I-TASSER results

I-TASSER results for job id Rv1978

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (282 residues)
MGEANIREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVPDEVKQKIIGVLDRVGTLT
NLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILELHPTATVTISDLDPTSVANIAA
GELGTHPRARTQVIDATAIDGHDHSYDLAVFALAFHHLPPTVACKAIAEATRVGKRFLII
DLKRQKPLSFTLSSVLLLPLHLLLLPWSSMRSSMHDGFISALRAYSPSALQTLARAADPG
MQVEILPAPTRLFPPSLAVVFSRSSSAPTESSECSADRQPGE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGEANIREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVPDEVKQKIIGVLDRVGTLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILELHPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYDLAVFALAFHHLPPTVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVLLLPLHLLLLPWSSMRSSMHDGFISALRAYSPSALQTLARAADPGMQVEILPAPTRLFPPSLAVVFSRSSSAPTESSECSADRQPGE
Prediction	CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEHCCCCHCCCCEEEEEEHCCCCCCCCHHHHHHCCCCCC
Conf.Score	998877666655678888875566666655554445766665789999888876778876757999999999968889985899879987899999998999789999699999999999987899986999867666999988743787644555699799999999985679789999599998656778888887655555555466577777688888779999999999985997588986665444676578887567788654566654667789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGEANIREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVPDEVKQKIIGVLDRVGTLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILELHPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYDLAVFALAFHHLPPTVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVLLLPLHLLLLPWSSMRSSMHDGFISALRAYSPSALQTLARAADPGMQVEILPAPTRLFPPSLAVVFSRSSSAPTESSECSADRQPGE
Prediction	745342444214303342543530232143633311426402540242014022101310411430041015106444444414231111200320063147041000201350023024544766240311100023031364030001001021234253014021301212200000002334312211100011132131221233331221000000101326302320541413031322323332222200000223443344344343355358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEHCCCCCHHHHHHHHHCCCCEEEEEHCCHHHHHHHHHHHHCCCCCEEEEHCCCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEEEHCCCCHCCCCEEEEEEHCCCCCCCCHHHHHHCCCCCC
MGEANIREQAIATMPRGGPDASWLDRRFQTDALEYLDRDDVPDEVKQKIIGVLDRVGTLTNLHEKYARIALKLVSDIPNPRILELGAGHGKLSAKILELHPTATVTISDLDPTSVANIAAGELGTHPRARTQVIDATAIDGHDHSYDLAVFALAFHHLPPTVACKAIAEATRVGKRFLIIDLKRQKPLSFTLSSVLLLPLHLLLLPWSSMRSSMHDGFISALRAYSPSALQTLARAADPGMQVEILPAPTRLFPPSLAVVFSRSSSAPTESSECSADRQPGE

4obwA

0.10

0.07

0.75

1.95

MUSTER

------------------------------------------------VANRYDLMNDVM-IHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEQGKRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

4obwA

0.10

0.08

0.75

2.71

dPPAS

------------------------------------------------VANRYDLMNDVMSIHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEKDPRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

4obwA

0.10

0.08

0.75

3.30

wdPPAS

------------------------------------------------VANRYDLMNDVM-IHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEQGPRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

4obwA

0.10

0.07

0.75

2.45

wMUSTER

------------------------------------------------VANRYDLMNDVM-IHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEQGKRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

4obwA

0.10

0.07

0.75

3.19

wPPAS

------------------------------------------------VANRYDLMNDVM-IHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEQGKRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

4obwA

0.10

0.08

0.75

3.89

dPPAS2

------------------------------------------------VANRYDLMNDVMSIHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEQGPRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

4obwA

0.10

0.08

0.75

2.54

PPAS

------------------------------------------------VANRYDLMNDVM-IHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEKDPRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

4obwA

0.10

0.08

0.75

3.12

Env-PPAS

------------------------------------------------VANRYDLMNDVMSIHRLWKDHFINKLNSTTPLNFIDVAGGSGDIAFGLLDHATESTMDIVDINPDMLKEGEKRAMEQGPRVRFLVSNGEKLEEIDDSKDIYTVSFGIRNFTIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQQWAKVLPVMGSMIADYDSYQYLVESIERFPDQETFKSMIEKAGF-KSAGYESLTFGICAIHWGIKV---------------------

