I-TASSER results

I-TASSER results for job id Rv1945

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (454 residues)
MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQ
LAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAA
QREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWL
HPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQ
TPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKEL
EAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPLALYHTKRLASPAQRIMLYAK
DRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAKGDT
EWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAKGDTEWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH
Prediction	CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHCCCCCCCHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHCHHHCCCCCCCEHCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCC
Conf.Score	9888889999999999999999996885559989999999999999999999999999999985645545886899999998887999999999999875544556556644576899999989999999999999998588878999999999999998755999999999999999988888988678887658689855899779999985989999999999888765668898877777888776556688887556554557788765567888888888756899986455556777764547888789999999987596799986899654566566778999999999858888999999986445555566666889999888555657765456788668867898668868999999999999999957766889999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAKGDTEWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH
Prediction	7636436302400420240033017031530324100200330141111110110200110242123552211001000100100121021002202302312221043034314401310311111220000002002301200234001200320052037131530250042004203463444465413422101033310000100010102000102201312033114224342122432244441241210211110100000010102224224322120000000214323423222022200101000001002402000000355321311232221241001000021300011204100220112103313521200040011003200212343312233443312011133134341231221203510463776758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHCCCCCCCHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCEEEEEEHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEHCHHHCCCCCCCEHCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCC
MRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPVVDDTPDADAVRRDTRSQAQRHHDGLLAGLRGLLASGELGQHRGLPVTVVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASNAHHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAKGDTEWLPPAHLDHGQPRINRYHHPEKILCEPDDDEPH

5gaoE

0.15

0.11

0.73

1.20

PPAS

----------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA--------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------

4cg4A

0.07

0.05

0.78

1.12

Env-PPAS

VALEHKKKIQKQLEHLKKLRKSGEEQRSYG--EEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQ--EHF----FVASLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKECQSEWELLQD---IGDILHRAKTVPVPEKWTTPQEIKQKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDAETAYPNLIFSDDLK-------------SVRLGNKWERLPDGPQRFDS--------------------------CIIVLGSPSFLSGRRYWEVEVG-----------------------------DKTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQA--SSVP--PTRLLIKEPPKRVGSYNVTARSHIYTFASCSFSGGTRDGGKNTAPLTICPVGGQGPDALEVLFQ----------------

2q8gA

0.13

0.10

0.80

1.09

Env-PPAS

--------------GVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISL---LPDNLLRTPSV-QLVQSWYIQSLQELLDFKDKSAED-AKAIYDFTDTVIRIRNRHDVIPTMAQGVIEYKESFDPVTSQNVQYFLDRFYM--SRISIRMLLNQHSLLFGKH-------------------IGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYV-PSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLG-----------------------------NEDLTVKMSDRGGGV---------PLRKIDRLFNYMYS------TAPRPRVETSRAVPLAGFGY-GLPISRLYAQYFQ-----GDLKLYSLEGDAVIYIKALSTDSIERLPVYNKAWKHYNTNDDCVP-

3crlB

0.13

0.11

0.80

1.06

Env-PPAS

-----------SLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINL---LPDRVLSTPSV-QLVQSWYVQSLLDIMEFLDKDPE-DHRTLSQFTDALVT--IRNRHNDVVPTMAQGVTYGDDPVSNQNIQYFLDRFYL--SRISIRMLINQHTLIFDGSTNPAH-------------PKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNATNATQPIHM-VYVPSHLYHMLFELFKNAMRATVESHESSLTLPPIKIMVAL--GEEDLSIKMSDRGGGVPLRKIERLFS--YMYSTAPLAGFGYGL--------PISRLYAKY--------------------F------QGDLQLFSM------------EGFGTDA-----VIYL-KALSTDSVERLPVYNKSAWRHYQTIQEAGD

4um2A

0.10

0.98

0.76

MUSTER

-----SMELHRLLRVADNQELQLSNLLSRDRISPEGLEKMAQLRAELLQLYERCILLIEFSDNQNVDQIL-QVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKN-----GRPYNQLALLAVYTRRKLDAVRSLAALTAKESLMSLFEETKRKAEQMEKGLGSLSPSDLNKRFILRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINAVHNSQRSVIQEQAAALGLAMFSLLVRRCTCLLKESLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLIPLLAAPQDPCYVEKTSDKVIAADCGQEEPL

4cgkA

0.11

0.08

0.74

0.65

dPPAS

NLTAQQQEAQKQVDQIQEQVSAIQAESNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVTSYINTIVNSSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAY------------KEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLGAQWATSAAAAGFRTGSTPQVGAIACWND----GGYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVAD--------------------------------------------------------------------------------------------------------

