I-TASSER results

I-TASSER results for job id Rv1808

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (409 residues)
MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGP
SSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSL
VATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATA
AQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTIL
ANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYI
GDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLPGTGAAPALAAEAPGAL
FGEMALSSLAGRALAGTAVRSGAGAARVAGGSVTEDVASTTTIIVIPAD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLPGTGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRSGAGAARVAGGSVTEDVASTTTIIVIPAD
Prediction	CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9855588556665556799958899999999999999999999999999987657878878999999999999999999999999999999999999999986998899999999999999984556766788999999999988889999887777888876578889998889888766665444556777776577899999999999999875677777777776554555544444445655544555566655565555554555555556666776666666777776777667788888765555576666677788887777888777776677888888888888888877888877777788888888888877777888888888888876678999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLPGTGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRSGAGAARVAGGSVTEDVASTTTIIVIPAD
Prediction	5411010001000102001000002000200220033012003102100110212213110010002003201300120033043203103100000110122223112011033100101110010010000030243034112100300211110011023233333224334453444433233433434334422421230133024103301332222333332232333233311233333222222233232223313122323321212222223213222232233322322333232110001112113104010010110132233323231222322233323323122111210011111222322333333433344344653443140130358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MDFGALPPEINSGRMYAGPGSGPLLAAAAAWDALAAELYSAAASYGSTIEGLTVAPWMGPSSITMAAAVAPYVAWISVTAGQAEQAGAQAKIAAGVYETAFAATVPPPVIEANRALLMSLVATNIFGQNTPAIAATEAHYAEMWAQDAAAMYGYAGSSATASQLAPFSEPPQTTNPSATAAQSAVVAQAAGAAASSDITAQLSQLISLLPSTLQSLATTATATSASAGWDTVLQSITTILANLTGPYSIIGLGAIPGGWWLTFGQILGLAQNAPGVAALLGPKAAAGALSPLAPLRGGYIGDITPLGGGATGGIARAIYVGSLSVPQGWAEAAPVMRAVASVLPGTGAAPALAAEAPGALFGEMALSSLAGRALAGTAVRSGAGAARVAGGSVTEDVASTTTIIVIPAD

2g38B

0.33

0.14

0.42

1.45

MUSTER

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5gaoE

0.25

0.19

0.78

1.61

PPAS

---------------------------------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-----AAAAAAAAAAAAAAAAAA-----------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKE

2g38B

0.32

0.13

0.42

1.75

dPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2d4yA

0.10

0.96

1.05

Env-PPAS

----------DAFITNQ---LRGAQNQSSGLTTRYEQMSKIDNLLADKSSSLSGS-LQSFFTSLQTLVSNAEPAARQALIGKAEGLVNQFKTTDQYLRDQDKQV--NIAIGSSVAQINNYAKQ--IANLNDQISRMTNDLLDQRDQLVSELNKIQGSTARQLAAVPSSADPTRTTVAYVDEAAGNIEIPEKLLNTGSLGGLLTFRSQDLDQTRNTLGQLALAAQHTKGYDADGNKGKDFFSIGSPVVYSNSNNADKTVSLTAKVVDSTKVQATDYKIVFDGTDWQVTRTADNTTFTATKDADGKLEIDGLKVTVGTGAQKNFLLKPVSNAIVDMNVKVTNEAEIAMASESKLSDNRNGQALLDLQNSNVVGGNKTFNDAYATLVSDVGNKTSTLKTSSTTQANVVKQLY

2g38B

0.33

0.14

0.42

2.96

wdPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4cgkA

0.11

0.09

0.85

1.01

Env-PPAS

-------------------------------SNLTAQQQEAQKQVDQIQEQVSA---IQAEQSNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQT--NGAVTSYINTIVNSKSIAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDA-----------------------INTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIACWNDGGYGHVA-VVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVTYIYAD

2g38B

0.33

0.14

0.42

1.92

wMUSTER

--FEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2ra1A

0.10

0.96

1.00

Env-PPAS

TDVATVVSQAKAQMKEAYYTYSHTVTETGQIKDVYAAYNKAKQAYANAVAVVNKGAKKDAYLADLQAIYETYVEARVATYIDAYNYATKLDKMRQELKAAVDAKDLKKAEELYHKISYELKTRTVYGQSELLRSTFKADAQALRDRLIYDITVAMKAREAQDAVK--------AGNLDKAKAALDQVNQYVSKVTDAFKAELQKAAQDAKAAYEAALTPKVESVSAIDSTSFKVTFTKPVDKATAIPKNFSITLKGTETKLYPKSVEVSESGLTATVTLYD------TLVDGKTYTVVTSGLKDTAGKEFETSTNEFTYN--KPVPASITFNFNKLPEDSAVDLTKYVTVKDAAGNVIKSGFELEFT-SSEKLTQGKFINTTGKKSVIVNATVKGTNVTTGNVILAVED