3dlcA

0.12

0.09

0.75

1.84

MUSTER

--------------------------------------GSENKKKFDKKGAKNDEISKTLPIYPIIAENIINRFGITAG-TCIDIGSGPGALSIALAKQS-DFSIRALDFSKHNEIALKNIADALNDRIQIVQGDVHNIPIEDNYADLIVSRGSVFFWEVATAFREIYRILKSGGKTYIGGGFGN------------KELRDSISAEIRKNPDWKEFNRKNISQENVERFQNVLDEIGIS-SYEIILGDE-----GFWIIISKTDQEVI-------------

3dtnA

0.18

0.13

0.76

2.61

dPPAS

--------------------------------------LSEIKRKFDAVSGKYDEQRRKFCFDDFYGVSVSIASVDTENPDILDLGAGTGLLSAFLMEKYPEATFTLVDMSEKMLEIAKNRFRG-NLKVKYIEADYSKYDF-EEKYDMVVSALSIHHLEKKELYKRSYSILKESGIFINADLVHGETAFIENLNKTIWRQYVENSGLTEEEIAAGYLDK----DIEMNQQLNWLKEAGFRVSCIYKYYQ------FAVMFGRKT------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.57

Estimated TM-score = 0.52±0.15

Estimated RMSD = 9.6±4.6Å

Download Model 2

C-score=-2.52

Download Model 3

C-score=-2.23

Download Model 4

C-score=-1.88

Download Model 5

C-score=-3.91

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4obwA	0.717	1.45	0.104	0.752
2	4krgA	0.637	3.80	0.131	0.787
3	4gekA	0.636	3.37	0.088	0.762
4	5egpA	0.621	3.19	0.134	0.723
5	1tw2B	0.617	3.83	0.138	0.762
6	5f2kA	0.616	3.68	0.084	0.755
7	4kvzA	0.616	4.07	0.140	0.794
8	4uy5A	0.615	4.23	0.135	0.801
9	1im8A	0.612	3.28	0.097	0.731
10	3ocjA	0.610	2.99	0.105	0.713

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.57	30	4iwnA	GEK	Rep, Mult	53,63,86,88,91,109,110,111,114,134,135,136,152,153,157,158,213
2	0.03	2	1d2hA	SAH	Rep, Mult	109,110,114,134,135,136,154,157
3	0.02	1	1yz30	III	Rep, Mult	65,68,183,226,227,247,248

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.147	3e05D	0.513	2.70	0.097	0.585	2.1.1.132	53,87
2	0.142	2iftA	0.460	2.60	0.123	0.525	2.1.1.52	87,97
3	0.070	1wznA	0.585	3.26	0.133	0.695	2.1.1.-	155
4	0.069	2pxxA	0.556	3.41	0.164	0.663	3.4.24.71	90
5	0.067	3e05B	0.510	2.57	0.097	0.578	2.1.1.132	NA
6	0.067	1xcjA	0.567	3.23	0.088	0.681	2.1.1.2	NA
7	0.067	2a14A	0.592	3.34	0.094	0.706	2.1.1.49	86,88,154
8	0.067	2cl5A	0.523	3.24	0.114	0.621	2.1.1.6	91
9	0.067	3bwmA	0.523	3.28	0.136	0.621	2.1.1.6	NA
10	0.067	3grzB	0.507	2.56	0.078	0.571	2.1.1.-	NA
11	0.067	1nt2A	0.497	2.88	0.092	0.575	2.1.1.-	NA
12	0.067	1f38A	0.497	2.81	0.142	0.575	2.1.1.-	NA
13	0.067	1xxlA	0.547	2.92	0.160	0.624	2.1.1.-	156
14	0.066	3cbgA	0.511	3.40	0.125	0.610	2.1.1.-	NA
15	0.060	1tw2B	0.617	3.83	0.138	0.762	2.1.1.-	NA
16	0.060	2h11B	0.556	3.67	0.067	0.681	2.1.1.67	85
17	0.060	2qyoA	0.532	4.31	0.150	0.681	2.1.1.46	156
18	0.060	1kpiA	0.580	4.47	0.143	0.759	2.1.1.79	241
19	0.060	2vdwG	0.582	3.62	0.104	0.706	2.7.7.50	NA
20	0.060	2aovA	0.561	4.17	0.113	0.699	2.1.1.8	NA
21	0.060	2pjdA	0.549	3.64	0.111	0.667	2.1.1.52	NA
22	0.060	3g5tA	0.573	3.82	0.098	0.709	2.1.1.145	110
23	0.060	1p91A	0.538	3.36	0.086	0.631	2.1.1.51	70
24	0.060	3hnrA	0.569	3.10	0.164	0.667	2.1.1.-	156
25	0.060	2fk8A	0.555	4.35	0.113	0.709	2.1.1.-	NA
26	0.060	1bhjA	0.611	4.22	0.127	0.769	2.1.1.20	270
27	0.060	3lccA	0.560	3.55	0.094	0.677	2.1.1.-	54,86
28	0.060	1ri1A	0.563	3.94	0.111	0.695	2.1.1.56	86,109
29	0.060	1fp1D	0.558	3.67	0.096	0.681	2.1.1.-	156
30	0.060	2o06A	0.539	4.12	0.073	0.681	2.5.1.16	86,88,158
31	0.060	2ex4A	0.591	3.62	0.125	0.720	2.1.1.-	NA
32	0.060	3bgdA	0.556	3.69	0.097	0.681	2.1.1.67	NA
33	0.060	3ftfA	0.535	3.48	0.124	0.652	2.1.1.-	86

