I-TASSER results

I-TASSER results for job id Rv1958c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (204 residues)
MIPTPSIGAVINAKISHRACRTFPRPTDIHPRRYLPRKHGGTNPRRLSMNPGGMRIRCRR
GDKSRKLLSRSQVQPLVGRPAKIPSPAANAPPSRARTASPVFENLELRAAAGLAFGFRLR
PFGGTAADSPPVAAQDLDPCRWADSPALHLAVGVETMVVGQLDSPSFGQGVPLVAGHWAP
GETGIGRDNISRVNGGSARRPVRS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MIPTPSIGAVINAKISHRACRTFPRPTDIHPRRYLPRKHGGTNPRRLSMNPGGMRIRCRRGDKSRKLLSRSQVQPLVGRPAKIPSPAANAPPSRARTASPVFENLELRAAAGLAFGFRLRPFGGTAADSPPVAAQDLDPCRWADSPALHLAVGVETMVVGQLDSPSFGQGVPLVAGHWAPGETGIGRDNISRVNGGSARRPVRS
Prediction	CCCCCCCCEEEHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCEEEEEHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCHCCCCCCCCCCCC
Conf.Score	999886444543433444554589888888755677777999976455688876899875875677766654556788888899988789975566776555567777776444566665578888889986545788776678865567664556666546888877786555556678766787665544568877788889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MIPTPSIGAVINAKISHRACRTFPRPTDIHPRRYLPRKHGGTNPRRLSMNPGGMRIRCRRGDKSRKLLSRSQVQPLVGRPAKIPSPAANAPPSRARTASPVFENLELRAAAGLAFGFRLRPFGGTAADSPPVAAQDLDPCRWADSPALHLAVGVETMVVGQLDSPSFGQGVPLVAGHWAPGETGIGRDNISRVNGGSARRPVRS
Prediction	734344122103241434104414434514344313564444434414244432302044365444225454044124443614543473446434424311541414211100110313323343374342336515314226330020012031112230444512431210123114343223463144154454444368
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCEEEHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEHCCCCCCEEEEEHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCEEEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEEEEHCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCHCCCCCCCCCCCC
MIPTPSIGAVINAKISHRACRTFPRPTDIHPRRYLPRKHGGTNPRRLSMNPGGMRIRCRRGDKSRKLLSRSQVQPLVGRPAKIPSPAANAPPSRARTASPVFENLELRAAAGLAFGFRLRPFGGTAADSPPVAAQDLDPCRWADSPALHLAVGVETMVVGQLDSPSFGQGVPLVAGHWAPGETGIGRDNISRVNGGSARRPVRS

4lgnA

0.17

0.16

0.98

0.67

MUSTER

LISPPSGAPLISALGDLGGFTHADVTAVPSTIFTSPVFTTGTSVDYAELNPSIIVRAGSFDPSSQPNDRHVAFSTDGGKNWFQGSEPGGVTTGGTVAASADGSRFVWAPGDPGQPVVYAVGFGNSWAASQGVPANAQ-IRSDRVNPKT-FYALSNGTFYRSTDGPSSGAVGVMFHAV--PGKEGDASSGLYH-NGGSSWSAITG

2xgfA

0.11

0.10

0.88

0.56

dPPAS

PWPSDSVGQTFDKSAYPKLAVAYPSGVDMRGQKPSGRAVLSAEADGVKAHSHSASASSTDLGT-------KTTSSFDYGTKGTNSTGGHTHSGSGSTST------------NGEHSHYIEAWNGTGVGGNKYAISYRAGGSNTNAAGNHSH----TFSFGTSSAGDHSHSVG-IGAHTHTVAIGSHGHTITVNSTGNTENTVKN

1giyD

0.30

0.21

0.68

0.51

wdPPAS

II-KDGIPGRV-ATIEY------PRSANIALINY---ADG----KRYIIAPKNLKV----GME---IMSGPDADIKIG----------NALPLENIPVGTLVHNIELKPGRGLV-----RA-AGTSAQ---VLGKE----KYV-----------------IVRLAS-GE-VRMILGKRA-GEVGGGRTDKPFVKAGNKHAPVRG

