I-TASSER results

I-TASSER results for job id Rv1780

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (187 residues)
MQNHDYVTYEEFGRRFFEVAVTPDRVAAAFADIAGSEFAMEPISQGPGGIAKVSANVKIR
EPRVTRKLGDLITFVIHIPLSIDLLLDLRLDKQRFMVAGDIALRATARAAEPLLLIVDVA
KPRPSDITVNVSSKSIRGEVLRILAGVDGEIRRFIAQYVSAEIDSPKSQAAQVINVAEQL
DSTWSGP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MQNHDYVTYEEFGRRFFEVAVTPDRVAAAFADIAGSEFAMEPISQGPGGIAKVSANVKIREPRVTRKLGDLITFVIHIPLSIDLLLDLRLDKQRFMVAGDIALRATARAAEPLLLIVDVAKPRPSDITVNVSSKSIRGEVLRILAGVDGEIRRFIAQYVSAEIDSPKSQAAQVINVAEQLDSTWSGP
Prediction	CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHCCCCCCCCEEEEEEEEEHCCEEEEHCCCCCEEEEEEEEEEEEEEEEEEHCCCEEEEEEEEHCCCCEEHCCCEEEEEHCCCCCCCCEEEEEEHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHCCCC
Conf.Score	9987557999999889888648999999999975997687556889986589999999876799865798689999976688999998756647898898755444454798799998699996548999985654367778876488999999999999998777877567667688888866899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MQNHDYVTYEEFGRRFFEVAVTPDRVAAAFADIAGSEFAMEPISQGPGGIAKVSANVKIREPRVTRKLGDLITFVIHIPLSIDLLLDLRLDKQRFMVAGDIALRATARAAEPLLLIVDVAKPRPSDITVNVSSKSIRGEVLRILAGVDGEIRRFIAQYVSAEIDSPKSQAAQVINVAEQLDSTWSGP
Prediction	6754531304400430043023472025103512455162332443343203030414244241344364312010301230302020415444141304030402341053020004065155540303043642313024112404630252015203631554534543414135415642758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180

                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCEEEHCCCCCCCCEEEEEEEEEHCCEEEEHCCCCCEEEEEEEEEEEEEEEEEEHCCCEEEEEEEEHCCCCEEHCCCEEEEEHCCCCCCCCEEEEEEHCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHCCCC
MQNHDYVTYEEFGRRFFEVAVTPDRVAAAFADIAGSEFAMEPISQGPGGIAKVSANVKIREPRVTRKLGDLITFVIHIPLSIDLLLDLRLDKQRFMVAGDIALRATARAAEPLLLIVDVAKPRPSDITVNVSSKSIRGEVLRILAGVDGEIRRFIAQYVSAEIDSPKSQAAQVINVAEQLDSTWSGP

4kghB

0.12

0.96

1.02

MUSTER

-SPTG---LAGSLTNALSNGLLSGGLLGILENLPGLLGKVTSVIPGNNVIDIKVTDPQLLELGLVQSPGHR--LYVTIPLGIKLQVNTPLGASLLRLAVKLDITAEILARDKIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVC-PLVNEVRGLDVHDIVNMLIHGL

4kghB

0.10

0.97

1.17

dPPAS

----SPTGLAGSLTNALSNGLLSGGLLGILENLGGLLGKVTSVIPGNNVIDIKVTDPQLLELGLVQSPDGH-RLYVTIPLGIKLQVNTPVGASLLRLAVKLDITAEILARDKIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVCPLVNEVLRGLDVHDIVNMLIHGL

4kghB

0.12

0.11

0.92

1.11

wdPPAS

--SPT-------LAGSLTNALSNGLLSGLLGILENLPLKVTSVIPGNNVIDIKVTDPQLLELGLVQSPDGH-RLYVTIPLGIKLQVNTPVGASLLRLAVKLDITAEILARDKIHLVLG----SPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVC-PLVNEVRGLDVHDIVNMLIHGL

4kghB

0.12

0.95

1.15

wMUSTER

PTG----LAGSLTNALSNGLLSGG-LLGILENLPGLLGKVTSVIPGNNVIDIKVTDPQLLELGLVQSPGHR--LYVTIPLGIKLQVNTPLGASLLRLAVKLDITAEILARDKIHLVLG--THSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVC-PLVNEVRGLDVHDIVNMLIHGL

4kghB

0.14

0.12

0.91

0.93

wPPAS

--SPT-------LAGSLTNALSNGLLSGLLGILENLPL-LDILGGLLGKVTSVIIDIKVTDPQL--ELGLVQSLYVTIPLGIKLQVNTPVGASLLRLAVKLDITAEILARDKIHLVLG----SPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVC-PLVNEVRGLDVHDIVNMLIHGL

