I-TASSER results

I-TASSER results for job id Rv1879

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (378 residues)
MADSAGSDLTRHTAEVPLIDQHVHGCWLTEGNRRRFENALNEANTEPLADFDSGFDSQLG
FAVRNHCAPILGLPRHVDPQTYWDRRSQFSEAELARRFLQAAGVTDWLVETGIGYDVSGM
ASVAGLGELSGSHAHEVVRLEQVAEQAVQASGDYASAFNEILRRRAATAVATKSILAYRG
GFDGDLTEPPAAQVAEAAKRWRDRGGVRLQDRVLLRFGLHQALRLGKPLQFHVGFGDRDA
DLHKANPLYLLDFLRQSGNTPIVLLHCYPYEREAGYLAQAFNNVYLDGGLSVHYLGARSP
AFIGRLLELAPFRKIVYSSDGFGPAELHFLGATLWRSGIQRVLRGFVERDDWCETDALRV
VDLIAHGTAARIYRLGDR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MADSAGSDLTRHTAEVPLIDQHVHGCWLTEGNRRRFENALNEANTEPLADFDSGFDSQLGFAVRNHCAPILGLPRHVDPQTYWDRRSQFSEAELARRFLQAAGVTDWLVETGIGYDVSGMASVAGLGELSGSHAHEVVRLEQVAEQAVQASGDYASAFNEILRRRAATAVATKSILAYRGGFDGDLTEPPAAQVAEAAKRWRDRGGVRLQDRVLLRFGLHQALRLGKPLQFHVGFGDRDADLHKANPLYLLDFLRQSGNTPIVLLHCYPYEREAGYLAQAFNNVYLDGGLSVHYLGARSPAFIGRLLELAPFRKIVYSSDGFGPAELHFLGATLWRSGIQRVLRGFVERDDWCETDALRVVDLIAHGTAARIYRLGDR
Prediction	CCCHHHHHHHHHHHHCCCEHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHHHHCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
Conf.Score	987589999999987985555666665666677887887646788765567776555678999999999989998899999999999859899999999875985899866898888877787899987587654544699999999985665899999999975787578777776466778888887599999999998655787778857999999999999996999858999998876689899999999889997999958966999999999699789987445677885799999999998588858866899988864557888999999999999999879999999999999999999999889999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MADSAGSDLTRHTAEVPLIDQHVHGCWLTEGNRRRFENALNEANTEPLADFDSGFDSQLGFAVRNHCAPILGLPRHVDPQTYWDRRSQFSEAELARRFLQAAGVTDWLVETGIGYDVSGMASVAGLGELSGSHAHEVVRLEQVAEQAVQASGDYASAFNEILRRRAATAVATKSILAYRGGFDGDLTEPPAAQVAEAAKRWRDRGGVRLQDRVLLRFGLHQALRLGKPLQFHVGFGDRDADLHKANPLYLLDFLRQSGNTPIVLLHCYPYEREAGYLAQAFNNVYLDGGLSVHYLGARSPAFIGRLLELAPFRKIVYSSDGFGPAELHFLGATLWRSGIQRVLRGFVERDDWCETDALRVVDLIAHGTAARIYRLGDR
Prediction	655432540351056130000000100345274340321022042431451423230220110132036007035515164024204723164003300520402000000103255651421530251362402300200300330064253024102510452053000000000011105142546414302520451275411304142002000110262700000000202451404202022024004514703000000100020001002410000000000001124501410220043044300000010000020100002202400140034006645042730340042003400320071768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHCCCEHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEHCCCCCCCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEHCCCCHHHHHHHHHHHCCCEEEEEHCCCCCCCCHHHHHHHHHHHHCCCCCEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
MADSAGSDLTRHTAEVPLIDQHVHGCWLTEGNRRRFENALNEANTEPLADFDSGFDSQLGFAVRNHCAPILGLPRHVDPQTYWDRRSQFSEAELARRFLQAAGVTDWLVETGIGYDVSGMASVAGLGELSGSHAHEVVRLEQVAEQAVQASGDYASAFNEILRRRAATAVATKSILAYRGGFDGDLTEPPAAQVAEAAKRWRDRGGVRLQDRVLLRFGLHQALRLGKPLQFHVGFGDRDADLHKANPLYLLDFLRQSGNTPIVLLHCYPYEREAGYLAQAFNNVYLDGGLSVHYLGARSPAFIGRLLELAPFRKIVYSSDGFGPAELHFLGATLWRSGIQRVLRGFVERDDWCETDALRVVDLIAHGTAARIYRLGDR

