I-TASSER results

Input Sequence in FASTA format

>protein (134 residues)
MVPFLMRAAVTGFALWVVTLFVPGMRFAGGDTTLQRVAIIFVVAVIFGLVNAFIKPIVQI
LSIPLYILTLGLFHVVVNASMLWLTAWITEHTTHWGLQIDHFWWTAIWAAILLSIVSWIL
SLLARDFRRVTRAH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 \| \| \| \| \| \| MVPFLMRAAVTGFALWVVTLFVPGMRFAGGDTTLQRVAIIFVVAVIFGLVNAFIKPIVQILSIPLYILTLGLFHVVVNASMLWLTAWITEHTTHWGLQIDHFWWTAIWAAILLSIVSWILSLLARDFRRVTRAH
Prediction	CCHHHHHHHHHHHHHHHHHHHCCCEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
Conf.Score	95699999999999999999859889967874688999999999999999999999999999789999999999999999999999986774565699966646899999999999999999857876554579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 \| \| \| \| \| \| MVPFLMRAAVTGFALWVVTLFVPGMRFAGGDTTLQRVAIIFVVAVIFGLVNAFIKPIVQILSIPLYILTLGLFHVVVNASMLWLTAWITEHTTHWGLQIDHFWWTAIWAAILLSIVSWILSLLARDFRRVTRAH
Prediction	73312231323331223313313303133344323322322221333133323333313331333333132333333223332301312432443303143333212331333133133122015576546678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120

                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHCCCEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
MVPFLMRAAVTGFALWVVTLFVPGMRFAGGDTTLQRVAIIFVVAVIFGLVNAFIKPIVQILSIPLYILTLGLFHVVVNASMLWLTAWITEHTTHWGLQIDHFWWTAIWAAILLSIVSWILSLLARDFRRVTRAH

3jbrE

0.15

0.14

0.94

1.10

wMUSTER

KVRVTLFCILVGIVLAMTAVVSDHWAVLSEFTTQKEYSISAAAISVFSLGFLIMGTICALMAKRDYLLRPASMFYVFAGLCLFVSLEVM-SVKRMIYYYSWSFACACAAFVLLFLGGISLLLFSLPR-------

4hzuS

0.13

0.12

0.93

1.09

wPPAS

MTENTIAAVLIAMTVALSILVIPAVTL----CEVGIYTSAILMGLLVGGASGFLIDILTPVWCLFSLVIHGTQGLVVGWLL-GIRSMLLPLL-VIGYCLATTLWPAGLASIFGNVVQVGFGAGVT---TRLKPD

2mawA

0.11

0.10

0.94

1.45

dPPAS2

ELYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPP--SIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGEG------GGEGIDRLCLMAFSVFTIICTIGILMSAPNFVEE

2mawA

0.07

0.97

1.20

PPAS

ELYYGLNLLIPCVLISALALL--VFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPSTSDSSP-SIAQYFASTMIIVGLSVVVTVIVL-HHHDPDGGEGGGEGIDRLCLMAFSVFTIICTIGILMSAPNFVEE

2mawA

0.11

0.10

0.92

1.10

wMUSTER

ELYYGLNLLIPCVLISALALLV--LPADSGEKISLGITVLLSLTVFMLLVAEIMPS-----SSP-SIAQYFASTMIIVGLSVVVTVIVLQYHHHDP---GGGEGIDRLCLMAFSVFTIICTIGILMSAPNFVEE

2mawA

0.10

0.94

1.09

wPPAS

ELYYGLNLLIPCVLISALALLV--LPADSGEKISLGITVLLSLTVFMLLVAEIMPST----SSP-SIAQYFASTMIIVGLSVVVTVIVL-HHHDPDGGEGGGEGIDRLCLMAFSVFTIICTIGILMSAPNFVEE

3jbrE

0.13

0.95

1.33

dPPAS2

KVRVTLFCILVGIVLAMTAVVSDHWAVLSEFTTQKEYSISAAAISVFSLGFLIMGTICALMKRDYLLRPASMFYVFAGLCLFVSLEVMRQSVKRMIYYYSWSFACACAAFVLLFLGGISLLLFSLPR-------