4kghB

0.13

0.11

0.85

1.59

dPPAS2

LPLLDILG----------------GLLGKVTSVI----------PGNNVIDIKVTDPQLLELGLVQSPDGH-RLYVTIPLGIKLQVNTPVGASLLRLAVKLDITAEILARDKIHLVLGDCTHSPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVC-PLVNEVRGLDVHDIVNMLIHGL

4kghB

0.13

0.12

0.92

1.01

PPAS

-SPTG-------LAGSLTNALSNGLLSGLLGILENLPL-LDILGGLLGKVTSVIIDIKVTDPQLLELSPDGHRLYVTIPLGIKLQVNT-VGASLLRLAVKLDITAEILARDKIHLVLG----SPGSLQISLLDGLGPLPIQGLLDSLTGILNKVLPELVQGNVC-PLVNEVRGLDVHDIVNMLIHGL

2x8aA1

0.19

0.15

0.79

0.76

Env-PPAS

------IGLEDIREELTMAILAPVRNPDQFKALGLVTLLAGPPGCGKTLLAKAVA-----------NESGLNFISVKGPELLNMYVGESERAVRFQ---------RAKNSAPCVIFFDVDALCPSV--------RVVNQLLTEMDGLEARQQVFIAATNRPDIIDPAILRPGRLD--KTL---FVG-

3zpmA

0.12

0.11

0.97

0.90

MUSTER

-AMAQQIPSSQITDALTQGLLDEGLLNTILDQVTGLLNILVGPLLGPSDAEIKLQDTRLLQLSLEFSPDSK-GIDIWIPLELSVYLKLLILEP-LTLYVRTDIRVQLRL-GKYRLAFGHCSLLPRAIELQSG-NPLSLPVNAVLGTIENALGNFITEDLGAGLC-PTLNSLSNLDVNNLINLILDRA

3zpmA

0.11

0.99

1.00

dPPAS

AQQIPPEVSSQITDALTQGLLDEGLLNTILDQVTGLLNILVGPLLGPSDAEIKLQDTRLLQLSLEFSPDSK-GIDIWIPLELSVYLKLLILEPYVRTDIRVQLRLESDEDGKYRLAFGHCSLLPRAIELQSG-NPLSLPVNAVLGTIENALGNFITEDLGAGLCPTLNSLVSNLDVNNLINLILDRA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.80

Estimated TM-score = 0.61±0.14

Estimated RMSD = 6.9±4.1Å

Download Model 2

C-score=-3.58

Download Model 3

C-score=-4.14

Download Model 4

C-score=-3.65

Download Model 5

C-score=-3.14

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4kghB	0.821	2.61	0.094	0.963
2	3zpmA	0.708	3.25	0.088	0.909
3	1bp1A1	0.668	3.47	0.056	0.877
4	4m4dA1	0.653	3.60	0.063	0.877
5	3uv1A	0.621	3.30	0.030	0.813
6	2obdA	0.609	3.85	0.057	0.845
7	2rckA	0.563	4.48	0.069	0.856
8	5gydA	0.559	4.58	0.075	0.840
9	3e8wA	0.554	4.64	0.070	0.866
10	1usvF	0.531	3.60	0.043	0.722

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	1bp1A	PC1	Rep, Mult	9,12,63,65,76,78,101,107,109,118,121,159,163,167,170,171,175
2	0.04	2	2dysN	DCW	Rep, Mult	127,156
3	0.04	2	2ckjD	FES	Rep, Mult	12,13,17,62,63,64
4	0.04	2	2hbkA	MN	Rep, Mult	41,148
5	0.04	2	2b51A	MN	Rep, Mult	70,87
6	0.02	1	1wrkB	TFP	Rep, Mult	11,12
7	0.02	1	4ep7B	MG	Rep, Mult	70,83
8	0.02	1	1smyF	MG	Rep, Mult	54,151
9	0.02	1	3mouB	XE	Rep, Mult	21,78,167
10	0.02	1	1usu1	III	Rep, Mult	62,76,78,125,127,129,131,142,148
11	0.02	1	2obdA	UUU	Rep, Mult	122,123,124,160,161
12	0.02	1	2wl3A	CA	Rep, Mult	42,91
13	0.02	1	3ke6B	MN	Rep, Mult	32,33,35
14	0.02	1	1yklG	DHB	Rep, Mult	46,47
15	0.02	1	3a0bd	CLA	Rep, Mult	147,151
16	0.02	1	1k9zA	ZN	Rep, Mult	32,162
17	0.02	1	3ehbB	HEA	Rep, Mult	80,163
18	0.02	1	2ckjD	PO4	Rep, Mult	78,107,118,120
19	0.02	1	1h9jA	MOO	Rep, Mult	106,109
20	0.02	1	4gfjA	ZN	Rep, Mult	11,179