2g38B

0.33

0.14

0.42

4.39

wPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALS-TPWKAPPPIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

2g38B

0.33

0.14

0.42

3.85

dPPAS2

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKTPWKAPPPIA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.14

Estimated TM-score = 0.36±0.12

Estimated RMSD = 14.6±3.7Å

Download Model 2

C-score=-3.52

Download Model 3

C-score=-3.94

Download Model 4

C-score=-3.69

Download Model 5

C-score=-2.17

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2d4yA	0.728	4.03	0.093	0.866
2	4ut1A	0.704	4.33	0.104	0.861
3	2p7nA	0.395	5.71	0.073	0.570
4	2amvA	0.384	7.25	0.039	0.665
5	4bqeA	0.378	7.18	0.057	0.648
6	3uqyL	0.375	7.16	0.056	0.624
7	3myrB	0.375	7.19	0.059	0.624
8	3ayxA	0.374	7.04	0.042	0.616
9	3btaA	0.373	5.65	0.023	0.531
10	4c3oA	0.373	6.94	0.060	0.602

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	3	1nkzA	BCL	Rep, Mult	89,92,93,96,97,100,151
2	0.04	3	2iegB	FRY	Rep, Mult	120,121,131,135
3	0.03	2	3cejB	AVF	Rep, Mult	104,105,106,109
4	0.03	2	1rzhL	BCL	Rep, Mult	92,97
5	0.03	2	3cemA	AVD	Rep, Mult	6,7,8,12
6	0.03	2	1exvA	700	Rep, Mult	104,106,150,154
7	0.03	2	3cvsC	NUC	Rep, Mult	130,131,132
8	0.01	1	4f8hA	LMD	Rep, Mult	90,93
9	0.01	1	1p2bA	GLC	Rep, Mult	38,39,41,42,79,82,86
10	0.01	1	3m9iA	3PE	Rep, Mult	94,98
11	0.01	1	3arcJ	III	Rep, Mult	75,76
12	0.01	1	1c8lA	CFF	Rep, Mult	3,18,20
13	0.01	1	3cejA	AVF	Rep, Mult	110,111,112,116
14	0.01	1	3qfeA	CA	Rep, Mult	155,158
15	0.01	1	2w0sB	BVP	Rep, Mult	24,28,31
16	0.01	1	1gfzA	CFF	Rep, Mult	50,55,57
17	0.01	1	4bjwB	I3C	Rep, Mult	79,80
18	0.01	1	2h8pC	GOA	Rep, Mult	153,154
19	0.01	1	3bd7A	CKB	Rep, Mult	18,20,21,22
20	0.01	1	1dxoA	DQN	Rep, Mult	57,87