2qpxA

0.29

0.27

0.94

2.09

MUSTER

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKYPLADTKNRLAYHGFLALAKEFA----LDANNPL-----AANDPGYATYNHRIFGHFHFKELLIDTGFVPD-DPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFI-DPLQFHVGYGDADTDY-LGNPL-LRDYLKAFKGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQL---PFVDLAQKKAWINAICWQTSAKLYHQERE

2qpxA

0.27

0.25

0.94

2.68

dPPAS

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKDPLADTKNRLAYHGFLALAKEFALDANNPLAAN---------DPGYATYNHRIFGHFHFKELLIDTGFV-PDDPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFIIDPLQFHVGYGDADTDYLGNPLLRDYLKAFTKKGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQL---PFVDLAQKKAWINAICWQTSAKLYHQERE

2qpxA

0.26

0.25

0.94

3.59

wdPPAS

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKDYP-----LADTKNRLAYHGFLALAKEFALDANNPLA---ANDPGYATYNHRIFGHFHFKELLIDTGFVPD-DPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFI-DPLQFHVGYGDADTDYLGNPLLRDYLKAFTKKGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQ---LPFVDLAQKKAWINAICWQTSAKLYHQERE

2qpxA

0.29

0.27

0.94

2.60

wMUSTER

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKYPLADTKNRLAYHGFLALAKEFA----LDANNPL-----AANDPGYATYNHRIFGHFHFKELLIDTGFVPD-DPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFI-DPLQFHVGYGDADTDY-LGNPL-LRDYLKAFKGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQL---PFVDLAQKKAWINAICWQTSAKLYHQERE

2qpxA

0.27

0.26

0.94

3.93

wPPAS

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKDPLADTKNRLAYHGFLALAKEFA----LDANNP-----LAANDPGYATYNHRIFGHFHFKELLIDTGFVPD-DPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFI-DPLQFHVGYGDADTDYLGNPLLRDYLKAFTKKGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQ---LPFVDLAQKKAWINAICWQTSAKLYHQERE

2qpxA

0.27

0.25

0.94

8.15

dPPAS2

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKDPLADTKNRLAYHGFLALAKEFALDANNPLAAN---------DPGYATYNHRIFGHFHFKELLIDTGFV-PDDPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFIIDPLQFHVGYGDADTDYLGNPLLRDYLKAFTKKGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQL---PFVDLAQKKAWINAICWQTSAKLYHQERE

2qpxA

0.29

0.27

0.94

3.44

PPAS

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKDPLADTKNRLAYHGFLALAKEFALDANNPLA---------ANDPGYATYNHRIFGHFHFKELLIDTGFV-PDDPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFI-DPLQFHVGYGDADTDY-LGNPL-LRDYLKAFTGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQL---PFVDLAQKKAWINAICWQTSAKLYHQERE

2qpxA

0.28

0.27

0.94

5.66

Env-PPAS

-----GDDLSEFVDQVPLLDHHCHFLIDGKVPNRRLAQVSTEADKDPLADTKNRLAYHGFLALAKEFALDANNPLA---------ANDPGYATYNHRIFGHFHFKELLIDTGF-VPDDPILDLDQTAELVGIPVKAIYRLETHAEDFLEHDNAWWQAFSNDVKQAKAHGFVGFSIAAYRVGLHLEPVN--VIEAAAGFDTWKHSGEKRLTSKPLIDYLYHVAPFIIDPLQFHVGYGDADTDYL-GNPL-LRDYLKAFTGLKVVLLHCYPYHREAGYLASVFPNLYFDISLLDNLGPSGASRVFNEAVELAPYTRILFASDASTYPE-YGLAARQFKQALVAHFNQL---PFVDLAQKKAWINAICWQTSAKLYHQERE

