I-TASSER results

I-TASSER results for job id Rv1842c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (455 residues)
MNLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARGGTSRDRFIQRAHHRLS
FQLSGAQLGISITTLATGYLTEPLVAELPHPGLVAVGMSDRVADGLITFFALVIVTSLSM
VFGELVPKYLAVARPLRTARSVVAGQVLFSLLLTPAIRLTNGAANWIVRRLGIEPAEELR
SARTPQELVSLVRSSARSGALDDATAWLMRRSLQFGALTAEELMTPRSKIVALQTDDTIA
DLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEVPPGDRAHTLLTTVAEPVAVVPSTL
DGDAVMAQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIVGDVRDEHDDATPDVVAAGNG
WRVSGLLRIDEVASATGYRAPDGPYETIGGLVLRELGHIPVAGETVELTALDQDGLPDDS
MRWLATVIQMDGRRIDLLELIKMGGHADPGSGRGR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARGGTSRDRFIQRAHHRLSFQLSGAQLGISITTLATGYLTEPLVAELPHPGLVAVGMSDRVADGLITFFALVIVTSLSMVFGELVPKYLAVARPLRTARSVVAGQVLFSLLLTPAIRLTNGAANWIVRRLGIEPAEELRSARTPQELVSLVRSSARSGALDDATAWLMRRSLQFGALTAEELMTPRSKIVALQTDDTIADLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEVPPGDRAHTLLTTVAEPVAVVPSTLDGDAVMAQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIVGDVRDEHDDATPDVVAAGNGWRVSGLLRIDEVASATGYRAPDGPYETIGGLVLRELGHIPVAGETVELTALDQDGLPDDSMRWLATVIQMDGRRIDLLELIKMGGHADPGSGRGR
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEHCHCCCCEEEEHCCCCHHHHHHHHHHCCCCEEEEHCCCCCEEEEEEEHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCEEEHCCEEEEEHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCCEEEEEEEHCCCEEEEEEEEHCCCCCCCCCCCCC
Conf.Score	97689999999999999999999999999998579999999998998999999999876778899999999999999999999999999999998589888888999999999999999999865566789876899999997999999999999999999999999999889888777668999999999999999799999999999988647886464435468848999789999999999998599867876799884878876889999887588889989975677656899999999999999899599999689986655458999999978888888888644488699899985678999999989999999988879999999878899988999878667766677775899999967984789999988998888777789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARGGTSRDRFIQRAHHRLSFQLSGAQLGISITTLATGYLTEPLVAELPHPGLVAVGMSDRVADGLITFFALVIVTSLSMVFGELVPKYLAVARPLRTARSVVAGQVLFSLLLTPAIRLTNGAANWIVRRLGIEPAEELRSARTPQELVSLVRSSARSGALDDATAWLMRRSLQFGALTAEELMTPRSKIVALQTDDTIADLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEVPPGDRAHTLLTTVAEPVAVVPSTLDGDAVMAQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIVGDVRDEHDDATPDVVAAGNGWRVSGLLRIDEVASATGYRAPDGPYETIGGLVLRELGHIPVAGETVELTALDQDGLPDDSMRWLATVIQMDGRRIDLLELIKMGGHADPGSGRGR
Prediction	15232111111100101220111000000002034420451076335203101400630430000000100100020120000000310131033030123000010102011221321020002201110122002000000230011022012201110220220010020424654544203500320052037434137502510320030562403300110430210327330530152037250000001444311000000000003213765643403400220000023140450054037541000000003231001001100000000004113264364046474101020302051016307160564401000100031044015442403043243434424444010102205632043020332665656765677
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEHCHCCCCEEEEHCCCCHHHHHHHHHHCCCCEEEEHCCCCCEEEEEEEHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHHHHHHHHHCCEEEEEEHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCEEEHCCEEEEEHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCCEEEEEEEHCCCEEEEEEEEHCCCCCCCCCCCCC
MNLTDTVATILAILALTAGTGVFVAAEFSLTALDRSTVEANARGGTSRDRFIQRAHHRLSFQLSGAQLGISITTLATGYLTEPLVAELPHPGLVAVGMSDRVADGLITFFALVIVTSLSMVFGELVPKYLAVARPLRTARSVVAGQVLFSLLLTPAIRLTNGAANWIVRRLGIEPAEELRSARTPQELVSLVRSSARSGALDDATAWLMRRSLQFGALTAEELMTPRSKIVALQTDDTIADLVAAAAASGFSRFPVVEGDLDATVGIVHVKQVFEVPPGDRAHTLLTTVAEPVAVVPSTLDGDAVMAQVRASALQTAMVVDEYGGTAGMVTLEDLIEEIVGDVRDEHDDATPDVVAAGNGWRVSGLLRIDEVASATGYRAPDGPYETIGGLVLRELGHIPVAGETVELTALDQDGLPDDSMRWLATVIQMDGRRIDLLELIKMGGHADPGSGRGR

4hg0A

0.30

0.15

0.48

1.76

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPF--RSDAEAFSDKVLRQAVVVPESKRVDR-LKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQAF-GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

