I-TASSER results

I-TASSER results for job id Rv1815

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (221 residues)
MVRLVPRAFAATVALLAAGFSPATASADPVLVFPGMEIRQDNHVCTLGYVDPALKIAFTA
GHCRGGGAVTSRDYKVIGHLRAIRDNTPSGSTVATHELIADYEAIVLADDVTASNILPSG
RALESRPGVVLHPGQAVCHFGVSTGETCGTVESVNNGWFTMSHGVLSEKGDSGGPVYLAP
DGGPAQIVGIFNSVWGGFPAAVSWRSTSEQVHADLGVTPLA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MVRLVPRAFAATVALLAAGFSPATASADPVLVFPGMEIRQDNHVCTLGYVDPALKIAFTAGHCRGGGAVTSRDYKVIGHLRAIRDNTPSGSTVATHELIADYEAIVLADDVTASNILPSGRALESRPGVVLHPGQAVCHFGVSTGETCGTVESVNNGWFTMSHGVLSEKGDSGGPVYLAPDGGPAQIVGIFNSVWGGFPAAVSWRSTSEQVHADLGVTPLA
Prediction	CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCEEEEEEHCCCCEEEEEHCCCCCCCCEEHCCCCEEEEEEEHCCCCCCCEEHCCCCCCCEEEEEEHCCCCCCCCCCCCCEEEEHCCCCCCCCCEEEEHCCEEHCCEEEEEEEHCCEEEEEHCCCCCCCCCCCCCEEEHCCCCEEEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
Conf.Score	98643467778777654456777777777755798579878978998886699679998557899986775688567789875577655556657888875999997899656776679857875677788998777756756575889999985858999878667899988668997689859999999767899987777679999999975777889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MVRLVPRAFAATVALLAAGFSPATASADPVLVFPGMEIRQDNHVCTLGYVDPALKIAFTAGHCRGGGAVTSRDYKVIGHLRAIRDNTPSGSTVATHELIADYEAIVLADDVTASNILPSGRALESRPGVVLHPGQAVCHFGVSTGETCGTVESVNNGWFTMSHGVLSEKGDSGGPVYLAPDGGPAQIVGIFNSVWGGFPAAVSWRSTSEQVHADLGVTPLA
Prediction	73322220001302221333333434344230022110344432200011364320000000015543224443332232233444333433334434220001011346142333243343232443442433231023121113111302335433221212121451403010002257330100000102324242323143015303441524548
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCEEEEEEHCCCCEEEEEHCCCCCCCCEEHCCCCEEEEEEEHCCCCCCCEEHCCCCCCCEEEEEEHCCCCCCCCCCCCCEEEEHCCCCCCCCCEEEEHCCEEHCCEEEEEEEHCCEEEEEHCCCCCCCCCCCCCEEEHCCCCEEEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
MVRLVPRAFAATVALLAAGFSPATASADPVLVFPGMEIRQDNHVCTLGYVDPALKIAFTAGHCRGGGAVTSRDYKVIGHLRAIRDNTPSGSTVATHELIADYEAIVLADDVTASNILPSGRALESRPGVVLHPGQAVCHFGVSTGETCGTVESVNNGWFTMSHGVLSEKGDSGGPVYLAPDGGPAQIVGIFNSVWGGFPAAVSWRSTSEQVHADLGVTPLA

1hpgA

0.24

0.19

0.79

1.79

MUSTER

-------------------------------VLGGGAIYGGGSRCSAAFNVGGARYFVTAGHCTNISANWSAS----------SGGSVVGVREGTSFPTNDYGIVRYTDGSSPAGDLYNGSTQDISSAANAVVGQAIKKSGSTTKVTSGTVTAVNVVYNMVRTTACSAGGDSGGAHFAGS-----VALGIHSGSSGCGTAGSAIHQPVTEALSAYGVTVY-

