I-TASSER results

I-TASSER results for job id Rv1931c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (259 residues)
MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARRVVTVCTGAFLAAEAGL
LGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRGWSHRRHRPRAGTGRRRPR
HRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAGGHRGRAGGAHRIGELAQ
RAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHDTVVAIAARCGFGTAETMR
RSFIRRVGISPDQYRKAFA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARRVVTVCTGAFLAAEAGLLGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRGWSHRRHRPRAGTGRRRPRHRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAGGHRGRAGGAHRIGELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHDTVVAIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA
Prediction	CCCCCCCCCCCCEEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEHCHHHHHHHHHCCCCCCEEEHCHHHHHHHCCCCCHCCCCEEEHCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHC
Conf.Score	9888999888878998899998767899999999999999899899876899999998899998666378999997988855688589968957866889999999999999999999999999975655578887654555555667776556788999999999975899999999999889865489999999899999999999999999999879999999999989999999999999999999799999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARRVVTVCTGAFLAAEAGLLGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRGWSHRRHRPRAGTGRRRPRHRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAGGHRGRAGGAHRIGELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHDTVVAIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA
Prediction	5414424644030200000332743343640040034017410100000010100010100552300000310550266051454201013200000000000000010015410440033004411231324354343334334344453433442243014103502746130430063073243222311362043012430351104303414542722034003402343472403032433512133136438
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCEEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEHCHHHHHHHHHCCCCCCEEEHCHHHHHHHCCCCCHCCCCEEEHCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHC
MVIVGFPGDPVDTVILPGGAGVDAARSEPALIDWVKAVSGTARRVVTVCTGAFLAAEAGLLGRTPSDDALGLCRTFRPRISGRSGRCRPDLHAQFAEGVDRGWSHRRHRPRAGTGRRRPRHRDCPDGCPLARPVSAPTRWADPVRGSGVDATRQTDLDPPGAGGHRGRAGGAHRIGELAQRAAMSPRHFTRVFSDEVGEAPGRYVERIRTEAARRQLEETHDTVVAIAARCGFGTAETMRRSFIRRVGISPDQYRKAFA

3mgkA

0.12

0.07

0.55

1.62

MUSTER

VETSLYDENIEKILFVPGGSGTREKVNDDNFINFIGNMVKESKYIISVCTGSALLSKAGILNGKRATTNKRSFKWV-EDVLWVKEARWVKDNIYTSSGVSAGIDMTLGFIEDLIGKEKALEISRSIEYFWNEDSNYDPFSKIY--------------------------------------------------------------------------------------------------------------------

3w6vA

0.32

0.13

0.41

2.98

Env-PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------SDPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYR

3mgkA

0.13

0.07

0.55

3.48

dPPAS

TSLYTRDENIEKILFVPGGSGTREKVNDDNFINFIGNMVKESKYIISVCTGSALLSKAGILNGKRATTNKRSFKWVTEDVLWVKEAWVKDGNIYTSSGVSAGIDMTLGFIEDLIGKEKALEISRSIEYFWNEDSNYDPFSKIY--------------------------------------------------------------------------------------------------------------------

3w6vA

0.32

0.13

0.41

2.29

wPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------SDPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYR

3mgkA

0.13

0.07

0.55

3.39

wdPPAS

TSLYTRDENIEKILFVPGGSGTREKVNDDNFINFIGNMVKESKYIISVCTGSALLSKAGILNGKRATTNKRSFKWV-EDVLWVKEAWVKDGNIYTSSGVSAGIDMTLGFIEDLIGKEKALEISRSIEYFWNEDSNYDPFSKIY--------------------------------------------------------------------------------------------------------------------

3w6vA

0.32

0.13

0.41

1.99

PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------SDPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYR

3mgkA

0.13

0.07

0.55

2.02

wMUSTER

VETSLYDENIEKILFVPGGSGTREKVNDDNFINFIGNMVKESKYIISVCTGSALLSKAGILNGKRATTNKRSFKWV-EDVLWVKEAWVKDGNIYTSSGVSAGIDMTLGFIEDLIGKEKALEISRSIEYFWNEDSNYDPFSKIY--------------------------------------------------------------------------------------------------------------------

