I-TASSER results

I-TASSER results for job id Rv1828

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (247 residues)
MSAPDSPALAGMSIGAVLDLLRPDFPDVTISKIRFLEAEGLVTPRRASSGYRRFTAYDCA
RLRFILTAQRDHYLPLKVIRAQLDAQPDGELPPFGSPYVLPRLVPVAGDSAGGVGSDTAS
VSLTGIRLSREDLLERSEVADELLTALLKAGVITTGPGGFFDEHAVVILQCARALAEYGV
EPRHLRAFRSAADRQSDLIAQIAGPLVKAGKAGARDRADDLAREVAALAITLHTSLIKSA
VRDVLHR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSAPDSPALAGMSIGAVLDLLRPDFPDVTISKIRFLEAEGLVTPRRASSGYRRFTAYDCARLRFILTAQRDHYLPLKVIRAQLDAQPDGELPPFGSPYVLPRLVPVAGDSAGGVGSDTASVSLTGIRLSREDLLERSEVADELLTALLKAGVITTGPGGFFDEHAVVILQCARALAEYGVEPRHLRAFRSAADRQSDLIAQIAGPLVKAGKAGARDRADDLAREVAALAITLHTSLIKSAVRDVLHR
Prediction	CCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	9987778888999999999986568999889999999988999887899986789999999999999999969999999999996767888875566678888999999998887777776666546899999999899999999999999966688899998999999999999998998788999999999999999999999987789578999999999999999999999999999998779
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSAPDSPALAGMSIGAVLDLLRPDFPDVTISKIRFLEAEGLVTPRRASSGYRRFTAYDCARLRFILTAQRDHYLPLKVIRAQLDAQPDGELPPFGSPYVLPRLVPVAGDSAGGVGSDTASVSLTGIRLSREDLLERSEVADELLTALLKAGVITTGPGGFFDEHAVVILQCARALAEYGVEPRHLRAFRSAADRQSDLIAQIAGPLVKAGKAGARDRADDLAREVAALAITLHTSLIKSAVRDVLHR
Prediction	6655646655403012005304663470315102201753104051375331302650030032023015644030620251054365564345525432542354345335424544442543434123520163061446104401633113234632035400300400220373404152033134005212310430132134454652353035104402500340232003520463178
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MSAPDSPALAGMSIGAVLDLLRPDFPDVTISKIRFLEAEGLVTPRRASSGYRRFTAYDCARLRFILTAQRDHYLPLKVIRAQLDAQPDGELPPFGSPYVLPRLVPVAGDSAGGVGSDTASVSLTGIRLSREDLLERSEVADELLTALLKAGVITTGPGGFFDEHAVVILQCARALAEYGVEPRHLRAFRSAADRQSDLIAQIAGPLVKAGKAGARDRADDLAREVAALAITLHTSLIKSAVRDVLHR

2dg6A

0.15

0.12

0.79

1.05

MUSTER

------------RLADLSKRS------VSTATIKYYLREGLLPPG--------YDEDHLRRLRLVRALIQVGKVPVATAREVLGHVDDDSLGRTVRLGAALWALPQDAEPDEA----DPAVAAARVE--VDRLLELLGWETSRELA--------------LSPVHRSLVVAVAALRRLDYPDAELAPYGELEVARRDLDFETH------ASEAEKVEAVAAAVLFQPVLRALHRLAQEEESARRYGI

2dg6A

0.14

0.11

0.79

1.00

dPPAS

------------RLADLSKRSG-----VSTATIKYYLREGLLPPG--------YDEDHLRRLRLVRALIQVGKVPVATAREVLGHVDDDSLGRTVRLGAALWALPQDAEPDPAVAAARVEVDRLLELLGWETSRELAPLS----------------------PVHRSLVVAVAALRRLDYP-----WDAELAPYGELEVARRDLDFETHASEAEKVEAVAAAVLFQPVLRALHRLAQEEESARRYGI

1q05B

0.21

0.11

0.50

1.76

wdPPAS

-----------MNISDVAKIT------LTSKAIRFYEEKGLVTPPRSENGYRTYTQQHLNELTLLRQARQV--FNLEESGELVNLFNDP-QHSADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDD-----SADCPIIENLSG--------------------------------------------------------------------------------------------------

