I-TASSER results

I-TASSER results for job id Rv1742

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (245 residues)
MSALLDGVLDAHGGLQRWRAAETVHGRVRTGGLLLRTRVPGNRFADYRITVHVQQARTVL
DPFPRDGYRGVFESGQVRIESHDGAVISSRAHPRAAFFGRSGLRRNIRWDPLDSVYFAGY
AMWNYLTTPYLLTREGVAVEEGAPWQQEGETWRRLIVSFPPDIDTHSPRQTFYVDASGLL
RRHDYVPEVVGHWARAAHYCADPVDVDGFVFPTCRWVHPIGPGNRSLPFPTLVSILLTDI
RVETD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSALLDGVLDAHGGLQRWRAAETVHGRVRTGGLLLRTRVPGNRFADYRITVHVQQARTVLDPFPRDGYRGVFESGQVRIESHDGAVISSRAHPRAAFFGRSGLRRNIRWDPLDSVYFAGYAMWNYLTTPYLLTREGVAVEEGAPWQQEGETWRRLIVSFPPDIDTHSPRQTFYVDASGLLRRHDYVPEVVGHWARAAHYCADPVDVDGFVFPTCRWVHPIGPGNRSLPFPTLVSILLTDIRVETD
Prediction	CCHHHHHHHHHHCCHHHHHHCCEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEHCCEEEEEEHCCCCCCEEEEHCCEEEEHCCCCCEEEHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEHCCCCEEEEEHCCCEHCCEEEEEEEEEHCCCCCCCCCCEEEEHCCCCEEEEHCEEEEHCCCCCCCEEEHCCEEEHCCEHCCEEEEEEEHCCCCCHCCCCEEEEEEEEEEEEHCC
Conf.Score	85899999999876999876777999999856543446788876657999995775899987678995899868889998589957753357466646787654456777555567877888888766634458997898856746688888899999889878888766899788754777666999858888754555465887888868577788858998556776689999989999869
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MSALLDGVLDAHGGLQRWRAAETVHGRVRTGGLLLRTRVPGNRFADYRITVHVQQARTVLDPFPRDGYRGVFESGQVRIESHDGAVISSRAHPRAAFFGRSGLRRNIRWDPLDSVYFAGYAMWNYLTTPYLLTREGVAVEEGAPWQQEGETWRRLIVSFPPDIDTHSPRQTFYVDASGLLRRHDYVPEVVGHWARAAHYCADPVDVDGFVFPTCRWVHPIGPGNRSLPFPTLVSILLTDIRVETD
Prediction	73620440052220253055153030303332311324245552552403030544403145144552303044530203367353254164145305444434241403411000000001113220001033460416525415564641440303137415334642302025602022240303124654421310232451430301332302233674442243010102034141548
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHCCHHHHHHCCEEEEEEEHCCCCCCCCCCCCCCCCEEEEEEHCCEEEEEEHCCCCCCEEEEHCCEEEEHCCCCCEEEHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEHCCCCEEEEEHCCCEHCCEEEEEEEEEHCCCCCCCCCCEEEEHCCCCEEEEHCEEEEHCCCCCCCEEEHCCEEEHCCEHCCEEEEEEEHCCCCCHCCCCEEEEEEEEEEEEHCC
MSALLDGVLDAHGGLQRWRAAETVHGRVRTGGLLLRTRVPGNRFADYRITVHVQQARTVLDPFPRDGYRGVFESGQVRIESHDGAVISSRAHPRAAFFGRSGLRRNIRWDPLDSVYFAGYAMWNYLTTPYLLTREGVAVEEGAPWQQEGETWRRLIVSFPPDIDTHSPRQTFYVDASGLLRRHDYVPEVVGHWARAAHYCADPVDVDGFVFPTCRWVHPIGPGNRSLPFPTLVSILLTDIRVETD

3buuA

0.12

0.10

0.78

1.20

wdPPAS

VTSILEKADEIRFP------QDSFQVNVAI-----RTAAPDHAEDLYRYQVLSKENSIVITEPASERGQAILKGRDLWVFPSVSQPIRLSLSQRLT--------------------VANGDIAR-------FTGD-YHPQLLRNESIDDEDYYVLELTGIDRSVTYQ-KVLLWVNQSNFR----YKAEFYSVSGR-TSRYENFDNILGER--PTRIIEDALKSGE------VSVLDYSDKLRDLP

3buuA

0.13

0.11

0.79

1.04

wPPAS

VTSILEKADEIRFPQDSF----QVNVAIRT-------AAPDHAEDLYRYQVLSKENSIVITEPASERGQAILKGRDLWVFPSVSQPIRL--SLSQRLTGQ----------------VANGDIAR-------FTGD-YHPQLLRNESIDDEDYYVLELTGIDRSVTYQK-VLLWVNQSNFR----YKAEFYSVSGR-TSRYENFDNILGER-PTRIIEDALKSGE-------VSVLDYSDKLRDLP