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1fo4A	0.430	5.38	0.062	0.738	1.17.1.4	NA
2	0.060	3d35A	0.452	4.00	0.093	0.631	2.3.1.48	NA
3	0.060	1sojL	0.445	4.37	0.042	0.652	3.1.4.17	14,66
4	0.060	1z45A	0.448	4.47	0.048	0.663	5.1.3.2,5.1.3.3	NA
5	0.060	3b9jC	0.497	4.97	0.056	0.791	1.17.3.2,1.17.1.4	NA
6	0.060	1wqlA	0.435	4.84	0.056	0.674	1.14.12.-	32
7	0.060	2x4mA	0.474	4.99	0.034	0.775	3.4.23.48	58,81,128
8	0.060	3hkzJ	0.455	5.17	0.096	0.727	2.7.7.6	129
9	0.060	3b8eC	0.443	4.96	0.020	0.727	3.6.3.9	29,33
10	0.060	1jroB	0.499	4.80	0.052	0.781	1.1.1.204	178
11	0.060	1eulA	0.425	4.82	0.052	0.679	3.6.3.8	NA
12	0.060	2qykB	0.435	4.28	0.050	0.626	3.1.4.17	20,62
13	0.060	1zklA	0.433	4.49	0.044	0.631	3.1.4.17	NA
14	0.060	1mo7A	0.284	4.76	0.031	0.433	3.6.3.9	20,163
15	0.060	1rm6A	0.490	4.63	0.052	0.749	1.3.99.20	NA
16	0.060	1e3pA	0.450	4.35	0.064	0.663	2.7.7.8	127
17	0.060	1b65A	0.434	5.26	0.091	0.727	3.4.11.9	56,81,99
18	0.060	3msuA	0.456	5.10	0.048	0.759	2.3.3.1	63
19	0.060	1ndoA	0.434	4.83	0.047	0.663	1.14.12.12	18,26,170