1y8pA

0.12

0.10

0.78

0.61

wdPPAS

---------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVN---LLPDNLLNR---SVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIK----NDVVPTMAQGVIEYKFGFDPFISTNIQYFLDRFYT--NRISFRMLINQHTLLFGGDTNPVH-------------PKHIGSIDPTCNVAVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLG----KEDLSIKISDLGGGVPLRKIDRLF--------------YMYSTAPRPLAGFGYGLPISRL---------------ARYF-------QGD---------------------LKLYSMEGDAVIYLKALSSESFERLPVFNKSKTTPEADDWSNPS

1y8pA

0.14

0.11

0.79

0.73

wMUSTER

---------------VPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVN---LLPDNLLNRPSV-GLVQSWYMQSFLELLEYENKSPED-PQVLDNFLQVLIK--VRNRHNDVVPTMAQGVKFGFDPFISTNIQYFLDRFYT--NRISFRMLINQHTLLFGGDTNPVH-------------PKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLG----KEDLSIKISDLGGGVPLRKIDRLFN-------------YMYSTAPRPLAG-----------------GY------------------G---LPISRLYARYFQ-----GDLKLYSMEGDAVIYLKALSSESFERLPVFNHYKTTPEADDWSNPS

4ogcA3

0.13

0.04

0.27

0.91

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DG--RDKANRRRYNDNQEAKKIQRDYGK-----EGYISRGDIVRLDALELQGCCLY--CGTGYHTCQLDHIVPQAGPGSNNRGNLVAVCERCNRSKSN--------------TPFVWAQKCGIPHVGVKRVRGWRKQTPNEDPE

5cwmA

0.13

0.07

0.50

0.92

dPPAS2

----DPEDELKRVEKLVKEAEELLRQAKEKGS-EEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEE-------AARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAE----KQGDPEVARR--------------------AVELVKRVAELLERIARESGSEEAKERAERVR-------------EEARELQERVKELRER-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.25

Estimated TM-score = 0.35±0.12

Estimated RMSD = 15.2±3.4Å

Download Model 2

C-score=-2.40

Download Model 3

C-score=-3.97

Download Model 4

C-score=-4.02

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1y8pA	0.739	2.31	0.122	0.788
2	3crlB	0.738	2.33	0.116	0.791
3	2q8gA	0.735	2.57	0.114	0.791
4	3d2rB	0.720	2.64	0.127	0.777
5	1gkzA	0.605	3.07	0.110	0.676
6	3ksyA	0.407	6.38	0.051	0.610
7	5amqA	0.391	7.06	0.016	0.639
8	3perA	0.381	6.51	0.036	0.571
9	2xsgA	0.379	7.18	0.047	0.621
10	2pi4A	0.374	7.15	0.054	0.606

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.19	14	3d2rA	ADP	Rep, Mult	270,273,274,310,315,323,358,359,392
2	0.08	6	1tf3A	ZN	Rep, Mult	364,369,379,380
3	0.06	4	2q8gA	AZX	Rep, Mult	31,35,36,39,48,49,52,53,172,175
4	0.04	3	1focA	HEM	Rep, Mult	364,369
5	0.03	2	2bu8A	TF4	Rep, Mult	61,92,126,127,130,165,169,170,173
6	0.03	2	3crlA	K	Rep, Mult	24,25,26,27,28,63,437,438,439
7	0.03	2	2zdxB	P4A	Rep, Mult	267,270,274,310,312,314,315,323,413
8	0.01	1	1s0vC	APC	Rep, Mult	258,262,263,266,267
9	0.01	1	2btz0	III	Rep, Mult	28,155,159,162,243,292,296,302,303,305,307,316,317,318,423,434,435,436,437,439
10	0.01	1	2bu7A	TF3	Rep, Mult	74,75,77,78,137,141,152,153,157,444
11	0.01	1	3knvA	ZN	Rep, Mult	364,369,380,399