4hg0A

0.30

0.15

0.48

4.01

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPFR--SDAEAFSDKVLRQAVVVPESKRVDR-LKEFRSQRY-HAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQAF-GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

4hg0A

0.30

0.14

0.48

5.12

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPFR--SDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQRY-HAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQA--GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

4hg0A

0.30

0.15

0.48

2.28

wMUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLP--FRSDAEAFSDKVLRQAVVVPESKRVD-RLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQAF-GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

4hg0A

0.30

0.14

0.48

2.75

wPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPFR--SDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQA--GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

4hg0A

0.30

0.15

0.48

7.03

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPFR--SDAEAFSDKVLRQAVVVPESKRVDR-LKEFRSQRY-HAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQAF-GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

4hg0A

0.30

0.14

0.48

2.57

PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPFR--SDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQAF-GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

4hg0A

0.30

0.14

0.48

4.06

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DEDTRDLEGVDIADQRVRD-IIPRSQI-TLKRNQTLDECLDVIIESAHSRFPVISEDKDHIEGILA-KDLLPFR--SDAEAFSDKVLRQAVVVPESKRV-DRLKEFRSQR-YHAIVIDEFGGVSGLVTIEDILELIVGEIEDEYDEEDDIRQLSRHTWTVRALASIEDFNEAFGTHFSDEEVDTIGGLVQAF-GHLPARGETIDIDG------------YQFKVA-ADSRRIIQVHVKIP------------

3oi8A

0.30

0.10

0.33

1.26

MUSTER

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNASAEDVLNLLRQAHEQEVFDADTLLRLEKVLDFSDLEVRDAITRSRNV--LKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKY--FNPEQFHLKSILRPAVFVPEGKSLTALLKEFREQRNH-AIVIDEYGGTSGLVTFEDIIE----------------------------------------------------------------------------------------------------------------------

3oi8A

0.30

0.10

0.33

3.45

dPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNASAEDVLNLLRQAHEQEVFDADTLLRLEKVLDFSDLEVRDAITRSRNV--LKENDSIERITAYVIDTAHSRFPVIGEDKDEVLGILHAKDLLKYF--NPEQFHLKSILRPAVFVPEGKSLTALLKEFREQRNH-AIVIDEYGGTSGLVTFEDIIE----------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.48

Estimated TM-score = 0.43±0.14

Estimated RMSD = 13.1±4.1Å

Download Model 2

C-score=-3.13

Download Model 3

C-score=-3.26

Download Model 4

C-score=-1.58

Download Model 5

C-score=-3.44

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4hg0A	0.466	1.43	0.297	0.481
2	3qr0A	0.394	7.00	0.058	0.629
3	2cse1	0.390	7.44	0.046	0.668
4	3ohmB	0.381	7.10	0.042	0.622
5	3orgA	0.368	6.36	0.084	0.541
6	1g7cA	0.368	7.16	0.040	0.609
7	1wygA	0.368	7.27	0.050	0.602
8	2ix8A	0.367	7.35	0.038	0.613
9	2r7oA	0.366	7.65	0.045	0.640
10	2y3aA	0.365	7.38	0.046	0.615

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.28	12	4iy0A	ADP	Rep, Mult	225,229,230,231,251,252,253,255,329,331,333,334
2	0.09	4	2ckjC	FES	Rep, Mult	67,70,71,73,78,79,80,81
3	0.07	3	2ckjD	FES	Rep, Mult	21,23,24,25,28,30,34
4	0.02	1	2ckjA	FES	Rep, Mult	64,66,69,71,76
5	0.02	1	2ckjB	FES	Rep, Mult	193,195,196,201,206

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1l5jA	0.339	7.76	0.060	0.589	4.2.1.3	NA
2	0.060	1mswD	0.314	7.43	0.052	0.525	2.7.7.6	NA
3	0.060	1g8kE	0.350	7.88	0.045	0.631	1.20.98.1	NA
4	0.060	3gpbA	0.351	7.33	0.063	0.582	2.4.1.1	205
5	0.060	1tmoA	0.341	7.54	0.056	0.587	1.7.2.3	NA
6	0.060	2zkmX	0.363	7.29	0.063	0.604	3.1.4.11	NA
7	0.060	1dgjA	0.350	7.47	0.051	0.589	1.2.-.-	NA
8	0.060	2x42A	0.340	7.56	0.052	0.587	3.2.1.21	NA
9	0.060	1n1hA	0.350	7.68	0.037	0.611	2.7.7.48	NA
10	0.060	1fa9A	0.299	7.27	0.040	0.501	2.4.1.1	326
11	0.060	2r7oA	0.366	7.65	0.045	0.640	2.7.7.48	NA
12	0.060	2rnpC	0.328	7.51	0.043	0.556	2.7.7.6	NA
13	0.060	3b9jC	0.307	7.17	0.072	0.503	1.17.3.2,1.17.1.4	337
14	0.060	1q16A	0.365	7.31	0.031	0.609	1.7.99.4	NA
15	0.060	1f60A	0.367	7.23	0.049	0.611	3.6.5.3	NA
16	0.060	1aroP	0.285	7.32	0.034	0.479	2.7.7.6	NA
17	0.060	1bxrA	0.342	7.77	0.048	0.604	6.3.5.5	122
18	0.060	3ikmD	0.351	6.95	0.027	0.569	2.7.7.7	81,122
19	0.060	1t3tA	0.354	7.59	0.052	0.600	6.3.5.3	45