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.827	2.57	0.10	0.97	5i7kB	GO:0002376 GO:0005576 GO:0005615 GO:0008289 GO:0019731 GO:0042742 GO:0045087 GO:0050828 GO:0050891 GO:1900229 GO:1902305
1	0.22	0.708	3.25	0.09	0.91	3zpmA	GO:0001659 GO:0005576 GO:0008289 GO:0050828
2	0.16	0.643	3.20	0.04	0.83	3uv1A	GO:0005576
3	0.12	0.631	3.74	0.07	0.85	4kegA	GO:0002376 GO:0005215 GO:0005363 GO:0005576 GO:0005615 GO:0006810 GO:0006974 GO:0008289 GO:0008643 GO:0015768 GO:0019731 GO:0030288 GO:0034289 GO:0042597 GO:0042742 GO:0042956 GO:0043190 GO:0045087 GO:0050828 GO:0050891 GO:0055052 GO:0060326 GO:1900229 GO:1901982 GO:1902305 GO:1990060
4	0.10	0.649	3.22	0.05	0.84	3h4zA	GO:0005215 GO:0005363 GO:0005576 GO:0006810 GO:0006974 GO:0008643 GO:0015768 GO:0030288 GO:0034289 GO:0042597 GO:0042956 GO:0043190 GO:0055052 GO:0060326 GO:1901982 GO:1990060
5	0.09	0.615	3.92	0.04	0.87	4m4dA	GO:0001530 GO:0001889 GO:0002232 GO:0002281 GO:0002376 GO:0005102 GO:0005576 GO:0005615 GO:0006810 GO:0006869 GO:0006953 GO:0008228 GO:0008289 GO:0009986 GO:0015920 GO:0016020 GO:0031663 GO:0032490 GO:0032496 GO:0032720 GO:0032722 GO:0032755 GO:0032757 GO:0032760 GO:0034145 GO:0042535 GO:0042742 GO:0043032 GO:0044130 GO:0045087 GO:0050829 GO:0050830 GO:0060100 GO:0060265 GO:0070062 GO:0070891 GO:0071222 GO:0071223 GO:0090023 GO:0090559
6	0.09	0.656	3.69	0.03	0.89	1bp1A	GO:0001530 GO:0005576 GO:0005615 GO:0005737 GO:0005887 GO:0006955 GO:0008289 GO:0016020 GO:0032715 GO:0032717 GO:0032720 GO:0042742 GO:0043031 GO:0050829 GO:0070062
7	0.07	0.605	3.71	0.06	0.83	4ewsA	GO:0005319 GO:0005548 GO:0005576 GO:0005615 GO:0006629 GO:0006641 GO:0006810 GO:0006869 GO:0006898 GO:0008202 GO:0008203 GO:0008289 GO:0010745 GO:0010874 GO:0015485 GO:0015914 GO:0017127 GO:0017129 GO:0030301 GO:0031210 GO:0031982 GO:0034197 GO:0034364 GO:0034372 GO:0034374 GO:0034375 GO:0042157 GO:0042632 GO:0043691 GO:0046470 GO:0055088 GO:0055091 GO:0070062 GO:0070328
8	0.07	0.531	3.60	0.04	0.72	1usvF	GO:0001671 GO:0005737 GO:0006457 GO:0006950 GO:0032781 GO:0034605 GO:0051087
9	0.06	0.370	5.37	0.04	0.65	3d8uB	GO:0003677 GO:0003700 GO:0006351 GO:0006355
10	0.06	0.375	4.59	0.03	0.57	4uwhA	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
11	0.06	0.338	5.25	0.04	0.56	3ihyC	GO:0000045 GO:0000166 GO:0000910 GO:0004672 GO:0005524 GO:0005768 GO:0005770 GO:0005776 GO:0005829 GO:0005930 GO:0005942 GO:0006468 GO:0006661 GO:0006914 GO:0007032 GO:0007049 GO:0016020 GO:0016236 GO:0016301 GO:0016303 GO:0016310 GO:0016485 GO:0016740 GO:0030496 GO:0030670 GO:0031410 GO:0032465 GO:0034162 GO:0035004 GO:0035032 GO:0036092 GO:0042149 GO:0043201 GO:0045022 GO:0045335 GO:0046854 GO:0048015 GO:0050708 GO:0051301
12	0.06	0.330	5.80	0.07	0.59	3r9rA	GO:0000166 GO:0004639 GO:0005524 GO:0006164 GO:0006189 GO:0016874
13	0.06	0.251	6.43	0.02	0.52	4kp1A	GO:0003861 GO:0008152 GO:0008652 GO:0009082 GO:0009097 GO:0009098 GO:0016829 GO:0016836 GO:0046872 GO:0047508 GO:0050075 GO:0051536 GO:0051539
14	0.06	0.258	5.31	0.07	0.43	1l0qA	GO:0016020 GO:0016021
15	0.06	0.299	5.50	0.02	0.51	4yplC	GO:0000166 GO:0004176 GO:0004252 GO:0005524 GO:0005737 GO:0006508 GO:0006515 GO:0008233 GO:0008236 GO:0016787 GO:0016887 GO:0030163 GO:0033554 GO:0043565
16	0.06	0.337	4.95	0.07	0.55	4ds4D	GO:0000166 GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0004518 GO:0006139 GO:0006260 GO:0006261 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0046872 GO:0071897 GO:0090305
17	0.06	0.352	5.08	0.03	0.57	1lrwA	GO:0005509 GO:0015945 GO:0016020 GO:0016491 GO:0016614 GO:0030288 GO:0042597 GO:0046872 GO:0052930 GO:0052931 GO:0052932 GO:0052933 GO:0055114
18	0.06	0.287	4.90	0.06	0.46	1j6xB	GO:0003824 GO:0005506 GO:0009372 GO:0016829 GO:0043768 GO:0046872
19	0.06	0.285	5.98	0.05	0.52	3k13C	GO:0005829 GO:0008168 GO:0008270 GO:0008705 GO:0008898 GO:0009086 GO:0016740 GO:0031419 GO:0032259 GO:0042558 GO:0044237 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0008289	GO:0015154	GO:0048030
GO-Score	0.51	0.42	0.42
Biological Processes	GO:0050828	GO:0034286	GO:0034288	GO:0070887	GO:0015774	GO:0033554	GO:0006935	GO:0016477	GO:0015766	GO:1902305	GO:0045087	GO:1900229	GO:0050891	GO:0019731
GO-Score	0.51	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.37	0.37	0.37	0.37	0.37
Cellular Component	GO:0098533	GO:0005887	GO:0030313	GO:0098797	GO:0005615
GO-Score	0.42	0.42	0.42	0.42	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
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