5a43A

0.09

0.08

0.89

1.10

PPAS

IKSLFAVIIGGSVGCTLRWLLSTKFNSLFPNLPPGTLVVNLLAGLIIGTLAYFLRPHLDPFWKLITTGLCGGLS--FSTFSVEVFALLQAGNYIWAL---TSVLVHVIGSLITALGFFIITILF----------

5a40A

0.08

0.07

0.90

1.03

wMUSTER

PLNFIAIGIGATLGAWLRWVL--GLKLNGAGWPWGTLTANLVGGYLIGVMVALIASHPEWPAWIRLAAVTGFLGGLFSTFSAETVDMLCRGVYATAA---AYAGASLAGSLAMTGLGLATVRLLLR--------

5a43A

0.11

0.09

0.82

1.04

wPPAS

IKSLFAVIIGGSVGCTLRWLL--STKFNFPNLPPGTLVVNLLAGLIIGTLAYFLRPFWKLITT-----LCGGLS--FSTFSVEVFALLQAGNYIWAL-----VLVHVIGSLITALGFFIITILF----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.89

Estimated TM-score = 0.49±0.15

Estimated RMSD = 8.6±4.5Å

Download Model 2

C-score=-2.77

Download Model 3

C-score=-3.24

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.43

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2mawA	0.810	2.33	0.085	0.970
2	3i9yA	0.747	2.79	0.016	0.940
3	2l7nA	0.739	2.37	0.057	0.903
4	3dyjA	0.734	2.83	0.062	0.948
5	5ic0A	0.721	2.84	0.047	0.940
6	2yfaA	0.720	2.82	0.032	0.940
7	1st6A	0.718	2.83	0.023	0.918
8	2j0oA	0.717	2.58	0.048	0.903
9	2kc3A	0.717	3.22	0.061	0.963
10	4iggA	0.712	3.10	0.101	0.948

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	11	3u3cA	III	Rep, Mult	6,9,10,13,121
2	0.07	6	3ag4P	CDL	Rep, Mult	6,10,13,17,20,118,121,122
3	0.05	4	1ow8C	III	Rep, Mult	40,43,44,47,51,54,68,71,75,78,79
4	0.04	3	2einC	CDL	Rep, Mult	61,65,68
5	0.03	2	1uo4B	PIH	Rep, Mult	67,71
6	0.03	2	5dwkA	78N	Rep, Mult	47,72,75,76,79,84
7	0.03	2	5d57C	78M	Rep, Mult	46,49,50,53,117
8	0.02	2	3b71A	III	Rep, Mult	14,17,111,114,118
9	0.01	1	2h2pA	SEK	Rep, Mult	78,82
10	0.01	1	4uxzD	79N	Rep, Mult	49,56,57,132
11	0.01	1	3k2sA	CLR	Rep, Mult	84,109,112,113
12	0.01	1	2plyA	CA	Rep, Mult	56,98
13	0.01	1	1ow6A	III	Rep, Mult	111,114,115,118,121
14	0.01	1	3kziK	CLA	Rep, Mult	56,57,60
15	0.01	1	5d56C	78M	Rep, Mult	43,53,75,78,124
16	0.01	1	2np5A	NDS	Rep, Mult	4,7
17	0.01	1	3whnA	CFO	Rep, Mult	9,46,47,50,67,71,117,120,121,124