2dg6A

0.15

0.12

0.78

1.20

wMUSTER

-------------LADLSKRS------VSTATIKYYLREGLLPPG--------YDEDHLRRLRLVRALIQVGKVPVATAREVLGHVDDDSLGRTVRLGAALWALPQDDEADPAVAAARVEVDRLLELLGWETSRELAPL----------------------SPVHRSLVVAVAALRRLDYPDAELAPYGELEVARRDLDFETH------ASEAEKVEAVAAAVLFQPVLRALHRLAQEEESARRYGI

1q05B

0.22

0.11

0.50

2.00

wPPAS

-----------MNISDVAKIT------LTSKAIRFYEEKGLVTPMRSENGYRTYTQQHLNELTLLRQARQV--FNLEESGELVNLFNDPQ-HSADVKRRTLEKVAEIERHIEELQSMRDQLLALANACPGDD-----SADCPIIENLS--G------------------------------------------------------------------------------------------------

2dg6A

0.15

0.12

0.79

1.49

PPAS

------------RLADLSKRS------VSTATIKYYLREGLLPPG--------YDEDHLRRLRLVRALIQVGKVPVATAREVLGHVDDDSLGRTVRLGAALWALPQDAEPDEA------DPAVAAARVEVDRLLELLGWETSRELAPL-------------SPVHRSLVVAVAALRRLDYPDAELAPYGELEVARRDLDFETH------ASEAEKVEAVAAAVLFQPVLRALHRLAQEEESARRYGI

3gp4A

0.18

0.10

0.53

2.18

dPPAS2

----------SLNIKEASEKSG-----VSADTIRYYERIGLIPPHRNESGVRKFGAEDLRWILFTRQMRRAG-LSIEALIDYLALFREGEHTLEARAELLKKQRIELKNRIDVMQEALDRLDFKIDNYDTHLIPAQEELKDFNVERS----------------------------------------------------------------------------------------------------

2dg6A

0.16

0.13

0.80

1.63

wdPPAS

------------RLADLSKRS------VSTATIKYYLREGLLPPG--------YDEDHLRRLRLVRALIQVGKVPVATAREVLGHVDDDSLGRTVRLGAALWALPQDDEADPAVAAARVEVDRLLELLGWETSRELAP-LSPVHRSLVVAVAALRRLDYPWDAELAPYGELEVARRDLDFETHASEAEKVEAVAAAVLFQPVLRALHRLAQEEESARRYGIELE-----------------------

5d8cA

0.14

0.07

0.51

2.45

Env-PPAS

MT---------YTTAKAAEKIG-----ISAYTLRFYDKEGLLPNGRDEYGNRRFTDKDLQWLSLLQCLKNT-GMSLKDIKRFAECTIIGDDTIEERLSLFENQTKNVKCQIAELKRYLDLLEYKLA---FYQKAKALGSVKAV--------------------------------------------------------------------------------------------------------

2dg6A

0.17

0.13

0.79

1.85

wPPAS

------------RLADLSKRS------VSTATIKYYLREGLLPPG--------YDEDHLRRLRLVRALIQVGKVPVATAREVLGHVDDDSLGRTVRLGAALWALPQDAEADPAVAAARVEVDRLLELLGWETSRELAP-LSPVHRSLVVA-VAALRRLDYWDAELAPYGELEVARRDLDFETHASEAEKVEAVAAAVLFQPVLRALHR---AQEEESARRYGIELE---------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.81

Estimated TM-score = 0.50±0.15

Estimated RMSD = 9.9±4.6Å

Download Model 2

C-score=-3.85

Download Model 3

C-score=-4.15

Download Model 4

C-score=-4.15

Download Model 5

C-score=-4.26

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2dg6A	0.723	2.14	0.136	0.802
2	2cse1	0.457	5.68	0.063	0.761
3	4a01A	0.456	5.99	0.045	0.773
4	3ayfA	0.455	5.95	0.058	0.777
5	1uc2A	0.447	5.98	0.048	0.769
6	2r7oA	0.445	6.00	0.049	0.769
7	5a22A	0.444	5.84	0.072	0.753
8	2epgB	0.442	6.16	0.090	0.769
9	4rbmA1	0.440	5.43	0.051	0.709
10	5lpcA	0.440	5.33	0.043	0.684