3v9fA1

0.09

0.07

0.84

1.53

dPPAS2

L------WFATEEGLNKFDGTRFITYYKEEQSSSVQSITGNEL---NEVYTDPVQPVIWIATQRAGLNAYNYETQSFSVYQYNPEDPQSLITNDVTHITSSVQAGKGLW--------------------VCTYYRGIEYLDIATG--------KFTHYNKSTVPALPSEWTATEAEDGYIGHVEGGLSILSLNDKSVKHFVHYKDTNGIWIGTSKGLALFNANTETF---TNLSSYIFSIKQLKD

3buuA

0.12

0.09

0.81

1.11

Env-PPAS

AQSILEKADEIRFPQDSF----QVNVAIRT-------AAPDHAEDLYRYQVLSKENSIVITEPASERGQAILKGRDLWVFPSVSQPIRLSLSQR----------------------LTGQVANGDIARANFTGD--YHPQLLRNESIDDEDYYVLELTGIDRSVTYQ-KVLLWVNQSFRPYKAEFYS--VSGRLLKTSRYENFDNILGER-PTRIIEDALKSGE-------VSVLDYSDKLRDLP

4fu4A

0.09

0.95

1.42

dPPAS2

MTSEVEKAFKKA--FKVWSDVTPLNFTRLHDGIADIMISIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG------DEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKI----SELGLPKE

4ld1A

0.18

0.11

0.60

1.30

dPPAS2

-------------------------------------------LPDGGRLVVFPNGTRKELSADGQTVKVMFFNGDVKHTMPDQRVIYYYAE--------AQTTHITYPDGMEVLQF----------------PNN-QTEKHFP---DG----RKEITFPDQTVKHPDGREESVLTDGTIIQLDGSKVIQFNTGQREIHTADFKRREG-------TVKTVYSDGRQYPT----------------

2qc5A

0.12

0.10

0.82

1.30

dPPAS2

DSGPYGITSSEDG---------KVWFTQHKANKISSLDQSGRI---KEFEVPTPDAKVMCLIVSSLGDFTENGANKIGKLSKKGGFTEYPLPQPDTEGLNGDIWFTQLNGDRIG----------------KLTADGTIYEYDLPN--KGSYPAFITLG-SDNFTENQNNSIGRITNTG-----KLEEYPLPTNAAAPVGI--TSGNDGFVEIMGNKIGRITTTGE------ISEYDPHAITAGKN

3hxjA

0.10

0.08

0.82

1.22

dPPAS2

GS-------------------DKVYAINPDGTEKWRFDTSDFTIFEDILYVTSDTEKWRFKTKKAIYATPIVSEDTIYVGSNDNYLYAINPDGTERFKTNDAITSAASIGKDGTIYFGS-------DKVYAINPDGTEKWNFYAGYWT-----------VTRPAISEDGTIYVTSLDGHLYAINWRFKTGKRIESSPVIGNTFGSYDGHLYPDGTEKWNFETGSWIIATPVIDE--------NGT

4q98A2

0.10

0.09

0.91

0.78

MUSTER

-TSLTAENQNA-------KNLIRVHAGISFAGVEVNATQYQNYYKPADAKIAALVAKKDSKIFGNS---LVSNTNAYLYGVQTPAGLYTPDAAGETYELEASLNTNYAVGA----GFYVLESKYDASNE---LRPTILCIYGKLLDKDGNPLTEPALTDAINAGFCDGDGTTYYP--VLVNYDGNGYIYSGAITQGQNKIVRNNHYK-ISLNITGPGTNTPENPQPVQANLNVTCQVTPWVVVNQ

4z48A

0.13

0.11

0.85

0.83

dPPAS

DPVKAGYDLAVRDQVDTSQDSYSEAVSINRGGKVLTRKHFGKDGKDEYSLIVFDRYLVWSYRGLEQDDDWVYLPAESLVRRISG------SSKFASFRSDLSNEDIQNLDD----------------------VDEYDYLLQGEENVDGIDCYILERTPKKGKETQYSRQVQWVRKDTLLRLRADYYD-KKDRLVKKLFFSRQEKIDGIWTVTQRVERPREG--------SFTVIDWSNLRYDVG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.13