4i6vA

0.13

0.97

1.22

MUSTER

--SSPIDQLCAQLDEIVLIDPHSH-INPHAAASKNLGDILGYIEAPGITALAHLDNTIQVKWLIELCERFFGFQDDRNWEALYDHSEKLSAPDWEQTVLQKSQLEAVFLTNDFDDPLTGFDTDDLVFHLQKPEVRQ--RLAKATGFDCATPAKLIHAIGQLFTHFVSH--GAK-ACAISLPPDFEPTPVSHVDAEGPLRAAYAGHVLTTEQSFVFWTIAEFCSEHHLPFDLIGVYQGQDLFDQRVSLYQYRRLFNAFPRVKFPISVLAHASNELVSYAWIFPNVIANGHWWYSNIPAFIEPDCRSRLEAIPRNKNIYYSDYKL---EFGWPKFQYRRVLAKVLFEDFVGRHWSEERAVELGRQILRGNVETIFSGA--

3irsA

0.16

0.11

0.72

1.49

dPPAS

---------------LKIIDFRLR----------------------PPAMGFLNARIYTRPDIRNRFTRQLGFEPA--------PSAEEKSLELMFEEMAAAGIEQGVCVGRNSSVLGSVS---------------------------------NADVAAVAKAYPDKFHPVGSI-------EAATRKEAMAQMQEILDLPGVWATPMHVDDRRLYPLYAFCEDNGIPVIMMTGG-NAGPDITYTNPEHIDRVLGDFPDLTVVSSHNWPWVQEIIHVAFRRPNLYLSPDMYLYNLPG--HADFIQAANSFLADRMLFGTAYPMCP--------------LKEYTEWFLTLPIK----PDAMEKILHGNAERLLAQAGR

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.04

Estimated TM-score = 0.86±0.07

Estimated RMSD = 4.5±3.0Å

Download Model 2

C-score=-2.40

Download Model 3

C-score=-2.47

Download Model 4

C-score=-4.16

Download Model 5

C-score=-4.84

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2qpxA	0.905	1.48	0.268	0.934
2	1j5sA	0.778	3.88	0.094	0.942
3	2q01B	0.777	4.22	0.124	0.966
4	3iacA	0.754	4.08	0.109	0.931
5	2pnkA	0.727	3.95	0.152	0.886
6	3irsA	0.576	4.03	0.144	0.706
7	1ituA	0.563	4.28	0.125	0.701
8	3itcA	0.563	4.34	0.120	0.704
9	3giqA	0.560	4.33	0.136	0.706
10	3b40A	0.559	4.55	0.094	0.714

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.67	47	4v1yF	FE	Rep, Mult	22,24,232,266,320,321
2	0.05	3	2qpxA	ZN	Rep, Mult	174,179,232,266
3	0.04	4	2vc5B	CO	Rep, Mult	22,174,232,266,290,320
4	0.02	2	1hzyA	PEL	Rep, Mult	312,313,360,363,364,369

