.656	2.83	0.127	0.719	2.7.1.78,3.1.3.32	205
16	0.060	1b0pA	0.292	7.48	0.026	0.484	1.2.7.1	NA
17	0.060	1ofdA	0.337	7.60	0.044	0.560	1.4.7.1	NA
18	0.060	1ej6A	0.340	7.20	0.045	0.546	2.7.7.50	328,334,406
19	0.060	2g49A	0.327	7.50	0.037	0.546	3.4.24.56	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.660	2.83	0.13	0.72	1yj5B	GO:0000166 GO:0003690 GO:0003824 GO:0005524 GO:0005634 GO:0005730 GO:0006281 GO:0006974 GO:0006979 GO:0008152 GO:0016020 GO:0016301 GO:0016310 GO:0016311 GO:0016740 GO:0016787 GO:0019201 GO:0032212 GO:0042769 GO:0046403 GO:0046404 GO:0046939 GO:0051973 GO:0098504 GO:0098506 GO:1904355
1	0.25	0.257	3.34	0.16	0.29	2ia5H	GO:0000166 GO:0005524 GO:0006281 GO:0006974 GO:0016032 GO:0016301 GO:0016310 GO:0016311 GO:0016740 GO:0016787 GO:0046404 GO:0047846
2	0.06	0.389	7.66	0.06	0.66	4lgyA	GO:0000166 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0006541 GO:0009156 GO:0016874 GO:0046872
3	0.06	0.289	7.91	0.05	0.50	3ikmD	GO:0002020 GO:0003676 GO:0003677 GO:0003682 GO:0003887 GO:0005739 GO:0005760 GO:0006259 GO:0006260 GO:0006261 GO:0006264 GO:0006287 GO:0007568 GO:0008408 GO:0009416 GO:0010332 GO:0016740 GO:0016779 GO:0042645 GO:0043195 GO:0043234 GO:0055093 GO:0070062 GO:0071333 GO:0071897 GO:0090305
4	0.06	0.269	3.52	0.12	0.31	3n2iB	GO:0000166 GO:0004798 GO:0005524 GO:0005737 GO:0006227 GO:0006233 GO:0006235 GO:0009041 GO:0009165 GO:0015949 GO:0016301 GO:0016310 GO:0016740 GO:0046939
5	0.06	0.257	3.21	0.13	0.29	4xrpA	GO:0000166 GO:0005524 GO:0046872
6	0.06	0.245	8.22	0.02	0.45	2hs3A	GO:0000166 GO:0000287 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0006541 GO:0009156 GO:0016874 GO:0046872
7	0.06	0.269	7.25	0.04	0.43	3wmgA	GO:0000166 GO:0005524 GO:0006810 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0055085
8	0.06	0.266	5.92	0.07	0.37	3u57A	GO:0004553 GO:0005975 GO:0008152 GO:0009820 GO:0009821 GO:0016740 GO:0016787 GO:0016798 GO:0050247 GO:0050506
9	0.06	0.239	7.50	0.05	0.40	2hruA	GO:0000166 GO:0000287 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0006541 GO:0009156 GO:0016874 GO:0046872
10	0.06	0.245	6.92	0.04	0.38	4zhtA	GO:0000166 GO:0003824 GO:0004553 GO:0005524 GO:0005737 GO:0005829 GO:0006045 GO:0006047 GO:0006054 GO:0007155 GO:0008152 GO:0008761 GO:0009384 GO:0016301 GO:0016310 GO:0016740 GO:0016787 GO:0046835 GO:0046872
11	0.06	0.257	3.47	0.11	0.30	1tevA	GO:0000166 GO:0004127 GO:0004550 GO:0004849 GO:0005524 GO:0005634 GO:0005737 GO:0005829 GO:0006139 GO:0006165 GO:0006207 GO:0006221 GO:0006222 GO:0009041 GO:0009142 GO:0009220 GO:0015949 GO:0016301 GO:0016310 GO:0016740 GO:0019205 GO:0046940 GO:0050145 GO:0070062
12	0.06	0.291	7.34	0.07	0.47	1r9jB	GO:0003824 GO:0004802 GO:0008152 GO:0016740 GO:0046872
13	0.06	0.265	8.16	0.04	0.47	3viuA	GO:0000166 GO:0000287 GO:0004642 GO:0005524 GO:0005737 GO:0006164 GO:0006189 GO:0016874 GO:0046872
14	0.06	0.223	6.81	0.05	0.35	4q1tD	GO:0000166 GO:0003723 GO:0004349 GO:0005524 GO:0005737 GO:0006561 GO:0008652 GO:0016301 GO:0016310 GO:0016740 GO:0055129
15	0.06	0.227	7.10	0.04	0.36	1pmiA	GO:0004476 GO:0005737 GO:0005975 GO:0008270 GO:0009298 GO:0016853 GO:0031505 GO:0046872
16	0.06	0.220	7.21	0.06	0.36	1a12A	GO:0000082 GO:0000790 GO:0000794 GO:0003677 GO:0003682 GO:0005085 GO:0005087 GO:0005634 GO:0005654 GO:0005737 GO:0007049 GO:0007052 GO:0007059 GO:0007067 GO:0007088 GO:0016032 GO:0031492 GO:0031965 GO:0042393 GO:0043547 GO:0051225 GO:0051301
17	0.06	0.226	6.67	0.03	0.35	1zc6B	GO:0016301 GO:0016310 GO:0016740 GO:0045127 GO:0046835
18	0.06	0.227	5.66	0.04	0.31	3vo2A	GO:0000166 GO:0004324 GO:0016491 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0046404	GO:0003690	GO:0046403	GO:0019201
GO-Score	0.57	0.51	0.34	0.34	0.34
Biological Processes	GO:0044764	GO:0044403	GO:0046939	GO:0006979	GO:1904355	GO:0051973	GO:0032212	GO:0098506	GO:0042769	GO:0098504
GO-Score	0.51	0.51	0.38	0.34	0.34	0.34	0.34	0.34	0.34	0.34
Cellular Component	GO:0016020	GO:0005730
GO-Score	0.34	0.34

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.