I-TASSER results

I-TASSER results for job id Rv1778c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (149 residues)
MRVSLFLSDAAQADAQSGKVHALGLGWRQCQTPTPPFALVLFLDIDWDETNKQHQLKCQL
LTADGDPVVVPGPHGPQRILFEAAAEAGRAPGAIHGTSVRMPLTLNIPAGIPLEPGIYEW
RVEVEGYERATAVEAFIVAGGGHPPASCG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 \| \| \| \| \| \| \| MRVSLFLSDAAQADAQSGKVHALGLGWRQCQTPTPPFALVLFLDIDWDETNKQHQLKCQLLTADGDPVVVPGPHGPQRILFEAAAEAGRAPGAIHGTSVRMPLTLNIPAGIPLEPGIYEWRVEVEGYERATAVEAFIVAGGGHPPASCG
Prediction	CEEEEEEHCCCCCCCCCCEEEEHCCCCEHCCCCCCCEEEEEEEEHCCCCCCCCEEEEEEEHCCCCCEEEHCCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCC
Conf.Score	95689875554445568957887443444489999879999999686548987579999986999956657999986577755789867999999877555599994898889986789999996755776678888679999998889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 \| \| \| \| \| \| \| MRVSLFLSDAAQADAQSGKVHALGLGWRQCQTPTPPFALVLFLDIDWDETNKQHQLKCQLLTADGDPVVVPGPHGPQRILFEAAAEAGRAPGAIHGTSVRMPLTLNIPAGIPLEPGIYEWRVEVEGYERATAVEAFIVAGGGHPPASCG
Prediction	65141200321424445230101111143344543211000102033731756140303033454441435347334414353314254474345435141201030433142634424030314455464131202134454346768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140

                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEEEEEHCCCCCCCCCCEEEEHCCCCEHCCCCCCCEEEEEEEEHCCCCCCCCEEEEEEEHCCCCCEEEHCCCCCCCEEEEEEEEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEEEEEEEHCCCCCCEEEEEEHCCCCCCCCCCC
MRVSLFLSDAAQADAQSGKVHALGLGWRQCQTPTPPFALVLFLDIDWDETNKQHQLKCQLLTADGDPVVVPGPHGPQRILFEAAAEAGRAPGAIHGTSVRMPLTLNIPAGIPLEPGIYEWRVEVEGYERATAVEAFIVAGGGHPPASCG

3j4uH

0.15

0.13

0.88

0.76

MUSTER

MIILLQVSDGQAVTASAASTDVIDFGQANPNTGMDRSKMVITVDESAD-AAGAATVTFSVQDSADNA------------TFADVAATGAIGKANLAAGKQ--VVIPMPTKL---RRYCRVYYTVATGPLTAKFSAQVVTGIQQNVAYPD

3j4uH

0.10

0.09

0.93

0.59

dPPAS

IDKLLQVSDGQAVTASAASTDVIDFGQANPNTGMDDRSKMVITVDESADAAGAATVTFSVQDSADNATFADVAATGAIGKANLAAGKQVVIPMPTKLRRYCRVYYTVATG-PLTAGKFSAQVVTGIQQNVAYPDSPRIA----------

3v8oA1

0.26

0.16

0.62

0.61

wdPPAS

-----------QAGVQ--KVRAWGPG---------ETGQV----------GKSADFVVEAIGTEVGGFSIEGPSQAK-IECDDK-----GDG---------SCDVRY---WPTEPGEYAVHVICDDEDIRD---PFIAHILPAPP----

3j4uH

0.16

0.14

0.86

0.77

wMUSTER

IDKLLQVSDGQAVTASAASTDVIDFGQANPNTGMDRSKMVITVDESAD-AAGAATVTFSVQDSAD------NAT------FADVAATGAIGKANLAAGKQ--VVIPMPTKLR----RVYYTVA-TGPLTAGKFSAQVVTGIPDSPRIA-

3j4uH

0.15

0.13

0.84

0.72

wPPAS

MIILLQVSDGQAVTASAASTDVIDFGQANPNTGMDRSKMVITVDESADAAGAA-TVTFSVQDSADNADVAATGAGKQ-------VVIPMPTKLRR-----CRVYYTVATG-PLTAGKFSAQVVTGIQQNVAYPDSPRIA----------