3j3bQ

0.28

0.22

0.76

0.55

wMUSTER

--------------------------VDIRHNK--DRKVRRKEPK--SQDI--LRLLV----KLYRFLARRTNSTFNQVVLKLFMSRTNRPP----SLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPVCA--LRVTSRARSRILR--AGGKILTFDQLDSPK-GCGTVLLSGHFAPGTPHVGR-KFERARG---RRASRG

3j39Q

0.33

0.23

0.70

0.47

wPPAS

-------G------I------------DIHKYD---RKVRRTEPK--SQDV---YLR-----KLYRFLQRRTNKKFI---LKLFMSKINRPPQRARFKAANQPE---STI--VVVGTVT---DARLLVVPKVCA--L---HVTQT-ARELKAGGEVLTFDQLRSPT-GKNTLLLQGHFAPGVPH-GR-KFERARG---RRSSCG

3j3bQ

0.24

0.19

0.79

0.52

dPPAS2

--------------------------MGVDIRHNKDRKVRRKEPK--SQDI-----YLRLLVKLYRFLARRTNSTFNQVVLKLFMSRTNRPPL---SLSRMIRKMKLPGRENKTAVVVGTITDDVRVQEVPVCALRV----TSRARSRILRAGGKILTFDQLDSPK-GCGTVLLSGHFAPGTPHKGR-KFERARGRRASRGYKN

4ghnA2

0.14

0.09

0.67

0.51

PPAS

DNEEQTVSRILQDSI--T-IKTNPVED----KAVY-PKVKDLP-R----NGGGN-------SNGVNICKY-----FIREAQPHCVSKSYIQPEADAYKGKI--D------------------TYTLSAA--FTLKESG--N-V-------------TLIGE---ATGGDTQPDVSSKGFPEGIGIPPH-H-QVSQTVADFKDED

2q9qB

0.22

0.19

0.83

0.62

Env-PPAS

LTPAELIERLEQAWMNEKFAELLESKPEIHMEENLDLKV---SIHQMEME----RIRCRLMKFFPHVLEKEKTRPE-GEPSSL-SPEELA------FAREFMANTESYLKNVA-----LKHM-------PP-NLQKVDLFRAVPKPDLDSYVFLRVREQENIEPDTDEQRDYVIDLEK--GSQHLIRKTIAPVASGAVQL----

4bujB

0.09

0.08

0.97

0.60

MUSTER

FYQHLKPGSLMAETIGRTPQDALLNLIKILSNIETTEIGKTLSQNRLKLKASDPDYQIKLNSFSWEIIKNSEIDQLYNQLVNILADDQEIENQWLEYRIKVLKSMPLDVKKDFFTKVKEMVEDMVLVNHQSLLAWQK-YFEWTDYEDLD---NMDAPLIIKYFKKFPKDPLAMILYSWL--SSKLSKYDIKSLESDDIEIGLLE

2eyyA

0.14

0.12

0.85

0.56

dPPAS

------------------------MAGNFDSEERSSWYWGRLSQRRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFY-----KIHYLDTTTLIEPVSRSRQGSGVILRQEEA-EYVRALFDFNGNDEEDLPFKKGRDKPEEQWWNAEDSEGKPYVEKYRPASASVSALI

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.50

Estimated TM-score = 0.25±0.07

Estimated RMSD = 16.5±3.0Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-4.66

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3j3bQ	0.508	3.85	0.145	0.676
2	1vx7S	0.504	4.02	0.101	0.672
3	3u5eQ	0.504	4.20	0.145	0.696
4	3iz5R	0.503	3.93	0.082	0.686
5	4a17N	0.499	3.96	0.106	0.672
6	3zf7I	0.498	4.07	0.093	0.672
7	3j39Q	0.495	3.87	0.092	0.662
8	2wjvA	0.456	5.35	0.040	0.755
9	4zdaA	0.453	4.91	0.063	0.726
10	3jywO	0.440	3.28	0.139	0.564