3w6vA

0.32

0.13

0.41

1.55

MUSTER

----------------------------------------------------------------------------------------------------------------------------------------------------------SDPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYR

3mgkA

0.13

0.07

0.55

5.83

dPPAS2

TSLYTRDENIEKILFVPGGSGTREKVNDDNFINFIGNMVKESKYIISVCTGSALLSKAGILNGKRATTNKRSFKWVTEDVLWVKEAWVKDGNIYTSSGVSAGIDMTLGFIEDLIGKEKALEISRSIEYFWNEDSNYDPFSKIY--------------------------------------------------------------------------------------------------------------------

3w6vA

0.32

0.13

0.41

3.16

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------SDPLAEVVAWALEHLHEQFDVETLAARAYMSRRTFDRRFRSLTGSAPLQWLITQRVLQAQRLLETSDYSVDEVAGRCGFRSPVALRGHFRRQLGSSPAAYRAAYR

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.31

Estimated TM-score = 0.44±0.14

Estimated RMSD = 11.2±4.6Å

Download Model 2

C-score=-2.48

Download Model 3

C-score=-3.08

Download Model 4

C-score=-3.20

Download Model 5

C-score=-3.05

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3mgkA	0.506	1.98	0.126	0.552
2	3nooA	0.490	3.21	0.147	0.587
3	1cjyA2	0.488	5.81	0.066	0.799
4	3ewnA	0.472	3.24	0.137	0.568
5	2i7xA	0.456	5.87	0.049	0.757
6	2c44C	0.452	6.41	0.087	0.819
7	2i7vA	0.452	5.76	0.058	0.730
8	2b3yA	0.451	6.09	0.052	0.784
9	2xr1A	0.450	5.95	0.070	0.757
10	1hdhA	0.449	5.10	0.073	0.683

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	4	1bl0A	NUC	Rep, Mult	184,185,187,188,191,206,234,241,242
2	0.08	3	1d5yB	NUC	Rep, Mult	206,238,241,245
3	0.05	2	5i50A	NUC	Rep, Mult	206,209
4	0.05	2	1bl0A	NUC	Rep, Mult	174,175,187,190,191,194,200,202,203,236,237,240,241,244,250,251,252,253
5	0.05	2	3iemA	SSU	Rep, Mult	13,15,45,54,55,56
6	0.03	1	1d5yC	NUC	Rep, Mult	184,185,187,188,191,192,245
7	0.02	1	3bg5D	BTI	Rep, Mult	213,216,217,221,241,251
8	0.02	1	3ho8B	COA	Rep, Mult	179,180,181,182,183,185
9	0.02	1	3etdA	B1T	Rep, Mult	106,107
10	0.02	1	4f8hD	LMD	Rep, Mult	208,212
11	0.02	1	3ho8A	COA	Rep, Mult	59,77,78,80,82
12	0.02	1	3n97A	NUC	Rep, Mult	217,223,224,237,240

