I-TASSER results

I-TASSER results for job id Rv1998c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (258 residues)
MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSSSGGHPDGHRATRGANI
ALAAALAPLQCYVSVDIEDGYSDEPDAIADYVAQLSTAGINIEDSSAEKLIDPALAAAKI
VAIKQRNPEVFVNARVDTYWLRQHADTTSTIQRALRYVDAGADGVFVPLANDPDELAELT
RNIPCPVNTLPVPGLTIADLGELGVARVSTGSVPYSAGLYAAAHAARAVSDGEQLPRSVP
YAELQARLVDYENRTSTT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSSSGGHPDGHRATRGANIALAAALAPLQCYVSVDIEDGYSDEPDAIADYVAQLSTAGINIEDSSAEKLIDPALAAAKIVAIKQRNPEVFVNARVDTYWLRQHADTTSTIQRALRYVDAGADGVFVPLANDPDELAELTRNIPCPVNTLPVPGLTIADLGELGVARVSTGSVPYSAGLYAAAHAARAVSDGEQLPRSVPYAELQARLVDYENRTSTT
Prediction	CHHHHHHHCCCCEEEHCCCCHHHHHHHHHHCCCEEEHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHCHHHHCCCCCHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHCCCEEEHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
Conf.Score	868999847997898588889999999998998999875899998699987889999999999998866898899957899877999999999989748898669999878999999999999998999899997445555578999999999999999899899868999999999999988998899858999999999989979997579999999999999999999599755689899999999988654579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSSSGGHPDGHRATRGANIALAAALAPLQCYVSVDIEDGYSDEPDAIADYVAQLSTAGINIEDSSAEKLIDPALAAAKIVAIKQRNPEVFVNARVDTYWLRQHADTTSTIQRALRYVDAGADGVFVPLANDPDELAELTRNIPCPVNTLPVPGLTIADLGELGVARVSTGSVPYSAGLYAAAHAARAVSDGEQLPRSVPYAELQARLVDYENRTSTT
Prediction	640250166740000000100100210141413000102200010102312130325302410430351400000001202253043004302301000000114546422415302310320464433000000000122445520320040042026000000012015335204402750602010022451317303711010001121011001300240052027644275414264025203513723448
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CHHHHHHHCCCCEEEHCCCCHHHHHHHHHHCCCEEEHCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEHCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHCHHHHCCCCCHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHCCCCEEEEHCCCCCHHHHHHHCCCEEEHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
MSFHDLHHQGVPFVLPNAWDVPSALAYLAEGFTAIGTTSFGVSSSGGHPDGHRATRGANIALAAALAPLQCYVSVDIEDGYSDEPDAIADYVAQLSTAGINIEDSSAEKLIDPALAAAKIVAIKQRNPEVFVNARVDTYWLRQHADTTSTIQRALRYVDAGADGVFVPLANDPDELAELTRNIPCPVNTLPVPGLTIADLGELGVARVSTGSVPYSAGLYAAAHAARAVSDGEQLPRSVPYAELQARLVDYENRTSTT

2duaA

0.20

0.99

2.43

MUSTER

QALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFPKLVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRQTPDEILAFVKSWPVPLVLVPTPQLTEADIAALKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2duaA

0.18

0.17

0.99

2.70

dPPAS

QALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFPKLVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRQTPDEILAFVKSWPGKVPLVLPQLTEADIAALSKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2duaA

0.18

0.99

3.08

wdPPAS

MALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFPKLVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRKTPDEILAFVKSWPGKVPLVLPQLTEADIAALSKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2duaA

0.18

0.99

2.95

wMUSTER

QALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFPKLVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRQTPDEILAFVKSWPVPLVLVPTQLTEADIAALSKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2duaA

0.18

0.99

3.67

wPPAS

MALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFPKLVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRQKPDEILAFVKSWPGKVPLVLPQLTEADIAALSKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2duaA

0.18

0.17

0.99

4.65

dPPAS2

QALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFPKLVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRQTPDEILAFVKSWPGKVPLVLPQLTEADIAALSKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2duaA