5eq2A1

0.08

0.06

0.75

0.80

dPPAS2

---------RRATDTTPPTITVPSD-----------------IIA---YRGEEFEFYFEITDDSGQELSTFGKPLGLNWLEYSEDNFNVPGNATSDNPLRVRVHGTVPLNEPIPADFTRTIRAWDAAGNVSSNITFVIKYR--------

3j4uH

0.17

0.15

0.86

0.80

PPAS

MIILLQVSDGQAVTASAASTDVIDFGQANPNTGMDRSKMVITVDESADAAGAA-TVTFSVQDSADNA------------TFADVAATGAIGKANLAAGKQ--VVIPMPTKLR----RVYYTVA-TGPLTAGKFSAQVVTGIPDSPRIA-

4rwwA

0.12

0.08

0.69

0.78

Env-PPAS

MKLIFAIVQDQDSNRKGNKLATTGGFLK-------AGNTTFIIGTEDERVEDALAI---IKENCKAREQMMTPSAS--------------LGVTVDTYVPYPIEVQVG-------GATVFVMPVESFHH------FLEHH---------

4o65A

0.14

0.13

0.97

0.72

MUSTER

LQSRFVKIEDETFSATRLITKAEFAKRTFGNSDLETLKQVDAMGCDPARRQDVLIVTGRLVSQVKQDLNAWISLFTNRWEFISRDPPGNVFTIPGGGEVPYKLCLSA-----LEPGTYHAHTQLNIASVGPGLMSIVVEGEPEKPSAWS

4ut1A2

0.12

0.09

0.76

0.57

dPPAS

------LAAGVATNSGTG---VISQGSVSAGYQLPSGTTTLAYNAASK----------TLSGFPVGTTVTIAGTPPTSINIT-----SATTPVPYDPSKGASMTISSTTQPAPSGVMNGVSVSLSGTPADG--DQFTIG----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.21

Estimated TM-score = 0.36±0.12

Estimated RMSD = 12.1±4.4Å

Download Model 2

C-score=-4.64

Download Model 3

C-score=-5.00

Download Model 4

C-score=-4.84

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3j4uH	0.603	3.34	0.137	0.826
2	4bk4A1	0.597	3.36	0.063	0.846
3	2wo2A	0.587	3.37	0.065	0.826
4	1jhnA	0.585	3.64	0.053	0.852
5	3fl7A	0.579	3.74	0.054	0.846
6	3etpA	0.576	3.43	0.040	0.832
7	4cuaA	0.573	3.86	0.078	0.852
8	5hcaC	0.569	3.84	0.068	0.859
9	4ycgA	0.568	4.00	0.061	0.839
10	3orjA	0.568	3.69	0.094	0.839

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.07	4	1ux7A	CA	Rep, Mult	6,8,9,134
2	0.05	3	1gwlA	BMA	Rep, Mult	16,57,121,123
3	0.05	3	2qbxA	III	Rep, Mult	12,13,14,44,47,48,99,130,131,132
4	0.03	2	3wnmA	GLC	Rep, Mult	12,14,130
5	0.03	2	3vbiC	BCT	Rep, Mult	75,76
6	0.03	2	2y6gA	BGC	Rep, Mult	18,81,119,121
7	0.03	2	1opoB	CA	Rep, Mult	9,14
8	0.02	1	2e26A	CA	Rep, Mult	44,46,98
9	0.02	1	2farA	MN	Rep, Mult	42,44,134
10	0.02	1	1vclA	CA	Rep, Mult	44,45,47,66
11	0.02	1	2aj8A	SC3	Rep, Mult	6,26
12	0.02	1	3achA	BGC	Rep, Mult	17,82,84
13	0.02	1	3pe7A	CA	Rep, Mult	123,125
14	0.02	1	3lm8C	VIB	Rep, Mult	48,50
15	0.02	1	1sbdA	UUU	Rep, Mult	7,20,21,116,117
16	0.02	1	2g4lA	SO4	Rep, Mult	62,64,65
17	0.02	1	2e26A	UUU	Rep, Mult	20,69,71,72,79
18	0.02	1	2c1lB	BCT	Rep, Mult	72,89