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1z0hB	0.275	7.15	0.021	0.467	3.4.24.69	137,140
2	0.060	3k1dA	0.345	6.77	0.039	0.565	2.4.1.18	100,102
3	0.060	3h0gA	0.340	7.53	0.034	0.599	2.7.7.6	202
4	0.060	1cc1L	0.359	6.56	0.058	0.557	1.12.99.6	50
5	0.060	1fa9A	0.287	7.33	0.037	0.482	2.4.1.1	NA
6	0.060	2ebsB	0.342	7.00	0.050	0.575	3.2.1.150	NA
7	0.060	1kqfA	0.296	7.22	0.051	0.511	1.2.1.2	NA
8	0.060	1h2rL	0.375	7.18	0.050	0.619	1.12.2.1	41
9	0.060	2wpnB	0.358	6.52	0.064	0.553	1.12.7.2	92,96
10	0.060	1ffuB	0.291	7.16	0.035	0.494	1.2.99.2	NA
11	0.060	2e9bA	0.340	6.61	0.048	0.543	3.2.1.41	52,71
12	0.060	1yiqA	0.330	6.50	0.061	0.516	1.1.99.-	NA
13	0.060	2pflA	0.337	7.71	0.043	0.616	2.3.1.54	NA
14	0.060	1t3qB	0.335	6.45	0.059	0.526	1.3.99.17	NA
15	0.060	3f41A	0.337	7.03	0.037	0.565	3.1.3.8	155
16	0.060	2e8yA	0.336	6.64	0.033	0.540	3.2.1.41	NA
17	0.060	2frvD	0.368	7.16	0.059	0.619	1.12.2.1	95
18	0.060	3ebgA	0.330	6.46	0.024	0.518	3.4.11.-	NA
19	0.060	3c46B	0.303	7.17	0.036	0.509	2.7.7.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.704	4.33	0.10	0.86	4ut1A	GO:0005198 GO:0009424 GO:0044780
1	0.25	0.728	4.03	0.09	0.87	2d4yA	GO:0005198 GO:0005576 GO:0009288 GO:0009424 GO:0044780 GO:0071973
2	0.09	0.272	6.98	0.05	0.45	2wssA	GO:0000166 GO:0005524 GO:0005739 GO:0005743 GO:0005753 GO:0005886 GO:0006754 GO:0006810 GO:0006811 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016820 GO:0033178 GO:0045261 GO:0046034 GO:0046933 GO:0046961
3	0.06	0.395	5.74	0.07	0.57	2p7nA	GO:0009405
4	0.06	0.287	7.33	0.04	0.48	1fa9A	GO:0000166 GO:0002060 GO:0003824 GO:0004645 GO:0005524 GO:0005536 GO:0005737 GO:0005829 GO:0005886 GO:0005975 GO:0005977 GO:0005980 GO:0006015 GO:0008144 GO:0008152 GO:0008184 GO:0016208 GO:0016740 GO:0016757 GO:0019842 GO:0030170 GO:0030246 GO:0032052 GO:0042593 GO:0042803 GO:0070062 GO:0070266
5	0.06	0.305	6.62	0.04	0.48	1ygpA	GO:0004645 GO:0005737 GO:0005975 GO:0005977 GO:0005980 GO:0008184 GO:0016740 GO:0016757 GO:0030170
6	0.06	0.339	5.77	0.03	0.48	2izpA	GO:0005576 GO:0009405
7	0.06	0.315	4.64	0.07	0.40	2j0oA	GO:0005576 GO:0009405
8	0.06	0.329	5.48	0.06	0.47	2ym9A	GO:0005576 GO:0009405
9	0.06	0.377	7.23	0.04	0.65	4bqfB	GO:0003824 GO:0004645 GO:0005737 GO:0005829 GO:0005975 GO:0005980 GO:0008152 GO:0008184 GO:0009414 GO:0009507 GO:0016740 GO:0016757 GO:0030170 GO:0046686
10	0.06	0.373	7.20	0.04	0.64	2qllA	GO:0000166 GO:0002060 GO:0003824 GO:0004645 GO:0005524 GO:0005536 GO:0005737 GO:0005829 GO:0005886 GO:0005975 GO:0005977 GO:0005980 GO:0006015 GO:0008144 GO:0008152 GO:0008184 GO:0016208 GO:0016740 GO:0016757 GO:0019842 GO:0030170 GO:0030246 GO:0032052 GO:0042593 GO:0042803 GO:0070062 GO:0070266
11	0.06	0.309	7.43	0.04	0.54	1e1yA	GO:0000166 GO:0003824 GO:0004645 GO:0005975 GO:0005977 GO:0008152 GO:0008184 GO:0016740 GO:0016757 GO:0030170
12	0.06	0.292	6.81	0.04	0.47	2c4mC	GO:0004645 GO:0005975 GO:0008184 GO:0016740 GO:0016757 GO:0030170
13	0.06	0.278	6.69	0.04	0.45	3peiA	GO:0004177 GO:0005622 GO:0005737 GO:0006508 GO:0008233 GO:0008235 GO:0016787 GO:0019538 GO:0030145 GO:0046872
14	0.06	0.384	7.19	0.04	0.65	1ahpA	GO:0003824 GO:0004645 GO:0005737 GO:0005829 GO:0005975 GO:0005980 GO:0008152 GO:0008184 GO:0016740 GO:0016757 GO:0030170 GO:0030980 GO:0031220
15	0.06	0.272	6.89	0.04	0.45	5fp2A	GO:0004872 GO:0005506 GO:0006810 GO:0009279 GO:0015891 GO:0016020
16	0.06	0.367	7.31	0.02	0.63	4l22A	GO:0004645 GO:0005975 GO:0008184 GO:0016740 GO:0016757 GO:0030170
17	0.06	0.250	7.63	0.06	0.45	4n0rA	GO:0005975
18	0.06	0.382	7.28	0.04	0.66	3gpbA	GO:0000166 GO:0003824 GO:0004645 GO:0005975 GO:0005977 GO:0008152 GO:0008184 GO:0016740 GO:0016757 GO:0030170

Consensus prediction of GO terms

Molecular Function	GO:0005198
GO-Score	0.48
Biological Processes	GO:0097588	GO:0044780
GO-Score	0.50	0.48
Cellular Component	GO:0009424
GO-Score	0.48

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.