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.27	0.659	3.79	0.14	0.81	4krgA	GO:0008152 GO:0008168 GO:0032259
1	0.27	0.533	2.72	0.14	0.61	4qtuB	GO:0000056 GO:0000447 GO:0005634 GO:0005730 GO:0005737 GO:0006364 GO:0008152 GO:0008168 GO:0008757 GO:0016435 GO:0016740 GO:0032259 GO:0070476
2	0.25	0.548	2.91	0.13	0.62	1vl5A	GO:0008152 GO:0008168 GO:0016740 GO:0032259
3	0.23	0.569	3.46	0.12	0.69	3mggB	GO:0008168 GO:0016740 GO:0032259
4	0.23	0.477	2.71	0.11	0.54	5bxyA	GO:0008168 GO:0032259
5	0.22	0.585	3.26	0.13	0.69	1wznA
6	0.22	0.522	3.03	0.18	0.61	3ccfB	GO:0008152 GO:0008168 GO:0016740 GO:0030798 GO:0032259
7	0.21	0.486	2.53	0.16	0.55	3hm2A	GO:0006479 GO:0008152 GO:0008168 GO:0008276 GO:0009236 GO:0016740 GO:0032259
8	0.20	0.493	2.93	0.13	0.57	3gdhA	GO:0000387 GO:0001510 GO:0005615 GO:0005634 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0006351 GO:0006355 GO:0008168 GO:0008173 GO:0009452 GO:0015030 GO:0016740 GO:0022613 GO:0030532 GO:0032259 GO:0036261 GO:0044255 GO:0071164 GO:0071167
9	0.20	0.568	3.76	0.09	0.70	3f4kA	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
10	0.20	0.596	4.01	0.13	0.74	4krhA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
11	0.20	0.720	1.45	0.10	0.76	4obwC	GO:0005739 GO:0005743 GO:0005759 GO:0006744 GO:0008168 GO:0009060 GO:0016020 GO:0016740 GO:0031314 GO:0032259 GO:0043334 GO:0102005
12	0.20	0.558	2.90	0.15	0.64	3sm3A	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872
13	0.19	0.589	3.74	0.11	0.72	4kifB	GO:0008168 GO:0016740 GO:0017000 GO:0032259
14	0.18	0.604	3.38	0.13	0.72	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
15	0.18	0.548	2.89	0.16	0.62	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
16	0.18	0.541	3.93	0.14	0.68	5bp7A	GO:0005737 GO:0008168 GO:0008757 GO:0016740 GO:0032259
17	0.18	0.605	3.02	0.14	0.70	3d2lC	GO:0008168 GO:0016740 GO:0032259
18	0.17	0.594	3.10	0.14	0.69	1x19A	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
19	0.17	0.621	3.19	0.13	0.72	5egpA	GO:0008168 GO:0016740 GO:0032259
20	0.17	0.497	2.81	0.14	0.57	1f38A	GO:0006479 GO:0008168 GO:0008276 GO:0009236 GO:0016740 GO:0032259 GO:0046140
21	0.17	0.608	4.14	0.11	0.77	1qzzA	GO:0008168 GO:0008171 GO:0016829 GO:0016831 GO:0017000 GO:0032259
22	0.17	0.579	3.04	0.12	0.68	2zfuA	GO:0000183 GO:0005634 GO:0005654 GO:0005677 GO:0005730 GO:0005737 GO:0005886 GO:0006351 GO:0006355 GO:0006364 GO:0008168 GO:0008757 GO:0016568 GO:0016740 GO:0032259 GO:0033553 GO:0035064 GO:0042149 GO:0044822 GO:0046015 GO:0071158 GO:0072332
23	0.17	0.617	3.83	0.14	0.76	1tw2B	GO:0008168 GO:0008171 GO:0016740 GO:0017000 GO:0032259 GO:1901771