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1uwwA	0.549	3.62	0.065	0.799	3.2.1.4	42,117
2	0.060	2z4fA	0.505	3.63	0.018	0.738	2.7.10.1	107
3	0.060	1kgyA	0.572	3.67	0.063	0.839	2.7.10.1	90
4	0.060	1p8jA	0.537	3.77	0.056	0.799	3.4.21.75	NA
5	0.060	1yq2A	0.520	3.66	0.073	0.738	3.2.1.23	123
6	0.060	3c8xA	0.554	3.64	0.076	0.799	2.7.10.1	90
7	0.060	1lnsA	0.558	3.92	0.065	0.826	3.4.14.11	NA
8	0.060	1nx9A	0.564	4.00	0.045	0.839	3.1.1.43	NA
9	0.060	1kfxL	0.524	3.98	0.056	0.785	3.4.22.53	NA
10	0.060	2vtcA	0.517	4.20	0.076	0.812	3.2.1.4	58
11	0.060	2rfwA	0.548	4.05	0.072	0.859	3.2.1.91	9,21
12	0.060	3dgtA	0.521	4.29	0.089	0.826	3.2.1.39	NA
13	0.060	1a39A	0.542	4.02	0.042	0.852	3.2.1.4	13
14	0.060	2nqaB	0.314	5.12	0.036	0.557	3.4.22.53,3.4.22.52	54
15	0.060	2q1fA	0.536	3.84	0.060	0.785	4.2.2.21	35
16	0.060	3ovwA	0.534	4.06	0.057	0.852	3.2.1.4	NA
17	0.060	1eusA	0.363	4.77	0.052	0.631	3.2.1.18	NA
18	0.060	1pmjX	0.567	3.73	0.064	0.826	3.2.1.78	7,20,24
19	0.060	1eutA	0.524	3.40	0.108	0.738	3.2.1.18	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.508	3.95	0.07	0.77	2v5yA	GO:0001937 GO:0004721 GO:0004725 GO:0005001 GO:0005737 GO:0005887 GO:0005911 GO:0005913 GO:0006470 GO:0007155 GO:0007156 GO:0007165 GO:0010596 GO:0010842 GO:0016020 GO:0016021 GO:0016311 GO:0016525 GO:0016787 GO:0016791 GO:0030027 GO:0031175 GO:0031290 GO:0035335 GO:0042493 GO:0042802 GO:0045296 GO:0045909 GO:0048471
1	0.07	0.513	3.33	0.06	0.71	3j40H	GO:0098021
2	0.07	0.578	3.67	0.05	0.84	2x11A	GO:0000166 GO:0001501 GO:0001525 GO:0001568 GO:0001570 GO:0001649 GO:0004672 GO:0004713 GO:0004714 GO:0005003 GO:0005524 GO:0005622 GO:0005886 GO:0005887 GO:0005913 GO:0005925 GO:0006468 GO:0006915 GO:0007155 GO:0007169 GO:0007275 GO:0008630 GO:0009986 GO:0010591 GO:0014028 GO:0016020 GO:0016021 GO:0016032 GO:0016301 GO:0016310 GO:0016477 GO:0016740 GO:0018108 GO:0021915 GO:0030054 GO:0030154 GO:0030182 GO:0030216 GO:0030316 GO:0031256 GO:0031258 GO:0032587 GO:0033598 GO:0033628 GO:0036342 GO:0042995 GO:0043491 GO:0043535 GO:0045765 GO:0046849 GO:0048013 GO:0048320 GO:0048570 GO:0051898 GO:0060035 GO:0060326 GO:0060444 GO:0070309 GO:0070372 GO:0070848 GO:0090004 GO:0090630 GO:0098609 GO:0098641
3	0.07	0.591	3.53	0.07	0.85	4m4rA	GO:0000166 GO:0004672 GO:0004713 GO:0004714 GO:0005003 GO:0005004 GO:0005005 GO:0005524 GO:0005737 GO:0005741 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005886 GO:0005887 GO:0006468 GO:0007155 GO:0007169 GO:0007275 GO:0007399 GO:0007411 GO:0007628 GO:0008045 GO:0008347 GO:0009986 GO:0014069 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0021957 GO:0030054 GO:0030175 GO:0030424 GO:0030425 GO:0031594 GO:0031901 GO:0042731 GO:0042802 GO:0042995 GO:0043087 GO:0043197 GO:0043204 GO:0043507 GO:0043679 GO:0044295 GO:0044297 GO:0045202 GO:0045211 GO:0046777 GO:0046875 GO:0048013 GO:0048681 GO:0048710 GO:0050770 GO:0050775 GO:0061001 GO:0072178 GO:0097155 GO:0097156 GO:0097161 GO:2001108