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.323	2ksfA	0.569	2.99	0.079	0.739	2.7.13.3	42,76,109
2	0.141	1k04A	0.584	3.09	0.070	0.776	2.7.10.2	110
3	0.137	1tqgA	0.548	2.73	0.031	0.731	2.7.13.3	11,47,69
4	0.117	1q0mD	0.599	2.78	0.048	0.776	1.15.1.1	34
5	0.101	2npuA	0.505	3.16	0.063	0.709	2.7.11.1	121
6	0.066	1i5nD	0.553	2.99	0.047	0.716	2.7.13.3	14,38,46,70,78
7	0.066	1wcrA	0.519	2.90	0.065	0.694	2.7.1.69	61
8	0.066	2e2aA	0.491	3.03	0.054	0.649	2.7.1.69	NA
9	0.060	3no9A	0.598	4.10	0.101	0.940	4.2.1.2	NA
10	0.060	2rd3D	0.582	3.53	0.053	0.813	3.5.99.2	72
11	0.060	1m56A	0.608	3.99	0.105	0.963	1.9.3.1	NA
12	0.060	2fenD	0.593	3.73	0.023	0.843	5.5.1.2	NA
13	0.060	3gzhA	0.576	3.73	0.038	0.836	4.3.2.2	NA
14	0.060	1jtnA	0.296	5.19	0.033	0.515	3.2.1.17	NA
15	0.060	1qleC	0.696	2.85	0.065	0.925	1.9.3.1	110
16	0.060	3g4xA	0.593	2.84	0.077	0.776	1.15.1.1	49
17	0.060	2epoA	0.569	3.38	0.040	0.784	3.2.1.52	NA
18	0.060	3gtdA	0.588	4.39	0.038	0.963	4.2.1.2	NA
19	0.060	1c3cA	0.584	3.83	0.032	0.851	4.3.2.2	NA
20	0.060	2a06C	0.586	4.03	0.082	0.910	1.10.2.2	NA
21	0.060	1xzpA	0.596	4.09	0.109	0.910	3.6.5.-	78
22	0.060	3eziA	0.618	2.51	0.068	0.769	2.7.13.3	15
23	0.060	3gm1B	0.702	3.05	0.070	0.940	2.7.10.2	79,109
24	0.060	3g61A	0.644	4.03	0.052	0.963	3.6.3.44	NA
25	0.060	3e04D	0.591	3.95	0.063	0.933	4.2.1.2	NA
26	0.060	1xmeA	0.644	3.78	0.115	0.963	1.9.3.1	73,74
27	0.060	1dcnB	0.583	3.25	0.055	0.798	4.3.2.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.28	0.659	2.85	0.07	0.88	1oedE	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
1	0.28	0.810	2.33	0.09	0.97	2mawA	GO:0000187 GO:0001540 GO:0001666 GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0006816 GO:0006874 GO:0007165 GO:0007271 GO:0007613 GO:0008284 GO:0015276 GO:0015464 GO:0015643 GO:0016020 GO:0016021 GO:0017081 GO:0022848 GO:0030054 GO:0032720 GO:0034220 GO:0035094 GO:0042166 GO:0042803 GO:0045202 GO:0045211 GO:0045766 GO:0050890 GO:0098655 GO:0099565
2	0.24	0.626	3.32	0.03	0.87	1oedC	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
3	0.23	0.663	2.96	0.07	0.90	1oedB	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
4	0.23	0.739	2.37	0.06	0.90	2l7nA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
5	0.22	0.656	3.42	0.10	0.94	4aq5A	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
6	0.22	0.657	2.99	0.07	0.90	1oedA	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
7	0.21	0.644	3.34	0.08	0.92	2ksrA	GO:0001508 GO:0001661 GO:0001666 GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0006816 GO:0006939 GO:0007165 GO:0007271 GO:0007274 GO:0007601 GO:0007605 GO:0007612 GO:0007613 GO:0007626 GO:0008144 GO:0008306 GO:0008542 GO:0009897 GO:0014059 GO:0015276 GO:0015464 GO:0016020 GO:0016021 GO:0019233 GO:0021562 GO:0021631 GO:0021771 GO:0021952 GO:0021955 GO:0030054 GO:0030890 GO:0032225 GO:0032226 GO:0033603 GO:0035094 GO:0035095 GO:0035176 GO:0042053 GO:0042113 GO:0042166 GO:0042220 GO:0042320 GO:0042391 GO:0045188 GO:0045202 GO:0045211 GO:0045471 GO:0045759 GO:0046982 GO:0048814 GO:0050877 GO:0050890 GO:0051291 GO:0051899 GO:0051963 GO:0060084 GO:0098655 GO:0099565
8	0.21	0.676	3.36	0.15	0.95	4aq5E	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
9	0.20	0.646	3.10	0.12	0.87	4pirC	GO:0004889 GO:0004993 GO:0005230 GO:0005232 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0007210 GO:0007271 GO:0015276 GO:0015464 GO:0016020 GO:0016021 GO:0022850 GO:0030054 GO:0034220 GO:0042166 GO:0045202 GO:0045211 GO:0051378 GO:0098655 GO:1904602
10	0.20	0.753	2.96	0.01	0.96	3o1jA	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004871 GO:0005524 GO:0005622 GO:0007165 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0023014
11	0.19	0.698	2.78	0.07	0.90	2kvpA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
12	0.18	0.735	2.38	0.07	0.91	3fyqA	GO:0001726 GO:0003779 GO:0005158 GO:0005178 GO:0005200 GO:0005856 GO:0005925 GO:0006909 GO:0007016 GO:0007155 GO:0007298 GO:0007390 GO:0007430 GO:0007475 GO:0007526 GO:0008360 GO:0016203 GO:0033627 GO:0035160 GO:0045214 GO:0045892 GO:0051015 GO:0060439 GO:0086042
13	0.18	0.747	2.79	0.02	0.94	3i9yA	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004871 GO:0005524 GO:0005622 GO:0007165 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0018106 GO:0023014
14	0.17	0.721	2.84	0.05	0.94	5ic0A	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
15	0.16	0.627	3.07	0.08	0.84	2lm2A	GO:0001508 GO:0001661 GO:0001666 GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0005892 GO:0006810 GO:0006811 GO:0006816 GO:0006939 GO:0007165 GO:0007271 GO:0007274 GO:0007601 GO:0007605 GO:0007612 GO:0007613 GO:0007626 GO:0008144 GO:0008306 GO:0008542 GO:0009897 GO:0014059 GO:0015276 GO:0015464 GO:0016020 GO:0016021 GO:0019233 GO:0021562 GO:0021631 GO:0021771 GO:0021952 GO:0021955 GO:0030054 GO:0030890 GO:0032225 GO:0032226 GO:0033603 GO:0035094 GO:0035095 GO:0035176 GO:0042053 GO:0042113 GO:0042166 GO:0042220 GO:0042320 GO:0042391 GO:0045188 GO:0045202 GO:0045211 GO:0045471 GO:0045759 GO:0046982 GO:0048814 GO:0050877 GO:0050890 GO:0051291 GO:0051899 GO:0051963 GO:0060084 GO:0098655 GO:0099565
16	0.16	0.680	3.21	0.10	0.94	3i9wA	GO:0000155 GO:0000160 GO:0000166 GO:0004673 GO:0004721 GO:0004871 GO:0005524 GO:0005622 GO:0005886 GO:0006470 GO:0007165 GO:0009061 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0016868 GO:0018106 GO:0023014 GO:0046777 GO:0071310
17	0.15	0.631	3.47	0.09	0.92	4aq5C	GO:0004889 GO:0005216 GO:0005230 GO:0005886 GO:0006810 GO:0006811 GO:0016020 GO:0016021 GO:0030054 GO:0034220 GO:0045202 GO:0045211 GO:0098655
18	0.13	0.755	2.77	0.08	0.96	3dyjA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527