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	1jj2N	NUC	Rep, Mult	46,47,66,67,70,75,76,79,86,87,97,99,100,103,104,120,122,123,124,125,142,143,144,169,170,171,172,173,174,177
2	0.05	3	1iw7F	MG	Rep, Mult	68,72
3	0.05	3	3ooyA	TDP	Rep, Mult	2,3,76,79
4	0.03	2	1w8qC	CO	Rep, Mult	35,39
5	0.03	2	2wghA	DTP	Rep, Mult	15,16,18,24,37
6	0.03	2	3hndA	TTP	Rep, Mult	5,11,13,14,15
7	0.03	2	2faqA	MN	Rep, Mult	136,138,188,192
8	0.03	2	1xhbA	CA	Rep, Mult	64,65
9	0.02	1	2zyqB	TAR	Rep, Mult	51,52
10	0.02	1	3d5bD	MG	Rep, Mult	180,187
11	0.02	1	3hnfB	TTP	Rep, Mult	79,85,86,88
12	0.02	1	3hnfA	TTP	Rep, Mult	11,15,16,19,20
13	0.02	1	2b0qA	MG	Rep, Mult	144,163
14	0.02	1	4q0pA	Z6J	Rep, Mult	59,62
15	0.02	1	2faqA	MN	Rep, Mult	136,138
16	0.02	1	2nvqB	DUT	Rep, Mult	93,94