4	0.07	0.575	3.58	0.07	0.83	3nruE	GO:0000166 GO:0001934 GO:0004672 GO:0004713 GO:0004714 GO:0005003 GO:0005004 GO:0005524 GO:0005886 GO:0005887 GO:0006468 GO:0006915 GO:0007169 GO:0007275 GO:0007399 GO:0007420 GO:0008046 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0022407 GO:0030425 GO:0031290 GO:0031594 GO:0031952 GO:0043025 GO:0043065 GO:0043281 GO:0043525 GO:0045211 GO:0045499 GO:0046875 GO:0048013 GO:0048671 GO:0048755 GO:0050730 GO:0050919 GO:0051964 GO:0070372 GO:0072178
5	0.07	0.571	3.72	0.06	0.84	3p1iA	GO:0000166 GO:0001525 GO:0001655 GO:0004672 GO:0004713 GO:0004714 GO:0005003 GO:0005524 GO:0005576 GO:0005829 GO:0005886 GO:0005887 GO:0006468 GO:0007169 GO:0007275 GO:0007399 GO:0007411 GO:0007413 GO:0008046 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016477 GO:0016740 GO:0018108 GO:0021952 GO:0022038 GO:0022407 GO:0030425 GO:0031290 GO:0034446 GO:0042995 GO:0043087 GO:0046777 GO:0048013 GO:0048538 GO:0048546 GO:0050770 GO:0051965 GO:0060021 GO:0060996 GO:0060997
6	0.07	0.569	3.64	0.05	0.83	4et7A	GO:0000166 GO:0004672 GO:0004713 GO:0004714 GO:0005003 GO:0005004 GO:0005005 GO:0005524 GO:0005791 GO:0005886 GO:0005887 GO:0006468 GO:0007169 GO:0007399 GO:0007411 GO:0009897 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0019933 GO:0021766 GO:0030424 GO:0030425 GO:0032793 GO:0032956 GO:0042995 GO:0043025 GO:0043087 GO:0048013 GO:0048471 GO:0048666 GO:0061178
7	0.07	0.564	3.70	0.08	0.83	2hleA	GO:0000166 GO:0001525 GO:0002042 GO:0003007 GO:0004672 GO:0004713 GO:0004714 GO:0005003 GO:0005524 GO:0005576 GO:0005829 GO:0005886 GO:0005887 GO:0006468 GO:0007155 GO:0007169 GO:0007275 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0046777 GO:0048013 GO:0070062
8	0.07	0.490	4.44	0.07	0.81	4l0pA	GO:0000166 GO:0004672 GO:0004713 GO:0004714 GO:0005003 GO:0005004 GO:0005524 GO:0005576 GO:0005769 GO:0005886 GO:0005887 GO:0006468 GO:0007155 GO:0007169 GO:0010717 GO:0010976 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016477 GO:0016740 GO:0018108 GO:0032956 GO:0043087 GO:0048013 GO:0051893 GO:0070507 GO:0071300 GO:0097155 GO:0097156
9	0.07	0.576	3.43	0.04	0.83	3etpA	GO:0000166 GO:0000902 GO:0001525 GO:0001655 GO:0004672 GO:0004713 GO:0004714 GO:0004872 GO:0005003 GO:0005005 GO:0005102 GO:0005524 GO:0005886 GO:0005887 GO:0006468 GO:0007169 GO:0007275 GO:0007399 GO:0007411 GO:0007413 GO:0007612 GO:0008046 GO:0009887 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0021631 GO:0021952 GO:0022038 GO:0030424 GO:0030425 GO:0031290 GO:0042472 GO:0042802 GO:0042995 GO:0043025 GO:0045202 GO:0048013 GO:0048168 GO:0048170 GO:0048593 GO:0050770 GO:0050771 GO:0050878 GO:0051965 GO:0060021 GO:0060996 GO:0060997 GO:0071679
10	0.07	0.524	3.17	0.10	0.70	4a44A	GO:0046872
11	0.06	0.451	4.89	0.04	0.74	2ibgA	GO:0001751 GO:0007224 GO:0008158 GO:0008201 GO:0008589 GO:0009986 GO:0016020 GO:0016021 GO:0035017 GO:0035222 GO:0042803 GO:0045746 GO:0045880 GO:0048749 GO:0097108