Estimated TM-score = 0.46±0.15

Estimated RMSD = 10.6±4.6Å

Download Model 2

C-score=-4.79

Download Model 3

C-score=-3.42

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3buuA	0.675	2.94	0.065	0.808
2	4z48A	0.658	3.16	0.110	0.812
3	3bk5A	0.643	3.24	0.076	0.800
4	1iwmA	0.528	3.72	0.065	0.690
5	2w7qA	0.524	3.53	0.061	0.669
6	4d51A	0.486	5.32	0.050	0.755
7	2zpdA	0.483	3.80	0.063	0.641
8	3bryA	0.478	5.30	0.064	0.739
9	1lshA2	0.475	4.56	0.053	0.686
10	3bs0A	0.471	5.56	0.057	0.759

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	3bmzA	PG4	Rep, Mult	28,49,60,123,124,215,235,237
2	0.06	3	1q5yA	NI	Rep, Mult	8,12
3	0.04	2	3pguA	NA	Rep, Mult	202,203,205,209
4	0.04	2	1icrA	NIO	Rep, Mult	135,136
5	0.02	1	2f2hA	XTG	Rep, Mult	5,6
6	0.02	1	2v43A	CYS	Rep, Mult	139,142,156,169,171
7	0.02	1	1ycfA	ZN	Rep, Mult	198,202
8	0.02	1	2w4zC	AMP	Rep, Mult	173,182
9	0.02	1	2qtkA	C8E	Rep, Mult	27,46,236,238
10	0.02	1	3kniH	MG	Rep, Mult	208,209
11	0.02	1	2y2xA	C8E	Rep, Mult	27,200,214,216,234,236
12	0.02	1	1ib4A	MAN	Rep, Mult	23,52
13	0.02	1	3uomA	CA	Rep, Mult	141,165
14	0.02	1	1tlzB	URI	Rep, Mult	47,60,69,71
15	0.02	1	3pyrY	MG	Rep, Mult	5,132,137
16	0.02	1	3fidB	CXE	Rep, Mult	56,58,71,73,78
17	0.02	1	1khrA	VIR	Rep, Mult	137,173,175
18	0.02	1	3m4wA	III	Rep, Mult	38,215,230,233,235
19	0.02	1	1uynX	CXE	Rep, Mult	200,202,204,214,216

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1usrA	0.379	5.54	0.050	0.612	3.2.1.18	NA
2	0.060	2h5uA	0.364	6.18	0.035	0.657	1.10.3.2	NA
3	0.060	1zwxA	0.439	5.64	0.041	0.727	3.1.4.12	NA
4	0.060	2jf6B	0.418	6.04	0.053	0.718	3.2.1.105	NA
5	0.060	1kyaA	0.363	6.07	0.036	0.645	1.10.3.2	NA
6	0.060	3gnrA	0.408	6.29	0.033	0.731	3.2.1.21	NA
7	0.060	1rm6A	0.421	5.64	0.069	0.686	1.3.99.20	NA
8	0.060	1np2A	0.407	6.02	0.049	0.710	3.2.1.21	NA
9	0.060	2hrgA	0.365	5.88	0.068	0.629	1.10.3.2	NA
10	0.060	1od0B	0.414	6.11	0.075	0.722	3.2.1.21	NA
11	0.060	1im0A	0.426	5.21	0.037	0.657	3.1.1.32,3.1.1.4	158
12	0.060	1dgjA	0.416	5.61	0.065	0.661	1.2.-.-	NA
13	0.060	2o06A	0.415	5.65	0.077	0.690	2.5.1.16	10,159
14	0.060	3aboA	0.412	5.94	0.051	0.710	4.3.1.7	NA
15	0.060	2cygA	0.410	6.04	0.048	0.722	3.2.1.39	140
16	0.060	1z4zA	0.430	6.06	0.051	0.747	3.2.1.18	NA
17	0.060	1qoxA	0.412	6.14	0.053	0.718	3.2.1.21	NA
18	0.060	3i4zA	0.415	5.21	0.069	0.641	2.5.1.34	125
19	0.060	2ddtA	0.433	5.60	0.032	0.714	3.1.4.12	239