24	0.17	0.596	3.41	0.11	0.71	1ve3B	GO:0046872 GO:0051536 GO:0051539
25	0.16	0.525	3.26	0.13	0.62	4xucA	GO:0000287 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006584 GO:0007565 GO:0007612 GO:0007614 GO:0008168 GO:0008171 GO:0008210 GO:0009712 GO:0014070 GO:0016020 GO:0016021 GO:0016036 GO:0016206 GO:0016740 GO:0030424 GO:0030425 GO:0032259 GO:0032496 GO:0032502 GO:0035814 GO:0042135 GO:0042417 GO:0042420 GO:0042493 GO:0043197 GO:0044297 GO:0045211 GO:0045963 GO:0046872 GO:0048265 GO:0048609 GO:0048662 GO:0050668 GO:0051930 GO:0070062
26	0.16	0.485	2.58	0.11	0.55	3njrA	GO:0006479 GO:0008152 GO:0008168 GO:0008276 GO:0009236 GO:0016740 GO:0032259 GO:0046025
27	0.16	0.613	4.17	0.12	0.77	4qvgC	GO:0008168 GO:0008171 GO:0032259
28	0.15	0.592	3.92	0.12	0.73	1xtpA	GO:0005737 GO:0006480 GO:0008168
29	0.15	0.595	4.03	0.12	0.74	4ineA	GO:0000773 GO:0005737 GO:0006656 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0080101
30	0.15	0.569	3.98	0.10	0.71	3kkzA	GO:0046872 GO:0051536 GO:0051539
31	0.15	0.474	3.53	0.12	0.57	4rx1A	GO:0008168 GO:0016740 GO:0032259
32	0.14	0.575	3.30	0.12	0.68	4qdkA	GO:0005737 GO:0008168 GO:0008757 GO:0015979 GO:0015995 GO:0016740 GO:0032259 GO:0036068 GO:0046406
33	0.13	0.528	2.81	0.08	0.60	3lpmA	GO:0008168 GO:0032259
34	0.13	0.478	3.57	0.12	0.57	3g07A	GO:0000122 GO:0001510 GO:0008168 GO:0008173 GO:0008757 GO:0016073 GO:0016740 GO:0032259 GO:0035562 GO:0040031 GO:0044822 GO:1900087
35	0.12	0.590	3.57	0.12	0.72	5cvdA	GO:0005634 GO:0005654 GO:0005737 GO:0006480 GO:0007051 GO:0007059 GO:0008168 GO:0008276 GO:0016740 GO:0018011 GO:0018012 GO:0018016 GO:0032259 GO:0035572 GO:0035573 GO:0071885
36	0.12	0.538	3.55	0.10	0.65	3h2bB	GO:0008168 GO:0016740 GO:0032259
37	0.07	0.605	3.11	0.09	0.71	1y8cA	GO:0008168 GO:0016740 GO:0032259
38	0.07	0.582	4.10	0.13	0.75	4eviA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0046983
39	0.07	0.596	3.95	0.08	0.73	3vc1D	GO:0008152 GO:0008168 GO:0008169 GO:0008757 GO:0016740 GO:0032259 GO:0042214
40	0.07	0.595	3.93	0.08	0.73	4f86A	GO:0008168 GO:0008169 GO:0008757 GO:0016740 GO:0032259 GO:0042214
41	0.07	0.592	3.99	0.11	0.73	4mwzB	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
42	0.07	0.581	3.35	0.14	0.69	2ip2A	GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0008649
GO-Score	0.53
Biological Processes	GO:0000466	GO:0000479	GO:0036265	GO:0070475	GO:0000054	GO:0000462
GO-Score	0.53	0.53	0.53	0.53	0.53	0.53
Cellular Component	GO:0043232	GO:0031981
GO-Score	0.53	0.53

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.