0.18

0.17

0.99

3.31

PPAS

QALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFPKLVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRQTPDEILAFVKSWPGKVPLVLPQLTEADIAALSKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2duaA

0.17

0.99

5.00

Env-PPAS

QALRAALDSGRLFTAMAAHNPLVAKLAEQAGFGGIWGSGFELSASYAVPDANILSMSTHLEMMRAIASVSIPLIADIDTGFGNAVHYVVPQYEAAGASAIVMEDKTFQELVRIEEFQGKIAAATAADRDFVVIARVEALIA--GLGQQEAVRRGQAYEEAGADAILIHSRQKPDEILAFVKSWPGKVPLVLPQLTEADIAALSKVGIVIYGNHAIRAAVGAVREVFARIRRDGGIREVDAALPSVKEIIELQGDERMR

2ze3A

0.36

0.35

0.98

2.38

MUSTER

RSFHALHQTG--FLLPNAWDVASARLLEAAGFTAIGTTSAGIAHARGRTDGQTLTRDEMGREVEAIVRAAIPVNADIEAGYGHAVRRTVEHFAALGVAGVNLEDATGLTLYDLDSQLRRIEAARAAIVPVFLNARTDTFLKGHGERLAETVRRGQAYADAGADGIFVPLALQSQDIRALADALRVPLNVMAFPSPVPRALLDAGAARVSFGQSLMLATLGLVQRMAAELHAAEQSPLMDSYFLGFGEGHDLFHR----

2ze3A

0.37

0.36

0.98

2.66

dPPAS

RSFHALHQTG--FLLPNAWDVASARLLEAAGFTAIGTTSAGIAHARGRTDGQTLTRDEMGREVEAIVRAAIPVNADIEAGYGHAVRRTVEHFAALGVAGVNLEDATGLTLYDLDSQLRRIEAARAAIVPVFLNARTDTFLKGHGARLAETVRRGQAYADAGADGIFVPLALQSQDIRALADALRVPLNVMAFPSPVPRALLDAGAARVSFGQSLMLATLGLVQRMAAELHAAEQSPLMDSYFLGFGEGHDLFHR----

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.07

Estimated TM-score = 0.86±0.07

Estimated RMSD = 3.7±2.5Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2duaA	0.961	1.14	0.199	0.992
2	1pymA	0.915	1.56	0.188	0.969
3	1zlpB	0.914	1.85	0.200	0.988
4	3lyeA	0.904	1.83	0.179	0.977
5	1f8mA	0.904	2.12	0.148	0.992
6	3e5bC	0.902	2.14	0.172	0.992
7	3i4eA	0.902	2.15	0.156	0.992
8	3fa3B	0.897	2.01	0.198	0.981
9	1dquA2	0.891	2.23	0.145	0.988
10	1oqfA	0.891	2.20	0.193	0.985

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.71	86	1f8iA	GLV	Rep, Mult	36,38,39,40,76,135,166,211
2	0.19	31	5e9hA	MN	Rep, Mult	50,76,135
3	0.04	8	1zlpB	GAQ	Rep, Mult	40,135,168,190,212
4	0.04	6	1o5qA	MG	Rep, Mult	76,135
5	0.02	4	4a21C	SO4	Rep, Mult	77,78,79,101,103,104
6	0.01	2	4a21B	SO4	Rep, Mult	189,190,191,209,210
7	0.01	2	4jdyA	GOL	Rep, Mult	17,76,209,210,211
8	0.00	1	3ih1B	PYR	Rep, Mult	46,61,62
9	0.00	1	2duaA	XYS	Rep, Mult	28,70
10	0.00	1	3ih1A	PYR	Rep, Mult	61,62,65
11	0.00	1	3ih1A	PYR	Rep, Mult	194,195,199
12	0.00	1	1gvf0	III	Rep, Mult	4,5,98,128,129,163
13	0.00	1	3ih1A	PYR	Rep, Mult	146,147