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.27	14	4r4eB	NUC	Rep, Mult	14,15,31,34,46,50,51,52
2	0.08	4	2zhgA	NUC	Rep, Mult	29,31,32,35,36,69,75,76
3	0.04	2	3o8oD	F6P	Rep, Mult	33,34,53,60,63
4	0.02	1	3gp4A	MED	Rep, Mult	124,128
5	0.02	1	1taqA	ZN	Rep, Mult	3,8,17,20
6	0.02	1	5ktqA	DCP	Rep, Mult	80,84,88
7	0.02	1	2ktqA	DCT	Rep, Mult	34,36,62,67
8	0.02	1	1q05A	CU1	Rep, Mult	128,141

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2e1qA	0.352	6.80	0.058	0.680	1.17.3.2,1.17.1.4	NA
2	0.060	1bxrA	0.421	6.38	0.053	0.761	6.3.5.5	30
3	0.060	1h19A	0.412	5.97	0.040	0.688	3.3.2.6	NA
4	0.060	1n2cB	0.332	6.29	0.069	0.591	1.18.6.1	NA
5	0.060	1y11A	0.414	5.15	0.064	0.619	4.6.1.1	NA
6	0.060	1hrdA	0.348	6.37	0.045	0.619	1.4.1.2	22,56,77
7	0.060	2r8oB	0.401	5.89	0.065	0.668	2.2.1.1	NA
8	0.060	1itzB	0.339	6.45	0.067	0.627	2.2.1.1	NA
9	0.060	2g25A	0.309	5.79	0.077	0.530	1.2.4.1	NA
10	0.060	2gtqA	0.416	6.05	0.067	0.725	3.4.11.2	NA
11	0.060	1bgxT	0.424	6.27	0.062	0.761	2.7.7.7	149
12	0.060	3ebgA	0.418	6.23	0.050	0.737	3.4.11.-	NA
13	0.060	3b9jJ	0.288	6.13	0.038	0.506	1.17.1.4,1.17.3.2	38
14	0.060	2amoA	0.383	6.15	0.057	0.664	1.14.13.39	NA
15	0.060	2p8uA	0.400	6.27	0.065	0.725	2.3.3.10	57
16	0.060	1l8aA	0.366	5.81	0.072	0.611	1.2.4.1	NA
17	0.060	2ckjA	0.312	6.62	0.018	0.595	1.17.1.4,1.17.3.2	NA
18	0.060	2v4wD	0.400	6.15	0.051	0.713	2.3.3.10	221
19	0.060	1fp4B	0.332	6.39	0.045	0.603	1.18.6.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.741	2.02	0.15	0.82	2dg6A	GO:0003677 GO:0006355
1	0.07	0.371	6.03	0.07	0.66	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
2	0.06	0.442	6.35	0.05	0.79	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
3	0.06	0.457	5.68	0.06	0.76	2cse1	GO:0000166 GO:0001172 GO:0003723 GO:0003968 GO:0016740 GO:0016779 GO:0019012 GO:0019013 GO:0019028 GO:0019079 GO:0032774
4	0.06	0.456	5.99	0.04	0.77	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
5	0.06	0.415	5.65	0.05	0.66	3r3jA	GO:0004354 GO:0006520 GO:0006537 GO:0016491 GO:0016639 GO:0020011 GO:0055114
6	0.06	0.360	3.40	0.17	0.45	3gp4A	GO:0003677 GO:0006355
7	0.06	0.356	6.06	0.05	0.63	4zchA	GO:0002376 GO:0005102 GO:0005125 GO:0005164 GO:0005576 GO:0005615 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006955 GO:0007165 GO:0008283 GO:0008284 GO:0016020 GO:0016021 GO:0030890 GO:0033209 GO:0043488 GO:0048298 GO:0048471 GO:0070062
8	0.06	0.327	6.14	0.04	0.57	3lstA	GO:0008168 GO:0008171 GO:0032259
9	0.06	0.393	5.82	0.08	0.64	4bhtA	GO:0004354 GO:0005737 GO:0005829 GO:0006520 GO:0006537 GO:0016491 GO:0016639 GO:0042802 GO:0055114