1hpgA

0.24

0.19

0.79

2.70

dPPAS

-------------------------------VLGGGAIYGGGSRCSAAFNVGGARYFVTAGHCTNISANWSASS----------GGSVVGVREGTSFPTNDYGIVRYTDGSSPAGTLYNGSTQDISSAANAVVGQAIKKSGSTTKVTSGTVTAVNVVYNMVRTTACSAGGDSGGAHFAGS-----VALGIHSGSSGCGTAGSAIHQPVTEALSAYGVTVY-

2oq5A

0.17

0.14

0.85

2.66

wdPPAS

-------------------------------IVGGTEVEEGDGSHRCGATLINATWLVSAAHCFTTYKNPARWTASFGVTIKPSKRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNTTCDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVS--WGDECAKPNKPGVYTRVTALRDWTGI-

1gbiA

0.24

0.19

0.79

2.27

wMUSTER

-------------------------------IVGGIEYSINNALCSVGFSVGATKGFVTAGHCGTVNATARIGGAVVGTFAARVF------------PGNDRAWVSLTSAQTLLPRVANGSFVTVRGSTEAAVGAAVCRSGRTTGYQCGTITAKNVVRGLTQGNACAGRGDSGGSWITSAG----QAQGVMSGLNGNNCGIPASQRSLQPILSQYGLSLVG

1hpgA

0.24

0.19

0.79

2.95

wPPAS

-------------------------------VLGGGAIYGGGSRCSAAFNVTGARYFVTAGHCTNISANWSASS----------GGSVVGVREGTSFPTNDYGIVRYTDGSSPAGTVYNGSTQDISSAANAVVGQAIKKSGSTTKVTSGTVTAVNVVYNMVRTTACSAGGDSGGAHFAGS-----VALGIHSGSSGCGTAGSAIHQPVTEALSAYGVTVY-

1hpgA

0.24

0.19

0.79

5.70

dPPAS2

-------------------------------VLGGGAIYGGGSRCSAAFNVGGARYFVTAGHCTNISANWSASS----------GGSVVGVREGTSFPTNDYGIVRYTDGSSPAGTLYNGSTQDISSAANAVVGQAIKKSGSTTKVTSGTVTAVNVVYNMVRTTACSAGGDSGGAHFAGS-----VALGIHSGSSGCGTAGSAIHQPVTEALSAYGVTVY-

1hpgA

0.24

0.19

0.79

3.23

PPAS

-------------------------------VLGGGAIYGGGSRCSAAFNVGGARYFVTAGHCTNISANWSASS----------GGSVVGVREGTSFPTNDYGIVRYTDGSSPAGTLYNGSTQDISSAANAVVGQAIKKSGSTTKVTSGTVTAVNVVYNMVRTTACSAGGDSGGAHFAGS-----VALGIHSGSSGCGTAGSAIHQPVTEALSAYGVTVY-

1hpgA

0.24

0.19

0.79

3.48

Env-PPAS

-------------------------------VLGGGAIYGGGSRCSAAFNVGGARYFVTAGHCTNISANWSASS----------GGSVVGVREGTSFPTNDYGIVRYTDGSSPAGTVYNGSTQDISSAANAVVGQAIKKSGSTTKVTSGTVTAVNVVYNMVRTTACSAGGDSGGAHFAGS-----VALGIHSGSSGCGTAGSAIHQPVTEALSAYGVTVY-

2pfeA

0.23

0.18

0.78

1.74

MUSTER

-----------------------------AAIIGGNPYYFGNYRCSIGFSVGSQTGFATAGHCGSTGTRVSS---------------PSGTVAGSYFPGRDMGWVRITSADTVTPLRYNGGTVTVTGSQEAATGSSVCRSGATTGWRCGTIQSKNTVTGLTRTTACAEGGDSGGPWLTGS-----QAQGVTSGGTGDCSGGITFFQPINPLLSYFGLQLVT