Consensus prediction of GO terms

Molecular Function	GO:0004889	GO:0042277	GO:0042165	GO:0015464	GO:0046983	GO:0070405	GO:0022824	GO:0016247	GO:0042802	GO:0032403	GO:0005102	GO:0050839	GO:0005198	GO:0019904	GO:0008092
GO-Score	0.70	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.46	0.46	0.46	0.46	0.46	0.46
Biological Processes	GO:0098655	GO:0042127	GO:0072503	GO:1903556	GO:0045765	GO:0014070	GO:0070838	GO:0032680	GO:0055074	GO:0036293	GO:0007611	GO:0006875	GO:1904018	GO:0032147	GO:0043406	GO:0007268	GO:0043279	GO:1905114	GO:0032507	GO:0030865	GO:0030168	GO:0034109	GO:0034329	GO:0030036
GO-Score	0.70	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.56	0.46	0.46	0.46	0.46	0.46	0.46
Cellular Component	GO:0045211	GO:0034702	GO:0005887	GO:0098802	GO:0031253	GO:1903561	GO:0031988	GO:0005924	GO:0031256	GO:0015630	GO:0044430
GO-Score	0.70	0.56	0.56	0.56	0.46	0.46	0.46	0.46	0.46	0.46	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.

I-TASSER results for job id Rv1903

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]