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jC	0.309	6.71	0.039	0.579	1.17.3.2,1.17.1.4	NA
2	0.060	1aknA	0.427	6.02	0.071	0.703	3.1.1.13,3.1.1.3	NA
3	0.060	2ckjA	0.296	6.41	0.057	0.540	1.17.1.4,1.17.3.2	NA
4	0.060	2qnoA	0.428	6.49	0.051	0.772	3.2.1.4	NA
5	0.060	2pffD	0.407	6.45	0.040	0.734	2.3.1.86	NA
6	0.060	1c7gA	0.421	6.58	0.057	0.780	4.1.99.2	NA
7	0.060	5acnA	0.438	6.25	0.067	0.772	4.2.1.3	NA
8	0.060	2qf7B	0.435	5.83	0.055	0.730	6.4.1.1	195
9	0.060	2dkfA	0.443	5.86	0.076	0.734	3.1.-.-	NA
10	0.060	2ipyA	0.404	5.89	0.063	0.672	4.2.1.3	67,105
11	0.060	2e1qA	0.339	6.10	0.052	0.579	1.17.3.2,1.17.1.4	NA
12	0.060	2fj0A	0.428	6.08	0.046	0.718	3.1.1.1	NA
13	0.060	2b3xA	0.432	6.42	0.052	0.772	4.2.1.3	NA
14	0.060	3b9jI	0.226	4.51	0.073	0.317	1.17.1.4,1.17.3.2	232
15	0.060	1ygpA	0.426	5.38	0.034	0.664	2.4.1.1	NA
16	0.060	2c44C	0.452	6.41	0.087	0.819	4.1.99.1	NA
17	0.060	1fo4A	0.418	6.15	0.047	0.710	1.17.1.4	NA
18	0.060	1ordA	0.436	6.89	0.044	0.853	4.1.1.17	NA
19	0.060	1cjyA	0.485	5.65	0.057	0.795	3.1.1.4,3.1.1.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.23	0.407	2.90	0.17	0.49	3er6A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0043565
1	0.11	0.504	2.04	0.13	0.55	3mgkB	GO:0006508 GO:0008233
2	0.07	0.485	5.65	0.06	0.80	1cjyA	GO:0001542 GO:0001554 GO:0004620 GO:0004622 GO:0004623 GO:0005509 GO:0005544 GO:0005634 GO:0005737 GO:0005743 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006629 GO:0006644 GO:0006654 GO:0006663 GO:0006690 GO:0007568 GO:0008152 GO:0008284 GO:0008970 GO:0009395 GO:0009408 GO:0009725 GO:0010033 GO:0010226 GO:0010243 GO:0016023 GO:0016042 GO:0016787 GO:0019369 GO:0030501 GO:0031340 GO:0031394 GO:0031410 GO:0031622 GO:0032496 GO:0033280 GO:0035035 GO:0035965 GO:0036148 GO:0036149 GO:0036150 GO:0036151 GO:0036152 GO:0042127 GO:0042542 GO:0042588 GO:0043065 GO:0043129 GO:0043231 GO:0046456 GO:0046697 GO:0046872 GO:0047498 GO:0048471 GO:0050482 GO:0050729 GO:0051384 GO:0051592 GO:0051597 GO:0071236
3	0.06	0.436	4.39	0.07	0.58	3uk7C	GO:0004462 GO:0016798 GO:0016829 GO:0019172 GO:0019243 GO:0019249
4	0.06	0.414	3.11	0.12	0.51	3ot1A	GO:0003713 GO:0003824 GO:0005634 GO:0005739 GO:0005829 GO:0006357 GO:0009228 GO:0019172 GO:0019243 GO:0019249 GO:0070301
5	0.06	0.421	5.88	0.05	0.70	5izrC	GO:0004620 GO:0004622 GO:0004623 GO:0005737 GO:0005829 GO:0006629 GO:0006644 GO:0006654 GO:0008152 GO:0008970 GO:0009395 GO:0016020 GO:0016042 GO:0016787 GO:0030659 GO:0031410 GO:0036148 GO:0036149 GO:0036150 GO:0036151 GO:0036152 GO:0046872
6	0.06	0.417	2.79	0.13	0.49	4e08A	GO:0003713 GO:0005634 GO:0005739 GO:0005829 GO:0006357 GO:0006979 GO:0008344 GO:0019172 GO:0019243 GO:0019249 GO:0042775 GO:0046626 GO:0048640 GO:0070301
7	0.06	0.446	5.73	0.05	0.73	5iz5A	GO:0004620 GO:0004622 GO:0004623 GO:0005737 GO:0005829 GO:0006629 GO:0006644 GO:0006654 GO:0008152 GO:0008970 GO:0009395 GO:0016020 GO:0016042 GO:0016787 GO:0030659 GO:0031410 GO:0036148 GO:0036149 GO:0036150 GO:0036151 GO:0036152 GO:0046872