2pfeA

0.23

0.18

0.78

2.53

dPPAS

-----------------------------AAIIGGNPYYFGNYRCSIGFSVGSQTGFATAGHCGSTGTRVSS---------------PSGTVAGSYFPGRDMGWVRITSADTVTPLRYNGGTVTVTGSQEAATGSSVCRSGATTGWRCGTIQSKNTVTGLTRTTACAEGGDSGGPWLTGS-----QAQGVTSGGTGCRSGGITFFQPINPLLSYFGLQLVT

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.21

Estimated TM-score = 0.56±0.15

Estimated RMSD = 8.2±4.5Å

Download Model 2

C-score=-1.26

Download Model 3

C-score=-1.47

Download Model 4

C-score=-3.85

Download Model 5

C-score=-2.31

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1gbiA	0.730	2.01	0.222	0.796
2	1hpgA	0.727	1.83	0.236	0.787
3	2sfaA	0.722	2.05	0.223	0.792
4	2pfeA	0.714	2.01	0.227	0.778
5	2qa9E	0.713	1.97	0.221	0.778
6	2ouaA	0.708	2.17	0.202	0.783
7	2ea3A	0.701	2.07	0.235	0.769
8	4xzyA	0.655	3.66	0.129	0.828
9	1fizA	0.655	3.92	0.154	0.860
10	3bn9B	0.653	3.78	0.161	0.837

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.46	71	1p01A	0EG	Rep, Mult	62,167,168,169,170,171,172,191,192,193,194,196
2	0.08	14	1zmjA	HDB	Rep, Mult	44,45,62,166,167,168,169,170,172,193,196,197,203
3	0.05	7	4ynnG	III	Rep, Mult	42,43,44,62,168,169,170,171,172,192,193,194
4	0.02	3	2ztxA	DTZ	Rep, Mult	45,62,172
5	0.01	2	3po1C	III	Rep, Mult	148,178,179,184,185
6	0.00	1	3m7uA	III	Rep, Mult	62,96,192,193,194
7	0.00	1	3p70B	NA	Rep, Mult	47,48,58,59,173,174,175,190
8	0.00	1	1sb1H	NA	Rep, Mult	34,46,140,141,171,174