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.230	2q8gA	0.735	2.57	0.114	0.791	2.7.11.2	NA
2	0.214	1y8pA	0.739	2.31	0.122	0.788	2.7.11.2	NA
3	0.207	2zdxA	0.683	2.14	0.127	0.729	2.7.11.2	NA
4	0.172	1gkzA	0.605	3.07	0.110	0.676	2.7.11.4,2.7.1.115	NA
5	0.150	2pnrF	0.686	2.41	0.128	0.738	2.7.11.2	411
6	0.060	1jqoA	0.355	6.56	0.057	0.542	4.1.1.31	NA
7	0.060	1mswD	0.291	7.12	0.023	0.476	2.7.7.6	NA
8	0.060	2pnrB	0.686	2.41	0.128	0.738	2.7.11.2	NA
9	0.060	3ffzA	0.361	7.06	0.026	0.597	3.4.24.69	NA
10	0.060	1fftA	0.362	6.11	0.049	0.522	1.10.3.-	NA
11	0.060	3crlB	0.738	2.33	0.116	0.791	2.7.11.2	265,325
12	0.060	2ckjA	0.355	7.00	0.033	0.573	1.17.1.4,1.17.3.2	NA
13	0.060	2e1qA	0.370	7.42	0.033	0.623	1.17.3.2,1.17.1.4	NA
14	0.060	2rnpC	0.325	7.45	0.014	0.540	2.7.7.6	NA
15	0.060	3ebgA	0.354	7.48	0.067	0.601	3.4.11.-	NA
16	0.060	1oqzB	0.370	7.31	0.056	0.626	3.5.1.93	NA
17	0.060	1xmeA	0.358	5.90	0.081	0.518	1.9.3.1	NA
18	0.060	1clqA	0.302	7.39	0.045	0.513	2.7.7.7	403
19	0.060	3d2rB	0.720	2.64	0.127	0.777	2.7.11.2	NA
20	0.060	2b4kA	0.315	6.99	0.050	0.504	3.1.1.43	361
21	0.060	3btaA	0.354	7.42	0.037	0.601	3.4.24.69	NA
22	0.060	2occN	0.367	6.14	0.042	0.529	1.9.3.1	99
23	0.060	2vuaA	0.276	7.27	0.061	0.458	3.4.24.69	128,131,172
24	0.060	2wj2A	0.361	6.90	0.047	0.577	3.5.1.99	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.738	2.33	0.12	0.79	3crlB	GO:0000166 GO:0004674 GO:0004740 GO:0005524 GO:0005739 GO:0005759 GO:0005967 GO:0005975 GO:0006006 GO:0006111 GO:0006468 GO:0006885 GO:0008286 GO:0010510 GO:0010565 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0031670 GO:0032403 GO:0042593 GO:0042803 GO:0045254 GO:0046982
1	0.22	0.735	2.57	0.11	0.79	2q8gA	GO:0000166 GO:0004672 GO:0004740 GO:0005524 GO:0005739 GO:0005759 GO:0005967 GO:0005975 GO:0006006 GO:0006468 GO:0008283 GO:0008631 GO:0010510 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0097411 GO:0098779
2	0.19	0.686	2.41	0.13	0.74	2pnrB	GO:0000166 GO:0004672 GO:0004674 GO:0004740 GO:0005524 GO:0005739 GO:0005759 GO:0005975 GO:0006006 GO:0010510 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0035357 GO:0071333 GO:0071398 GO:0097411 GO:2000377
3	0.14	0.739	2.31	0.12	0.79	1y8pA	GO:0000166 GO:0004672 GO:0004674 GO:0004740 GO:0005524 GO:0005739 GO:0005759 GO:0005975 GO:0006006 GO:0010510 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0018105 GO:0035357 GO:0071333 GO:0071398 GO:0097411 GO:2000377
4	0.11	0.720	2.64	0.13	0.78	3d2rB	GO:0000166 GO:0002230 GO:0004672 GO:0004740 GO:0005524 GO:0005739 GO:0005743 GO:0005759 GO:0005975 GO:0006006 GO:0006468 GO:0006885 GO:0008286 GO:0009267 GO:0010510 GO:0010565 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0042304 GO:0042593 GO:0042594 GO:0045124 GO:0046320 GO:0071398 GO:0072593 GO:0098792 GO:2000811
5	0.09	0.683	2.14	0.13	0.73	2zdxA	GO:0000166 GO:0002230 GO:0004672 GO:0004740 GO:0005524 GO:0005739 GO:0005743 GO:0005759 GO:0005975 GO:0006006 GO:0006468 GO:0006885 GO:0008286 GO:0009267 GO:0010510 GO:0010565 GO:0010906 GO:0016301 GO:0016310 GO:0016740 GO:0042304 GO:0042593 GO:0042594 GO:0045124 GO:0046320 GO:0071398 GO:0072593 GO:0098792 GO:2000811
6	0.07	0.605	3.07	0.11	0.68	1gkzA	GO:0000166 GO:0004672 GO:0004674 GO:0005524 GO:0005739 GO:0005759 GO:0005947 GO:0006468 GO:0009083 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0047323