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.440	2duaA	0.961	1.14	0.199	0.992	3.11.1.3	40,50
2	0.325	2qiwA	0.788	2.07	0.258	0.872	2.7.8.23	85,117,153,160
3	0.235	3ng3A	0.599	2.96	0.155	0.702	4.1.2.4	NA
4	0.227	1oy0D	0.694	3.03	0.126	0.822	2.1.2.11	NA
5	0.216	3exrA	0.596	2.59	0.098	0.682	4.1.1.85	76
6	0.207	1m1bA	0.939	1.54	0.184	0.992	5.4.2.9	NA
7	0.197	1xbzB	0.590	2.78	0.077	0.686	4.1.1.85	76
8	0.192	3eooA	0.890	2.20	0.208	0.988	4.1.3.30	NA
9	0.188	1oqfA	0.891	2.20	0.193	0.985	4.1.3.30	NA
10	0.126	1j2wA	0.597	2.76	0.125	0.686	4.1.2.4	NA
11	0.110	2czfA	0.577	3.01	0.097	0.694	4.1.1.23	NA
12	0.106	3ez4H	0.657	2.83	0.128	0.764	2.1.2.11	103
13	0.081	1vlwB	0.567	2.94	0.116	0.670	4.1.3.16	NA
14	0.078	2cz5A	0.580	3.01	0.108	0.698	4.1.1.23	NA
15	0.077	2yw3E	0.549	3.27	0.134	0.667	4.1.2.14	NA
16	0.076	1vqtA	0.556	3.16	0.066	0.670	4.1.1.23	76
17	0.075	1nsjA	0.566	3.19	0.122	0.682	5.3.1.24	NA
18	0.073	2v81A	0.555	3.10	0.116	0.663	4.1.2.21	NA
19	0.072	3f4wA	0.587	2.58	0.111	0.674	4.1.2.-	NA
20	0.060	3gayA	0.685	3.49	0.116	0.845	4.1.2.13	188
21	0.060	2fiqC	0.696	3.82	0.093	0.899	2.7.1.144	89,118,140,161
22	0.060	1bwkA	0.654	4.09	0.096	0.849	1.6.99.1	NA
23	0.060	2hsaA	0.667	3.89	0.081	0.841	1.3.1.42	NA
24	0.060	3eolA	0.807	2.55	0.170	0.903	4.1.3.1	135
25	0.060	1gvfB	0.691	3.52	0.163	0.849	4.1.2.40	NA
26	0.060	1igwC	0.898	2.30	0.163	0.996	4.1.3.1	NA
27	0.060	1q45B	0.667	3.81	0.073	0.837	1.3.1.42	81
28	0.060	1ps9A	0.711	3.90	0.108	0.899	1.3.1.34	NA
29	0.060	1dosA	0.706	4.24	0.091	0.926	4.1.2.13	NA
30	0.060	3kruA	0.656	3.76	0.068	0.814	1.6.99.1	NA
31	0.060	3b8iF	0.785	2.42	0.202	0.884	4.1.1.3	76,81,103,111,135
32	0.060	1m3uA	0.669	3.08	0.125	0.791	2.1.2.11	39
33	0.060	1zlpB	0.914	1.85	0.200	0.988	4.1.3.22	23,32,68
34	0.060	1gynA	0.669	4.23	0.085	0.899	4.1.2.13	NA
35	0.060	1dquA	0.891	2.23	0.145	0.988	4.1.3.1	135
36	0.060	3fa3B	0.897	2.01	0.198	0.981	4.1.3.32	135
37	0.060	3gr7A	0.654	3.67	0.092	0.810	1.6.99.1	NA
38	0.060	2q3rA	0.653	3.80	0.073	0.830	1.3.1.42	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.55	0.851	2.69	0.34	0.97	2ze3A
1	0.48	0.939	1.54	0.18	0.99	1m1bA	GO:0003824 GO:0016853 GO:0032923 GO:0046872 GO:0050188
2	0.47	0.897	2.01	0.20	0.98	3fa3B	GO:0003824 GO:0008152 GO:0016787
3	0.47	0.961	1.14	0.20	0.99	2duaA	GO:0003824 GO:0016787 GO:0033978 GO:0046872
4	0.45	0.869	2.33	0.29	0.98	4lsbB	GO:0003824 GO:0016829
5	0.44	0.810	2.13	0.33	0.89	4mg4C	GO:0003824
6	0.41	0.905	1.80	0.17	0.98	3m0jA