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.456	2sfaA	0.722	2.05	0.223	0.792	3.4.21.-	62,101,170,172
2	0.427	1qy6A	0.645	3.31	0.119	0.796	3.4.21.19	62,101,170
3	0.400	1ds2E	0.713	1.95	0.221	0.778	3.4.21.81	45,137,141,144,172
4	0.387	2as9A	0.610	3.57	0.088	0.765	3.4.21.-	62,101,170,172
5	0.266	2j92A	0.593	3.61	0.135	0.738	3.4.22.28	62
6	0.260	1sgcA	0.698	1.82	0.246	0.756	3.4.21.80	59
7	0.249	1b0fA	0.631	3.76	0.160	0.810	3.4.21.37	62
8	0.239	1l1nA	0.577	3.11	0.104	0.697	3.4.22.29	62,170
9	0.236	1cqqA	0.576	3.02	0.117	0.697	3.4.22.28,3.4.22.29	62,170
10	0.152	1ssxA	0.720	2.13	0.229	0.792	3.4.21.12	NA
11	0.098	2vidB	0.616	3.44	0.134	0.765	3.4.21.-	62,101,172
12	0.075	2rg3A	0.633	3.74	0.167	0.810	3.4.21.37	173
13	0.071	2hrvA	0.464	2.80	0.104	0.561	3.4.22.28	170
14	0.067	1fujC	0.631	3.79	0.182	0.810	3.4.21.76	172,174
15	0.067	2wv4A	0.588	3.73	0.140	0.742	3.4.22.28	NA
16	0.067	2b0fA	0.565	3.39	0.102	0.710	3.4.22.28	62,170
17	0.066	1dylA	0.471	3.36	0.113	0.597	3.4.21.90	170
18	0.066	1svpA	0.485	3.46	0.095	0.620	3.4.21.90	170,175
19	0.060	3dfjA	0.642	3.82	0.155	0.833	3.4.21.-	62,101,170,172,173
20	0.060	1hylA	0.642	3.68	0.148	0.819	3.4.21.49	59,164
21	0.060	1fizA	0.655	3.92	0.154	0.860	3.4.21.10	163,191
22	0.060	1bbrH	0.386	4.09	0.121	0.516	3.4.21.5	NA
23	0.060	1csoE	0.713	1.95	0.221	0.778	3.4.21.81	59,165
24	0.060	2gv6A	0.650	3.92	0.170	0.846	3.4.21.109	NA
25	0.060	3govB	0.645	3.89	0.123	0.851	3.4.21.-	62,101,170,172,173
26	0.060	1riwB	0.383	4.08	0.115	0.511	3.4.21.5	62
27	0.060	1ucyE	0.288	3.12	0.120	0.348	3.4.21.5	171
28	0.060	2ea3A	0.701	2.07	0.235	0.769	3.4.21.-	62,101,170,172
29	0.060	2za5A	0.637	3.89	0.162	0.833	3.4.21.59	62,101,170,172,173
30	0.060	1ekbB	0.649	3.81	0.161	0.842	3.4.21.9	62
31	0.060	1hpgA	0.727	1.83	0.236	0.787	3.4.21.82	NA
32	0.060	1boqA	0.728	2.03	0.222	0.796	3.4.21.12	62,101,170,172
33	0.060	1fiwA	0.654	3.85	0.149	0.855	3.4.21.10	NA
34	0.060	1bdaA	0.644	3.92	0.128	0.846	3.4.21.68	NA
35	0.060	1yc0A	0.647	3.76	0.134	0.837	3.4.21.-	62,170,172,173
36	0.060	1a0lA	0.642	3.85	0.167	0.837	3.4.21.59	45,62,170,172,196
37	0.060	1bruP	0.638	3.90	0.174	0.837	3.4.21.71	59