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.249	2q01C	0.778	4.22	0.122	0.966	5.3.1.12	299,320
2	0.161	1zzmA	0.506	4.20	0.119	0.630	3.1.21.-	NA
3	0.067	2vc7B	0.540	4.01	0.104	0.664	3.1.8.1	175,295,320
4	0.060	1a5kC	0.528	4.67	0.097	0.685	3.5.1.5	NA
5	0.060	1qw7A	0.562	3.86	0.120	0.680	3.1.8.1	320
6	0.060	1itqA	0.563	4.27	0.125	0.701	3.4.13.19	NA
7	0.060	2ftyA	0.547	4.75	0.126	0.714	3.5.2.2	320
8	0.060	1a0eD	0.519	5.70	0.061	0.754	5.3.1.5	289,295
9	0.060	1gkrA	0.536	4.77	0.125	0.691	3.5.2.2	320
10	0.060	2z00A	0.523	4.88	0.121	0.693	3.5.2.3	303
11	0.060	2v3eA	0.518	5.22	0.081	0.717	3.2.1.45	110,267
12	0.060	1a0dD	0.518	5.66	0.081	0.757	5.3.1.5	NA
13	0.060	1a0dA	0.518	5.66	0.081	0.757	5.3.1.5	293
14	0.060	1j5sA	0.778	3.88	0.094	0.942	5.3.1.12	24,269
15	0.060	2a3lA	0.547	5.26	0.091	0.765	3.5.4.6	NA
16	0.060	2z26A	0.542	4.23	0.105	0.669	3.5.2.3	320
17	0.060	3iacA	0.754	4.08	0.109	0.931	5.3.1.12	288,320
18	0.060	1a4lA	0.526	4.76	0.104	0.698	3.5.4.4	266,268
19	0.060	1a5lC	0.528	4.68	0.097	0.685	3.5.1.5	319
20	0.060	2zc1A	0.547	3.77	0.125	0.661	3.1.8.1	236,265
21	0.060	1kraC	0.527	4.69	0.097	0.685	3.5.1.5	174
22	0.060	2vr2A	0.555	4.53	0.104	0.704	3.5.2.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.781	3.76	0.12	0.94	4i6vB	GO:0006064 GO:0008880 GO:0016787 GO:0016853 GO:0046872
1	0.25	0.757	3.83	0.15	0.91	2pnkA	GO:0008880 GO:0046872
2	0.24	0.576	4.03	0.14	0.71	3irsA	GO:0016787
3	0.22	0.778	3.88	0.09	0.94	1j5sA	GO:0006064 GO:0008880 GO:0016853
4	0.21	0.916	1.57	0.27	0.95	2qpxA	GO:0016787 GO:0046872
5	0.15	0.777	4.22	0.12	0.97	2q01B	GO:0006064 GO:0008880 GO:0016853
6	0.15	0.528	4.63	0.10	0.68	4qroA	GO:0016787 GO:0046872
7	0.14	0.774	3.96	0.11	0.95	3iacA	GO:0006064 GO:0008880 GO:0016853
8	0.12	0.508	4.32	0.12	0.64	4icmA	GO:0016787 GO:0046872
9	0.07	0.528	4.60	0.11	0.68	2dvtA	GO:0016787 GO:0046872
10	0.07	0.522	4.70	0.13	0.68	4ofcA	GO:0001760 GO:0005829 GO:0006568 GO:0006569 GO:0008270 GO:0016787 GO:0016829 GO:0016831 GO:0046872 GO:0046874 GO:0051259 GO:0070062 GO:1904984 GO:1905004 GO:1905012
11	0.07	0.440	5.60	0.05	0.65	3wdhA	GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0046872 GO:0051060
12	0.06	0.457	4.86	0.07	0.62	1h7rA	GO:0003824 GO:0004655 GO:0005829 GO:0006779 GO:0006782 GO:0006783 GO:0008270 GO:0016829 GO:0032791 GO:0033014 GO:0046872
13	0.06	0.398	5.04	0.04	0.56	4k3zA	GO:0016491 GO:0055114
14	0.06	0.375	5.78	0.07	0.56	3v1hA	GO:0004436 GO:0005576 GO:0006629 GO:0008081 GO:0009405 GO:0016042 GO:0016829
15	0.06	0.407	4.57	0.06	0.53	3n2bA	GO:0003824 GO:0008652 GO:0008836 GO:0009085 GO:0009089 GO:0016829 GO:0016831 GO:0030170