12	0.06	0.407	5.07	0.07	0.68	2q7nA	GO:0004896 GO:0004897 GO:0004923 GO:0004924 GO:0005127 GO:0005576 GO:0005886 GO:0008284 GO:0010656 GO:0014070 GO:0016020 GO:0016021 GO:0019221 GO:0019838 GO:0019955 GO:0031100 GO:0034097 GO:0038165 GO:0043235 GO:0046982 GO:0048812 GO:0048861 GO:0070062 GO:0070120
13	0.06	0.375	4.21	0.06	0.57	1tdqA	GO:0005178 GO:0005576 GO:0005578 GO:0007155 GO:0007162 GO:0007399 GO:0050767
14	0.06	0.403	4.82	0.06	0.66	3e0gA	GO:0004896 GO:0004897 GO:0004923 GO:0004924 GO:0005127 GO:0005576 GO:0005886 GO:0005887 GO:0007166 GO:0008284 GO:0010656 GO:0014070 GO:0016020 GO:0016021 GO:0019221 GO:0019838 GO:0019955 GO:0031100 GO:0034097 GO:0038165 GO:0043235 GO:0046982 GO:0048812 GO:0048861 GO:0070062 GO:0070120
15	0.06	0.383	3.58	0.06	0.56	4bq6A	GO:0004872 GO:0005654 GO:0005794 GO:0005886 GO:0005887 GO:0006355 GO:0007155 GO:0007399 GO:0007411 GO:0007520 GO:0016020 GO:0016021 GO:0030513 GO:0039706 GO:0045296 GO:0050709 GO:0051149 GO:0055072 GO:0070700 GO:0098797
16	0.06	0.398	4.59	0.07	0.64	3f7qA	GO:0001664 GO:0004872 GO:0005634 GO:0005886 GO:0006914 GO:0007154 GO:0007155 GO:0007160 GO:0007229 GO:0008305 GO:0009611 GO:0009986 GO:0016020 GO:0016021 GO:0030054 GO:0030056 GO:0030198 GO:0031252 GO:0031581 GO:0031994 GO:0035878 GO:0038132 GO:0043235 GO:0043588 GO:0048333 GO:0048565 GO:0048870 GO:0070062 GO:0072001 GO:0097186
17	0.06	0.363	4.37	0.09	0.57	4n68A	GO:0005737 GO:0005886 GO:0007155 GO:0007605 GO:0016020 GO:0031225
18	0.06	0.370	4.91	0.06	0.60	3lpwA	GO:0000166 GO:0000794 GO:0002020 GO:0002576 GO:0003300 GO:0004672 GO:0004674 GO:0004713 GO:0005509 GO:0005516 GO:0005524 GO:0005576 GO:0005634 GO:0005737 GO:0005829 GO:0005859 GO:0005865 GO:0006468 GO:0006936 GO:0006941 GO:0007076 GO:0008307 GO:0016301 GO:0016310 GO:0016740 GO:0018108 GO:0019899 GO:0019901 GO:0030018 GO:0030049 GO:0030240 GO:0030241 GO:0031430 GO:0031433 GO:0031674 GO:0035995 GO:0042802 GO:0042805 GO:0043621 GO:0045214 GO:0045859 GO:0046872 GO:0048739 GO:0048769 GO:0050790 GO:0051015 GO:0051371 GO:0051592 GO:0055003 GO:0055008 GO:0060048 GO:0070062 GO:0097493
19	0.06	0.375	3.64	0.04	0.55	4urtB	GO:0001764 GO:0004888 GO:0005042 GO:0005829 GO:0005886 GO:0006915 GO:0007275 GO:0007399 GO:0007409 GO:0007411 GO:0010977 GO:0016020 GO:0016021 GO:0021965 GO:0030424 GO:0033563 GO:0033564 GO:0038007 GO:0048671 GO:0097192 GO:1901214 GO:2000171
20	0.06	0.368	3.92	0.13	0.56	2cumA	GO:0005178 GO:0005518 GO:0005576 GO:0005578 GO:0005583 GO:0005615 GO:0005622 GO:0006629 GO:0006631 GO:0006641 GO:0007155 GO:0007160 GO:0008201 GO:0016337 GO:0030036 GO:0030198 GO:0030199 GO:0031012 GO:0032963 GO:0043206 GO:0043506 GO:0048251 GO:0070062

Consensus prediction of GO terms

Molecular Function	GO:0005515	GO:0032559	GO:0032550	GO:0035639	GO:0004714
GO-Score	0.38	0.37	0.37	0.37	0.37
Biological Processes	GO:0022610	GO:0007411	GO:0007169	GO:0006468	GO:0018212
GO-Score	0.49	0.38	0.37	0.37	0.37
Cellular Component	GO:0031226	GO:0044424	GO:0005911	GO:0005912
GO-Score	0.59	0.38	0.38	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.