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.35	0.722	2.05	0.22	0.79	2sfaA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
1	0.33	0.714	2.01	0.23	0.78	2pfeA	GO:0004252 GO:0005576 GO:0006508 GO:0008236
2	0.32	0.728	2.03	0.22	0.80	1boqA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
3	0.31	0.701	2.07	0.23	0.77	2ea3A	GO:0004252 GO:0005576 GO:0006508 GO:0008236
4	0.31	0.715	1.92	0.22	0.78	1csoE	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
5	0.30	0.727	1.83	0.24	0.79	1hpgA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787
6	0.28	0.708	2.17	0.20	0.78	2ouaA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236
7	0.24	0.698	1.82	0.25	0.76	1sgcA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
8	0.23	0.617	2.93	0.14	0.73	3qo6B	GO:0004252 GO:0005634 GO:0006508 GO:0008233 GO:0008236 GO:0009507 GO:0009534 GO:0009535 GO:0009536 GO:0009579 GO:0009735 GO:0010206 GO:0016020 GO:0016787 GO:0030163 GO:0031977
9	0.20	0.613	3.26	0.17	0.75	2z9iA	GO:0004252 GO:0005576 GO:0006508 GO:0006950 GO:0008233 GO:0008236 GO:0009405 GO:0016020 GO:0016021 GO:0030163
10	0.19	0.635	3.66	0.14	0.80	4afqA	GO:0002003 GO:0004175 GO:0004252 GO:0005576 GO:0005737 GO:0006508 GO:0006518 GO:0006955 GO:0008233 GO:0008236 GO:0016485 GO:0016787 GO:0022617 GO:0030901 GO:0031012 GO:0042277 GO:0043231 GO:0045766 GO:0050720 GO:0050727 GO:0071333
11	0.17	0.655	3.92	0.15	0.86	1fizA	GO:0001669 GO:0004040 GO:0004252 GO:0005537 GO:0006508 GO:0007190 GO:0007338 GO:0007340 GO:0007341 GO:0008144 GO:0008233 GO:0008236 GO:0016787 GO:0042806 GO:0043159 GO:0043234
12	0.15	0.656	3.91	0.15	0.86	1fiwA	GO:0001669 GO:0004040 GO:0004252 GO:0005537 GO:0006508 GO:0007190 GO:0007338 GO:0007340 GO:0007341 GO:0008144 GO:0008233 GO:0008236 GO:0016787 GO:0042806
13	0.11	0.634	3.69	0.17	0.80	1fq3A	GO:0001772 GO:0004252 GO:0005634 GO:0005737 GO:0005739 GO:0005829 GO:0006508 GO:0006915 GO:0008233 GO:0008236 GO:0016020 GO:0016485 GO:0016787 GO:0019835 GO:0042267 GO:0043231 GO:1900740
14	0.09	0.612	3.40	0.15	0.75	1l1jA	GO:0004252 GO:0006508 GO:0008233
15	0.08	0.626	3.81	0.15	0.81	3s9aA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
16	0.08	0.630	3.45	0.15	0.80	4m7gA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787
17	0.07	0.626	3.87	0.15	0.81	2aipA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
18	0.07	0.630	3.73	0.15	0.80	3rp2A	GO:0004252 GO:0005737 GO:0006508 GO:0006955 GO:0008233 GO:0008236 GO:0016485 GO:0016787 GO:0043231
19	0.07	0.627	3.83	0.13	0.80	1tonA	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0046872
20	0.07	0.627	3.84	0.13	0.81	1eq9A	GO:0004252 GO:0005576 GO:0005615 GO:0006508 GO:0008233 GO:0008236 GO:0016787
21	0.07	0.617	3.84	0.15	0.81	4gsoA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
22	0.07	0.623	3.84	0.13	0.81	1npmA	GO:0004252 GO:0005576 GO:0005615 GO:0005737 GO:0006508 GO:0007613 GO:0008219 GO:0008233 GO:0008236 GO:0009611 GO:0016787 GO:0031642 GO:0043616 GO:0048681 GO:0048812 GO:0050807 GO:0050808
23	0.07	0.637	3.94	0.14	0.83	1eltA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0046872
24	0.07	0.616	3.89	0.17	0.81	3qumP	GO:0002778 GO:0004175 GO:0004252 GO:0005576 GO:0005615 GO:0005634 GO:0006508 GO:0008233 GO:0008236 GO:0016525 GO:0016787 GO:0016811 GO:0043234 GO:0044267 GO:0070062
25	0.07	0.604	3.89	0.12	0.80	1gvzA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
26	0.07	0.616	3.93	0.14	0.81	1bqyA	GO:0004252 GO:0005576 GO:0006508 GO:0008233 GO:0008236 GO:0016787
27	0.07	0.462	3.15	0.07	0.58	1z8rA	GO:0000166 GO:0001172 GO:0003723 GO:0003724 GO:0003968 GO:0004197 GO:0004386 GO:0005198 GO:0005216 GO:0005524 GO:0006260 GO:0006351 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008234 GO:0016020 GO:0016032 GO:0016740 GO:0016779 GO:0016787 GO:0017111 GO:0018144 GO:0019012 GO:0019028 GO:0019062 GO:0030430 GO:0030683 GO:0033644 GO:0034220 GO:0039503 GO:0039520 GO:0039522 GO:0039540 GO:0039544 GO:0039611 GO:0039618 GO:0039657 GO:0039690 GO:0039694 GO:0039707 GO:0044161 GO:0044162 GO:0044385 GO:0044694 GO:0046718 GO:0046872 GO:0051259 GO:0075509
28	0.06	0.364	6.04	0.04	0.65	1k3iA	GO:0005576 GO:0016491 GO:0045480 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0004252
GO-Score	0.86
Biological Processes	GO:0006508
GO-Score	0.86
Cellular Component	GO:0005576
GO-Score	0.86

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.