16	0.06	0.333	7.33	0.10	0.59	3ij3A	GO:0004177 GO:0005622 GO:0005737 GO:0006508 GO:0008233 GO:0008235 GO:0016787 GO:0019538 GO:0030145 GO:0046872
17	0.06	0.317	6.73	0.04	0.53	2z72A	GO:0004725 GO:0016787 GO:0035335 GO:0046872
18	0.06	0.345	6.00	0.07	0.53	3kzhA	GO:0016301 GO:0016310 GO:0016740
19	0.06	0.308	6.71	0.02	0.51	1w52X	GO:0004806 GO:0005576 GO:0006629 GO:0046872 GO:0052689
20	0.06	0.277	6.95	0.03	0.47	4bhwA	GO:0000122 GO:0000123 GO:0000785 GO:0000978 GO:0000979 GO:0001047 GO:0001085 GO:0001102 GO:0001159 GO:0001228 GO:0001666 GO:0001756 GO:0001889 GO:0001934 GO:0002039 GO:0002223 GO:0003677 GO:0003682 GO:0003684 GO:0003700 GO:0003712 GO:0003713 GO:0003823 GO:0004402 GO:0004468 GO:0005634 GO:0005654 GO:0005667 GO:0005737 GO:0006283 GO:0006351 GO:0006355 GO:0006366 GO:0006473 GO:0006475 GO:0006915 GO:0006977 GO:0006990 GO:0007049 GO:0007219 GO:0007399 GO:0007507 GO:0007519 GO:0007613 GO:0007623 GO:0008013 GO:0008022 GO:0008134 GO:0008270 GO:0009749 GO:0009887 GO:0010506 GO:0010560 GO:0010628 GO:0010942 GO:0014070 GO:0014737 GO:0016032 GO:0016407 GO:0016573 GO:0016740 GO:0016746 GO:0018076 GO:0018393 GO:0019901 GO:0030183 GO:0030220 GO:0030307 GO:0030324 GO:0031324 GO:0031325 GO:0031490 GO:0032025 GO:0032092 GO:0032403 GO:0032481 GO:0032526 GO:0032967 GO:0032993 GO:0033160 GO:0033613 GO:0034212 GO:0034612 GO:0034644 GO:0035066 GO:0035257 GO:0035259 GO:0035690 GO:0035855 GO:0035984 GO:0042493 GO:0042542 GO:0042771 GO:0042975 GO:0043154 GO:0043388 GO:0043425 GO:0043491 GO:0043627 GO:0043923 GO:0043966 GO:0043967 GO:0043969 GO:0045444 GO:0045471 GO:0045727 GO:0045773 GO:0045793 GO:0045815 GO:0045862 GO:0045893 GO:0045944 GO:0046332 GO:0046872 GO:0048511 GO:0048565 GO:0050681 GO:0050714 GO:0050821 GO:0051019 GO:0051059 GO:0051091 GO:0051592 GO:0051726 GO:0060177 GO:0060298 GO:0060548 GO:0060765 GO:0061418 GO:0065004 GO:0070301 GO:0070542 GO:0071236 GO:0071300 GO:0071320 GO:0071333 GO:0071389 GO:0071407 GO:0071548 GO:0071549 GO:0090043 GO:0097157 GO:1900034 GO:1901796 GO:1901985 GO:1904837 GO:1990090 GO:1990405 GO:2000629
21	0.06	0.270	5.58	0.06	0.40	2wc1A	GO:0009055 GO:0009399 GO:0010181 GO:0055114
22	0.06	0.244	6.64	0.04	0.40	5iz1A	GO:0005975 GO:0016311 GO:0016787 GO:0042132 GO:0042578
23	0.06	0.206	6.74	0.02	0.34	2i82A	GO:0000455 GO:0001522 GO:0003723 GO:0006364 GO:0008033 GO:0009451 GO:0009982 GO:0016853 GO:0019239 GO:0031118 GO:0031119

Consensus prediction of GO terms

Molecular Function	GO:0008880	GO:0046872	GO:0016787
GO-Score	0.58	0.58	0.57
Biological Processes	GO:0006064
GO-Score	0.44
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.