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.25	0.487	1.58	0.29	0.51	4hg0A	GO:0003824 GO:0006810 GO:0016614 GO:0050660 GO:0055114
1	0.18	0.274	2.26	0.28	0.29	3ocoA	GO:0003824 GO:0016020 GO:0016021 GO:0016614 GO:0050660 GO:0055114
2	0.16	0.321	2.07	0.30	0.34	3oi8A	GO:0003824 GO:0016614 GO:0046872 GO:0050660 GO:0055114
3	0.16	0.245	2.74	0.32	0.27	3i8nB	GO:0016020 GO:0016021
4	0.16	0.252	2.17	0.31	0.27	3lhhA	GO:0000166 GO:0003824 GO:0016020 GO:0016021 GO:0016614 GO:0050660 GO:0055114
5	0.14	0.256	1.93	0.31	0.27	3jtfB	GO:0000166 GO:0003824 GO:0016614 GO:0050660 GO:0055114
6	0.12	0.258	2.63	0.29	0.28	3lfrB	GO:0000166 GO:0003824 GO:0016614 GO:0050660 GO:0055114
7	0.12	0.248	2.53	0.26	0.27	3hf7A	GO:0000166 GO:0003824 GO:0016020 GO:0016021 GO:0016614 GO:0050660 GO:0055114
8	0.12	0.259	2.57	0.32	0.28	3lv9A	GO:0003824 GO:0016020 GO:0016021 GO:0016614 GO:0050660 GO:0055114
9	0.12	0.274	3.06	0.25	0.31	4iysA	GO:0005886 GO:0006810 GO:0006811 GO:0010960 GO:0015693 GO:0016020 GO:0016021 GO:0016323
10	0.09	0.262	2.80	0.25	0.29	4iy3C	GO:0005886 GO:0006810 GO:0006811 GO:0007601 GO:0010960 GO:0015081 GO:0015095 GO:0015693 GO:0016020 GO:0016021 GO:0016323 GO:0031214 GO:0035725 GO:0050896 GO:0070166 GO:1903830
11	0.07	0.285	3.32	0.23	0.33	3ocmA	GO:0000166 GO:0003824 GO:0016020 GO:0016021 GO:0016614 GO:0050660 GO:0055114
12	0.06	0.394	7.00	0.06	0.63	3qr0A	GO:0004435 GO:0004871 GO:0005622 GO:0006629 GO:0007165 GO:0008081 GO:0016042 GO:0016787 GO:0035556 GO:0046872
13	0.06	0.383	6.93	0.07	0.61	4gnkB	GO:0003073 GO:0004435 GO:0004629 GO:0004871 GO:0005509 GO:0005516 GO:0005654 GO:0005829 GO:0005913 GO:0006629 GO:0006892 GO:0007165 GO:0007186 GO:0007223 GO:0007268 GO:0008081 GO:0016020 GO:0016042 GO:0016787 GO:0035556 GO:0042383 GO:0043234 GO:0043647 GO:0098609 GO:0098641
14	0.06	0.363	7.29	0.06	0.60	2zkmX	GO:0004435 GO:0004629 GO:0004871 GO:0005509 GO:0005737 GO:0005829 GO:0006629 GO:0006644 GO:0007165 GO:0007202 GO:0007223 GO:0008081 GO:0016042 GO:0016787 GO:0035556 GO:0043647 GO:0046872 GO:0050913
15	0.06	0.333	7.10	0.03	0.54	1djgB	GO:0004435 GO:0004871 GO:0005509 GO:0005543 GO:0005546 GO:0005634 GO:0005829 GO:0006629 GO:0007165 GO:0007186 GO:0008081 GO:0010044 GO:0010243 GO:0010701 GO:0016020 GO:0016042 GO:0016787 GO:0031966 GO:0032962 GO:0034696 GO:0035556 GO:0043434 GO:0045121 GO:0046872 GO:0051480 GO:0051482 GO:0051592 GO:0055093 GO:1900274
16	0.06	0.281	6.19	0.10	0.40	4dqwA	GO:0000166 GO:0003824 GO:0003938 GO:0005524 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
17	0.06	0.243	3.52	0.10	0.28	3lfzA
18	0.06	0.229	7.66	0.04	0.40	2ahuA	GO:0008152 GO:0008410 GO:0008775 GO:0016740 GO:0046459 GO:0046952 GO:0051289

Consensus prediction of GO terms

Molecular Function	GO:0050660	GO:0016614	GO:0043169
GO-Score	0.57	0.57	0.33
Biological Processes	GO:0055114	GO:0051234
GO-Score	0.57	0.50
Cellular Component	GO:0016021
GO-Score	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.