10	0.06	0.346	6.56	0.06	0.64	2wbeC	GO:0000166 GO:0000278 GO:0000922 GO:0001578 GO:0003774 GO:0003777 GO:0005524 GO:0005634 GO:0005737 GO:0005783 GO:0005794 GO:0005813 GO:0005818 GO:0005819 GO:0005856 GO:0005871 GO:0005873 GO:0005874 GO:0005875 GO:0007018 GO:0007030 GO:0007049 GO:0007052 GO:0007059 GO:0007067 GO:0007100 GO:0008017 GO:0008574 GO:0009306 GO:0022008 GO:0031535 GO:0042998 GO:0045169 GO:0045478 GO:0048085 GO:0051289 GO:0051298 GO:0051299 GO:0051301 GO:0072686 GO:0090307 GO:0097431 GO:1990498
11	0.06	0.301	6.31	0.04	0.55	1ainA	GO:0000733 GO:0001533 GO:0001780 GO:0001891 GO:0002250 GO:0002376 GO:0002548 GO:0002685 GO:0003697 GO:0003727 GO:0004386 GO:0004859 GO:0005102 GO:0005198 GO:0005509 GO:0005543 GO:0005544 GO:0005576 GO:0005615 GO:0005634 GO:0005654 GO:0005737 GO:0005768 GO:0005769 GO:0005886 GO:0005913 GO:0005925 GO:0005929 GO:0006909 GO:0006954 GO:0007165 GO:0007166 GO:0007187 GO:0008360 GO:0009725 GO:0009986 GO:0010008 GO:0010165 GO:0014070 GO:0014839 GO:0016020 GO:0016023 GO:0016323 GO:0016324 GO:0016328 GO:0018149 GO:0019834 GO:0019898 GO:0030073 GO:0030216 GO:0030659 GO:0030674 GO:0030850 GO:0031018 GO:0031232 GO:0031313 GO:0031340 GO:0031394 GO:0031410 GO:0031514 GO:0031532 GO:0031901 GO:0031960 GO:0031966 GO:0031982 GO:0032355 GO:0032508 GO:0032652 GO:0032743 GO:0033031 GO:0033676 GO:0036292 GO:0036310 GO:0042063 GO:0042102 GO:0042127 GO:0042383 GO:0042493 GO:0042629 GO:0042803 GO:0042995 GO:0043065 GO:0043066 GO:0043234 GO:0043434 GO:0044849 GO:0045087 GO:0045627 GO:0045629 GO:0045920 GO:0046632 GO:0046872 GO:0046883 GO:0048306 GO:0050482 GO:0050709 GO:0050727 GO:0051384 GO:0070062 GO:0070301 GO:0070365 GO:0070459 GO:0070555 GO:0071385 GO:0071621 GO:0090303 GO:0097350 GO:0098641 GO:1900087 GO:1900138 GO:2000483
12	0.06	0.312	5.59	0.06	0.49	2qtqA	GO:0003677 GO:0006351 GO:0006355
13	0.06	0.328	5.47	0.04	0.53	4kzxB	GO:0003735 GO:0005622 GO:0005634 GO:0005737 GO:0005840 GO:0006412 GO:0022627 GO:0030154 GO:0030529
14	0.06	0.316	2.58	0.18	0.36	4wlwA	GO:0000986 GO:0001131 GO:0001204 GO:0003677 GO:0003700 GO:0005507 GO:0005737 GO:0006351 GO:0006355 GO:0045893 GO:0046872 GO:0071248
15	0.06	0.304	3.01	0.10	0.35	4ua1B	GO:0003677 GO:0006355 GO:0045340 GO:0046689
16	0.06	0.292	4.53	0.04	0.41	3k3cA	GO:0000155 GO:0000160 GO:0000287 GO:0003824 GO:0004035 GO:0005622 GO:0006355 GO:0016311 GO:0016791 GO:0023014 GO:0030145
17	0.06	0.303	5.57	0.05	0.50	1p2fA	GO:0000160 GO:0003677 GO:0005622 GO:0006351 GO:0006355 GO:0046872
18	0.06	0.277	6.39	0.03	0.49	4qrzA	GO:0005215 GO:0006810

Consensus prediction of GO terms

Molecular Function	GO:0003676	GO:0015405	GO:0016462	GO:0043169
GO-Score	0.48	0.36	0.36	0.36
Biological Processes	GO:0010468	GO:2000112	GO:1903506	GO:0006351	GO:0006818	GO:0015672
GO-Score	0.48	0.48	0.48	0.48	0.36	0.36
Cellular Component	GO:0005887	GO:0019013	GO:0005774
GO-Score	0.13	0.07	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.