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2wghB	0.424	5.57	0.049	0.740	1.17.4.1	NA
2	0.060	3n58A	0.402	5.66	0.038	0.696	3.3.1.1	93
3	0.060	2vjyA	0.409	5.62	0.052	0.701	4.1.1.1	NA
4	0.060	1yirC	0.404	5.40	0.047	0.662	2.4.2.11	158
5	0.060	1kbpA	0.402	5.25	0.059	0.662	3.1.3.2	NA
6	0.060	2ji6A	0.405	5.34	0.027	0.676	4.1.1.8	NA
7	0.060	3ctzA	0.404	5.73	0.023	0.711	3.4.11.9	NA
8	0.060	1hwxA	0.411	5.59	0.060	0.716	1.4.1.3	NA
9	0.060	1itzB	0.426	5.35	0.069	0.711	2.2.1.1	NA
10	0.060	1ybeA	0.412	5.71	0.043	0.696	2.4.2.11	NA
11	0.060	3etdA	0.410	5.70	0.043	0.716	1.4.1.3	5,79,104
12	0.060	1djnA	0.407	5.73	0.068	0.726	1.5.8.2,1.5.99.7	NA
13	0.060	2panA	0.420	5.58	0.057	0.706	4.1.1.47	NA
14	0.060	4kbpA	0.402	5.24	0.048	0.662	3.1.3.2	NA
15	0.060	2vk1A	0.340	6.08	0.062	0.632	4.1.1.1	NA
16	0.060	3komA	0.403	5.27	0.071	0.672	2.2.1.1	NA
17	0.060	1pg3B	0.414	5.85	0.039	0.745	6.2.1.1	14,103
18	0.060	1z01A	0.409	5.63	0.058	0.691	1.14.13.61	NA
19	0.060	5r1rA	0.413	6.10	0.047	0.774	1.17.4.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.495	3.87	0.09	0.66	4v6wCQ	GO:0000022 GO:0003723 GO:0003735 GO:0005622 GO:0005737 GO:0005840 GO:0006412 GO:0007052 GO:0022625 GO:0030529
1	0.07	0.508	3.85	0.14	0.68	4v6xCQ	GO:0000184 GO:0003723 GO:0003735 GO:0005622 GO:0005634 GO:0005730 GO:0005737 GO:0005829 GO:0005840 GO:0005925 GO:0006364 GO:0006412 GO:0006413 GO:0006614 GO:0016020 GO:0019083 GO:0022625 GO:0030529
2	0.07	0.498	4.07	0.09	0.67	4v8mBI	GO:0003723 GO:0003735 GO:0005622 GO:0005737 GO:0005840 GO:0006412 GO:0022625 GO:0030529
3	0.07	0.503	3.93	0.08	0.69	4v3pLR	GO:0003735 GO:0005622 GO:0005840 GO:0006412
4	0.07	0.504	4.02	0.10	0.67	3j79S	GO:0003723 GO:0003735 GO:0005622 GO:0005840 GO:0006412 GO:0022625
5	0.07	0.499	4.03	0.14	0.68	5apnQ	GO:0002181 GO:0003723 GO:0003735 GO:0005622 GO:0005737 GO:0005840 GO:0006412 GO:0022625 GO:0030529
6	0.07	0.499	3.96	0.11	0.67	4v8pBN	GO:0003735 GO:0005622 GO:0005737 GO:0005840 GO:0006412 GO:0030529
7	0.06	0.328	4.58	0.06	0.49	4b3fX	GO:0000049 GO:0000166 GO:0003676 GO:0003677 GO:0003678 GO:0003697 GO:0003723 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0006260 GO:0006281 GO:0006310 GO:0006351 GO:0006355 GO:0006357 GO:0006412 GO:0008026 GO:0008094 GO:0008134 GO:0008186 GO:0008270 GO:0016020 GO:0016787 GO:0030424 GO:0030426 GO:0030529 GO:0032508 GO:0032575 GO:0032797 GO:0042995 GO:0043022 GO:0043141 GO:0046872 GO:0051260
8	0.06	0.425	3.23	0.11	0.54	4adxO	GO:0003723 GO:0003735 GO:0005622 GO:0005840 GO:0006412 GO:0019843 GO:0030529
9	0.06	0.457	5.43	0.03	0.78	4pj3A	GO:0000398 GO:0003723 GO:0005634 GO:0005654 GO:0005681 GO:0006283 GO:0006397 GO:0008380 GO:0016020 GO:0044822 GO:0071013
10	0.06	0.343	5.30	0.04	0.56	2xzlA	GO:0000166 GO:0000184 GO:0000956 GO:0003677 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005844 GO:0006310 GO:0006449 GO:0006452 GO:0008270 GO:0008298 GO:0016567 GO:0016787 GO:0016887 GO:0030466 GO:0043024 GO:0046872 GO:0070478
11	0.06	0.319	5.96	0.03	0.58	5ffjA	GO:0000166 GO:0003676 GO:0003677 GO:0004518 GO:0004519 GO:0005524 GO:0006306 GO:0008168 GO:0008170 GO:0016787 GO:0032259 GO:0090305
12	0.06	0.421	5.58	0.04	0.71	5eanA	GO:0000076 GO:0000166 GO:0000723 GO:0000729 GO:0000784 GO:0003677 GO:0003678 GO:0003824 GO:0004386 GO:0004518 GO:0004519 GO:0005524 GO:0005634 GO:0005739 GO:0005760 GO:0006260 GO:0006264 GO:0006281 GO:0006284 GO:0006974 GO:0008152 GO:0016787 GO:0016890 GO:0017108 GO:0032508 GO:0033567 GO:0042645 GO:0043137 GO:0043139 GO:0043142 GO:0043504 GO:0045740 GO:0046872 GO:0051536 GO:0051539 GO:0090305 GO:1902990
13	0.06	0.299	6.37	0.03	0.59	4krhA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
14	0.06	0.319	6.12	0.07	0.58	4bjpA	GO:0008658 GO:0008955 GO:0016020 GO:0016021 GO:0016740 GO:0016757
15	0.06	0.326	5.74	0.04	0.56	4ohwA	GO:0000166 GO:0005524 GO:0005634 GO:0005849 GO:0006378 GO:0006379 GO:0006388 GO:0006397 GO:0031124 GO:0046939 GO:0051736
16	0.06	0.319	5.66	0.06	0.58	5a5bM	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006511 GO:0008540 GO:0016787 GO:0016887 GO:0017025 GO:0030163 GO:0030433 GO:0031595 GO:0031597 GO:0036402 GO:0045899 GO:0070682 GO:1901800
17	0.06	0.276	6.10	0.05	0.50	2iy3A	GO:0000166 GO:0003723 GO:0003924 GO:0005525 GO:0005737 GO:0006612 GO:0006614 GO:0008312 GO:0030529 GO:0048500
18	0.06	0.346	5.51	0.05	0.57	1d2mA	GO:0000166 GO:0003677 GO:0004386 GO:0004518 GO:0005524 GO:0005737 GO:0006281 GO:0006289 GO:0006974 GO:0009381 GO:0009432 GO:0016787 GO:0090305

Consensus prediction of GO terms

Molecular Function	GO:0005198	GO:0003676
GO-Score	0.58	0.48
Biological Processes	GO:0044267	GO:0034645	GO:0043043	GO:0010467
GO-Score	0.58	0.58	0.58	0.58
Cellular Component	GO:0022626	GO:0015934
GO-Score	0.48	0.48

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.