7	0.40	0.903	2.00	0.22	0.99	4iqdA	GO:0000287 GO:0003824 GO:0008152 GO:0008807 GO:0016829 GO:0019629 GO:0046421 GO:0046872
8	0.39	0.914	1.85	0.20	0.99	1zlpB	GO:0003824 GO:0008152 GO:0016740 GO:0016787 GO:0016829 GO:0030603 GO:0046872 GO:0047776
9	0.36	0.903	2.13	0.17	0.99	3oq8A	GO:0003824 GO:0004451 GO:0008152 GO:0016829 GO:0019752
10	0.35	0.900	2.19	0.17	0.99	3lg3A	GO:0003824 GO:0004451 GO:0005737 GO:0006097 GO:0008152 GO:0016829 GO:0019752 GO:0046912
11	0.35	0.890	2.20	0.21	0.99	3eooA	GO:0000287 GO:0003824 GO:0008152 GO:0016829 GO:0019629 GO:0046421 GO:0046872
12	0.34	0.905	2.10	0.15	0.99	1f8iA	GO:0001101 GO:0003824 GO:0004451 GO:0005829 GO:0005886 GO:0006097 GO:0006099 GO:0006102 GO:0008152 GO:0009405 GO:0010034 GO:0016829 GO:0019752 GO:0046421 GO:0046872 GO:0046912 GO:0052572 GO:0070542 GO:0071456 GO:0075141
13	0.34	0.891	2.20	0.19	0.98	1oqfA	GO:0000287 GO:0003824 GO:0005737 GO:0006097 GO:0008152 GO:0016829 GO:0019629 GO:0046421 GO:0046872 GO:0046912
14	0.33	0.800	2.04	0.25	0.88	2qiwA	GO:0003824 GO:0008807 GO:0016740
15	0.33	0.893	2.19	0.14	0.99	5e9fB	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
16	0.31	0.787	2.40	0.20	0.89	3b8iA	GO:0000287 GO:0003824 GO:0005737 GO:0006097 GO:0006107 GO:0008948 GO:0016829 GO:0016831 GO:0019629 GO:0042866 GO:0046421 GO:0046872 GO:0046912
17	0.30	0.891	2.23	0.14	0.99	1dquA	GO:0003824 GO:0004451 GO:0005777 GO:0005782 GO:0006097 GO:0006099 GO:0008152 GO:0009062 GO:0009514 GO:0015976 GO:0016829 GO:0019752 GO:0045733 GO:0046421 GO:0046872 GO:0046912
18	0.29	0.807	2.55	0.17	0.90	3eolA	GO:0003824 GO:0004451 GO:0008152 GO:0016829 GO:0019752
19	0.24	0.898	2.30	0.16	1.00	1igwC	GO:0003824 GO:0004451 GO:0005829 GO:0006097 GO:0006099 GO:0008152 GO:0016829 GO:0019752 GO:0043169 GO:0046872 GO:0046912
20	0.23	0.902	2.15	0.16	0.99	3i4eA	GO:0003824 GO:0004451 GO:0008152 GO:0016829 GO:0019752
21	0.22	0.894	2.19	0.13	0.99	5e9hB	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
22	0.21	0.891	2.23	0.14	0.99	5e9fD	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872
23	0.21	0.890	2.21	0.17	0.98	1igwA	GO:0003824 GO:0004451 GO:0005829 GO:0006097 GO:0006099 GO:0008152 GO:0016829 GO:0019752 GO:0043169 GO:0046872 GO:0046912
24	0.20	0.893	2.19	0.14	0.99	5e9gD	GO:0003824 GO:0004451 GO:0005777 GO:0006097 GO:0006099 GO:0008152 GO:0009514 GO:0016829 GO:0019752 GO:0046421 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0050188	GO:0033978	GO:0016829
GO-Score	0.72	0.48	0.47	0.45
Biological Processes	GO:0032923
GO-Score	0.48
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.