7	0.06	0.342	3.76	0.07	0.40	4javA	GO:0000155 GO:0000160 GO:0000166 GO:0005524 GO:0005622 GO:0007165 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0023014
8	0.06	0.323	4.35	0.06	0.39	4i5sB	GO:0000155 GO:0000160 GO:0000166 GO:0005524 GO:0005622 GO:0006355 GO:0007165 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0023014
9	0.06	0.320	4.61	0.07	0.39	4gczB	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0005524 GO:0005622 GO:0006351 GO:0006355 GO:0007165 GO:0009399 GO:0009881 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0018298 GO:0023014 GO:0046872 GO:0050896
10	0.06	0.291	7.44	0.05	0.49	4rizC	GO:0003824 GO:0016829 GO:0016831 GO:0019752 GO:0030170
11	0.06	0.314	3.74	0.09	0.37	3d36B
12	0.06	0.284	7.22	0.04	0.46	4oh3A	GO:0005215 GO:0005886 GO:0006810 GO:0006857 GO:0009414 GO:0009635 GO:0009734 GO:0010167 GO:0015112 GO:0015293 GO:0015706 GO:0016020 GO:0016021 GO:0042128 GO:0055085
13	0.06	0.281	7.15	0.04	0.46	4oh3B	GO:0005215 GO:0005886 GO:0006810 GO:0006857 GO:0009414 GO:0009635 GO:0009734 GO:0010167 GO:0015112 GO:0015293 GO:0015706 GO:0016020 GO:0016021 GO:0042128 GO:0055085
14	0.06	0.281	7.28	0.05	0.46	5a2nA	GO:0005215 GO:0005886 GO:0006810 GO:0006857 GO:0009414 GO:0009635 GO:0009734 GO:0010167 GO:0015112 GO:0015293 GO:0015706 GO:0016020 GO:0016021 GO:0042128 GO:0055085
15	0.06	0.242	7.10	0.02	0.39	4zviA	GO:0000166 GO:0000287 GO:0003677 GO:0003916 GO:0003918 GO:0005524 GO:0005694 GO:0005737 GO:0006261 GO:0006265 GO:0016853 GO:0046677 GO:0046872
16	0.06	0.284	2.64	0.10	0.31	4pl9A	GO:0000155 GO:0000160 GO:0000166 GO:0001944 GO:0002237 GO:0004673 GO:0005524 GO:0005783 GO:0005789 GO:0006952 GO:0007165 GO:0009408 GO:0009625 GO:0009651 GO:0009690 GO:0009723 GO:0009727 GO:0009733 GO:0009737 GO:0009739 GO:0009873 GO:0010105 GO:0010119 GO:0010182 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0023014 GO:0038199 GO:0042742 GO:0042802 GO:0046872 GO:0050665 GO:0050896 GO:0051301 GO:0051740 GO:0052544 GO:0071281 GO:1900140
17	0.06	0.280	2.68	0.11	0.31	3sl2A	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004871 GO:0005524 GO:0005622 GO:0005886 GO:0007165 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0023014
18	0.06	0.232	6.62	0.06	0.36	4xeoA	GO:0000049 GO:0000166 GO:0001942 GO:0002161 GO:0003676 GO:0003723 GO:0004812 GO:0004813 GO:0005524 GO:0005737 GO:0005739 GO:0005829 GO:0006400 GO:0006412 GO:0006418 GO:0006419 GO:0006450 GO:0006457 GO:0008033 GO:0008270 GO:0016020 GO:0016597 GO:0016874 GO:0016876 GO:0021680 GO:0030968 GO:0034620 GO:0043039 GO:0043200 GO:0043524 GO:0043588 GO:0046872 GO:0050885 GO:0050905 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0004740	GO:0046983	GO:0044877	GO:0042802	GO:0004674
GO-Score	0.67	0.67	0.60	0.60	0.60	0.51
Biological Processes	GO:0010906	GO:0010510	GO:0006094	GO:0043255	GO:0007584	GO:0031669	GO:0018105	GO:0097411	GO:0000423	GO:0036473	GO:0098780	GO:0097193	GO:0071398	GO:0006885	GO:0008286	GO:0035357	GO:0071333	GO:2000377
GO-Score	0.67	0.67	0.60	0.60	0.60	0.60	0.51	0.46	0.44	0.44	0.44	0.44	0.38	0.38	0.38	0.31	0.31	0.31
Cellular Component	GO:0005967
GO-Score	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.