8	0.06	0.417	2.91	0.16	0.50	2ab0A	GO:0003713 GO:0005634 GO:0005739 GO:0005829 GO:0006357 GO:0009228 GO:0009408 GO:0016787 GO:0019172 GO:0019243 GO:0019249 GO:0034599 GO:0042026 GO:0042254 GO:0070301
9	0.06	0.418	2.66	0.14	0.49	3b38A	GO:0000785 GO:0001047 GO:0001933 GO:0001963 GO:0003690 GO:0003697 GO:0003713 GO:0003723 GO:0003729 GO:0005102 GO:0005507 GO:0005634 GO:0005737 GO:0005739 GO:0005747 GO:0005758 GO:0005759 GO:0005783 GO:0005829 GO:0005886 GO:0005913 GO:0006469 GO:0006508 GO:0006517 GO:0006914 GO:0006954 GO:0006979 GO:0007005 GO:0007265 GO:0007338 GO:0008134 GO:0008233 GO:0008344 GO:0010273 GO:0010628 GO:0010629 GO:0016020 GO:0016532 GO:0016605 GO:0016684 GO:0016787 GO:0018323 GO:0019172 GO:0019243 GO:0019249 GO:0019899 GO:0019900 GO:0019955 GO:0030424 GO:0031397 GO:0032091 GO:0032148 GO:0032435 GO:0032757 GO:0033138 GO:0033234 GO:0034599 GO:0034614 GO:0036470 GO:0036471 GO:0036478 GO:0042177 GO:0042493 GO:0042542 GO:0042743 GO:0042802 GO:0042803 GO:0043005 GO:0043066 GO:0043523 GO:0043524 GO:0044297 GO:0044388 GO:0044390 GO:0045121 GO:0045340 GO:0045560 GO:0045944 GO:0046295 GO:0046826 GO:0048471 GO:0050681 GO:0050727 GO:0050787 GO:0050821 GO:0051091 GO:0051444 GO:0051583 GO:0051881 GO:0051897 GO:0051899 GO:0051920 GO:0060081 GO:0060548 GO:0060765 GO:0070062 GO:0070301 GO:0070491 GO:0090073 GO:0097110 GO:0098609 GO:0098641 GO:0098793 GO:0098869 GO:1900182 GO:1901215 GO:1901671 GO:1901984 GO:1902177 GO:1902236 GO:1902903 GO:1902958 GO:1903073 GO:1903094 GO:1903122 GO:1903135 GO:1903136 GO:1903168 GO:1903178 GO:1903181 GO:1903190 GO:1903197 GO:1903200 GO:1903202 GO:1903204 GO:1903206 GO:1903208 GO:1903377 GO:1903384 GO:1903428 GO:1903599 GO:1990381 GO:1990422 GO:2000157 GO:2000277 GO:2000679 GO:2000825 GO:2001237 GO:2001268
10	0.06	0.436	3.93	0.08	0.56	3fseB	GO:0016798
11	0.06	0.410	2.89	0.16	0.49	4k2hD	GO:0000987 GO:0003700 GO:0005829 GO:0006355 GO:0006508 GO:0008233 GO:0019172 GO:0019243 GO:0046872
12	0.06	0.372	6.35	0.07	0.64	4x6uA	GO:0004806 GO:0016787 GO:0046872
13	0.06	0.399	2.56	0.11	0.46	3f5dA	GO:0006508 GO:0008233 GO:0016787
14	0.06	0.358	6.20	0.06	0.63	1nqkA	GO:0004497 GO:0008726 GO:0009408 GO:0016491 GO:0016705 GO:0042802 GO:0046306 GO:0055114
15	0.06	0.386	3.44	0.10	0.48	3efeB	GO:0006541 GO:0016740
16	0.06	0.367	2.75	0.14	0.43	1g2iA	GO:0005737 GO:0006508 GO:0008233 GO:0016787 GO:0016798
17	0.06	0.368	2.71	0.15	0.43	1oi4A	GO:0005737 GO:0006979 GO:0009268 GO:0009408 GO:0009411 GO:0016787 GO:0016798 GO:0019172 GO:0019243 GO:0019249 GO:0042802
18	0.06	0.363	2.87	0.12	0.43	3l18A	GO:0006508 GO:0008233 GO:0016798

Consensus prediction of GO terms

Molecular Function	GO:0001071	GO:0003677
GO-Score	0.46	0.46
Biological Processes	GO:1903506	GO:0010468	GO:2000112
GO-Score	0.46	0.46	0.46
Cellular Component	GO:0005634	GO:0005829	GO:0048471	GO:0042588	GO:0005789	GO:0005794	GO:0005743
GO-Score	0.13	0.13	0.07	0.07	0.07	0.07	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.