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.524	3.53	0.06	0.67	2w7qA	GO:0006810 GO:0008565 GO:0015031 GO:0042597 GO:0042953 GO:0042954 GO:0044874 GO:0072323
1	0.07	0.529	3.74	0.07	0.69	3wjtA	GO:0006810 GO:0008565 GO:0009279 GO:0015031 GO:0016020
2	0.07	0.491	4.94	0.05	0.73	4v3gA	GO:0016021 GO:0098657
3	0.07	0.489	3.70	0.06	0.64	2zpcA	GO:0006810 GO:0008565 GO:0015031 GO:0030288 GO:0042597 GO:0042953 GO:0042954 GO:0044874 GO:0072323
4	0.07	0.496	3.68	0.04	0.64	4ki3I	GO:0006810 GO:0008565 GO:0015031 GO:0042597 GO:0042953 GO:0042954
5	0.06	0.313	6.10	0.04	0.55	1r88A	GO:0005576 GO:0016740 GO:0016746
6	0.06	0.342	6.10	0.04	0.59	3wt0D	GO:0005886 GO:0007049 GO:0008360 GO:0009898 GO:0016020 GO:0032153 GO:0043093 GO:0051301
7	0.06	0.361	6.31	0.03	0.66	3sajC	GO:0001919 GO:0001965 GO:0004872 GO:0004970 GO:0004971 GO:0005216 GO:0005234 GO:0005769 GO:0005783 GO:0005789 GO:0005829 GO:0005886 GO:0006810 GO:0006811 GO:0007616 GO:0008179 GO:0008328 GO:0009636 GO:0009986 GO:0010226 GO:0014069 GO:0014070 GO:0016020 GO:0016021 GO:0019228 GO:0019901 GO:0019904 GO:0021510 GO:0030054 GO:0030165 GO:0030425 GO:0031267 GO:0031489 GO:0031594 GO:0031623 GO:0031681 GO:0031698 GO:0032279 GO:0032281 GO:0032355 GO:0034220 GO:0035235 GO:0035249 GO:0042220 GO:0042493 GO:0042802 GO:0042803 GO:0042995 GO:0043005 GO:0043025 GO:0043197 GO:0043198 GO:0043234 GO:0043434 GO:0044309 GO:0045202 GO:0045211 GO:0045838 GO:0046685 GO:0048167 GO:0050804 GO:0050806 GO:0051018 GO:0051602 GO:0060076 GO:0060992 GO:0071230 GO:0071359 GO:0071363 GO:0071375 GO:0071407 GO:0071418
8	0.06	0.305	5.35	0.05	0.49	3c8wA	GO:0016829 GO:0047602
9	0.06	0.338	6.34	0.07	0.61	5ez3B	GO:0003995 GO:0008152 GO:0016491 GO:0016627 GO:0050660 GO:0055114
10	0.06	0.315	6.15	0.06	0.57	4w8iA	GO:0003824 GO:0008117 GO:0016829 GO:0016831 GO:0019752 GO:0030170
11	0.06	0.336	6.37	0.04	0.62	1kblA	GO:0000166 GO:0003824 GO:0005524 GO:0006090 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872 GO:0050242
12	0.06	0.321	4.50	0.04	0.46	2ft9A	GO:0005215 GO:0005504 GO:0005737 GO:0006810 GO:0008289
13	0.06	0.310	6.30	0.07	0.56	3hnaA	GO:0000122 GO:0002039 GO:0005634 GO:0005654 GO:0005694 GO:0006306 GO:0008168 GO:0008270 GO:0009790 GO:0016279 GO:0016568 GO:0016571 GO:0016740 GO:0018024 GO:0018026 GO:0018027 GO:0032259 GO:0034968 GO:0045892 GO:0046872 GO:0046974 GO:0046976 GO:0051567 GO:0060992 GO:0070734 GO:0070742 GO:1901796
14	0.06	0.297	5.80	0.04	0.50	5a9q5	GO:0000059 GO:0000776 GO:0000973 GO:0003723 GO:0005215 GO:0005487 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005829 GO:0006260 GO:0006405 GO:0006406 GO:0006409 GO:0006810 GO:0006913 GO:0006999 GO:0007062 GO:0007077 GO:0008139 GO:0010827 GO:0015031 GO:0016020 GO:0016032 GO:0016925 GO:0017056 GO:0019083 GO:0031047 GO:0031080 GO:0031965 GO:0034398 GO:0034399 GO:0042277 GO:0042405 GO:0044614 GO:0044615 GO:0051028 GO:0051292 GO:0075733 GO:1900034
15	0.06	0.262	6.72	0.01	0.50	3gygA
16	0.06	0.250	4.49	0.08	0.35	1s66L	GO:0000155 GO:0000160 GO:0000287 GO:0005622 GO:0006351 GO:0006355 GO:0016787 GO:0019826 GO:0020037 GO:0023014 GO:0046872 GO:0050896 GO:0070482 GO:0071111
17	0.06	0.271	6.22	0.04	0.48	5ex1C	GO:0000413 GO:0003755 GO:0006457 GO:0016853
18	0.06	0.239	4.89	0.07	0.36	2gt4A	GO:0000287 GO:0008727 GO:0009103 GO:0016787 GO:0030145 GO:0046872 GO:0047917

Consensus prediction of GO terms

Molecular Function	GO:0022892
GO-Score	0.48
Biological Processes	GO:0071702	GO:0045184	GO:0044872	GO:0044765
GO-Score	0.48	0.48	0.37	0.37
Cellular Component	GO:0044464
GO-Score	0.30

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.